작동시스템의 파라미터 불확실성을 고려한 강건 진동제어

안종국,김효준 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.1

This paper present the design of a robust controller for a computer-controlled active vibration isolation system in the battle ship. Firstly, isolation system model is constructed considering the isolation structure equipped with precision electric devices actuator dynamic of a nonlinear hydraulic system. An active control system is designed based on sliding mode control theory regarding parametric uncertainties of the isolation structure induced by laden condition and varying parameters of the hydraulic system resulting from leakage, pressure drop of pressurized line and temperature-effected viscosity. Finally, the performance of the active isolation system is evaluated by simulation under certain disturbance condition with are transmitted from base structure of the battle ship induced by an under water explosion or firing of machine gun.

집단검진에서 발견된 고협압증에 관한 역학적 연구

홍종관,박종안 順天鄕大學 1987 순천향대학논문집 Vol.10 No.2

집단검진에서 발견된 고혈압증에 관한 역학적연구

홍종관,박종안 순천향대학교 1987 논문집 Vol.10 No.2

This study was made on 28,257 national officers including and private school personnels through the annual physical examination undergone at the SCH Univ. Hosp. in Seoul, Chunan and Gumi from April 1 to July 31, 1986 to figure out any relations between the asymptomatic hypertension found through the physical examination and the variables of physical examination items related with hypertension. The results were as follows : 1. Not only the mean blood pressure of systolic and diastolic but also the prevalence rate of hypertension were increased with higher age in both male and female. 2. The prevalence rate of hypertension was increased with higher Rohrer index in both sexes. 3. The normal group on the tests related with hypertension, i.e. blood sugar, total cholesterol, urine protein, and urine sugar showed the prevalence rate in hypertension, higher than without them. And the tests as serum creatinine, occult blood, and hemoglobin were not related with the prevalence rate of hypertension in both groups. 4. The result of multiple regression analysis on the variables related to hypertension in screening physical examination showed that the variables such as age, body weight, Hb., and Rohrer index were significant with hypertension. 5. The result of multiple regression analysis on 19 variables related to hypertension showed that the variables as age, retinal finding and drinking were significant with systolic pressure, and dizziness and glycosuria were with diastolic pressure in male, while the ECG finding, smoking, edema on extremities, cough, dizziness and glycosuria were significant with systolic pressure, and drinking, fatigur, glycosuria and diet habit were with diastolic pressure in female respectively.

지반의 진행성 파괴와 기초의 크기 효과를 고려한 지지력 특성에 관한 실험적 연구

임종철,안민홍,홍석우,강정철,여종인 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

얕은 기초의 지지력을 산정하는데 있어서 기존 이론의 지지력계수(Nc,Nr,Nq)는 흙의 내부마찰 각 φ만의 함수로 표현되어져 있다. 그리고 조밀한 모래지반에서는 동시파괴(전반전단파괴)가 발생한다고 가정하고 있다. 본 논문에서는 주문지 표준사를 이용하여 중간·조밀한 모래지반을 제작하여, 재하폭 B를 변화시켜 실험하였다. 실험 결과, 조밀한 모래지반에서도 진행성파괴가 발생하며, 지지력계수 Nr의 평가에 있어서 내부마찰각 φ뿐만 아니라, 재하폭 B의 영향이 고려되어져야 함을 알 수 있었다. The bearing capacity factors(Nc,Nr,Nq) of an existing formulae are the function of only internal friction angle(φ) in calculating of ultimate bearing capacity of shallow foundations. And it is assumed that the simultaneous failure(general shear failure) occurs in the dense sand. In this study, the medium to dense sand grounds are formed by Joomunjin standard sand, and the laboratory medel tests are made with the change of load-width(B). By test it is known that the progressive failure is also occurred in the dense sand ground and so the bearing capacity factor(Nr) should be considered for not only internal friction angle(φ) but also the effect of load-width(B).

Classical Swine Fever (Hog cholera) Virus 약독순화주 (Suri 주)의 gp55 Gene 염기서열 분석

김귀현,장경수,강경임,이병형,박종현,안수환,전무형 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

An attenuated classical swine fever virus (CSFV), Suri strain, is a variant derived from a vaccine virus, LOM strain. This study was performed to elucidate the molecular biologcal properties of CSFV Suri strain, and to obtain the basic data for molecular epidemiological approaches for the disease. The truncated form of gp55 gene without the C-terminal trasmembrane domain, in size of 1,023bp, was amplified by RT-PCR and sequenced by dye terminator cyclic sequencing method, and inserted into BamHI site of pAcGP67B baculovirus vector, establishing a cloned pAcHEG plasmid. By the nucleotide sequences determined, 341 amino acid sequences were predicted. As compard the nucleotide and amino acid sequences of gp55 of Suri with the various CSFV, Suri strain showed the high homology over 99.1% with ALD and LOM strains, but comparably the lower homology with Alfort and Brescia. In comparison of amino acid sequence in variable domain of gp55 protein, the similar tendency of homology was observed. In hydrophobicity analysis, all of four CSFV strains revealed the analogous patterns of hydrophobicity. The numbers and locations of N-glycosylation site and cysteine residuse in gp55 were analyzed, those of Suri strain being coincident with ALD and LOM strains. The results suggest that gp55 in Suri strain has the high similarity to those in ALD and LOM strains in terms of the nucleotide and amino acid sequences and the functional properties of gp55 protein.

