수중운동이 다운증후군 청소년의 신체조성 및 등속성 근력과 평형성에 미치는 영향

신영륜,전종귀 충남대학교 체육과학연구소 2006 體育科學硏究誌 Vol.24 No.1

The purpose of this study was to evaluate the effects of aquatic exercise on body composition, isokinetic strength and balance in the adolescences with Down's syndrome. Seven adolescences with Down's syndrome, aged 13 to 18(average age of 15.14), with an average height of 144.28cm and weight of 47.68kg, participated in this study after the informed consent had been done by their parents. They participated in the aquatic exercise program for 12 weeks, 3 times a week, for 50 min at a time. No individuals extended their participation over this period of time. The subjects' body composition and isokinetic strength were measured before and after the aquatic exercise. Also, two ways of balance test were done. The static balance test was used by Stick test, the other dynamic balance test was used by Straight walking test. Data were analyzed by paired t-test. The significance was considered under 0.05. The results were as follows; First, after the 12 weeks' aquatic exercise, the body composition was positively changed in the adolescences with Down's syndrome. Second, after the 12 weeks' aquatic exercise, the peak torque, peak torque %body weight and flexor/extensor ratio at the angular velocity of the low speed(60 deg./sec) in knee isokinetic strength were significantly increased in the adolescences with Down's syndrome. Also, the peak torque, peak torque %body weight and flexor/extensor ratio in shoulder isokinetic strength were significantly increased in the adolescences with Down's syndrome. Third, the aquatic exercise had positive effects on static balance test, Stick test, for adolescences with Down syndrome. Also, the aquatic exercise had very positive effects on dynamic balance test, Straight walking test. Therefore, the aquatic exercise had positive effects on the balance of adolescences with Down syndrome. In Conclusion, the aquatic exercise program had significant effects on increasing functions of muscle strength and balance sensory, which were retarded at the adolescences with Down's syndrome.

PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adentis) 증후군 1예

강혜련,김신우,배기범,박지현,강영모,이종명,김능수 대한감염학회 2001 감염 Vol.33 No.3

PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis) syndrome has characteristic features of an early onset, periodicity (interval <4 weeks), and a brisk rising high fever (>39℃) of 3 to 6 days' duration without signs of infection. An 18-year-old male was admitted for high fever, sore throat, headache, and abdominal pain. He had suffered from periodic fevers associated with pharyngitis and cervical adenitis for 14 years without any evidence of infection. The fever recurred approximately every 4 weeks lasting 4 to 7 days with intervening asymptomatic periods. Physical examination was unremarkable except for slightly injected tonsils. Most laboratory tests including CBC were normal except for elevation of Creactive protein level (3.47 mg/dL). Bacteriologic and radiologic studies were negative. The fever was spontaneously subsided in 6 days. To our knowledge, this is the first case report of PFAPA syndrome in Korea. (Korean J Infect Dis 33:219∼222, 2001)

Fraunhofer Diffraction Method를 이용한 Plasma파동 측정에 관한 이론적 해석

곽옥련,박종만,정중현 釜山水産大學校 1993 釜山水産大學 硏究報告 Vol.33 No.1

The theoretical analysis of Fraunhofer diffraction method as a new means to measure the wave number spectrum, spatial position and propagating direction of plasma waves is presented. A general theory of the Fraunhofer diffraction method is discribed by using the volume integration of electric fields induced by individual electrons integrating with the incident beam over the diffracting volume, and can include such conditions as the oblique incidence of the electromagnetic wave and a finite width and a spatial position of plasma wave. The principle for measurement of wave number spectra of plasma waves is discussed by using theoretical analysis of the approximate solution of the Fraunhofer diffraction theory. In measurement of the wave number of the long wave length region, the information of the wave number is easily obtained from the ratio of the intensity at u=0 to the intensity at u=0.75, where the normalized coordinate is given in the peak point. Further, effects of the incident angle and the plasma wave width are discussed by the intensity profile. From the envelope profile, the wave number, width and propagating direction of plasma waves are obtained by a process of curve fitting.

