Korean Association for Clinical Oncology : Slide Session ; P-46 : Lung Cancer ; EGFR Activating Mutation and Pattern of Brain Metastasis in Non-Small Cell Lung Cancer

( Hee Kyung Ahn ),( Young Saing Kim ),( In Keun Park ),( Jun Shik Hong ),( Sun Jin Sym ),( Jinny Park ),( Dong Bok Shin ),( Jae Hoon Lee ),( Eun Kyung Cho ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The aim of this study is to examine the association of the timing andsurvival of brain metastasis(BM) according to EGFR mutation status in patients with non-small cell lung cancer(NSCLC). Methods: We retrospectively reviewed patients with advanced non-small cell lungcancer (NSCLC) who underwent EGFR mutation analysis at a single center from January 2010 to August 2013. Among 268 patients identifi ed, 67 patients with BM during the course of the disease were fi nally included in analysis. Survival was estimated with the Kaplan-Meier method and compared using the log-rank test. Results: Among the 67 patients with BM, 25 patients had EGFR activating mutations (deletion in exon 19 or L858R). Two patients had missense mutations in exon 20 and 40 patients had wild-type EGFR. BM was signifi cantly more prevalent in patients with EGFR mutation (39%) than those with EGFR WT (23%) (p=0.015). BM was the fi rst metastasis site in 30% of patients with EGFR mutation and 14% of patients with EGFR WT. Among patients with metachronous BM development, median time to BM development had a trend toward longer in patients with EGFR mutation (13.6 months) than in patients with EGFR WT (8 months) without signifi cance. Median overall survival from BM(BM-OS) was signifi cantly longer in patient with EGFR mutation (25.1 months vs. 6.9 months, p<0.001). In subgroup analysis, BM-OS was significantly longer in patients with EGFR mutation among those with synchronous BM(p<0.001), however the difference in BM-OS was not signifi cant in patients with metachronous BM development. Conclusions: NSCLC patients with EGFR mutation were more prevalent with synchronous BM. EGFR mutation was associated with signifi cantly longer survival from BM diagnosis, especially in those with synchronous BM development.

노래 게임을 이용한 기부 어플리케이션

허진희(Jinny Huh),박소라(So-Ra Park),고민희(Min-Hee Ko),김선혜(Sun-Hye Kim),안효선(Hyo-Seon Ahn),하얀(Yan Ha) 한국컴퓨터정보학회 2013 한국컴퓨터정보학회 학술발표논문집 Vol.21 No.2

본 논문에서는 기존의 앱 중에서 사회에서 대두되고 있는 기부와 관련된 앱을 조사 비교하며, 이와 관련해서 기부의 확산을 위해 필요한 기능을 알아보고 이를 설계하도록 한다. 기부문화에 대한 인식이 점차 변화하고, 기부문화를 좀 더 확산시키고자 게임을 통해 쉽게 기부에 다가갈 수 있는 앱이 필요하다. 기부와 관련된 앱으로써 기부를 할 수 있게 한다. 더 나아가 기업과 SNS 매체에 연계하여 자연스레 기부에 대한 문화를 일상생활의 일부분으로 만든다.

Prognosis of HER2 overexpression in small T1N0M0 breast cancer: A single center experience in Korea

