본태성 혈소판 증다증 2예

주기산,임현성,김미자,양태영,허경,김완중,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Essential thrombocythemia is a chronic myeloproliferative disorder of unknown origin, charcterized by excessive number of morphologically and functionally abnormal platelet in peripheral blood and abnormal proliferation of megakaryocytes in bone marrow. Its main clinical manifestations are hemorrhages and thromboses. The aim of therapy is suppression of the excessive bone marrow activity, which can be achieved by radioactive phosphorus, alkylating agent, hydroxyurea and interferon. Two cases were diagnosed at our hospital which had laboratory and clinical features compatible with this disease. We have successfully treated patient with hydroxyurea and platelet antiaggregating agent.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

유색 보리 종실의 품종별 색소 특성

주완택,민경수,박노동 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4

유색보리 4품종과 보통보리 4품종 종실의 종피에 함유되어 있는 색소의 특성을 분석하여 해당작물의 신품종 육성시 우수계통 선발에 유용한 자료를 제공코자 하였다. 유색(검정)쌀보리인 Ab2231을 표준시료로 하여 실험한 결과 에탄올의 농도가 80%일 때 색소추출 효율이 양호하였다. 80% 에탄올에 1.0% 염산을 첨가한 것이 추출효율이 가장 좋았다. 추출시간에 따른 추출효율성을 조사한 결과 1시간 추출이면 충분하였다. 추출된 색소의 안정성을 유지하기 위하여 첨가시키는 산의 적정농도를 알아본 결과 1.0% HCl을 첨가한 농도에서 가장 낮은 색소량 감소율이 나타났다. 각 보리 품종 시료에서 추출한 색소의 흡광스펙트럼을 조사하였던 바, Ab2231의 그것은 535㎚에서 최대흡광파장을 나타내어 안토시아닌계 색소로 판단되었으며, 호계4호의 그것은 안토시아닌계 이외의 색소를 주로 함유하는 것으로 보였다. 한편, 추출된 색소의 특성에 따라 유색보리의 품종은 Ab2231와 모찌무기로 대표되는 쌀보리 그룹과 Lion과 호계4호로 대표되는 겉보리 그룹으로 분류되었다. The characteristics of the pigments extracted from grains of the colored barley varieties Ab2231. Mozzimugi, Lion, and Hogye 4 were studied. Extraction of the pigments from powder (80 mesh) of the barley grains was most efficient in 80% ethanol containing 1.0% HCI for 1 hr at 60℃. The pigments were also stable in 80% ethanol containing 1.0% HCI. Depending on the absorption spectra, maximal peak wavelength, and the ratio of A_(440)/Anu_(max), the varieties were separated into two groups, colored naked barley (Ab2231 and Mozzimugi) and colored covered barley (Lion and Hogye 4).

다량의 하부위장관출혈이 병발된 Vibrio vulnificus 패혈증 1예

최주연,유진홍,한석원,이대훈,최민호,박순민,김연식,김선우,신완식,강문원,강성구 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

최근 저자들은 Vibrio vulnificus 감염에 의해 패혈증 및 이차성 피부 병변을 보인 42세의 남자 환자의 치료중 하부 위장관 출혈이 병발된 1예를 경험하였기에 보고하는 바이다. We experienced a case of Vibrop vulnificus septicemia which showed an unusual manifestation such as hematochezia. The patient was a 42-year-old man with chronic liver disease. The blood and wound culture revealed the organism. During intensive care, he suffered from massive hematochezi for several days. Colonoscopy and abdominal CT showed findings suspicious of ischemic colitis. To our knowledge, this is the first unusual case of V.vulnificus infection which showed massive lower gastrointestinal bleeding.

STS 교육운동의 국내 연구 경향 분석과 적용 방안에 관한 조사 연구

정완호,권용주,김영신 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1

The purposes of this study are to analyse trend of STS movement in Korea and to collect basic data on application of STS to school science education. It investigated, from 1990 to March 1993, journals of 6 associations, a monthly magazine of science education, and printed materials of seminars or workshops about science education. It also surveied a question to 47 science teachers and 26 researchers who had experienced STS workshop. The results of the study are as follows: (1) The studies of STS increased since 1990, but they are made at a introduction or background of STS. (2) The 98.7% of the respondents want to apply STS in school science education. (3) They responded that a device for the application of STS which is added last part of each chapter or last chapter, will use the STS program that made by subject, still maintain current science curriculum. (4) They responded that the knowledge & compreshion domain and inquiry process domain contain more high than others. (5) The STS subjects for application to the school science education are as follows: Environment pollution, science for living, ethics of science, human health and disease, information communication, an ecosystem destruction, development and storage of natural resources. This study suggested that establishment of a research institute for systematic research of STS, in-service training, a new evaluation process, a balancing of other subjects and increasing learning hour and changing objectives.

STS 프로그램이 중학생들의 과학에 관련된 태도에 미치는 효과

정완호,김영신,권용주 한국교원대학교 과학교육연구소 1995 청람과학교육연구논총 Vol.5 No.1

The purpose of this study was to evaluate the effects of STS Programs on science-related attitude of junior high school students. For this study, samples of 198 students who are in grade 8 were selected. The eight STS Programs were used in this study. One group pretest-posttest design was used in this study as an experimental design. The TOSRA was used in this study as the science-related attitude evaluation instrument. The major results of this study are as followings: 1. The effects of STS programs about the junior high school students' science-related attitude indicated that there were no statistically significant differences between pretest and posttest. 2. Total students were classified as high(above about mean) or low (bellow about mean) on the basis of science-related attitude pretest scores. The low level students have improved from using of STS programs in teaching science on science-related attitude scores. The high level students have dropped from using of STS programs in teaching science on science-related attitude scores.

