Significance of 40-, 45-, and 48-kDa Proteins in the Moderate-to-Severe Clinical Symptoms of Buckwheat Allergy

Joongbum Cho,Jeong-Ok Lee,Jaehee Choi,Mi-Ran Park,손동화,Ji Hyun Kim,안강모,Youngshin Han 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.1

Purpose: This study was aimed to investigate the relationship between the allergen components and moderate-to-severe allergic reactions in patients with buckwheat allergy. Methods: Fifteen patients with a history of buckwheat ingestion and a buckwheat specific IgE level≥0.35 kU/L were enrolled. They were divided into 2 groups according to clinical severity scores, with 0–1 being asymptomatic-to-mild and 2–4 being moderate-to-severe symptoms. Immunoblotting was performed to investigate IgE reactivity toward buckwheat allergens and to measure intensity of each component by using a reflective densitometer. Results: The proportions of positive band to the 16 kDa (62.5% vs 0%, P=0.026) and 40–50 kDa (87.5% vs 28.6%, P=0.041) buckwheat allergens in the grade 2-4 group were higher than those in grade 0-1 group. The level of buckwheat specific IgE of grade 2-4 group was higher than that of grade 0-1 group (41.3 kU/L vs 5.5 kU/L, P=0.037). The median optical densities (ODs) of IgE antibody binding to 40-50 kDa protein were higher in the grade 2-4 group, compared with those in the grade 0-1 group (130% OD vs 60.8% OD, P=0.037). Conclusions: The 40–50 kDa protein is implicated as an important allergen to predict moderate-to-severe clinical symptoms in Korean children with buckwheat allergy.

Pneumothorax caused by delayed tracheal rupture in a pediatric patient with acute respiratory distress syndrome

Joongbum Cho,Minyoung Jung,Jong Ho Cho,Ah Young Choi,Minji Kim 대한중환자의학회 2019 Acute and Critical Care Vol.34 No.2

Tracheal rupture is a potentially lethal complication of endotracheal intubation [1-3] and usually occurs shortly after intubation [4]. Such rupture presents as a linear tear and is caused by movement of an over-inflated cuff or stylet [5]. Herein, we describe a case of pneumothorax caused by tracheal rupture after 30 days of intubation. A previously healthy 8-year-old boy was admitted to the pediatric intensive care unit for severe acute respiratory distress syndrome. The patient was treated with mechanical ventilation and extracorporeal membrane oxygenation. Cuff pressure was managed between 20 to 30 cm H 2 O, and the endotracheal tube was not changed before extubation. On hospital day 30, extubation was perfomred, and spontaneous breathing was noted. On the same day, massive pneumothorax was developed and was not controlled by chest tubes. Computed tomography showed a new lesion on the trachea (Figure 1), and bronchoscopy showed an oval ischemic lesion surrounded by a Cshaped tear (Figure 2). Since the position and size of the ischemic lesion were similar to those of the cuff, we suspected that prolonged cuff pressure created ischemia, and active breathing tore the weak margin. Managing cuff pressure in children requires high caution, and suspicion of tracheal rupture should be considered as a cause of pneumothorax.

소아에서 급성 호흡곤란증후군의 정의

조중범 ( Joongbum Cho ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4

소아 환자에서 척수 자기공명영상을 이용한 요추천자 깊이의 예측

조중범(Joongbum Cho),서정민(Jung Min Suh),이보련(Bo Lyun Lee),이문향(Munhyang Lee),이지훈(Jeehun Lee) 대한소아신경학회 2008 대한소아신경학회지 Vol.16 No.2

