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Jonghoo Lee,Jae-Uk Song 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3
Background/Aims:Although pneumococcal urinary antigen tests (PUATs) have universally been used for the diagnosis of pneumococcal pneumonia, data on the efficacy of these exams are limited. The objective of our study was to investigate the clinical impact of the PUAT in patients with community-onset pneumonia (CO-pneumonia). Methods: We conducted a retrospective cohort study of patients diagnosed with CO-pneumonia. Patients were classified according to their PUAT results and were matched using the propensity score-matching method. The primary outcome was 30-day mortality. Results: A total of 1,257 patients were identified and 163 (13.0%) demonstrated positive PUAT results. The sensitivity and specificity values of PUAT for overall pneumococcal pneumonia were 56.5% and 91.4%, respectively. In the full cohort, there were no significant differences in 30-day mortality between the two groups (6.1% in the positive PUAT group vs. 8.2% in the negative PUAT group, p = 0.357). However, in the propensity-matched cohort, the 30-day mortality rates were lower in the positive PUAT group (5.6% vs. 17.4%, p = 0.001). With respect to secondary outcomes, the proportion of patients with potentially drug-resistant pathogens, changes in antibiotics, and failure rates of initial antibiotic therapy were significantly lower in the positive PUAT group than in the negative PUAT group of the propensity-matched cohort. Conclusions:We found that the sensitivity of the index test was low and specificity was high in this clinical setting. And our findings suggest that positive PUAT results may be associated with favorable clinical outcomes in patients with CO-pneumonia.
( Jonghoo Lee ),( Jae-uk Song ),( Yee Hyung Kim ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.3
Background: Although the Quidel Sofia rapid influenza fluorescent immunoassay (FIA) is widely used to identify influenza A and B, the diagnostic accuracy of this test remains unclear. Thus, the objective of this study was to determine the diagnostic performance of this test compared to reverse transcriptase-polymerase chain reaction. Methods: A systematic literature search was performed using MEDLINE, EMBASE, and the Cochrane Central Register. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), and a hierarchical summary receiver-operating characteristic curve (HSROC) of this test for identifying influenza A and B were determined using meta-analysis. A sensitivity subgroup analysis was performed to identify potential sources of heterogeneity within selected studies. Results: We identified 17 studies involving 8,334 patients. Pooled sensitivity, specificity, and DOR of the Quidel Sofia rapid influenza FIA for identifying influenza A were 0.78 (95% confidence interval [CI], 0.71-0.83), 0.99 (95% CI, 0.98-0.99), and 251.26 (95% CI, 139.39-452.89), respectively. Pooled sensitivity, specificity, and DOR of this test for identifying influenza B were 0.72 (95% CI, 0.60-0.82), 0.98 (95% CI, 0.96-0.99), and 140.20 (95% CI, 55.92-351.54), respectively. The area under the HSROC for this test for identifying influenza A was similar to that for identifying influenza B. Age was considered a probable source of heterogeneity. Conclusion: Pooled sensitivities of the Quidel Sofia rapid influenza FIA for identifying influenza A and B did not quite meet the target level (≥80%). Thus, caution is needed when interpreting data of this study due to substantial between-study heterogeneity.
Free-standing 박막의 전계 방출 특성을 이용한 고에너지 이온 디텍터에 관한 연구
박종후(Jonghoo Park) 한국자기학회 2011 韓國磁氣學會誌 Vol.21 No.5
We describe modified Fowler-Nordheim (FN) field emission equation for the free-standing nanomembrane cathode, which has mechanical degrees of freedom. The derived FN equation agrees well with the experimental data. The free-standing nanomambrane cathode demonstrates its unique ability to detect large biomolecure ions.
Lee Jonghoo,Park Hye Kyeong,Kwon Min-Jung,Ham Soo-Youn,Gil Hyun-Il,Lim Si-Young,Song Jae-Uk 대한의학회 2024 Journal of Korean medical science Vol.39 No.6
Background: Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort. Methods: We performed a cohort study on 68,418 healthy Koreans (34,797 males, mean age: 38.1 years) who underwent a health examination in 2019. ApoB/apoA-I ratio was categorized into quartiles. Spirometric values at the fifth percentile in our population were considered the lower limit of normal (LLN), which was used to define lung function impairment. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs), using the lowest quartile as the reference, were estimated to determine lung function impairment. Results: Mean apoB/apoA-I ratio was 0.67 ± 0.21. Subjects with the highest quartile of this ratio had the lowest predicted forced expiratory volume in one second (FEV1%) and forced vital capacity (FVC%) after controlling for covariates (P < 0.001). However, FEV1/FVC ratio was not significantly different among the four quartiles (P = 0.059). Compared with the lowest quartile (Q1, reference), the aORs (95% CI) for FEV1% < LLN across increasing quartiles (from Q2 to Q4) were 1.216 (1.094–1.351), 1.293 (1.156–1.448), and 1.481 (1.311– 1.672) (P for trend < 0.001), respectively. Similarly, the aORs for FVC% < LLN compared with the reference were 1.212 (1.090–1.348), 1.283 (1.147–1.436), and 1.502 (1.331–1.695) with increasing quartiles (P for trend < 0.001). However, the aORs for FEV1/FVC < LLN were not significantly different among groups (P for trend = 0.273). Conclusion: High apoB/apoA-I ratio was associated with decreased lung function. However, longitudinal follow-up studies are required to validate our findings.
일본 대학에서 비전공 한국어 과목 수강자의 수강 동기에 대한 현황과 추이
박종후 ( Park Jonghoo ),정선영 ( Jung Sunyoung ) 연세대학교 언어연구교육원 한국어학당 2019 외국어로서의 한국어교육 Vol.55 No.-
The aim of this study is to investigate the motivation of learning the Korean language for Japanese university students who do not major in Korean. In the analysis, we compared different types of motivation for the participants classified with two different variables: gender and presence of former experience in Korea-related fields. In addition, we compared this study with the 2014 survey to examine if there were any longitudinal differences. We conducted a survey with 552 students in twelve different regions in Japan. We found that most of the students who were enrolled in a non-major Korean language course had an internal motivation. Not many students, both male and female, were taking the Korean language class for a practical reason. This study also showed that those students who previously visited Korea were taking the language class with an internal motivation. Former experience in making Korean friends or learning the language did not seem to play an important role to form students’ motivation to take the Korean language class. As we compare the results of the current study and the 2014 study, it is noteworthy that external motivation has decreased and internal motivation has increased in contrast. Namely, internal motivation has become more crucial over time. The findings of this study will contribute to recalibrating the purpose of Korean language education as an elective subject in Japanese universities. (Dokkyo University · Former Yonsei KLI)
박종후(Park, Jonghoo),하지경(Ha, Jikyung) 한국사전학회 2012 한국사전학 Vol.- No.20
This research aims to build practical and useful models of dictionary to help foreign learners learning Korean foreign words. Foreign words go through a morphological, syntactic, and pragmatic change when incorporated into the Korean vocabulary system. If the information is provided inaccurately, then the words will not be fully understood and used. Foreign words dictionary is needed in order to provide accurate meaning of original words to the learners. First, research investigated Korean foreign words dictionary’s problems in selection and arrangement of headwords in terms of the macro-structure. Then, we considered how to present detailed explanation, meaning, phonology, grammar, and pragmatic information of headwords in terms of microstructure. Therefore, the research recommends selecting frequently used foreign words as headwords and present appropriate examples to fill out the information gap from the changes in semantic and syntactic areas. This approach will improve learner’s ability to understand and express Korean foreign words.