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Evolutionary conservation and expression of miR-10a-3p in olive flounder and rock bream
Jo, A.,Im, J.,Lee, H.E.,Jang, D.,Nam, G.H.,Mishra, A.,Kim, W.J.,Kim, W.,Cha, H.J.,Kim, H.S. Elsevier/North-Holland 2017 Gene Vol.628 No.-
MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that mainly bind to the seed sequences located within the 3' untranslated region (3' UTR) of target genes. They perform an important biological function as regulators of gene expression. Different genes can be regulated by the same miRNA, whilst different miRNAs can be regulated by the same genes. Here, the evolutionary conservation and expression pattern of miR-10a-3p in olive flounder and rock bream was examined. Binding sites (AAAUUC) to seed region of the 3' UTR of target genes were highly conserved in various species. The expression pattern of miR-10a-3p was ubiquitous in the examined tissues, whilst its expression level was decreased in gill tissues infected by viral hemorrhagic septicemia virus (VHSV) compared to the normal control. In the case of rock bream, the spleen, kidney, and liver tissues showed dominant expression levels of miR-10a-3p. Only the liver tissues in the rock bream samples infected by the iridovirus indicated a dominant miR-10a-3p expression. The gene ontology (GO) analysis of predicted target genes for miR-10a-3p revealed that multiple genes are related to binding activity, catalytic activity, cell components as well as cellular and metabolic process. Overall the results imply that the miR-10a-3p could be used as a biomarker to detect VHSV infection in olive flounder and iridovirus infection in rock bream. In addition, the data provides fundamental information for further study of the complex interaction between miR-10a-3p and gene expression.
배좌섭,오종희,강원필 한국의료복지시설학회 2008 의료·복지 건축 Vol.14 No.2
This study is the architectural planning of 5 distribution supporting facilities for traditional herbal medicine cultivated in the rural areas. The main function of the facility consists of storage, pre-treatment/processing, loading/unloading and the assistant function consists of inspection, office, exhibition/sale, technical equipment etc. The planning shows the modular plan and the section plan of the storage space reflecting the shape and size of storage container, the action radius of carrier and the possibilities of space lease. The total floor area of the storage is 3,192m²consisting of 27 space. The total floor area of the pre-treatment/processing is 1,488m²consisting of 7 space. The total floor area of the loading/unloading is 329m²consisting of 4 space. The total floor area of each facility storage is 8,284m²including of public space 2,170m². Also this planning shows the preliminary design, "fundamental model design" for 5 rural government BTL project. Therefore, this result of planning will be the guidelines of the RFP(Request For Proposal) for the private sector company interested in this BTL project.
클러스터형 VOD서버에서 고가용성을 고려한 자체 복구 시스템
이좌형,서동만,방철석,김병길,정인범 강원대학교 정보통신연구소 2004 정보통신논문지 Vol.8 No.-
While clustered VOD (Video On Demand) servers that have been proposed for building large-scale VOD system recently, have the advantages of high availability and scalability, the system level reliability of the clustered VOD servers could be decreased by adding more servers to scale up the capacity of the server. To alleviate this reliability problem and support server-level fault tolerance, this paper proposes and analyzes self recovery system based on RAID-3 and 4 with pipelining concept. The proposed self recovery system could increase the efficiency of the disk by accessing the disk with large size block as in RAID-4. The network resource could be used efficiently and the workload of memory could be decreased by sending data in small size block as in RAID-3. By introducing pipeline concept, the recovery tasks are processed at several nodes in parallel so that the workload in CPU, network, and memory could be distributed to several nodes.
센서노드에서의 빠른 데이터 전달을 위한 효율적 패킷 전송 기법
이좌형,정인범 江原大學校 産業技術硏究所 2007 産業技術硏究 Vol.27 No.B
Sensor network is used to obtain sensing data in vahous area. The interval to sense the events depends on the type of target application and the amounts of data generated by sensor nodes are not constant. Many applications exploit long sensing interval to enhance the life time of network but there are specific applications that requires very short interval to obtain fine-grained, high-precision sensing data. If the number of nodes in the network is increased and the interval to sense data is shortened, the amounts of generated data are greatly increased and this leads to increased amount of packets to transfer to the network. To transfer large amount of packets fast, it is necessary that the delay between successive packet transmissions should be minimized as possible. In Sensor network, since the Operating Systems are worked on the event driven, the Timer Event is used to transfer packets successively. However, since the transferring time of packet completely is varies very much, it is very hard to set appropriate interval. The longer the interval, the higher the delay and the shorter the delay, the larger the fail of transfer request. In this paper, we propose ESTEO which reduces the delay between successive packet transmissions by using SendDone Event which informs that a packet transmission has been completed.In ESTEO, the delay between successive packet transmissions is shortened very much since the transmission of next packet starts at the dme when the transmission of previous packet has completed, irrespective of the transmission timee. Therefore ESTEO could provide high packet transmission rate given large amount of packets.
Joa, Kyung-Lim,Kim, Chang- Hwan Lippincott Williams Wilkins, Inc. 2013 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITA Vol.92 No.2
OBJECTIVE: The aim of this study was to understand the meaning of the double-peak responses in digital nerve conduction study in normal and diabetic patients. DESIGN: This was a cross-sectional and correlative study. Sixty healthy subjects (10 people per decade from 20 to 79 yrs of age; 26 men; mean age, 48 yrs) and 60 diabetic patients (10 people per decade from 22 to 79 yrs of age; 36 men, mean age, 53 yrs) were included. The composite score of the nerve conduction study was obtained. Orthodromic sensory nerve conduction studies were performed on the median nerves using submaximal stimulation. The latencies and amplitudes of first and second peaks were measured. The Toronto clinical scoring system for diabetic neuropathy was applied to all diabetic patients. RESULTS: The first and second peak latencies of both 3- and 4-cm interpeak distance in diabetic patients were significantly increased compared with those of age-matched control subjects (P < 0.05). The correlation between the Toronto clinical scoring system and first and second peak latency and amplitude were significantly high, and the correlation between the composite score and first and second peak latency and amplitude was also related. CONCLUSIONS: The double-peak response represents the far distal nerve pathophysiology. The authors suspect that they will find an increasing role in diagnosing the peripheral neuropathy, which starts at the distal nerve in centripetal pattern.