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Lee, Jongkeun,Lee, Andy ,Jinseok,Lee, June-Koo,Park, Jongkeun,Kwon, Youngoh,Park, Seongyeol,Chun, Hyonho,Ju, Young Seok,Hong, Dongwan Oxford University Press 2018 Nucleic acids research Vol.46 No.w1
<P><B>Abstract</B></P><P>Somatic genome mutations occur due to combinations of various intrinsic/extrinsic mutational processes and DNA repair mechanisms. Different molecular processes frequently generate different signatures of somatic mutations in their own favored contexts. As a result, the regional somatic mutation rate is dependent on the local DNA sequence, the DNA replication/RNA transcription dynamics and epigenomic chromatin organization landscape in the genome. Here, we propose an online computational framework, termed Mutalisk, which correlates somatic mutations with various genomic, transcriptional and epigenomic features in order to understand mutational processes that contribute to the generation of the mutations. This user-friendly tool explores the presence of localized hypermutations (<I>kataegis</I>), dissects the spectrum of mutations into the maximum likelihood combination of known mutational signatures and associates the mutation density with numerous regulatory elements in the genome. As a result, global patterns of somatic mutations in any query sample can be efficiently screened, thus enabling a deeper understanding of various mutagenic factors. This tool will facilitate more effective downstream analyses of cancer genome sequences to elucidate the diversity of mutational processes underlying the development and clonal evolution of cancer cells. Mutalisk is freely available at http://mutalisk.org.</P>
( Jongkeun Lee ),( Jae Young Kim ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
If biomass contains heavy metals, heavy metals may be released from biomass during biodegradation and inhibit the anaerobic digestion process. The objective of this study is to examine the leaching characteristics of heavy metals from biomass for prediction of heavy metal amounts in anaerobic digester. In this study, sunflower (i.e., Helianthus annuus) grown in heavy metal-contaminated soils was used as a substrate for anaerobic digestion. The released heavy metals in anaerobic digester can be classified as decomposition of biomass with microorganism activity and leaching themselves without microorganism activity. Lab-scale anaerobic batch digesters containing anaerobic sludge and autoclaved distilled water were set up to investigate the amount of heavy metals leached from biomass with and without microorganism activity. About 70% by wt. of Cu and Zn were leached from biomass with microorganism activity while about 50% by wt. of biomass was degraded for 28 days, whereas Cd, Pb, and Ni were barely leached. Only 14.3% by wt. of Cu and 21.6% by wt. of Zn were also partially leached from the biomass without microorganism activity while leaching of Cd, Pb, and Ni were hardly observed.
A study on Optimizing Mobile 3D Game Engine using JSR-184
JongKeun Cho,ShinJun Lee,MoonWon Choo 한국콘텐츠학회 2007 International Journal of Contents Vol.3 No.4
This study focuses on modeling mobile 3D game engine and suggesting modified skinned-mesh schema based on JSR-184 in order to improve the performance in terms of memory consumption and time complexity. Most of the 3D games have used OpenGL-ES low-level APIs, which may limit portability and fast developing time, Hence, the 3D mobile game engine providing high-level APIs which works on GSM (Global System for Mobile Communication) phones on J2ME, is proposed here in order to optimize the performance for Java environment abiding JSR-184 standard. To prove performance enhancement, skinned-mesh schema on JSR-184 engine is modified and tested. The experimental results are shown.
Jongkeun Jung,강용한 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
In this work, the key intermediate, 4-amino-4'-(2-amino-4-anilino-1,3,5-triazine-6-yl)-aminostilbene-2,2'-disulfonic acid, was prepared from 4-(2-amino-4-anilino-1,3,5-triazine-6-yl)amino-4'-nitrostilbene-2,2'-disulfonate by using Tin(II) chloride as the reducing agent. Using this intermediate, nineteen new asymmetrically substituted bistriazinylstilbene fluorescent brightening agents were synthesized. Chemical structures of the obtained compounds 5a-s were analyzed by proton NMR spectrum. The physical properties of the new compounds 5a-s were characterized by fastness test and whiteness measurement test and the obtained data were compared to measurements obtained from CI 86.
Jongkeun Park,Jongbaik Ree*,Sang Kwon Lee,김유항 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.12
The reaction between gas-phase atomic hydrogen and highly covered chemisorbed bromine atoms on a silicon(001)-(21) surface is studied by use of the classical trajectory approach. The model is based on reaction zone consisting of H, Br and Si atom interacting with a finite number of primary system silicon atoms, which are coupled to the heat bath. The calculations were carried out in the temperature range 300-2500 K for the gaseous H atom and 0-700 K for the surface, respectively. All reactive events occur in a single impact collision on a subpicosecond scale, following the Eley-Rideal mechanism. The reaction probability is dependent upon the gas temperature and the largest near 800 K, but it is essentially independent of the surface temperature. The reaction energy available for the product state is small, and most of the reaction exothermicity deposits in vibration and translation of the product, HBr molecule.
Lee, Jongkeun,Kim, Joonrae Roger,Jeong, Seulki,Cho, Jinwoo,Kim, Jae Young Elsevier 2017 Waste management Vol.59 No.-
<P><B>Abstract</B></P> <P>In order to investigate the long-term stability on the performance of the anaerobic digestion process, a laboratory-scale continuous stirred-tank reactor (CSTR) was operated for 1100 days with sunflower harvested in a heavy metal contaminated site. Changes of microbial communities during digestion were identified using pyrosequencing. According to the results, soluble heavy metal concentrations were lower than the reported inhibitory level and the reactor performance remained stable up to OLR of 2.0g-VS/L/day at HRT of 20days. Microbial communities commonly found in anaerobic digestion for cellulosic biomass were observed and stably established with respect to the substrate. Thus, the balance of microbial metabolism was maintained appropriately and anaerobic digestion seems to be feasible for disposal of heavy metal-containing crop residues from phytoremediation sites.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Stability of AD was evaluated for the treatment of heavy metal-containing crop residues. </LI> <LI> Changes of microbial communities during digestion were identified using pyrosequencing. </LI> <LI> AD process remained stable throughout the experimental periods without effects of heavy metals. </LI> <LI> Microbial communities did not suffer from heavy metals and conformed to the substrate. </LI> </UL> </P>
양종근(Jongkeun Yang) 한국영미어문학회 2011 영미어문학 Vol.- No.100
The purpose of this paper is to trace Ernesto Laclau’s theory of ‘radical democracy.’ After the ‘Cold War’ the world is going straightly toward globalized capitalism, called New Liberalism. Under the global triumph of capitalism, democracy is on the skids, and freedom and equality is under threat. In the meanwhile, socialism is no longer accepted as an alternative social system of capitalism. It is this instance that Laclau intervenes in with his famous concepts such as ‘hegemony,’ ‘antagonism,’ and, ‘radical democracy.’ He attempts to deconstruct both Marxist theory and liberal democratic thought in order to reinterpret them in such a way that they could contribute to a more sufficient understanding of contemporary politics. On the one hand, he opposes persistently the global tendency toward capitalism. He also rejects the proletariat as a ‘universal’ class for the Revolution, on the other hand. In stead of the Marxist orthodox notions of class contradiction or class struggle, he introduces ‘antagonism(s)’ of the social. His ‘antagonism(s)’ reflects the over-determined social contradictions and various anti-capitalistic movements such as green, feminist, racial, local movements. He argues that ‘antagonism’ is constitutive of human society and that radical democracy is an effect(or a process) of its articulation. The model of radical democracy maintains the idea of an expanded version of democracy in more aspects of social life and of an attempt for constitution and multiplication of new identities.