목 적 : 저자들은 국내 소아 환자를 대상으로 요추천자의 성공률을 높이고 외상성 요추천자를 줄이기 위하여 적절한 천자깊이를 예측하는 수식을 찾고자 본 연구를 실시하였다. 방 법 : 2007년 8월부터 2008년 6월까지 시행된 척수 자기공명영상을 검사한 20세 이하의 환자 중 검사일로부터 10일 이내의 신체 계측이 기록된 88명의 환자를 대상으로 연구를 시행하였다. 대상 환자에서 척수 자기공명영상을 이용하여 요추 2번과 3번 사이, 3번과 4번 사이, 그리고 4번과 5번 사이의 시상면을 기준으로 후경막 깊이와 전, 후경막 너비를 측정하였다. 선형회귀분석을 이용하여 체중과 키 등의 독립변수들의 결정계수를 비교하여 후경막 깊이 예측식을 결정하였으며, 추가 삽입을 하였을 때 경막낭을 벗어나 는 빈도를 비교하여 천자깊이를 결정하였다. 결 과 : 각 천자위치에서 경막낭을 벗어나는 빈도가 가장 낮은 천자깊이는 다음과 같다. L2-3 천자깊이(mm)=126.5×체중/키(kg/cm)+7.1 또는 0.613×체중(kg)+16.1 L3-4 천자깊이(mm)=136.0×체중/키(kg/cm)+7.6 또는 0.656×체중(kg)+17.3 L4-5 천자깊이(mm)=138.3×체중/키(kg/cm)+7.5 또는 0.665×체중(kg)+17.5 결 론 : 국내 소아환자에서 요추천자를 시행할 때 체중, 체중과 키를 이용하여 천자깊이를 예측할 수 있는 선형회귀식을 구하였으며, 이러한 예측 선형회귀식은 천자위치에 따라 상수의 차이를 보였다. 이러한 예측식을 통하여 요추천자의 성공률을 높이고 합병증을 감소시킬 것이 예상되나, 향후 추가 연구를 통한 검증이 선행되어야 할 것으로 사료된다. Purpose : This study was performed to find the applicable equations which determine the proper needle depth for lumbar puncture in Korean pediatric patients using spine magnetic resonance imaging(MRI). Methods : The authors enrolled the patients who had spine MRI from August 2007 to June 2008 and were aged less than 20 years. Eighty eight patients whose height(Ht.) and weight(Wt.) were recorded within 10 days from spine MRI were recruited. The posterior dural depths and dural widths were measured on each L2-3, L3-4, and L4-5 levels of intervertebral space. By comparing the R squares, the most significant independent variables for posterior dural depth were selected, and by calculating malposition rate, the further insertion distance from posterior dural depth and the final puncture depth equation were determined. Results : The proper puncture depths with the lowest malposition rate were as follows. L2-3 puncture depth (mm) = 126.5×Wt./Ht. (kg/cm)+7.1 or 0.613×Wt. (kg)+16.1 L3-4 puncture depth (mm) = 136.0×Wt./Ht. (kg/cm)+7.6 or 0.656×Wt. (kg)+17.3 L4-5 puncture depth (mm) = 138.3×Wt./Ht. (kg/cm)+7.5 or 0.665×Wt. (kg)+17.5 Conclusion : Lumbar puncture depth is best predicted using weight and height as independent variables. And the equations of each tap sites were different in constants. Using this formula, the rate of failure and complication in lumbar can be diminished, but it should be validated by further studies.

Do Norms Theories Matter?: Viability of Constructivist Approach for the Studies of Foreign Aid

Young Soo Kim,Joongbum Shin 한국국제정치학회 2019 The Korean Journal of International Studies Vol.17 No.2

모델예측방법을 이용한 무인주행자동차의 실시간 경로탐색 및 충돌회피 알고리즘

송석기(Seokki Song),이중범(Joongbum Lee),공경철(Kyoungchul Kong) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

A real-time position control algorithm of an unmanned vehicle is introduced in this paper. The proposed algorithm is capable of collision avoidance, as well as determination of an optimal path to reach a destination. Conventional path planning algorithms (e.g., A-star algorithm) shows limitations, such as long calculation time and its off-line characteristics. On the other hand, the proposed algorithm determines the optimal direction considering both the destination and obstacles simultaneously in real-time. Once the optimal direction is determined, the proposed method calculates the steering angle and the vehicle speed for the control of driving and steering actuators. In this paper, the proposed methods are verified by simulation results.

Tailored management of life-threatening complications related to severe obesity in a young adult with Prader-Willi syndrome

Kim Min-Sun,Kim Jiyeon,Cho Joongbum,Cho Sung Yoon,Jin Dong-Kyu 대한소아내분비학회 2022 Apem Vol.27 No.2

Prader-Willi syndrome (PWS) is characterized by hypotonia, distinctive facial features, hyperphagia, obesity, short stature, hypogonadism, intellectual disability, and behavior problems. Uncontrolled hyperphagia can lead to dangerous food-seeking behavior and with life-threatening obesity. Severe obesity is prone to obstructive sleep apnea (OSA) and can lead to cor pulmonale. This study reports on a case involving a 21-year-old man with PWS who developed OSA due to severe obesity, which led to cor pulmonale, a life-threatening complication. Multidisciplinary care provided in the intensive care unit included weight reduction, ventilation support, antipsychotics, sedative drugs, rehabilitation, and meticulous skin care. The patient did recover. To prevent severe obesity in adults with PWS, hyperphagia must be controlled, and the patient must also be managed by an endocrinologist throughout childhood.

