Inhibitory effect of (-)-epigallocatechin gallate on titanium particle-induced TNF-${\alpha}$ release and $in$ $vivo$ osteolysis

Jin, Shan,Park, Ju-Young,Hong, Jung-Min,Kim, Tae-Ho,Shin, Hong-In,Park, Eui-Kyun,Kim, Shin-Yoon Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.7

Tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and inflammatory cytokines released from activated macrophages in response to particulate debris greatly impact periprosthetic bone loss and consequent implant failure. In the present study, we found that a major polyphenolic component of green tea, (-)-epigallocatechin gallate (EGCG), inhibited Ti particle-induced TNF-${\alpha}$ release in macrophages $in$ $vitro$ and calvarial osteolysis $in$ $vivo$. The Ti stimulation of macrophages released TNF-${\alpha}$ in a dose- and time-dependent manner, and EGCG substantially suppressed Ti particle-induced TNF-${\alpha}$ release. Analysis of signaling pathway showed that EGCG inhibited the Ti-induced c-Jun N-terminus kinase (JNK) activation and inhibitory ${\kappa}B$ ($I{\kappa}B$) degradation, and consequently the Ti-induced transcriptional activation of AP-1 and $NF-{\kappa}B$. In a mouse calvarial osteolysis model, EGCG inhibited Ti particle-induced osteolysis $in$ $vivo$ by suppressing TNF-${\alpha}$ expression and osteoclast formation. Therefore, EGCG may be a potential candidate compound for osteolysis prevention and treatment as well as aseptic loosening after total replacement arthroplasty.

High-efficiency removal of phenol and coking wastewater via photocatalysis-Fenton synergy over a Fe-g-C3N4 graphene hydrogel 3D structure

Jinshan Hu,Pengfei Zhang,Jifang Cui,Weijia An,Li Liu,Yinghua Liang,Qingbin Yang,Hongjun Yang,Wenquan Cui 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.84 No.-

To achieve rapid separation of electron-hole pairs and improve photocatalytic degradation activity, theFe-g-C3N4 reduced graphene hydrogel (rGH/Fe-g-C3N4) with a 3D network structure was fabricated viathe hydrothermal method. Using visible light irradiation, H2O2 was added to form a photocatalysis-Fenton synergy system. The results showed that the synergistic degradation rate constant of 10% rGH/Feg-C3N4 was 52% higher than that of the multiphase Fenton reaction and 1.5 times higher than that of theFe-g-C3N4. In the seventh cycle, the catalytic efficiency was still as high as 86.9%. Based on the optimizedconditions from phenol degradation, the system was further applied to coking wastewater treatment,and the degradation efficiency of TOC and COD in 60 min reached 66.3% and 68.1%, respectively. Such highand stable degradation performance was ascribed to the synergy effect of photocatalysis and Fenton. Because of the photogenerated electrons not only can promote the Fe3+/Fe2+ cycle, accelerate thedecomposition of H2O2, but also can quickly transfer to graphene and directly decompose H2O2 to formOH. Thus, a large amount ofOH were generated through the two different channels, which greatlyimprove the degradation efficiency. Furthermore, rGH/Fe-g-C3N4 can be regenerated usingfilters withoutthe need for additional complicated processing. This work provides an effective strategy for the deeptreatment of industrial wastewater.

Research on stiffness control of a redundant cable-driven parallel mechanism

Jinshan Yu,Jianguo Tao,Guoxing Wang,Xiao Li,Haowei Wang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.11

Controlling the stiffness of cable-driven parallel mechanisms (CDPM) is of great significance for improving performance in different tasks. A method for stiffness control of a redundant CDPM is presented in this paper. The stiffness matrix of the redundant CDPM is established. On this basis, considering the effect of coupling stiffness, a complete analytical formula for stiffness in different directions is established. Then, the influence of the vector λ on the stiffness of the CDPM in different directions is analyzed, and a method to control the stiffness of the CDPM through adjusting the vector λ is proposed. To avoid traversing the value of λ in the polygon formed by the set of λ to obtain the appropriate cable tension and keep the cable tension away from the upper and lower limit values, a change path of the vector λ is designed. When the vector λ changes along the path, the stiffness of the mechanism can be changed from the minimum value to the maximum value. This method has high computational efficiency and safety. Finally, the correctness and effectiveness of the stiffness control method are verified by experiments. The stiffness control method proposed in this paper can be used to control the stiffness in different directions, and can also be used for different types of redundant CDPMs.