Streptococcus mutans의 우식 활성에 미치는 Propolis의 효과

송완엽,백병주,주훈,김대범,송요한 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

Propolis, a natural resinous product collected by honey bees, is known to exhibit various biological activities including anti-microbial, anti-inflammatory, and anti-tumor activities. The present study was designed to investigate the effects of ethanol extracted propolis(EEP) on the growth, glucosyltransferase(GTase) activity, and adherence to the saliva-coated hydroxyapatite(S-HA) beads of Streptococcus mutans JC-2(serotype c), S.mutans LMM-7(serotype e), and S. mutans OMZ-175(serotype f) in vitro. We found that the EEP had minimal inhibitory concentrations of 500-1000㎍/㎖ against S.mutans strains when these strains were cultured for 48 hours, and inhibited both water-insoluble and water-soluble glucan synthesizing GTase activities of S. mutans strains to the 93-100% at the concentration of 1600㎍/㎖, and also we found that the EEP inhibited the adherence of S. mutans strains to S-HA beads to the 76-96% at the concentrations of 200㎍/㎖. These results indicate that EEP has anti-cariogenic activity in vitro.

6개원소로 이루어진 짝이중결합화합물과 AsCl_3와의 반응

주완철,육명화,김용주 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.2

6개의 원소로 이루어진 오르토히드록시짝이중결합화합물, 즉 시남알데히드-오르토-히드록시아닐(cinnam-aldehyde-ortho-hydroxyanil), 벤질모노히드록시아닐(benzil-mono-hydroxyanil), 오르토-히드록시벤잘아세톤페논(ortho-hydroxy benzalacetophenone)과 알진트리클로라이드(AsCI_3)와의 반응으로부터 고체반응생성물을 분리해 냈다. 이들 반응생성물의 적외선 및 자외선분광학으로부터, 이들 모든 반응생성물은 비소의 전하이동착물임을 획인했다. 이 반응으로부터 3원자가 비소화합물의 화학적거동이 인의 3원자가 화합물과 유사하지 않다는 것을 알 수 있었다. Solid products were isolated by the reaction of orthohydroxy-6-membered conjugated system such as cinnamaldehyde-ortho-hydroxyanil, benzil-mono-orthohydroxyanil and ortho-hydroxybenzalacetophenon with AsCl_3. All of these products were confirmed to be Charge-transfer complexes of As from the examination of IR and UV spectra. It could be found that the chemical behavior of trivalent As is not analogous with that of triv alent P.

초등학교 학생들의 비례논리 전략의 발달에 대한 연구

정완호,권용주,김영신 한국교원대학교 과학교육연구소 1998 청람과학교육연구논총 Vol.8 No.1

The purpose of the present study was to investigate the development of elementary school student's reasoning strategies used in proportional tasks. Three hundred and ninety elementary students were sampled to investigate their reasoning strategies used in Pouring Water Tasks. Results showed that 4 percentage of students used proportional reasoning strategy. By the way, about 80% of students used qualitative guess or additive strategies to solve proportion tasks. Further, about fifth-grade or 11-year-old students began to use proportional reasoning strategy. Also, female and male students' development of reasoning strategies improved from 1st grade across 5th grade and from 6-year-old across 11-year-old. However, female did not show the improvement of strategy development after 5th-grade or 11-year-old. However, male students showed a continuous improvement after the grade or age. In addition, students showed developmental patterns of spurts and plateau, rather than a linear developmental pattern. The present study also discussed educational implications of this findings in school curriculum.

G.E. 레싱과 J.M. 괴쩨와의 단편 논쟁

맹주완 한국헤세학회 2003 헤세연구 Vol.10 No.-

1. 「Von Verschreiung der Vernunft von den Kanzeln」 2. 「Unmoglichkeit einer Offenbarung, die alle Menschen auf eine gegrundete Art glauben konnten」 3. 「Durchgang der Israeliten durchs Rote Meer」 4. 「Daβ die bucher des AT nicht geschrieben worden, eine Religion zu offenbaren」 5. 「Uber die Auferstechungsgeschichte」 Hayptpastor Goeze schaltet sich erstmalig am 17. Dezember 1777 in den Streit ein. Lessing antwortet hinfort auf die Angriffe des Hauptpastors Goeze gegen den Ungenannten mit dem Titel: 「Anti-Goeze」. Der Lessing Goeze-Streit wird aber durch herzoglichen Erlass gewaltsam beendet. Am 6. Juli wird Lessing der weitere Druck und Vertrib der Beitrage verboten. Die grundlegenden Differenzen des Goeze-Lessing-Streits gab es wegen des Verstandnises der Religion bzw. der Bibel. Lessing schrieb einmal Folgendes: "Die Wunder, die Christus und seine Junger taten, waren das Geruste, und nicht der Bau. Das Geruste wird abgerissen, sobald der Bau vollendet ist." Goeze dagegen insistierte auf einem am Buchstablichen ausgerichteten Verstandnis: "Auf den Lehren und Taten Christi und der Apostel beruhet also die gesamte christliche Religion. Woher konnen wir nun diese Lehren und Taten wissen ? allein aus den Schriften der Evangelisten und Apostel."