한국인에게서 그레이브스병 약물치료의 적정기간

이형숙,이동훈,정희선,이종우,김정은,신승수,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: 그레이브스병의 치료에는 항갑상선제, 수술 및 방사성 요오드법이 선택되어 사용되고 있다. 이중 항갑상선제는 가장 많이 선호되고 있으나 낮은 관해율과 높은 재발율로 장기간 치료기간이 요구된다. 저자들은 그레이브스병 환자에게서, 선택되는 치료법의 선호도와 각 치료법의 관해율을 조사하고자 본 연구를 시행하였다. 또한 본 연구에서는 항갑선제 치료의 적정기간을 평가하고자 하였다. 방법: 아주대학교병원에 내원한 환자 중 1년 이상 추적관찰이 가능한 205명의 그레이브스병 환자를 대상으로 조사하였다. 항갑상제군, 수술군 및 방사성 요오드군은 각각 170명, 29명 그리고 6명이었다. ROC curve를 이용하여 약물치료의 예후예측인자를 분석하였다. 결과: 1) 그레이브스병 환자의 치료 방법의 선택은 항갑상선제군, 수술군 및 방사성 요오드군 각각 170명(83.0%), 29명(14.1%) 그리고 6명(2.9%)으로 항갑상선제 치료가 가장 선호되었다. 2) 그레이브스병의 관해율은 항갑상선제군, 수술군 및 방사성 요오드군에서 각각 60.0%(102/170명), 96.5%(28/29명) 그리고 83.0%(5/6명)으로 수술군이 가장 높았다. 3) ROC curve의 AUC는 치료기간과 진단시 TBII가 각각 0.709 및 0.648이었고 적절한 약물투여 추적 관찰기간은 26개월이었다. 결론: 그레이브스병의 일차 치료법으로는 항갑상선제가 선호되고 있으나 수술 및 방사성 요오드 치료군에 비해 상대적으로 낮은 관해율을 보였다. 따라서 항갑상선제 치료로 26개월 이상 관해가 되지 않을 경우에는 치료 방법의 변경을 고려하는 것이 관해율을 높이는데 도움이 될 것으로 생각된다. Background: Graves' disease in an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment. Subjects & Methods : The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve. Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis. Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted (J Kor Soc Endocrinol 18:24∼31, 2003).

연안 도시 대기오염 물질의 농도분포 특성

박종길,석경하,김지형,차주완 한국환경과학회 2002 한국환경과학회지 Vol.11 No.12

This paper aims to find the characteristics of concentration distribution of coastal urban air pollutants. For this purpose, It was used the daily meteorological data and hourly concentration data O_3 and NO_2 in Busan metropolitan city from 1994 to 1996. It was investigated the annual and monthly distribution of ozone and nitrogen dioxide concentration at each site in Busan, and also investigated the characteristics of concentration change of air pollutants with time under the sea breeze. As a results, the concentration of nitrogen dioxide and ozone tend to be increased every year and nitrogen dioxide concentration is higher than ozone concentration at all site in Busan. The concentration of ozone is high in summer season and low in winter season, but the concentration of nitrogen dioxide have a reversed trend. The monthly peak concentration of ozone occurred in April and September, while the monthly minimum concentration of nitrogen dioxide occurred in August. Their trend were indentified by sites near the coastline than sites stands apart from the coastline. The sea breeze occurred annual mean 81 days in Busan from 1994 to 1996. The main wind direction of sea breeze was classified into southeasterly. In case of southwesterly, It was pronounced the south wind and southwest wind. In case of southeasterly, the occurrence frequency of east wind was high. Especially, the concentration of urban air pollutants, such as ozone and nitrogen dioxide, were high on time which the sea breeze flow, and the areas that ozone concentration was high moved from outside part to central part of city with time. In costal urban such as Busan, the wind direction of sea breeze is influenced the influenced the change of ozone and nitrogen dioxide concentration on time which the sea breeze flow at each site and air pollutants concentration of sites on the pathway of sea breeze.