Jointed Energy Saving and Cluster Route in the Mobile Ad-HOC Network

Jinshan Huang 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.8

The LNCR-IDS for the mobile Ad-HOC network is put forward for the problem that the redundancy clusters are adverse to energy saving because leaf node independent clusters exist in the CHS and cluster partition in the traditional mobile Ad-Hoc network containing IDS. Firstly, make analysis on the traditional random cluster partition method and find that the method easily results in the problem of redundancy partition, put forward the new method which carries out cluster partition starting from the leaf node, try to solve the problem of redundancy of cluster partition, so as to lower the energy consumption; secondly, make analysis on the realization of algorithm, construct the algorithm of single node elimination and give the process of cluster partition via simple analysis example in allusion to the proposed method; finally, carry out simulation comparison with the existed algorithm via the experimental platform created, the proposed algorithm should be about 30% less than the comparing algorithm in the number of clusters, which is beneficial to the improvement of network service life.

Research on the Data Transmission Methods in the Magneto-Thermal Coupling Model for Eddy Current Braking

Tian Jinshan,Li Desheng,Ning Keyan,Ye Lezhi 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.5

The eddy current braking (ECB) is often installed on heavy-duty vehicles as the auxiliary braking component. When it works for a long time, the thermal derating of braking torque will reach about 18.5 % due to high temperature. It is important to establish an accurate magneto-thermal coupling model for the ECB high temperature steady-state braking torque prediction. In multi-field coupling calculation, there are two commonly used data transmission methods between two physics fields. One of them is transmitting average data to important geometry based on the idea of lumped parameters (lumped parameters method), and the other is mapping the data distribution to each grid cell (direct mapping method). This paper takes the ECB as the research object, analyzes the influence of the above two data transmission methods, and proposes to replace the fluid thermal coupling model with the heat conduction model in the magneto-thermal coupling model. Through calculation and analysis, using the lumped parameters method to transmit the heat generation rate, temperature and convective heat transfer coefficient all have a certain impact on the calculation accuracy of the coupling model comparing with the direct mapping method.

Effect of characteristics of submicrometer powder on the sintering behaviors of Al2O3 ceramic

Qingbo Tian,Jinshan Dai,Zhijie Lv,Tongguang Zhai 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.7

The sintering behaviors of high purity Al2O3 ceramics prepared from a submicron-scale powder were investigated. The effectsof ball milling on the evolution of alumina powders’ compressibility, sinterability, grain growth and microstructure duringsintering process were studied. It was observed that the relative density of the Al2O3 ceramics increased with increasingcompaction pressure on the green compacts and the sintering temperature. However, the applied pressure had less influenceon the relative density of ceramics sintered from green compact with narrower size distribution and finer powder. The fastgrain growth of the Al2O3 ceramics occurred in different temperature ranges and was influenced by milling time and formingmethods. The effect of milling on the microstructural evolution of alumina during sintering was also discussed.

