小物 Feeding을 위한 專用 自動化 기기의 開發

장종훈(Jang Jong_hun),김재열(Kim Jae_yeal),홍석주(Hong Suk_ju) 한국생산제조학회 1997 한국공작기계학회 추계학술대회논문집 Vol.1997 No.-

측두엽 간질 환자에서 언어 우성 반구의

이주헌,강중구,이상암 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

렙틴 수용체가 형질 도입된 신경세포에서 ER Stress로 유도된 렙틴저항성에 대한 일산화탄소의 억제작용

김성주,김택상,류현열,정헌택 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

연구 배경 및 목적: 렙틴이 음식의 섭취 양과 체중의 증가를 억제하는 중요한 호르몬 역할을 한다는 사실은 잘 알려졌다. 또한 렙틴에 대한 저항성이 비만의 중요한 원인이라는 연구가 많이 보고되고 있다. 그러나 렙틴 저항성에 대한 구체적인 기전은 아직 밝혀져 있지 않았다. 최근 endoplasmic reticulum (ER) 스트레스에 의한 unfolded protein response (UPR) 가 렙틴에 대한 저항성을 유발한 다는 보고가 있었다. 연구 대상 및 방법: 일산화탄소(carbon monoxide, CO)는 heme oxygenase (HO)-1이 헴(heme)을 산화적 분해로 만들어내는 무색, 무미, 무취의 기체로 항산화, 항염증, 항세포분열 및 항세포고사 작용을 나타내며 조직의 손상에 대한 세포보호작용을 한다. 최근 CO는 ER stress sensor 중의 하나인 protein kinase R-like endoplasmic reticulum kinase (PERK) 를 선택적으로 활성화 시키며 인산화된 PERK 는 HO-1의 전사조절인자인 Nrf2를 인산화로 활성화시켜 결국 HO-1의 유전자 발현을 촉진함이 보고 되였다. 또한 CO로 유도된 PERK의 활성화는 eukaryotic translation initiation factor (eIF) 2a를 인산화로 활성화 시키고 인산화된 eIF2a는 전사인자인 activating transcription factor (ATF)-4의 발현을 유도하지만 CO는 ER stress의 다른 두 개 sensors인 inositol requiring enzyme (IRE) 1a와 하위신호전단물질인 X-box binding protein (xbp)-1이나 ATF6의 활성화에는 영향을 미치지 아니한다. 그러나 ER stress 유발인자들인 thasigargin (TG), tunicamycin (TM), homocysteine 등으로 Xbp-1이나 ATF6가 활성화되는 것을 억제한다. 연구 결과: 본 연구에서는 ER stress 에 의해 활성화되는 UPR에 의해 유발되는 렙틴 저항성이 CO에 의하여 차단될 것이라는 가정을 세우고 다음과 같은 실험결과를 얻었다. TG나 TM에 의해 유도된 ER stress반응 즉 UPR은 렙틴의 신호전달로 야기되는 phospho-signal transducer and activation of transcription (STAT) 3로 인산화되는것을 억제시켰다. 그러나 ER stress를 유도시킬 시 CO를 CO releasing molecule (CORM)으로 처리하였을 때 UPR에 의한 렙틴의 신호전달로 말미암는 STAT3 인산화의 차단이 CO의 양과 노출 시간에 비례하여 제거 되었다. 결론: 이러한 실험결과는 CO에 의한 PERK 인산화는 ER stress 유도체에 의한 IRE1a의 하위 신호전달물질인 Xbp-1 이나 ATF6의 활성화를 억제하여 ER stress 반응인 UPR에 의한 렙틴 저항성을 차단함을 시사한다. 결론적으로 이러한 실험결과는 CO유도체를 이용하여 병인적인 렙틴 저항에 의한 여러 질병을 치료할 수 있음을 시사한다. Background: It is well known that leptin is an important circulating signal for the inhibition of food intake and the gain of body weight. Accumulating data suggest that leptin resistance has been considered to be one of the main causes of obesity. However, the detailed mechanism of leptin resistance is not known yet. Recently, endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) is reported to be responsible for the leptin resistance. Materials & methods: Carbon monoxide (CO), a reaction product of the cytoprotective heme oxygenase (HO)-1, is anti-apoptotic in a variety of models of cellular injury. Exogenous CO activated Nrf2 through the phosphorylation of protein kinase R-like endoplasmic reticulum kinase (PERK), resulting in HO-1 expression. CO-induced activation of PERK was followed by the phosphorylation of eukaryotic translation initiation factor 2a and the expression of activating transcription factor 4. However, CO fails to induce X-box binding protein-1 expression and activating transcription factor 6 cleavage. CO prevented X-box binding protein-1 expression and activating transcription factor 6 cleavage induced by ER-stress inducer such as thasigargin (TG), tunicamycin (TM) and homocysteine. Results: In the present study, we hypothesized that exogenous CO might block the leptin resistance which is induced by UPR during ER stress. Thasigargin or tunicamycin was used to induce ER stress. The activation status of leptin signals were measured by western blotting analysis using a phospho-signal transducer and activation of transcription3 (STAT3) antibody. In this study, ER stress markedly inhibited leptin-induced STAT3 phosphorylation. Conculusion: These results suggest that ER stress induces leptin resistance and exogenous CO-induced phosphorylation of PERK branch reversed ER stress-induced leptin resistance. Moreover, CO releasing molecule (CORM) blocks the inhibition of leptin-induced STAT3 phosphorylation. Together, the pathological mechanism of leptin resistance could be ameliorated by the use of exogenous CO..