Pseudorabies Virus의 Major Capsid Protein 유전자의 클론닝과 Baculovirus Vector System에 의한 발현

안동준,전무형,송재영,박종현,현방훈,장경수,안수환 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

Pseudorabies is caused by Pseudorabies virus (PRV: Aujeszky's disease virus) of Herpesviridae that is characterized by 100 to 150nm in size with a linear double-stranded DNA molecule with of approximately 90 × 10 exp (6)Da. This disease affects most of domestic animals such as swine, cattle, dog, sheep, cat, chicken, etc. causing high mortality and economic losses. In swine, young piglets show high mortality and pregnant sows, reproductive failures. However the adult swine reveals no clinical signs in general. But they become a carrier state and play an importnat role for propagation of the disease. In this study, the nucleotide sequence of major casid protein gene of PRV, Yangsan strain isolated from the diseased swine in Korea was analyzed, and the recombinant MCP was produced by expression of the MCP gene in Sf-9 cell using baculovirus transfer vector system. As result, in BamHI digestion, MCP gene locus of PRV YS strain showed different from that of Indiana S strain. The patterns of enzyme mapping were also found to be unidentical each other. The sequence of the MCP gene partially analyzed showed 98.09% identity to Indiana S strain. The expression of MCP in Sf-9 cell cotransfected by pVLMCP-44 baculovirus expression vector was characterized by Southern blot hybridization, immunofluoresent and immunocytochemical tests, SDS-PAGE and Western blotting. The rMCP with M.W. 142kDa was most effectively expressed in Sf-9 cells at the 3-4th days post inoculation of the recombinant baculovirus by 2 moi.

한국의 정신분열병 외래 환자의 직ㆍ간접비용

박종익,송선희,서동우,장현종,이종국,장안기,김윤,이철,홍진표 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 정신분열병 외래 환자의 직접 비용과 간접 비용을 추산해 보고, 의료 자원의 적절한 운용과 효과적인 배분을 위한 보건 정책의 기초자료로 사용하고자 한다. 방 법 : 정신분열병 진단을 받은 289명의 환자를 대상으로 6개월간 외래를 방문하면서 사용한 의료비와 시간을 조사하여 직접 비용을 추산하였고, 이 기간 동안 소실된 생산성을 간접 비용으로 환산하였다. 만성질환인 관상동맥 질환을 앓고 있는 환자 82명을 대조군으로 하여 비용을 비교하였다. 결 과 : 정신분열병 환자의 실업률은 72.1%였으며, 직장을 가지고 있는 경우에도 단순노무직의 비율이 64.5%로 매우 높았다. 정신분열병의 직접 비용은 평균 81.5만원으로 관상동맥 질환의 평균 71.5 만원보다 상대적으로 많이 추산되었으나 유의하지는 않았다. 간접 비용은 평균 645.6만원, 258.9 만원으로 정신분열병군이 2.5배 정도 높았다. 결 론 : 정신분열병은 다른 만성질환에 비하여 상대적으로 매우 고비용이 요구되는 질환이며, 보다 체계적인 비용의 추산을 통하여 양질의 정신 보건 서비스를 제공할 수 있는 토대가 마련되어야 할 것이다. Objectives : We have aimed to estimate the direct and indirect costs of treating out-patients with schizophrenia in Korea, to use this fundamental data for the effective management and proper distribution of the medical resource. Method : To estimate the direct cost, we surveyed the medical cost and time of two hundred and eighty-nine out-patients with schizophrenia for six months. And the lost productivity as many months was converted into the indirect cost. Those of eighty-two coronary heart disease patients were also estimated as a comparison group. Results : An unemployement rate of schizophrenic patients was 72.1 percent. Moreover the ratio of the laborer in the sample was, even if employed, 64.5 percent. The mean direct cost of schizophrenic patients was, about 815,000 won, higher than that of coronary heart disease, 715,000 won however it was not statistically significant. The former was also estimated 2.5 times more than the latter for the indirect cost, or 6,456,000 won versus 2,589,000 won. Conclusion : Schizophrenia is a relatively costly illness compared to other chronic illness, so the systematic estimation of the cost is necessary to provide mental health service of high quality.