Primary Ciliary Dyskinesia(PCD) Registry Study in Korean Children and Adolescents

( Eun Hee Chung ),( Dong In Suh ),( Joongbum Cho ),( Jinho Yu ),( Young Min Ahn ),( Jung Yeon Shim ),( Ju-Hee Seo ),( Hai Lee Chung ),( Yoon Young Jang ),( Eun Lee ),( Jung hee Kim ),( Hye-young Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0

Background Primary ciliary dyskinesia (PCD) is an autosomal recessive congenital disease caused by dysfunctional cilia. Methods From January 2000 to August 2020, the medical records of pediatric and adolescent patients diagnosed or suspected of PCD at secondary and tertiary hospitals in Korea were reviewed retrospectively. Results A total of 29 patients were diagnosed with PCD in 15 medical institutions and the male to female ratio was 1:1.2. Among them, 21 patients were confirmed by histology (electron microscopy; EM) and 7 patients by gene study, and the median age at diagnosis was 9 years 3 month(1 month -19 years). According to the clinical findings, all of them were born full term, 15 cases had neonatal dyspnea, and 6 cases had Kartagener syndrome. According to the Results of EM, 11 patients with dynein arms defect (I), one patient with radial spokes with eccentric central core defect (II), one patient with microtubular transposition type (III), one with (I + II) and one with (I + II + III) were found. Nine patients were genetically tested, and the causative gene mutations were found in 7 PCD patients; 2 DNAAF1 gene mutation, 2 DNAH5 gene mutation, 1 DNAH11 gene mutation, 1 CCDC40 gene, and 1 CCDC39 gene. Tree cases were diagnosed by genetic testing without mucosal biopsy. Bronchiectasis was noted in 23 of 28 patients who had chest CT. Conclusions In addition to mucosal biopsy, early diagnosis of PCD can be diagnosed through genetic testing. Due to the inaccuracies and difficulties of existing diagnostic Methods, the prevalence of low diagnosis or misdiagnosis is likely to be higher. Multicenter studies are required to identify various phenotypes and genotypes of PCD in Korea.

Clinical Manifestations and Genotype of Primary Ciliary Dyskinesia Diagnosed in Korea: Multicenter Study

Kim Minji,Lee Mi-Hee,Hong Soo-Jong,Yu Jinho,Cho Joongbum,서동인,Kim Hyung Young,Kim Hye-Young,Jung Sungsu,Lee Eun,Lee Sooyoung,Jeong Kyunguk,Shim Jung Yeon,Kim Jeong Hee,Chung Hai Lee,Jang Yoon Young,Kwo 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6

Purpose: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder that leads to secondary ciliary dysfunction. PCD is a rare disease, and data on it are limited in Korea. This study systematically evaluated the clinical symptoms, diagnostic characteristics, and treatment modalities of pediatric PCD in Korea. Methods: This Korean nationwide, multicenter study, conducted between January 2000 and August 2022, reviewed the medical records of pediatric patients diagnosed with PCD. Prospective studies have been added to determine whether additional genetic testing is warranted in some patients. Results: Overall, 41 patients were diagnosed with PCD in 15 medical institutions. The mean age at diagnosis was 11.8 ± 5.4 years (range: 0.5 months-18.9 years). Most patients (40/41) were born full term, 15 (36.6%) had neonatal respiratory symptoms, and 12 (29.3%) had a history of admission to the neonatal intensive care unit. The most common complaint (58.5%) was chronic nasal symptoms. Thirty-three patients were diagnosed with transmission electron microscopy (TEM) and 12 patients by genetic studies. TEM mostly identified outer dynein arm defects (alone or combined with inner dynein arm defects, n = 17). The genes with the highest mutation rates were DNAH5 (3 cases) and DNAAF1 (3 cases). Rare genotypes (RPGR, HYDIN, NME5) were found as well. Chest computed tomography revealed bronchiectasis in 33 out of 41 patients. Among them, 15 patients had a PrImary CiliAry DyskinesiA Rule score of over 5 points. Conclusions: To our knowledge, this is the first multicenter study to report the clinical characteristics, diagnostic methods, and genotypes of PCD in Korea. These results can be used as basic data for further PCD research.

Pediatric Mycoplasma pneumoniae Infection Presenting with Acute Cholestatic Hepatitis and Other Extrapulmonary Manifestations in the Absence of Pneumonia

Song, Won Jae,Kang, Ben,Lee, Hwa Pyung,Cho, Joongbum,Lee, Hae Jeong,Choe, Yon Ho The Korean Society of Pediatric Gastroenterology 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.2

Mycoplasma pneumoniae infections mainly involve respiratory tract; however, also can manifestate other symptoms by site involved. Extrapulmonary manifestations of M. pneumoniae infection are rarely known to occur without pneumonia. Herein we report a case of a 9-year-old boy who presented with acute cholestatic hepatitis in the absence of pneumonia. Rhabdomyolysis, skin rash, and initial laboratory results suspicious of disseminated intravascular coagulopathy were also observed in this patient. M. pneumoniae infection was identified by a 4-fold increase in immunoglobulin G antibodies to M. pneumoniae between acute and convalescent sera by enzyme-linked immunosorbent assay. This is the first pediatric case in Korea of M. pneumoniae infection presenting with acute cholestatic hepatitis in the absence of pneumonia.