Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

만주 재현 소설에 나타난 ‘고향’의 의미 : 만주국 후기 소설을 중심으로

김향화 이화어문학회 : 이화여자대학교 한국어문학연구소. 2015 이화어문논집 Vol.36 No.-

‘만주’는 제국주의에 의해 고향으로부터 추방당한 근대의 조선인이 희망과 절망을 반반씩 지니고 이주하여 새로운 삶을 지향했던 곳이다. 본고에서는 재만(在滿) 경험을 토대로 창작을 진행한 작가들이 ‘제2의 고향’으로서의 ‘만주’를 어떻게 서사하고 있으며 고향(조선)에 대한 작중 주인공의 인식의 변화과정을 통하여 특정한 작가의 특수한 ‘재만’의 경험에 주목하고자 한다. 동시에 이러한 특수한 ‘재만’의 경험에 대한 중층적인 분석을 통하여 ‘민족’과 ‘국민’ 사이에서 정체성의 혼란을 겪었던 ‘식민지 조선인’에게 시사된 고향의 다양한 의미를 분석하는 것을 연구목적으로 삼는다. 조선인 작가의 ‘재만’(在滿)이라는 경험은 단순하게 해석할 수 없는바 그것은 객관적으로 역사의 변천과 정치적인 제도의 변화과정과 관계되는 동시에 주관적으로 작가의 경력과 문학 창작 의도와 긴밀히 연관되어 있다. 본고에서는 당대에 만주에서 살았고 직접적으로 만주를 체험했지만 각각 다양한 신분과 경력을 가진 대표적인 작가로 안수길과 김창걸, 박계주의 일부 작품을 연구대상으로 한다. 아울러 ‘재만’이라는 작가적 경험의 특수성을 재해석하고 그에 따라 다양하게 표상되는 ‘고향’의 의미에 대해 되짚어봄으로써 만주의 조선인에게 ‘고향’은 어떤 의미로 각인되고 변천되어왔는가를 연구한다. 물론 단순하게 이주민의 강한 정착 의지와 망향의식, 향토의식 등으로는 해석의 제한이 뒤따르고 있는 건 사실이다. 이에 본고에서는 오랜 시간 동안 만주에 거주하면서 창작 활동을 했고 만주 재현 문학의 대표적인 작가로 손꼽히는 안수길의 후기 작품인 「土城」과 「牧畜記」, 만주에서 태어나고 교육을 받았지만 다시 조선으로 돌아가서 만주에서의 경험을 토대로 창작을 진행한 박계주의 「處女地」와 「母土」, 어렸을 때 만주로 이주하여 해방 후에 만주에 남은 중국 조선족의 대표적인 작가 김창걸의 「두번째 고향」을 텍스트로 삼아 연구를 진행한다. 상기 작품들은 모두 만주국 후기에 창작되었으며 만주국의 이념인 ‘왕도낙토(王道樂土)’와 ‘오족협화(五族協和)’ 사상을 일정하게 반영함으로써 시국에 편승하는 양상을 보이고 있는데 본고는 이러한 특수한 사회 정치적 상황에서 조선 이주민들에게 시사된 ‘고향’의 의미를 분석하고 나아가서는 ‘재만’이라는 삶의 중층성과 다양성을 발굴하는데 그 연구 의의를 둔다. In this manuscript we examine how the writers who have slightly different experiences of Manchuria and composed based on that experience describe “Manchuria,” their “2ndhome,”and how the special “Manchuria” of each particular writer is detailed by the process of change of the character’s awareness in regards to their original hometown(Joseon).Also, our research purpose is to analyze the various meanings of this forced hometown for the “colonial Korean people,”who have experience didentity confusion between“Ethnicity” and“Nation,”through the multi-level analysis of this special“Manchuria.”“Manchuria”was the place where the“Joseon People”were exiled from their hometown and forced to take root due to Imperialismand where they started anewlife after emigrating with both, hope and despair, in their hearts. The experience of “Manchuria(在滿)” of the Joseon writers is not simple to analyze since objectively it’s related to the historical change as well as the change in political system while subjectively it’s deeply related to the writers’ career and the intention of their literary creations. In this manuscript, the study object is the partial works of Ahn Soo-kil, Kim Changgeol, and Park Gyeju, who are representative authors who have directly experienced Manchuria and have various positions and work experiences. It also seeks to reinterpret the distinct characteristics of the authors experience that is “Manchuria” and research the various presentations of the meaning of “hometown” and how this meaning of “hometown” is imprinted or changed for the people of Joseon living in Manchuria. Of course there will be limits to the simple interpretation of the emigrant’s strong will to take root, their nostalgia, indigenous awareness, and others. In this manuscript we used the late「土城」 and 「牧畜記」works of Ahn Soo-kil, who lived and wrote in Manchuria for a long time and is a renowned representative author of Manchurian literature, 「處女地」and「母土」of Park Gyeju, who was born and educated in Manchuria but returned to Korea to write based on his experience, and “2ndHometown” by Kim Changgeol, who emigrated to Manchuria when he was young and stayed there after the Liberation of Korea as a representative Chinese-Korean author. The texts mentioned above were all written during the latter period of the Manchuria nation and reflects the Manchurian philosophy of “왕도낙토(王道樂土)” and “오족협화(五族協和) thought in a slightly different manner and seems to take advantage of the current state of affairs and this manuscripts seeks to discover the diverse layers of life in “Manchuria” analyzing the meaning of the forced “hometown” of the emigrants during that socio-political time.