( Jihong Bae ),( Hee Kyung Ahn ),( Kwan Il Kim ),( Heung Kyu Park ),( Yong Soon Chun ),( Young Saing Kim ),( Inkeun Park ),( Junshik Hong ),( Sun Jin Sym ),( Jinny Park ),( Eun Kyung Cho ),( Jae Hoon 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Introduction: A role of adjuvant treatment in patients with T1abN0M0 human epidermal growth factor receptor 2 (HER2)-positive breast cancer remains controversial. In this study, we investigated the prognosis of pT1abN0M0 breast cancer according to HER2 and hormone-receptor status. Methods: We retrospectively reviewed consecutive 536 patients diagnosed with T1a-cN0M0 breast cancer between 2003 and 2012 in a single center. Invasive disease free survival (IDFS), distant recurrence free survival (DRFS), and overall survival (OS) were estimated and compared by Kaplan-Meier method and log-rank test. Results: With a median estimated potential follow-up of 53 months, 5-year IDFS rate was 96.1% (92.3% in T1abN0, 97.3% in T1cN0), DRFS rate 98.3% (97.6% in T1abN0, 98.5% in T1cN0), and OS rate 98.4% (97.6% in T1abN0, 98.6% in T1cN0). Among 142 patients with T1abN0M0, IDFS in HER2 (+) disease (n=31, 5-year IDFS rate 73.2%, 5-year DRFS rate 96.3%) was significantly inferior to those with HR (+)/HER2 (-) disease (n=63, 5-year IDFS rate 98.4%, no distant recurrence has occurred during follow-up period) or TN (n=14, no recurrence has occurred during follow-up period). IDFS in HER2 (+) T1abN0 disease was not significantly different by HR status (5-year IDFS rate 64.1% in HR (+) HER2 (+) vs. 40.0% in HR (-) HER2 (+), p=0.104). Conclusions: In Korean patients with T1abN0M0 breast cancer, HER2 overexpression was associated with worse IDFS.

Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with nonsmall cell lung cancer

Min Young Baek,Hee Kyung Ahn,Kyu Ree Park,Hwa-Sun Park,Shin Myung Kang,Inkeun Park,Young Saing Kim,Junshik Hong,Sun Jin Sym,Jinny Park,Jae Hoon Lee,Dong Bok Shin,Eun Kyung Cho 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1

Background/Aims: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status. Methods: We retrospectively investigated the medical records of 259 patients diagnosed with advanced NSCLC from January 2010 to August 2013, who were tested for EGFR mutations. The time from the diagnosis of advanced NSCLC to the development of BM and the overall median survival after BM development (BMOS) were evaluated and compared by EGFR mutational status. Results: Sixty-seven patients (25.9%) developed BM. Synchronous BM occurred more often in patients with EGFR mutation type (MT) (n = 20, 27.4%) compared with EGFR wild type (WT) (n = 27, 14.5%, p < 0.009). The median BM-OS was significantly longer in patients with EGFR MT than in those with EGFR WT (25.7 months vs. 3.8 months, p < 0.001), and a similar trend was noticed for patients with synchronous BM (25.7 months for EGFR MT vs. 6.8 months for EGFR WT, p < 0.001). However, in patients with metachronous BM development, the difference in BM-OS between patients with EGFR MT (14.6 months) and EGFR WT (2.5 months) did not reach statistical significance (p = 0.230). Conclusions: Synchronous BM was more common in NSCLC patients with EGFR MT than in those with EGFR WT. However, EGFR mutations were associated with significantly longer median BM-OS, especially when the brain was the first metastatic site.

Central nervous system blast crisis of chronic myeloid leukemia and treatment with dasatinib

( Hong Suk Park ),( Jinny Park ),( Young Saeng Kim ),( In Geun Park ),( Jun Sik Hong ),( Hee Kyong Ahn ),( Sun Jin Sim ),( Eun Kyoung Joe ),( Dong Bok Shin ),( Jae Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Chronic myeloid leukemia (CML) is a myeloproliferative disorder driven by the BCR-ABL1. Owing to the high efficacy of imatinib mesylate for CML in chronic phase, the frequency of the blast crisis is greatly reduced. Some CML cases develop extramedullary disease caused by infiltration of blast cells. However, the central nervous system (CNS) as an isolated site of extramedullary blast crisis is rare. Herein, we report case of dasatinib-based maintenance therapy for lymphoid blast crisis of the CNS in a patient with CML who was receiving imatinib mesylate therapy. In July 2012, a 55 years old man was diagnosed with Philadelphia chromosome positive CML in the chronic phase. Immediately, imatinib mesylate administration was initiated. Four months after the diagnosis, he complained of headache. On cerebrospinal fluid (CSF) examination, the CSF had increased number of WBCs (6289/iL); almost all WBCs were lymphoid cells. Brain MRI revealed abnormal leptomeningeal enhancement of the frontal lobes. In addition to a complete hematological, cytogenetic response and evidence of the absence of malignant lymphoblasts in the peripheral blood and bone marrow samples, these findings led to the diagnosis of isolated lymphoid blast crisis in CNS. Immediately, the patient was treated with scheduled intrathecal methotrexate, cerebrospinal radiotherapy and TKI dasatinib. Major molecular response was achieved after 4 months after treatment change, followed by matched related allogeneic peripheral blood SCT. During the course of dasatinib maintenance therapy, several follow-up tests were performed and persistently yielded results indicating complete hematologic, molecular, and cytogenetic responses. The patient was neurological symptom-free for 2 years. In addition, the abnormal enhancement of the frontal lobe observed on the initial brain MRI had disappeared. This report is meaningful of significance as because we used a minimal treatment of intrathecal chemotherapy, radiotherapy, allogeneic peripheral blood SCT and an oral TKI without using cytotoxic chemotherapy such as hyper-CyVAD.