진주시에 유통중인 채소류의 중금속 함량에 관한 조사

김형갑,김명종 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14

The samples of 31 vegetable items, showing the high average intake per day in the 2001 National Health and Nutrition Report(Ministry of Health and Welfare), were selected from the 4 areas in Jinju - Jayu Market, Joong-ang Market, Chunjun Market, and E Mart. Among them, the heavy metal uptakes by the 8 items, i.e. Chinese cabbage, lettuce, leek, dropwort, radish, onion, and red pepper were analyzed, utilizing Inductively Coupled Plasma Spectrometer(ICP). The following are the results of Hg, Cd, Pb, As, Zn, Cu, Mn, Cr, Fe content analysis of the samples. 1. The minimum, maximum, and average level of the respective heavy metal content [mini.~maxi.(mean)]ppm(mg/kg) was as follows. Hg: ND~0.014(0.001), Cd: ND~0.024(0.003), Pb: ND~0.980(0.187), As: ND~0.322(0.097), Zn: 0.335~5.386(1.257), Cu: 0.276~1.598(0.675), Mn: 0.278~12.543(2.433), Cr: ND~0.629(0.053), Fe: ND~6.103(1.793) 2. Compared with the permissible limit, the average heavy metal content detected from each area showed that the level of Mn was somewhat higher than the limit while that of Pb was close to the limit. The levels of the rest of the heavy metals were lower than the limit. The detected amount of the heavy metals followed the order of Mn>Fe>Zn>Cu> As>Pb. 3. Even if this study was conducted in a limited area within a short period of time, each area did not show a noticeably different result, reflecting the fact that in terms of heavy metal concentration, there is no significant environmental difference between the general agricultural area and the organic agricultural area. The heavy metal concentrations of the vegetables circulated in Jinju were within the safe limit regulated by the WHO/FAO.

한국 내륙지방 충주ㆍ중원지역 학동의 치아우식발생빈도에 관한 통계학적 연구

이종갑,정태형 大韓小兒齒科學會 1984 大韓小兒齒科學會誌 Vol.11 No.1

1,840 school children aged 6 to 13 years who live in inland area in CHOONG CHUNG BUKDO were surveyed epidemiologically on the dental caries prevalence. The results were as follows; 1. The prevalence of dental carries was 76.35 percentage in male, 76.15 percentage in female, and 76.25 percentage in both sexes. 2. d.m.f rate was 77.72 percentage in male, 80.07 percentage in female, and 78.86 percentage in both sexes. D.M.F rate was 30.73 percentage in male, 38.52 percentage in female, and 34.51 percentage in both sexes. 3. d.m.f.t. rate and index was 27.94 percentage, 2.55T, and d.m.f.s. rate & index was 13.62 percentage, 6.22T. 4. D.M.F.T rate & index in permanent teeth was 4.86 percentage, 0.72T, and D.M.F.S rate & index was 1.20 percentage, 0.89T. 5. The filling rate was 3.90 percentage in decidious teeth, 2.00 percentage in permanent teeth.

가교된 공중합 폴리이미드막에 의한 벤젠/싸이클로헥산 혼합액의 분리

김종환,이형록,김진환 한국공업화학회 2003 응용화학 Vol.7 No.1

Crosslinked copolyimide membranes containing both sulfony1 group(-SO_2) andtrifluoromethy1 group(-CF_3) which have high affinity for benzene, were prepared andthe pervaporation properties of these membranes were investigated for the separationof benzene/cyclohexane mixtures. Crosslinked copolyimide membranes were obtainedby a polycondensation of 6FDA with DDBT and DABA and a crosslinking withethylene glycol. Sorption and pervaporation experiments were performed at 323K,333K and 351K It has been found that all the crosslinked copolyimide membranes show high separation performances and good chemical and thermal stability.