요통을 호소하는 신병들의 정신의학적 특성

이종훈,조주연 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

저자는 요통을 호소하는 입대한 장병들의 정신의학적 특성을 알아보기 위해 본 연구를 시도하였다. 환자군은 1996년 9월 6일부터 11월 15일사이에 ○○사단 신병교육대에 입대한 48명이고, 대조군은 이들과 같은 시기에 입대한 장병중에서 통증을 호소하지 않는 장병 48명을 무작위 추출하였다. 각 군은 MMPI, Beck의 우울척도, Zung의 자가통증척도, 그리고 Barron의 자아강도척도를 실시했다. 자료는 chi-square test 또는 t-test에 의해 분석되었다. 검사의 결과는 다음과 같다. 1) 인구학적 변인상 환자군이 경제적으로 낮은 계층에 더 많이 분포한다(p<.05). 2) Beck의 우울척도와 Zung의 자가통증 평가척도는 환자군에서 유의하게 더 높았다(p<.01). 3) 다면적 인성검사에서 양군 모두 각 척도별 T 점수의 평균값은 정상범위 내에 있었다. 4) 다면적 인성검사는 환자군에서 척도 Pa(p<.05)와, 척도 F, Hs, D, Hy, Pd, Pt, Sc(p<.01)가 유의하게 더 높은 점수를 보여주었다. 5) 자아강도척도는 환자군에서 대조군에 비해 더 낮았다(p<.01). 이와 같은 소견은 요통환자가 정서적인 요인들과 강하게 관련되어 있다는 기존의 가설을 강하게 지지하고 있다. Objectives & Methods : The authors had attempted to find psychiatric characteristics of recruites who had complained lumbar pain. The patient group were 48 recruites who had admitted at recruit training center of the OO division from September 6 1996 to November 15 1996. The control group were 48 healthy recruites who had been chosen randomly during the same period. Each group had been examined by MMPI, BDI(Beck's depression inventory), Zung's self-rating pain & distress scale, and Barron's ego strength scale. The data were analyzed by chi-square test or t-test. Results : The results of this study were as follows : 1) On demographic data, patient group had distributed more common in lower level of economic status(p<.05). 2) The score of BDI & Zung's self rating pain & distress scale of patients group were significantly higher than those of control group(p<.01). 3) The mean T-score on each scale were within normal rang in both group. 4) The group of patients showed significantly higher score on scales of Pa(p<.05), and scales of F, Hs, D, Hy, Pd, Pt, Sc(p<.01). 5) Ego strength of patients group was significantly lower than that of control group(p<.01). Conclusion : This finding supports the existing hypothesis that lumbar pain patients are strongly related to emotional factor.