Topographic Distribution Area of the Infraorbital Nerve and Course of the Internal Nasal Branch

Kyung-Seok Hu,Jinny Kwak,Ki-Seok Koh,Shinichi Abe,Christian Fontaine,Hee-Jin Kim 대한체질인류학회 2007 대한체질인류학회 학술대회 연제 초록 Vol.50 No.-

중년비만여성의 사상체질별 특성에 관한 연구

임진희,이임순,고병희,송일병,이수경,Lim, Jinny,Lee, In-Soon,Koh, Byung-Hee,Song, Il-Byung,Lee, Soo-Kyung 사상체질의학회 2004 사상체질의학회지 Vol.16 No.3

1. Objectives This research is to ascertain relations between the Sasang Constitution and characteristics of the eating attitudes, mental state, body composition, various examination results of obese middle-aged women. 2. Methods The subjects were 31 female patients whose BMI(Body Mass Index) was over $25kg/m^2$ and age was 35~55. It was analysed statistically the results of EAT(The Eating Attitudes Test), DEBQ(Dutch Eating Behavior Questionnaire), BDI(Beck Depression Inventory), STAI(State-Trait Anxiety Inventory), body composition analyser, biochemistry, abdominal ultrasonography, mammography which was surveyed from them. 3. Results and Conclusions 1)There was no relation between the Sasang Constitution and the eating attitudes, eating behaviors. But Taeumin got statistically lower score than Non-Taeumin in 23rd question for emotional eating and 33rd question for environmental eating of DEBQ 2)On the mental state, Taeumin got statistically lower score than Non-Taeumin in BDI, STAI-S 3)On the body composition, Taeumin got statistically higher value than Non-Taeumin in BMI. Soyangin got statistically lower value than Non-Soyangin in BMI, left upper limb water, soft lean mass, body water, trunk water. 4)On the various examinations, Taeumin got statistically lower value than Non-Taeumin in serum albumin. Soyangin got statistically lower value in BMI and higher frequency in gallstone, breast nodule than Non-Soyangin. 5)It was thought that Taeumin's obesity is managed by controling physical factor such as excessive 'Gathering Qi(吸聚之氣)' rather than eating attitudes and psychological factor.

부신백질이영양증(Adrenoleukodystrophy:ALD)을 진단받은 태음인(太陰人) 환자의 치험 1례

임진희,황민우,함통일,이수경,고병희,송일병,Lim, Jinny,Hwang, Min-Woo,Ham, Tong-Il,Lee, Soo-Kyung,Koh, Byung-Hee,Song, Il-Byung 사상체질의학회 2004 사상체질의학회지 Vol.16 No.1

Purpose The primary purpose of this case study is to report that a Taeumin patient diagnosed to Adrenoleukodystrophy was managed with Taeumin constitutional treatment. Subject A male patient diagnosed to Adrenoleukodystrophy that was treated Kyung-Hee Oriental Medicine. Result A Taeumin patients diagnosed to Adrenoleukodystrophy was treated with a herb-medicine and acupuncture treatment, and change of his subjective symptom & general condition was managed. Conclusion The consitutional treatment with herb-medicine and acupuncture may have an effect on Management of Adrenoleukodystrophy. Further study on management of this disease is needed.