Identification and characterization of microRNAs involved in double-color formation in Paeonia suffruticosa ‘Shima Nishiki’ by high-throughput sequencing

Xinpeng Zhang,Jinshan Jia,Ming-yuan Zhao,Cheng Li,Xu Han,Zongda Xu 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.1

Paeonia suffruticosa ‘Shima Nishiki’ is a valuable double-color cultivar, but the mechanism of its double-color formationis still unknown at the post-translational level. Moreover, many studies have shown that microRNAs (miRNAs) play a keyrole in regulating anthocyanin biosynthesis. In this study, small RNA sequencing was performed to identify and characterizemiRNAs in six libraries of the red (LH) and pink (LF) petals. A total of 591 conserved and 53 novel miRNAs wereidentified, among which 68 conserved and 2 novel miRNAs were differentially expressed between the LH and LF libraries. Meanwhile, the corresponding target genes for these differentially expressed miRNAs (DEMs) were successfully predictedand annotated. Among them, two DEMs (miR858 and miR156a-5p) and their corresponding target genes possibly relatedto anthocyanin biosynthesis were screened. We further confirmed the relative expression of 15 candidate miRNAs (2 DEMsand other 13 miRNAs) and the 4 corresponding target genes of these DEMs by quantitative real-time PCR (qRT-PCR). Among these four target genes, only CL2846.Contig2_All [Annotation: transcription factor MYB12] showed a substantiallyhigher differential expression between the red and pink petals. Based on the above results, we concluded that miR858 andmiR156a-5p (especially miR858) are possibly involved in mediating double-color formation. These results provide a newunderstanding about the mechanism of double-color formation in P. suffruticosa ‘Shima Nishiki’.

Fully Recrystallized Al0.5CoCrFeNi High-Entropy Alloy Strengthened by Nanoscale Precipitates

Haoxue Yang,Jinshan Li,Tong Guo,William Yi Wang,Hongchao Kou,Jun Wang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.5

The correlation among the strength, ductility and precipitates in a dual-phase Al0.5CoCrFeNihigh-entropy alloy has beeninvestigated. The property of plastic was improved in the recrystallized Al0.5CoCrFeNiHEA prepared as the master alloy. Formation of the stable nanosized L12phases after aging at 650 °C was revealed, along with the lath-like BCC phasesprecipitated in the grain, as the primary contribution of the strength enhancement. Excellent balanced tensile properties atroom temperature were achieved through aging treatment, as the yield strength and ultimate tensile strength show 2.68, 1.63times higher in 650 °C/140 h aged condition than that in initial states, respectively, superior to many high-entropy alloysand conventional alloys.

Simultaneous Identification of structures and unknown seismic excitations for chain-like systems with unknown mass using partial absolute responses

Hao Qiu,Jinshan Huang,Zhupeng Zheng 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.6

It is necessary to identify structures with unknown mass and unknown seismic excitations simultaneously, but very limited methods have been proposed. In this paper, an algorithm is proposed to identify structural element mass, stiffness, and seismic excitations using only partial absolute structural responses of chain-like systems. In the first stage, the identification of structural element stiffness-mass coupled coefficients and unknown seismic excitations is conducted based on the generalized extended Kalman filter with unknown input (GEKF-UI) developed by the authors. In the second stage, these coupled coefficients are decoupled by cluster analysis and the least squares estimation (LSE) to obtain structural element stiffness and mass changes. The effectiveness of the proposed algorithm is numerically investigated using a four-story frame structure under three scenarios of changed conditions. Moreover, experimental validation by the shaking table test of a shear structure under two scenarios is also performed to identify structures and seismic excitations simultaneously.

Workplace Employees' Annual Physical Checkup and During Hire on the Job to Increase Health-care Awareness Perception to Prevent Disease Risk: A Work for Policy-Implementable Option Globally

Hakro, Saifullah,Jinshan, Li Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.2

Background: Increasing workplace health-care perception has become a major issue in the world. Most of the health-related problems are faced because of the lack of health management instruments. The level of health care can be improved through workplace health well-being regulations. The aim of the present study is to formulate a conceptual model of physical checkup. Methods: This study applied conceptual theories and figures and used secondary data from articles and relevant websites for evaluating the validity of the study. Results: Annual health checkup increases health-care awareness perception of states, organizations, employees, and their families and manages the annual health record of employees, organizations, and states. Conclusions: Health care and awareness perception of states, organizations, employees, and families improves with annual health checkup, and annual health checkup also prevents unhealthy acts.