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      • 當歸鬚散이 實驗的 白鼠肝 瘀血에 미치는 影響

        林準圭 大田大學校 1982 論文集 Vol.1 No.1

        Dengkwisoo-San has been applied to various conditions with congestions and extravasated blood in the Oriental Medicine. The effectiveness of Dangkwisoo-San on the repair of carbon tetrachloride ( CCl₄) induced-liver damage in Albino rats was biochemically and histologically studied. The results were summarized as follows : 1. Dangkwisoo-San had a reducing action of serum alkaline phosphatase, alpha-hydroxy-butyrate dehydrogenase, lactate dehydrogenase, leucine aminopeptidase, glutamic oxalacetic transaminase and glutamic pyrubic transaminase activities of the rats pretreated with CCl₄. 2. Dangkwisoo-San had an action of increase in serum albumin and total protein without interference with serum globulin values of the rate pretreated with CCl₄. 3. Dangkwisoo-San appeared to promote restoration of the impaired functions following congestion, necrosis and fatty change of hepatic cells damaged by CCl₄injection, and the repair process was manifested by a slight increase in periodic acid Schiff positive substances it necrotic hepatocytes. 4. The effect of Dangkwisoo-San was observed biochemically and histologcally 48 hours after the administration of the preparation. 5. No clear-cut difference on the effect of Dangkwisoo-San was present between types (decoction or extract) and dosages of the preparation prescribed. In summary of the experimental results described above, Dangkwisoo-San appeared helpful for promoting repair of liver cell necrosis followed by congestion, and it was suggested that Dangkwisoo-San was effective on liver cell damage.

      • 국내 말라리아 상황과 연구동향

        고원규,정준용 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1S

        Vivax malaria has re-emerged in the northern part of the Republic of Korea from 1993 after over 10 years absence. The number of cases has increased every year and reached to about 3000-4000 a year. Thanks to this epidemic researches and developments on malaria is activated in the country. Some important achievements produced by Institute of Malariology. Inje University are introduced. The geographical distributions of patients and antibody titers showed the characteristic of border malaria. Thus collaborative efforts with North Korea are necessary to control this epidemic successfully. In this epidemic, two different genotypes were found In the genes of CSP, DBP, MSP-1 (ICB 4-5), and AMA-1. The DNA structures of the genes were similar to them from East Asia. 58% of 80 patients' blood shows single genotype in each gene had a combination of genotypes (CSP SK-A:DBP SK-I:MSP-1), and 29% of them has another (CSP SK-B:DBP SK-Ⅱ:MSP-2). Thus it was concluded that genetically different two strains (KOR1 and KOR2) of P. vivax were mainly distributed in the endemic area. One-shot multiplex PCR was designed for differential diagnosis of two major species of Plasmodium by targeting the 18s rRNA gene. In an evaluation on 210 clinical samples the new PCR test showed very high feasibility, sensitivity (100%), and specificity (100%). Malaria is one of major infectious diseases in the world, causing 300-500 million clinical cases and more than one million deaths each year. The importance of vaccine and new drugs for malaria must be stressed.

      • 위치결정 스테이지의 정밀위치결정을 위한 가상모드 입력성형기 응용에 관한 연구

        장준원,박상원,서용규,홍성욱 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

        This paper deals with precise positioning of positioning stage by input shaping, Input shaping is well known to be a very effective tool for suppressing the residual vibration of flexible structures. However, the input shaping tends to increase the rise time of the system. This problem often degrades the performance of system, In order to improve this problem, this paper proposes an input shaping method using the virtual mode concept for positioning stage. The virtual-mode input shaper is proved effective through experiments.