서울역을 중심으로 하는 공공공간 서비스 디자인

박휘원(Park, Hyeu Won),김진이(Kim, Jinnie),윤선희(Yun, Seon Hee),김승인(Kim, Seung In) 한국디지털디자인협의회 2015 디지털디자인학연구 Vol.15 No.1

서비스 디자인의 확대와 함께 모든 산업과 분야에서 서비스 디자인 프로세스를 적용하기 시작했다. 본 논문은 지하철, 버스, 공항철도, KTX 등 다양한 대중교통 노선들이 집중되어 있는 서울역을 중심으로 서비스 디자인을 개선하고자 한다. 해외 공공공간의 서비스 디자인 개선 사례에서 드러난 감성적 요소를 서울역의 각 공간에 적용해 보았다. 또한 HCI(Human Centered Innovation)방법론을 통해 사용자 중심의 시스템과 프로세스가 어떻게 적용되고 있는지 관찰하여 이용객들의 공간 활용이 낮다는 페인 포인트(pain point)를 발견하였다. 그 결과 지하철, 공항철도, 버스 등을 이용하는 환승객을 위한 2층 공간에는 동선표시와 표지판을 개선하고 의자를 배치했으며, KTX를 기다리는 이용객을 위한 3층 공간에는 이용객의 다양성을 고려하여 여러 가지 테마와 색으로 공간을 구성하였다. 이렇듯 유동인구가 많은 대중교통 플랫폼에서 사용자 중심의 방법론을 바탕으로 다양한 서비스디자인을 적용할 수 있을 것으로 기대한다. As the service design industry has been enlarged, most of industry fields begin to apply the service design process. In this thesis, we propose the service design on Seoul station, the place that lots of transportation is converging such a subway, bus, and KTX. We apply emotional factors in each area referring to foreign cases of service design improvement. In addition, we find out the pain point that there is lack of user space in usage. We use HCI (Human Centered Innovation) method with observing by user-centered system and process. As the result, we design the signage, stool, and flow system on the second floor that most of the user is transfer passenger. On the third floor we composed the area by several themes and colors considered various types of user. We expect the service design could be applied in many ways based on user-centered method on public traffic station.

사상의학(四象醫學) 약리(藥理)에 관한 문헌적(文獻的) 고찰(考察)

임진희,이수경,고병희,송일병,Lim, Jinny,Lee, Soo-Kyung,Koh, Byung-Hee,Song, Il-Byung 사상체질의학회 2004 사상체질의학회지 Vol.16 No.1

1. Objects of Research This research is purposed to find Dong-mu's thought on Pharmacology, through summarizing sentences related to pharmacology proposed in the chief writings on Sasang Constitutional Medicine. 2. Methods of Research It was researched bibliologically with Dong-mu's chief medical writings such as "Dongyi Suse Bowon Sasang Chobongyun(東醫壽世保元四象草本卷)", "Dong-mu's posthumos work(東武遺藁)", "Dongyi Suse Bowon(東醫壽世保元)". 3. Results and Conclusions 1. The grouping criteria according to the constitution proposed in "Dongyi Suse Bowon Sasang Chobongyun" is 'Spreading Outside' 'Hardening Inside' 'Cooling Organ' 'Warming Inside', but the grouping of medical herbs according to the constitution is yet not accomplished, and medical herbs is comprehended on base of effectiveness as like existing oriental medicine. 2. The grouping criteria according to the constitution proposed in "Dong-mu's posthumos work"is 'Spreading Choking Raising Lowering' and 'Perfume Smell Fluid Taste', and medical herbs is comprehended on base of effectiveness as like "Chobongyun", and the example on mixing of the herb classified according to the constitution is showed. 3. The medical herbs are comprehended on the basis of how to effect on treatment of constitutional disease, and the principle that it's not to mix of the herb classified according to the constitution is proposed in "Dongyi Suse Bowon". 4. The pharmacology of Sasang Constitutional Medicine is accomplished after it is modified many ti mes through clinic experience for a long time. 5. The pharmacology of Sasang Constitutional Medicine in the early period, is to comprehend herbs on the basis of how to complement 'Spreading Gathering Raising Lowering' of 'Small-Organ(偏小之臟)' according 'Qi-Mei(氣味)' and effectiveness, but that in the late period is to comprehend herbs on the basis of how to complement or to control 'Small-Organ(偏小之臟)' and 'Large Organ(偏大之臟)'.