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권준오,김우혁,정영덕 조선대학교 국토개발연구소 1997 국토개발연구 Vol.17 No.1
The aim of this study is to find out appropriate solutions to various problems created by wrong applied assumption of population. And these solutions are to be applied to establishment of urban planning. Besides assuming the population of urban planning is the most important yardstick of deciding the size of future urban and physical environment. Therefore to develop the plan more efficiently, I suggest these as followings. First of all, the mathematical methods which is proper to the characteristics of urban must be applied and produced through the outlook based on analysis of natural population, such as birth, death, transference in the past. Secondly, the moving in population of society must be limited on the target year. Thirdly, the population division plan by regional groups must be proceeded. The last but not least, the examination and evaluation on population plan must be performed.
( Joon Seong Ahn ),( Dong Hyun Sinn ),( Geum Youn Gwak ),( Jong Man Kim ),( Choon Hyuck Kwon ),( Jae Won Joh ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The degree of steatosis of donated liver is one of decisive factors that determine graft function in recipient and recovery of remnant liver in living donor. Hence, the assessment of hepatic steatosis is a critical element to judge donor compatibility. We evaluated the prevalence and predictors of steatosis among liver donors who had no evidence of fatty liver on screening ultrasonography (US-negative). Methods: Degree of hepatic steatosis was reviewed for 492 US-negative liver donors (age: 30.1 ± 9.9, male: 301 (61.2%)). Clinical and laboratory variables were analyzed to identify predictors for steatosis. Results: The prevalence of severe (≥ 60%), moderate (30 ∼ 59%), mild (5 ∼ 29%) and no steatosis (<5%) were 0.6% (3/492), 10.8% (53/492), 39.6% (195/492) and 49.0% (241/492), respectively. In multivariate analysis, BMI [kg/㎡, OR (95% CI): 1.15, p = 0.021] and serum triglyceride level [mg/dl, OR (95% CI): 1.01, p = 0.004] were independent factors associated with steatosis ≥ 30%. The optimal cutoff for steatosis ≥ 30% by receiver operator curve analysis was 23 kg/㎡ for BMI and 88 mg/dl for triglyceride. Steatosis ≥ 30% was significantly more prevalent for liver-donors with high BMI (15.2% vs. 9.0% for BMI ≥ 23 vs. < 23 kg/m2, p = 0.034) and with high serum triglyceride level (15.5% vs. 8.7% for triglyceride ≥ 88 vs. < 88 mg/dl, p = 0.021). Based on these two parameters, the prevalence of steatosis ≥ 30% was 6.6%, 13.0% and 28.6% for none, one and both risk factors, respectively. Conclusions: About a half of US-negative liver donors have steatosis ≥ mild degree and one-tenth of them has ≥ moderate degree. USG assessment is not sufficient to exclude donors with significant steatosis especially for those with high BMI and triglyceride level, and thus, pre-operative liver biopsy should be positively considered for them.
Joon-Hyeok Kim,Eun-Kyung Bae,Young-Im Choi,Seo-Kyung Yoon,Hyoshin Lee 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Plant senescence is a final process of growth and a survival strategy to use limited nutrients efficiently during development and adaptation. Tree, however, runs senescence annually for winter dormancy. Therefore understanding senescence procedure and mechanism is striking issue for tree breeding and wood productivity. In this study, we isolated a SENESCENCE 1 (PagSEN1) gene from Populus alba ⨯ P. glandulosa and determined its expressional characteristics under various conditions. The PagSEN1 encodes a putative 243 amino acid protein containing a rhodanese domain. Southern blot analysis suggested that two copies of the PagSEN1 gene are present in the poplar genome. The PagSEN1 is expressed most strongly in mature leaves but most weakly in roots. The gene is significantly up-regulated by treatment with mannitol, NaCl, ABA and JA, but not by cold, SA and GA3. These results indicate that the PagSEN1 is involved in senescence response induced by natural aging and environmental stresses. This research will provide valuable information for senescence study. To clarify SEN1 gene in poplar, we will make PagSEN1 over-expressed poplar to understand senescence procedure in detail.