상악 전치부 INTRUSION시 초기 응력 분포에 관한 광탄성학적 분석 : Utility archwire, Burstone intrusion archwire, "J" hook headgear에 의한 By Utility Archwire, Burstone Intrusion Archwire, and "J" hook Headgear

백혜정,백형선 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.3

부정교합은 전후방, 측방, 수직적 부조화로 분류할 수 있는데, 수직적인 부조화 중 과개 교합을 해소하기 위하여 환자의 상태에 따라 구치부의 정출 혹은 전치의 intrusion이 시도되고 있으며, intrusion은 여러 선학들에 의해 다양한 방법들이 사용되어지고 있다. 본 연구는 전치의 intrusion 방법으로 임상에서 많이 사용되어지고 있는 utility archwire, Burstone intrusion archwire, "J" hook headgear에 의한 상악 전치부 intrustion시 초기 응력 상태를 광탄성법으로 비교 연구하기 위하여 치아와 치조골 모형을 광탄성물질로 대체시키고 wire와 baacket을 주어진 조건으로 위치시킨 후 편광판을 이용하여 초기 응력 상태를 분석하였고, 아래와 같은 결과를 얻었다. 1. utility archwire에서는 중등도의 응력이 전치부의 치근단 부위에서 비교적 균일하게 나타났고, 제1대구치의 치근단 부위에서는 집중되어 나타났다. 2. Burstone의 3-piece intrusion archwire에서는 중등도의 응력이 전치부와 구치부의 치근단 부위에서 비교적 균일하게 나타났다. 3. "J" hook headgear에서는 강한 응력이 치조골 전반과 전치부 치근단 부위에 넓게 분포되어 나타났고, 특히 중절치와 측절치 사이 치조골 부위에 가장 강한 응력을 나타냈다. 다른 군과는 달리 전체 치아의 periodontal ligament space를 따라 약한 응력이 나타났다. The purpose of this study was to analize the initial stress distribution around apex and the alveolar bone of the upper anterior teeth when applying intrusive force by the use of utility archwire, Burstone 3-piece intrusion archwire, and "J" hook headgear which is usually used in clinical practice. By the use of the polarization plate, initial stresses were analized when 80g and 150g force applied. The results were as follows. 1. With the utility archwire, moderate levels of stress were evenly distributed on the areas of the anterior teeth and concentrated on the apical areas of the first molars. 2. With the Burstone`s 3-piece intrusion archwire, moderate levels of stress were evenly distributed on the apical areas of the anterior and posterior teeth. 3. With the "J" hook headgear, severe levels of stress were widely distributed on the alveolar bone and apical areas of the upper anterior teeth, and concentrated on the apical area between the central and the lateral incisors. Especially, weak levels of stress appeared along the periodontal ligament space of all teeth.

비행체 탑재 빔 조향 안테나

함형석,문상만,우종명 충남대학교 산업기술연구소 2005 산업기술연구논문집 Vol.20 No.1

This paper presents the Beam steering antenna on aircraft. An proposed and advanced printed type monopole antenna which overcomes drawbacks of conventional monopole antennas. On the front part, it has parasitic elements as a reflector to increase directivity gain in one direction. The Beam Steering antenna proposed in this paper has pin diode attached between two parasitic elements and ground, enabling control of beam directivity by the diode switch. The proposed antenna on aircraft shows the characteristics of the back directivity antenna with the gain of 1.5dBd and F.B. ratio 8.8dB, which leads us to conclude that the antenna has advantages in improving the gain and F.B. ratio.

淸末 新政期의 敎育改革과 財政問題 : 江蘇省의 事例를 中心으로 the Case of Jiang-su Province

金衡鍾 韓國外國語大學校 歷史文化硏究所 1998 역사문화연구 Vol.8 No.-

토착형 P. vivax에 의한 Malaria 4례

박형렬,이성원,이경미,김태겸,한진영,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.2

국산 머루주의 품질 특성 및 생리기능성

이대형,유형은,이종수 배재대학교 자연과학연구소 2004 自然科學論文集 Vol.15 No.1

To develop a new functional fruit wine, quality characteristics and physiological functionality of wild grape wine(WGW) were investigated and compared with that of foreign grape wine(FGW). Ethanol contents of WGW was 11.0%, similar to that of FGW(10.6%), but total acidity(0.67%) and total anthocyanin content(A_(520): 0.32) of WGW were higher than those of FGW(0.4%, 0.22). Antioxydant activity and SOD-like activity of WGW which is related in anti-aging functionality were 93.6% and 53.0%, respectively, higher than those of FGW(85.9%, 42.5%). From this results, we concluded domestic wild grape wine is very excellent functional fruit wine.