백서의 과부하 좌심실에서 Myosin Heavy Chain Gene의 발현 양상과 심근의 형태 변화에 미치는 Cyclosporine의 영향

고광련,박종태 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Background: In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of fetal cardiac genes. Recently, the calcineurin inhibitor, cyclosporine has been reported to prevent the development of cardiac hypertrophy, however, others reported data which are disagreed to the cyclosporine effect on the prevention of cardiac hypertrophy. Objective and Method: To clarify whether the calcineurin signaling pathway is a critical for overloaded hypertrophy in vivo and to characterize the cyclosporine effect on the development of cardiac hypertrophy, I examined the effects of cyclosporine on the left ventricular overload in the experimental model of clipping of abdominal aorta between the diaphragm and renal artery for three weeks in rats. Results: Left ventricular mass was larger in the group of clipping of abdominal aorta than in the group of cyclosporine injection after clipping of abdominal aorta, however, which had larger ventricular mass rather than control group. It means that cyclosporine suppress hypertrophic growth. Both treated and untreated animals showed increased nuclear polymorphism and euchromatin pattern, and also, ultrastructurally, showed degenerative changes in the cardiac myocytes such as swelling of subsarcolemmal cytoplasm with indistinct sarcoplasmic reticulum and "T" tubules, loosening of myofibril bundles with decreased electron density, and electron dense mitochondria with decreased number, Characteristically, the group of cyclosporine injection after clipping of abdominal aorta showed polymorphic electron dense unswollen giant mitochondria which was not characteristic in other groups. α-MyHC mRNA including non-spliced mRNA of the group of abdonminal aortic clipping was downregulated in the both groups of clipping of abdominal aorta. β-MyHC mRNA was upregulated in the group of clipping of abdominal aorta and downregulated in the group of cyclosporine injection after clipping of abdominal aorta. From the above results, initial response to overload is a degenerative changes of cardiac myocytes and cyclosporine may suppress hypertrophic response and the fetal gene reactivation such as β-MyHC mRNA in this experiment.

고인슐린 혈증과 다낭성난소증후군의 병태 생리

김세련,김종욱 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Polycystic ovary syndrome (PCOS) is a heterogenous and a common disorder in the women of reproductive age. In these women the ovary seems to be the primary site of endocrine abnormalities, especially hyperandrogenism. Insulin resistance and hyperinsulinism, the main causes of PCOS, augment hyperandrogenism. There are evidences for underlying genetic causes for PCOS and several candidate genes are suggested. But a lot of thing in genetics still remain to be elucidated. The pathophysiology of PCOS appears to be multifactorial and polygenic and adverse health consequences such as cardiovascular disease, diabetes mellitus, and endometrial cancer are related with PCOS. So, treatment methods should be multiple and individualized.

간이 폐기능측정기 (mini-Wright)와 비강세척액 (Nasal Lavage)을 이용한 대기오염물질과 호흡기 건강영향 분석

이종태,정용,현연주,조혜련 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.1

A large number of studies have indicated associations between the impairment of respiratory health and exposure to ambient air pollutants such as ozone (O₃), nitrogen dioxide (N0₂), sulfur dioxide (S0₂), particulate matters (PM_(10)). To evaluate this associations, we used the pulmonary function tests (peak expiratory flow rate: PEFR) by mini-wright peak flow meter and counting neutrophils in the nasal lavage (NL) as biomarker. From 15 June to 16 July 1998, for the workers in the highway tollgates, PEFR and NL were measured three times daily and twice per week, and association between the level of air pollutants and PEFR and NL were analyzed using the multiple regression model and the poisson regression model respectively. The results indicated that the effects of all measured air pollutants (SO₂, NO₂, O₃, PM_(10)) were not significantly associated with the value of PEFR. On the other side, S0₂, NO₂, PM_(10) were significantly associated with the number of neutrophils in NL. The increase in SO₂, N0₂ of 10ppb and in PM_(10) of 10μg/m³ was associated with 24%, 21%, 35% increases in neutrophil counts. But the ozone exposure was not associated with NL.

소아치과 개원의 진료 현황 분석

최은정,정태련,한세현,김영재 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

A study on aerodynamic characteristics with the supersonic nozzle quantity

Jong-Hoon Lee(이종훈),Kyoung-Ryun Kim(김경련),Jong-Ho Park(박종호) 한국유체기계학회 2015 유체기계 연구개발 발표회 논문집 Vol.2015 No.6