카드뮴이 마우스 뇌에서 아연의 항상성에 관여하는 유전자발현에 미치는 영향

박종안,여은영,남상훈,장봉기,이종화,김완종 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4

Metallothionein (MT), a small protein molecule which can bind of release metal tons, is involved in the regulation of cellular metal homeostasis This study was investigated the accumulation of cadmium in blood, tissue (liver, kidney and brain), and the effect of cadmium on several key genes (MT-Ⅰ, MT-Ⅱ, ZnT-1) in zinc metabolism m the mouse Mouses weighing 20-25g were randomly assigned to control and cadmium treated group (Cd group) Cd group was intraperitoneally injected with cadmium 2, 4, 8 mg/kg and control group was administerd with saline Mouses of each group were sacrificed by decapitation 4 hours after the administration of cadmium Cadmium contents in blood, fiver, kidney and brain were increased by a dose-dependent manner Accumulation of cadmium was mainly occurred in liver and kidney Induction of MT-I and MT-11 protein was increased, but ZnT-1 expression was decreased to a dose-dependent manner by the treatment of 2~8mg/kg cadmium These results suggested that cadmium can be transported to brain and alter the expression of several key genes in zinc homeostasis.

일부 아연광산지역에서 Cadmium이 주민의 건강에 미치는 영향

박종안,한구웅,홍종관,남택승 순천향대학교 1987 논문집 Vol.10 No.1

The cadmium contents of environment and human body were measured for the health status of the residents in the selected area near an old zinc-mining site assuming that cadmium contamination in the environment would affect the health status of the residents and the results were as follows: 1. The cadmium contents of the environment were 0.021±0.012 mg/m3 in the air. 0.019±0.011 mg/ml in the water, 0.382±0.233 mg/g in the rice and 0.342±0.211 mg/g in the tooth. 2. The major complaints of the residents were excessive sputum, dyspnea and pains on both extremities. F드믿 complained more frequently than male in dyspnea, lumbago and pains on both extremities. 3. An assessment of the nutritional health status of residents revealed that for male 8.5% were weak, 10.1% were fat and 32.5% were anemic, while for female 17.6% were weak, 15.3% were fat and 30.1% were anemic. 4. The prevalence rate of hypertension was 152.8?(male; 84.7?. female;200.0?) and the prevalence rate of diastolic hypertension was higher than that of systolic hypertension. 5. The diagnostic variables verifing the assumption mode in this study were blood pressure(0.76, p〈0.05) and E.S.R.(0.57, p〈0.01). From the above results, the environmental cadmium contamination affects the health status of the residents in the area near an old zinc-mining site to a certain extent, but not to a great extent(R2=0.55).

製鐵産業의 有害作業環境에 關한 調査

朴鍾安 순천향대학교 1982 논문집 Vol.5 No.2

This study was conducted in order to provide the methods for the efficient managements of harmful working environment. For this study, a total of 13 plants in an iron and steel making industry was surveyed during the period of May 1, 1980 to July 31, 1080. The results obtained were as follows; 1. The convert checking workers in the steel making plant were exposed to the highest wet bulb globe temperature(WBGT) of an average of 39.8℃(37.0∼42.5℃), the casting machine operaters in the blast furnace plant to 38.3℃(35.3∼40.7℃), and the blast furnace keepers of the plant to 38.0℃(30.5∼41.7℃) respectively in order of high temperature exposure. 2. The dust concentration in the working field operating the rolling mill in the cold rolling mill was 5.8mg/㎥(5.1∼6.5mg/㎥), that in charging the blast furnace with raw materials was 5.3mg/㎥, and lastly that in keeping the blast furnace was 5.1mg/㎥ respectively. These dust concentrations were higher than TLV(5mg/㎥) of the second class dust but those in all other working fields surveyed were lower than TLV. 3. The noise level was the highest as 111 dBA(102∼120 dBA) in the working field of welders connecting the hot coils in the cold rolling mill. The noise levels in all working fields surveyed in the hot strip rolling mill were higher than TLV, but those surveyed in the sintering plant were lower. 4. Regarding the noxious gases; the concentration of sulfur dioxide and carbon monoxide in the atmosphere exceeded the TLV in all working fields of 13 plants surveyed for this study. The concentration of ammonia was 325ppm(300∼400ppm) at ammonia decomposing work, 180ppm(80∼300ppm) at operation of gas producer and 147.5ppm(50-200ppm) at tar gathering work respectively. 5. The concentration of benzene and toluene in the atmosphere also exceeded the TLV in all working fields in the chemical plants surveyed. 6. The concentration of xylene in the atmosphere showed 150ppm (50∼200ppm) at tar gathering work in the chemical p1ant, which exceeds TLV by about 50ppm.