백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

농촌 자활사업참여자의 음주 문제 개입프로그램 개발: 동기강화상담의 적용

이종례(Jong Rea Lee),장수미(Soo Mi Jang),허성희(Seong Hui Heo) 한국지역사회복지학회 2022 한국지역사회복지학 Vol.- No.83

본 연구의 목적은 동기강화상담(Motivational Interviewing: MI) 모델을 적용하여 농촌 자활사업참여자의 음주 문제 개입프로그램을 개발하는 것이다. 개입연구(Intervention Research: IR)의 절차에 따라 문헌고찰, 실무자 인터뷰를 시행한 후 농촌 자활사업참여자의 음주문제 양상을 파악하고, 동기강화상담의 원리와 전략에 기반하여 1차 프로그램을 구성하였다. 전문가 자문을 통해 수정 보완 후 2차 프로그램을 도출하였고, 음주 문제를 가진 농촌 자활사업참여자를 실험집단(n=10)과 통제집단(n=10)으로 무작위 배치한 후, 실험집단에 동기강화상담 기반 음주 문제 개입프로그램을 실시하였다. 사전‧사후‧추후 조사를 통해 개입프로그램의 효과성을 평가한 결과, 실험집단의 음주 지식, 단주 자기효능감, 변화 동기, 음주 문제, 자활 성과의 사전‧사후 점수에서 유의미한 변화가 발생하였고, 음주 문제를 제외한 모든 변인에서 사전‧추후 점수의 유의미한 변화가 나타났다. 음주 문제의 경우 사전‧추후, 사후‧추후 모두 유의미한 변화가 발생하지 않아 효과성이 유지되지 않음을 확인하였다. 이후 현장 실험 결과에 대한 피드백을 반영하여 최종(3차) 프로그램을 개발하였다. 결론에서는 주요 연구 결과를 바탕으로 논의하고, 자활 현장을 중심으로 사회복지 실천 및 정책에의 함의를 제시하였다. The purpose of this study is to develop an intervention program for the drinking problem of participants in rural self-sufficiency center by applying the Motivational Interviewing(MI) model. According to the stages of Intervention Research(IR), the aspects of drinking problems of rural self-sufficiency participants was identified through literature review and interviews with practitioners, and the 1st program was constructed based on the principles and strategies of MI. After revising with experts advice, a 2nd program was derived, and rural self-sufficiency participants with drinking problems into an experimental group(n=10) and a control group(n=10) by random assignment, MI was conducted only in the experimental group. As a result of the program, significant changes occurred in the pre and post scores of the experimental group’s drinking knowledge, abstinence self-efficacy, change motive, drinking problem, and self-sufficiency outcomes, and significant changes in pre and 6 weeks later scores were found in all variables except for drinking problems. The drinking problem was not significant in pre and 6 weeks later, post and 6 weeks later, it could be seen that the effectiveness was not maintained. The 3rd(final) program was developed by evaluating the effectiveness of the programs, and reflecting feedbacks from field experiment. In conclusion, the implications for social welfare practices and policies were presented, focusing on the field of self-sufficiency.

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

박송암제 화청에 관한 음악 연구

이종미(Lee Jong-Mi) 한국전통음악학회 2007 한국전통음악학 Vol.- No.8

Hwachoeng is the musical result of missionary activities of Buddhism as a trial to make Buddhism popular. It is a precious cultural asset to Korean Music. It is considered to be worthwhile to study as music in the form of a song with ethnic emotion from the prehistory times to the modern times. Here are the summary of the results of the disscussion up to now. First, Hwacheong means the invitation to Bulbosal. It became a song by putting ‘Yul’ on the pre-existing verse. All the buddhist songs except Beompae can be classified as Hwacheong. As anyone can create it because ‘Yul’ goes freely, we can classify it as popular music. Second, when we see its musical characteristics of Hwacheong, tune and musical scale is Major Key D, which is similar to Folk Song Tune and Musical Scale of the Eastern Part such as Menarijo that uses the three keys Mi-Ra-Do. Among them Ra is most frequently used. Third, rhythm is mostly 9/8 and sometimes we can see other rhythms such as 4/8, 12/8, and 15/8. For the pattern, it does not have special pattern unlike other musical notes. It has the pattern of A-A'-A''-A'''. Fourth, Hwacheong is classified as free style music. From the analysis of the collected notes, we could confirm that they do not have uniform or consistent rhythm or phrase. Although they have the same words in the first phrase, they have different verse from the second phrase. Hwachong can be considered as our unique and original music in our history. We need to try diverse and various approaches to it, perceiving it as inclusive and pure music in our musical history.