( Joon Seong Ahn ),( Dong Hyun Sinn ),( Geum Youn Gwak ),( Jong Man Kim ),( Choon Hyuck Kwon ),( Jae Won Joh ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: The degree of steatosis of donated liver is one of decisive factors that determine graft function in recipient and recovery of remnant liver in living donor. Hence, the assessment of hepatic steatosis is a critical element to judge donor compatibility. We evaluated the prevalence and predictors of steatosis among liver donors who had no evidence of fatty liver on screening ultrasonography (US-negative). Methods: Degree of hepatic steatosis was reviewed for 492 US-negative liver donors (age: 30.1 ± 9.9, male: 301 (61.2%)). Clinical and laboratory variables were analyzed to identify predictors for steatosis. Results: The prevalence of severe (≥ 60%), moderate (30 ~ 59%), mild (5 ~ 29%) and no steatosis (<5%) were 0.6% (3/ 492), 10.8% (53/492), 39.6% (195/492) and 49.0% (241/492), respectively. In multivariate analysis, BMI [kg/m2, OR (95% CI): 1.15, p = 0.021] and serum triglyceride level [mg/dl, OR (95% CI): 1.01, p = 0.004] were independent factors associated with steatosis ≥ 30%. The optimal cutoff for steatosis ≥ 30% by receiver operator curve analysis was 23 kg/m2 for BMI and 88 mg/dl for triglyceride. Steatosis ≥ 30% was significantly more prevalent for liver-donors with high BMI (15.2% vs. 9.0% for BMI ≥ 23 vs. < 23 kg/m2, p = 0.034) and with high serum triglyceride level (15.5% vs. 8.7% for triglyceride ≥ 88 vs. < 88 mg/dl, p = 0.021). Based on these two parameters, the prevalence of steatosis ≥ 30% was 6.6%, 13.0% and 28.6% for none, one and both risk factors, respectively. Conclusions: About a half of US-negative liver donors have steatosis ≥ mild degree and one-tenth of them has ≥ moderate degree. USG assessment is not sufficient to exclude donors with significant steatosis especially for those with high BMI and triglyceride level, and thus, pre-operative liver biopsy should be positively considered for them.
Joon-Hyeok Jeon, Hae-Won Jung, Hee-Chun Lee, Byeong-Teck Kang, Jung-Hyang Sur, Dong-In Jung 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.3
Ischemic stroke is the most common type of stroke in humans. The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) in a canine model of stroke. Ischemic stroke was induced by using prepared autologous thrombus. The dogs were placed in lateral recumbency on the operation table and the cervical area of each dog was sterilized by using alcohol. After making a cervical incision, the common carotid artery and internal carotid artery (a branch of the common carotid artery that supplies an anterior part of the brain) were exposed. A 200 μL injection of the autologous thrombus prepared 24 hr prior to surgery was delivered with a 20 gauge venous catheter through an internal carotid artery. After successful delivery of the autologous thrombus, the venous catheter was removed, and the cervical incision was sutured. Neurologic signs including generalized seizures, tetraparesis, and altered mental status, were observed in all 3 dogs after induction of ischemic stroke and the signs manifested immediately after awakening from anesthesia. T1- and T2-weighted images and fluid-attenuated inversion recovery (FLAIR) images of the brain were acquired 1 day before and 1 day after surgery. On the day following ischemic stroke induction, MRI revealed multifocal lesions in the cerebral cortex and subcortex such as T1 hypointensity, T2 hyperintensity, FLAIR hyperintensity, and diffusion-weighted hyperintensity in all 3 dogs. Upon postmortem examination, ischemic lesions were found to be consistent with the MRI findings and they were unstained with 2% triphenyltetrazolium chloride. Histologic features of the earliest neuronal changes such as cytoplasmic eosinophilia with pyknotic nuclei were identified. Neuropil spongiosis and perivascular cuffing were also prominently observed at the infarcted area. The present study demonstrated the features of MRI and histopathologic findings in canine ischemic stroke models.