http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Menezes, José,C. J. M. D. S.,Orlikova, Barbora,Morceau, Franck,Diederich, Marc Taylor Francis 2016 Critical reviews in food science and nutrition Vol.56 No.-
<P>Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory, and antiviral activities. These flavonoids can also act as chemopreventive agents by their interaction with different proteins and can play a vital role in chemotherapy, suggesting a positive correlation between a lower risk of cancer and a flavonoid-rich diet. These agents interfere with the main hallmarks of cancer by various individual mechanisms, such as inhibition of cell growth and proliferation by arresting the cell cycle, induction of apoptosis and differentiation, or a combination of these mechanisms. This review is an effort to highlight the therapeutic potential of natural and synthetic flavonoids as anticancer agents in leukemia treatment with respect to the structure-activity relationship (SAR) and their molecular mechanisms. Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family.</P>
An analytical framework for consensus-based global optimization method
Carrillo, José,A.,Choi, Young-Pil,Totzeck, Claudia,Tse, Oliver World Scientific Publishing Company 2018 MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES Vol.28 No.6
<P>In this paper, we provide an analytical framework for investigating the efficiency of a consensus-based model for tackling global optimization problems. This work justifies the optimization algorithm in the mean-field sense showing the convergence to the global minimizer for a large class of functions. Theoretical results on consensus estimates are then illustrated by numerical simulations where variants of the method including nonlinear diffusion are introduced.</P>
Molecular Cosensitization for Efficient Panchromatic Dye-Sensitized Solar Cells
Cid, Juan-José,Yum, Jun-Ho,Jang, Song-Rim,Nazeeruddin, Mohammad K.,Martí,nez-Ferrero, Eugenia,Palomares, Emilio,Ko, Jaejung,Grä,tzel, Michael,Torres, Tomá,s WILEY-VCH Verlag 2007 Angewandte Chemie Vol.46 No.44
<B>Graphic Abstract</B> <P>Dyeing together: An efficient panchromatic dye-sensitized solar cell is constructed by using a “molecular cocktail” composed of an organic dye and a zinc phthalocyanine (see picture). The use of multiple, complementary dyes (cosensitization) is an important step towards solar cells that operate across the full spectrum of solar irradiation. <img src='wiley_img/14337851-2007-46-44-ANIE200703106-content.gif' alt='wiley_img/14337851-2007-46-44-ANIE200703106-content'> </P>
Más sobre verbos modales y auxiliares
José María Areta 한국스페인어문학회 2005 스페인어문학 Vol.0 No.37
La categoría de verbos auxiliares (AUX) ha sido poco estudiada por la gramática generativa porque, basándose en datos del inglés, principalmente, ha presentado hipótesis elegantes que se adaptan bien a la teoría. Una de las hipótesis más aceptadas es que los AUX son categorías funcionales. La Gramática Tradicional, por el contrario, basándose en criterios semánticos, ha dado explicaciones variadas de qué es un AUX y cómo identificarlo. Intentamos en este trabajo criticar los análisis generativistas comparando datos del inglés y del español. Esto nos llevará a descartar la transformación de movimiento de núcleo a núcleo para las interrogativas con AUX y definir una nueva estructura del sintagma verbal (SV). Según nuestra hipótesis, los AUX no son elementos de inflexión (I), sino categorías léxicas adjuntas al SV.
Cabrera-Miranda, José,Manuel,Paik, Jeom Kee Elsevier 2018 Ocean engineering Vol.149 No.-
<P><B>Abstract</B></P> <P>A top-tensioned riser is a slender pipe that conveys fluids between a floater and a subsea system. High top-tension keeps its straight configuration and helps to prevent compressive loads. Because of the floater's heave motion, the tension on the riser fluctuates giving rise to dynamic buckling. This paper examines the dynamic buckling characteristics of a top-tensioned riser analyzing the governing equation with nonlinear damping. The equation is discretized in space by the finite difference method and then is numerically integrated by the Runge-Kutta method. As main objective, an ultimate limit state function for risers is used to investigate its reliability during parametric excitation. While the short-term stationary Gaussian random motion of a floater can be described by a response spectrum, the uncertainties of a long-term response are considered by Monte Carlo simulation. In view of an applied example, it is found that the dynamic buckling would occur often, and although the probability of failure is acceptable, it can cause serious failure when axial excitation is of significance in harsher sea states. This study aims to contribute in clarifying the role of parametric vibrations (dynamic buckling) in the reliability of risers for ultimate limit state.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dynamic buckling of a top-tensioned riser in floating structures is studied. </LI> <LI> The effect of dynamic buckling on the ultimate limit state based reliability of a riser is also studied. </LI> <LI> The nonlinear governing differential equation is solved by Runge-Kutta method. </LI> <LI> The uncertainties of a long-term response are considered by Monte Carlo simulation. </LI> <LI> The dynamic buckling can cause serious failure of a riser in harsher sea states. </LI> </UL> </P>
On design criteria for a disconnectable FPSO mooring system associated with expected life-cycle cost
Cabrera-Miranda, José,Manuel,Sakugawa, Patrí,cia Mika,Corona-Tapia, Rafael,Paik, Jeom Kee Informa UK (TaylorFrancis) 2018 SHIPS AND OFFSHORE STRUCTURES Vol.13 No.4
<P>Some floating production, storage and offloading units (FPSOs) possess disconnectable systems to avoid harsh environments. According to a literature survey, the practice is based on perceptions and experiences of operators to judge disconnection; however, this paper offers a rational approach. A life-cycle cost model is proposed to optimise (1) the disconnection criteria and (2) the design of mooring lines under reliability format. Relevant ultimate limit states are considered in association with hull, moorings and green water failure. Effects of future failure costs are considered (downtime, environmental damage, reputation, etc.). Disconnection criteria are then formulated in terms of significant wave height and wind speed limits. Because a permanent mooring system may exhibit excessive resistance, it is possible to reduce the lines' thickness until the cost is optimised for non-permanent service. Results for an example in the Gulf of Mexico show that important savings can be achieved by implementing the proposed optimisations.</P>
In vitro and in vivo experimental models for drug screening and development for Chagas disease.
Romanha, Alvaro José,Castro, Solange Lisboa de,Soeiro, Maria de Nazaré,Correia,Lannes-Vieira, Joseli,Ribeiro, Isabela,Talvani, André,Bourdin, Bernadette,Blum, Bethania,Olivieri, Bian O Instituto 2010 Memórias do Instituto Oswaldo Cruz Vol.105 No.2
<P>Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain serious challenges, including the maintenance of sustainable public policies for Chagas disease control and the urgent need for better drugs to treat chagasic patients. Since the introduction of benznidazole and nifurtimox approximately 40 years ago, many natural and synthetic compounds have been assayed against Trypanosoma cruzi, yet only a few compounds have advanced to clinical trials. This reflects, at least in part, the lack of consensus regarding appropriate in vitro and in vivo screening protocols as well as the lack of biomarkers for treating parasitaemia. The development of more effective drugs requires (i) the identification and validation of parasite targets, (ii) compounds to be screened against the targets or the whole parasite and (iii) a panel of minimum standardised procedures to advance leading compounds to clinical trials. This third aim was the topic of the workshop entitled Experimental Models in Drug Screening and Development for Chagas Disease, held in Rio de Janeiro, Brazil, on the 25th and 26th of November 2008 by the Fiocruz Program for Research and Technological Development on Chagas Disease and Drugs for Neglected Diseases Initiative. During the meeting, the minimum steps, requirements and decision gates for the determination of the efficacy of novel drugs for T. cruzi control were evaluated by interdisciplinary experts and an in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.</P>