마황윤폐탕의 병용이 Quinolone계 항생제 중 Rufloxacin의 호기성 Gram(+) 세균주에 대한 시험관 내 항균력에 미치는 영향

박미연 ( Park Mi Yeon ),김대준 ( Kim Dae Jun ),김종대 ( Kim Jong Dae ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4

N/A Objectives : In order to evaluate the in uitro synergic effect of Mawhngympye-tang which was a traditional poly-herbal formula has been used in the treatment of respiratmy diseases in Korea, with quinolone antibiotics, rufloxacin the minimal inhibitory concentration (MIC), MI& and MIGO of single use of quinolones and concomitant treatment with Mawhangyoonpye-fnng against 9 strains of gram positive bacteria. Methods : Agal plate dilution methods. Results : 1. In the case of aerobic gram positive bacteria, the MIC, MI& and MI& against S@&loconus aweus, Stqphyl- aweus smith, Staphyl- epidermidis, SWwlocoaxrs pyogens, Streptoamus pneumoniue Type I, Type II and Type III was significantly decreased in concomitant treated groups with Mawhrutgyoonpye-tang compared to those of single treated groups of RUFX. Conclusions : It is considered that the in uitro antibacterial activity of RUFX were increased against some strains of gram positive strains, especially, pneumococcus such as Stc&~loaxxus, Streptococcus by concomitant use of Mawwoorapye- tang.

Mycobacterium intracellulare에 의한 요추부 척추염 1예

장은영,김미영,김정욱,송은희,백관미,정용필,성흥섭,김미나,김양수,우준희,이상호 대한감염학회 2007 감염과 화학요법 Vol.39 No.3

비결핵성 미코박테리아에 의한 척추염에 대한 증례 보고가 국내에서는 아직 없었다. 저자들은 기저질환이 없는 환자에서 M. intracellulare에 의한 척추염을 rpoB 유전자에 대한 PCR-RFLP 방법을 통해 진단하였고 수술적 치료와 3제 병합 항균 요법으로 성공적인 임상 경과를 보인 1예를 경험하였기에 보고하는 바이다. We report a case of vertebral osteomyelitis due to Mycobacterium intracellulare in a 60-year-old man without predisposing conditions. He was successfully treated with surgical excision of the inflamed tissue and combined antimycobacterial therapy consisting of clarithromycin, ethambutol, and rifampin. In this case, polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) based on the rpo B gene of cultured isolates allowed rapid identification of M. intracellulare. Although very rare, nontuberculous mycobacteria (NTM) should be suspected as a causative pathogen of vertebral osteomyelitis. To the best of our knowledge, this is the first case of vertebral osteomyelitis caused by NTM reported in the Korean literature.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

향기요법이 통증을 주소증으로 입원한 환자의 수면장애에 미치는 영향

박수곤 ( Soo Gon Park ),양미성 ( Mi Sung Yang ),김오영 ( Oh Young Kim ),조희근 ( Hee Guen Jo ),최진봉 ( Jin Bong Choi ),김선종 ( Sun Jong Kim ),설재욱 ( Jae Uk Sul ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :The purpose of this study is to investigate the effects of aroma therapy on sleep disorder patients with musculoskeletal pain. Methods :The 44 patients were divided into 2 groups: Experimental group(Exp. group) was treated with aroma therapy and control group was treated except aroma therapy. To evaluate the efficiency of aroma therapy, the Korean sleep scale A(Jin-Joo Oh, Mi-Soon Song, Sin-Mi Kim. 1998) and visual analogue scale(VAS) were applied before treatment and after 5 days treatment. Results :1. The Experimental group has improved statistical significance in sleep disorder score as compare to the control group. 2. The improvement of sleep disorder score of Exp.group has difference according to impression. 3. The improvement of sleep disorder has an effect on pain decrease. Conclusions :Aroma therapy has effects of improvement on sleep disorder with musculoskeletal pain.

보문 : Polyethylene Film포장이 포도 Sheridan의 저장력에 미치는 영향

남상영(Sang Young Nam),김경미(Kyoung Mi Kim),박종천(Jong Chun Park),주선종(Seon Jong Joo),정재현(Jai Hyun Jung) 한국식품저장유통학회(구 한국농산물저장유통학회) 1997 한국식품저장유통학회지 Vol.4 No.1

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.