가정 주부의 골프 참여와 생활 만족도와의 관계

이공훈,함주현,최종인 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This study purpose for figuring out the influence on household life satisfaction of Golf participation of Married women. The target of this study is 350 married women who participate in playing golf, The survey tool was inspection sheet, The autonomous variable is social population(ages, incomes, school career) and extent of Golf participation (participation career, frequency of weekly participation, daily playing hour) and suboridinate varibles was Household life satisfactions, The result was Household life satisfactions. The result was followed by arranging the data. The date was collected by using spess 10.0 setting up technical statistics and one way-ANOVA. The result follows ; like these: First, There wasn't any difference between the ages of married women and Household life satisfaction(p>.05). Second, The household life satisfaction depended on their ducational careers(p<.001). Third, The household life satisfaction depended on their incomes(p<.001). Forth, The household life satisfaction depended on their golf participation careers(p<.05). Fifth, The household life satisfaction depended on the extent of weekly using golf field(p<.001). Sixth, The household Life satisfaction depended on ther daily hours at golf field(p<.05). From these results we concluded that the household life satisfaction was higher when their school careers incomes and intensity of participations.

저장안정성이 개선된 천연장 소시지의 제조를 위한 감마선 조사

이주운,조철훈,변명우 경산대학교 생명자원개발연구소 2001 생명자원과 산업 Vol.5 No.-

Quality properties in the sausage stuffed into the irradiated natural lamb and pork intestine for manufacturing the high quality emulsion-type meat produces were studied. The microbial changes of irradiated casings and the microbial growth of the sausages with gamma-irradiated natural casings were observed. Population of Total aerobia bacteria was decreased by gamma irradiation, dependent upon the irradiation dose. The number of microflora in lamb and pork casings was reduced by about 5.5 log cycle at 5kGy. Population of total aerobic bactelia of sausages stuffed in non-irradiated lamb and pork casing was about 3.6 log cfu/g after just manufacture and was about 7 log after 10 day storage. However, population of total aerobic bacteria of sausages with 3 key-irradiated and 5 kGy-irradiated casings was 2.48 and 0.32 log in lamb, and 2.78 and 0.60 log in pork respectively. The sausages vacuum-packaged and stored were shown no chance in the 2-thiobarbituric acid reactive substances value during storage. Irradiated sausage showed the higher TBARS value than that of nonirradiatd control at 5-day with pork casing and at 10day with lamb casing. Shear force of the sausages were decreased in both irradiated casings but the sensory evaluation showed no difference. Therefore, the gamma irradiation was a useful tool to sanitize the natural pork and lamb casings and extend the shelf-life of the high quality, value-added sausage made with those casings.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

과도 절삭에서의 절삭 공정 시뮬레이션

고정훈,조동우,윤원수,김주한 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

In most of the existing mechanistic models, the cutting process simulation is often restricted to a single path machining operation under a fixed cutting condition. Complex cutting processes such as die or mold manufacturing, however, are performed under two- or three-dimensional multiple tool paths. Since the tool paths in CNC machining are composed of line and arc segments, transient cuts are frequently occured due to the multiple paths. Even in steady cuts, the width of cut is varied with each segment. In this regard, this paper deals with the development of process simulation system for transient cuts, where continuously changing cutting configuration is computed, and then the cutting forces are predicted.

급성 세균성 감염증에 대한 Cefotetan(Yamatetan^ⓡ)의 임상적 효과

김주옥,안원전,박종훈,노흥규,박종우 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

Total 20 cases of infectious diseases were treated with Cefotetan at the Dept. of internal medicine, Chung Nam National University Hospital, Dae Jeon, Korea, from January 1985 to April 1985. Among 20 cases, 6 were the patients with acute pyelonephritis, 7 were pneumonia, 2 were acute cholecystitis, 2 were chronic bronchitis, 2 were cellulitis and 1 was lung abscess. The response was good in 16 cases, and poor in 4 cases. The laboratory tests were normal except I which was reversible. (mild elevation of SGOT and SGPT) The side effects were noted in 2 cases, such as skin eruption and drug fever, which were improved with supportive care. Cefotetan was thought to be useful against acute bacterial infections of respiratory, urinary, biliary tracts and cutaneous tissue.

社會體育指導者의 業務參與 程度와 專門性에 관한 實態調査

김주훈,정명수 조선대학교 스포츠과학연구소 1995 스포츠科學硏究 Vol.7 No.-

A significant change in the curriculum in Korean Sports and Leisure leaders can be observed recently. The major reason for this change is the increasing demand for instructors in the commercial sport sector. The purpose of this study was to clarify the professional knowledge and abilities required for an instructor in the commercial sport managemant. A Survey was conducted by using a random sample of employees in the commercial Sport facilities. The results of the survey show the majority of sport instructors are required not only teach but to do task involved in sport managemant. Nevertheless, they are not really ready to do all the managemant tasks required.