      • KCI등재후보

        개인의 특성과 검사조건이 신경행동검사의 신뢰도에 미치는 영향

        사공준,전만중,성낙정,김규태 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.2

        목적: 대상자의 특성과 검사조건 중 성, 연령, 교육수준, 컴퓨터 친숙도, 검사간격 및 검사시간대의 차이가 신경행동검사의 재검사 신뢰도에 미치는 영향을 평가하였다. 방법: 의과대학생 85명(남자 45명, 여자 40명)과 병원근무자 35명(남자 23명, 여자 12명)을 대상으로 연령, 성 교육수준, 컴퓨터 친숙도를 조사하였다. 84명을 1개월 간격, 20명을 1년 간격, 16명을 3년 간격으로 검사 및 재검사를 실시하였으며 65명을 동일한 검사시간대에, 44명을 다른 시간대에 재검사를 실시하였다. 컴퓨터 신경행동검사로는 SPES-K 중 단순반응시간, 숫자더하기, 부호숫자 짝짓기, 숫자외우기 및 손가락 두드리기를, 면접식 신경행동검사 중 Benton 시각기억검사, 숫자부호 짝짓기, 숫자외우기, 목적점찍기 및 핀꽂기의 재검사 신뢰도를 요인에 따라 층화하여 비교하였다. 결과: 컴퓨터 신경행동검사 중 숫자더하기, 부호숫자 짝짓기, 숫자외우기 및 손가락 두드리기의 재검사 신뢰도가 다른 검사에 비해 연령과 성별의 영향을 적게 받았으며 손가락 두드리기의 재검사 신뢰도가 다른 검사항목에 비해 교육수준의 차이의 영향을 적게 받았다. 컴퓨터 신경행동검사항목 중 단순반응시간의 재검사 신뢰도가 다른 검사들에 비해 컴퓨터에 대한 친숙도에 따른 차이가 크게 나타났다. 부호숫자 짝짓기와 손가락 두드리기의 재검사 신뢰도는 다른 검사에 비해 검사간격의 영향을 적게 받았으며 컴퓨터 신경행동검사 중 숫자더하기, 숫자외우기와 손가락 두드리기 및 면접식의 숫자부호 짝짓기의 재검사 신뢰도가 다른 검사들에 비해 검사시간대 차이의 영향을 적게 받았다. 결론: 향후 산업장 근로자들을 대상으로 한 신경행동검사를 선택하는데 있어 면접식 신경행동검사에 비해 컴퓨터 신경행동검사의 재검사 신뢰도가 상대적으로 안정적으로 나타났으며 이는 우리 나라 근로자의 특성과 산업보건제도에 적합한 신경행동검사 배터리의 구성에 도움이 될 것으로 생각된다. Objectives: This study was conducted to select neurobehavioral tests that are more reliable and less affected by subjects characteristics and test conditions. Methods: Five computerized and five traditional neurobehavioral tests and retests were administered to 85 medical school students and 35 hospital workers. The computerized tests consisted of the Simple Reaction Time, Addition, Symbol Digit, Digit Span, and Finger Tapping Speed, while the traditional tests comprised the Benton Visual Retention test, Digit Symbol, Digit Span, Pursuit Aiming, and pegboard. In addition, the effects of various factors on the reliability of the neurobehavioral tests, including age, sex, educational level, computer familiarity, test intervals, and test time of day, were also evaluated. Results: Among the computerized neurobehavioral tests, the reliability of Addition, Symbol Digit, Digit Span, and Finger Tapping Speed were not affected significantly by age, sex, test interval, or computer familiarity. It was found that Finger Tapping Speed is not affected by educational level. When the time of retest was incongruous with the time of the first test, test-retest reliability was lower in most neurobehavioral tests except computerized Addition, Digit Span, and Finger Tapping Speed, and traditional Digit Symbol. Conclusions: These results suggest that the computerized Addition, Symbol Digit, Digit Span, and Finger Tapping Speed, and the traditional Digit Symbol are more satisfactory for our purposes. These results should facilitate selection of the most appropriate tests for periodical evaluation of the central nervous system of workers exposed to neurotoxic substances in Korea.

      • 위팔근육 위축 양측마비 2예

        안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-

        Brachial amyotrophic diplegia, a relatively stable variant of motor neuron disease, is characterized by weakness that is isolated to upper limbs and spared lower extremities, respiratory and bulbar musculature. This disease should be differentiated from other disease such as multifocal motor neuropathy, amyotrophic lateral sclerosis, monomelic amyotrophy and progressive muscular atrophy. We report two cases of brachial amyotrophic diplegia.

      • 세균성 수막염에서 발생한 치명적 뇌경색 1례

        안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-

        Bacterial meningitis is frequently fetal or lead to severe neurological impairment. Cerebral infarction is a well known sequele of meningitis, occurring in as many as 10-20% of patients. But fetal cerebral infarction in bacterial meningitis is rare. We report a 61 year old woman who was admitted due to fever, headache and mental change for 3 days. On admission 7 days follow up Brain-CT revealed large and massive infarctions on both hemispheres. When bacterial meningitis is caused by Streptococcus pneumonia, there is a high prevalence of cerebral infarctions. The underlying mechanisms of cerebral infarction in bacterial meningitis are vasculitis, thrombosis, arachnoiditis, and compression of the arterial supply at the foramen magnum by herniation of the cerebellar tonsil.

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