할로아세틸시코닌 유도체의 합성 및 항암성 평가 : Synthesis and Evaluation of Antitumor Activity

鄭相國,金光洙,송규용,조훈,안병준 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The secondary hydroxy group at side chain of shikonin structure was selectively acylated with various haloacetic acids in presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine to produce haloacetylshikonin derivatives. The cytotoxicity of monohaloacetylshikonin derivatives against L1210 cells increased in the following order: monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖) nonobromoacetylshikonin (ED_50, 0.158㎍/㎖)>monoiodoacetylshikonin (ED_50, 0.173 ㎍/㎖). Introduction of larger halogen atoms decreased the cytotoxic activity, presumably due to steric hinderance. The cytotoxicity of chloroacetylshikonin derivatives was dependent on the number of chlorine atom, thus increasing in the following order : trichloroacetylshikonin (0.032 ㎍/㎖)>dichloroacetylshikonin (0.059 ㎍/㎖)> monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖). Thus, the electron-withdrawing effect seems to be important for the cytotoxicity of chloracetylshikonin derivatives. Consistent with the above, dichloracetylshikonin (T/C, 182%) and trifluoroacetylshikonin (195%) showed higher T/C values than monochloroacetyl-(T/C, 122%), monobromoacetyl-(T/C, 154%) and monoiodoacetylshikonin (T/C, 117%) derivatives. Haloacetylshikonin derivatives showing lower cytotoxic activities against L1210 cells exhibited lower T/C values. It seems that there is a relationship between the cytotoxicity of haloacetylshikonin and their antitumor activity.

중국 전통 원림에 나타난 경관 조형미에 관한 연구

徐周煥,崔現翔,邊成晉,孟祥彬 경희대학교 부설 디자인연구원 1999 예술· 디자인학연구 Vol.2 No.1

The purpose of this study is to find out the components and the beauty of the landscape formation in the traditional Chinese garden. Firstly, the formal is divided into the aesthetic characteristics and the method. And the aesthetic characteristics is divided into the impression of the sense organ time and space, visual field and visual sense, and enjoying the landscape in motion and in motionless which both have the sense of beauty. The method of the landscape formation is divided into 11 ways-①a main landscape and a secondary landscape, ②deepening space and landscape by degrees, ③ framing the landscape, ④borrowing the landscape, ⑤pointing out the landscape with a horizontal inscribed boards, written on scrolls, etc, ⑥a landscape which is situated in the end of a visual axis or a visual line, ⑦a landscape which can not be seen directly by obstacles, ⑧a landscape by using things of both sides with a perspective line or with a visual axis, ⑨a landscape which is divided by walls, creating more space, ⑩seeing a landscape by open work window and the like, ⑪an additional landscape. Secondary, the latter is divided into 6 ways-①proportion and scale, ②balance on stable, ③contrast and harmony, ④rhythm, ⑤association by metaphors, ⑥a variety of unity.

Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-kB signaling pathway

Xiang Xu,Lan Jin,Tong Jiang,Ying Lu,Fumie Aosai,Hu-Nan Piao,Guang-Hua Xu,Cheng-Hua Jin,Xue-Jun Jin,Juan Ma,Lian-Xun Piao 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.5

Background: Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarified yet. Methods: The effect of GRh2 against T. gondii was assessed under in vitro and in vivo experiments. The BV2 cells were infected with tachyzoites of T. gondii RH strain, and the effects of GRh2 were evaluated by MTT assay, morphological observations, immunofluorescence staining, a trypan blue exclusion assay, reverse transcription PCR, and Western blot analyses. The in vivo experiment was conducted with BALB/c mice inoculated with lethal amounts of tachyzoites with or without GRh2 treatment. Results and conclusion: The GRh2 treatment significantly inhibited the proliferation of T. gondii under in vitro and in vivo studies. Furthermore, GRh2 blocked the activation of microglia and specifically decreased the release of inflammatory mediators in response to T. gondii infection through TLR4/NF-kB signaling pathway. In mice, GRh2 conferred modest protection from a lethal dose of T. gondii. After the treatment, the proliferation of tachyzoites in the peritoneal cavity of infected mice markedly decreased. Moreover, GRh2 also significantly decreased the T. gondii burden in mouse brain tissues. These findings indicate that GRh2 exhibits an antieT. gondii effect and inhibits the microglial activation through TLR4/NF-kB signaling pathway, providing the basic pharmacological basis for the development of new drugs to treat toxoplasmic encephalitis.

Increased Serum Cathepsin K in Patients with Coronary Artery Disease

Xiang Li,Lan Cui,Yuzi Li,Jiyong Jin,Dehao Jin,Xiangshan Li,Yanna Rei,Haiying Jiang,Guangxian Zhao,Guang Yang,Enbo Zhu,Yongshan Nan,Xianwu Cheng 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.4

Purpose: Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). Materials and Methods: Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls. Results: The subjects’ serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterolwere measured. The patients with CAD had significantly higher serum cathepsinK levels compared to the controls (130.8±25.5 ng/mL vs. 86.9±25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1± 26.9 ng/mL vs. 102.6±12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01). Conclusion: These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.

중국 대학생소비자의 유행추구와 외국제품추구 행동에 관한 연구 : 자아존중감, 물질주의 및 화폐태도의 영향을 중심으로

JIN XIANG,홍은실 한국소비자정책교육학회 2022 학술대회 Vol.2022 No.06

CEO Core Self-evaluation: Impacts on Market Orientation and Innovation Performance

Xiang-Lan Jin,박영근,Zhiqi Dong 한국무역연구원 2019 무역연구 Vol.15 No.3

Purpose - This research aims to develop and test an integrative model examining the relationship between CEO core Self-evaluation (CSE) and innovation performance. The CEO’s personality plays a crucial role in organizational performance. However, its impact on market orientation and innovation has not been well developed. Additionally, CEO personality research has been hobbled by the absence of a unifying construct that captures core dimensions of personality. Design/methodology/approach - After follow-up telephone calls, 145 CEOs agreed to participate; only 103 questionnaires were usable. The hypotheses were tested using moderated regression analysis Findings - The result indicated CEOs who have strong CSEs greatly influence their firm’s market orientation and innovation. In addition, CEO CSE has a stronger impact on innovation when the TMT is highly collaborative. Research implications or Originality - CEOs with strong CSE feel more competent and pay greater attention to outside forces, which then affects the firm’s market orientation and innovation. Thus, this research goes beyond the relatively conservative and static review adopted in previous studies of CEO personality affection

Improvement of the extraction yield and nutritional composition of Tofu by-products (Biji) by ultra high pressure homogenization process

Jin-mi Yoon,Sha Li,Myung-Chul Yun,Yong-Xiang Wu,Jin-young Kim,Hyun-Seok Kim,Taewan Kim 한국식품영양과학회 2013 한국식품영양과학회 학술대회발표집 Vol.2013 No.11

Proteomic Analysis and Extensive Protein Identification from Dry,Germinating Arabidopsis Seeds and Young Seedlings

Xiang Jin,Kai-hua Wei,Qiang Fu,Bai-Chen Wang,Hong-Bing Li,Pei Han,Xue-min Zhang,Yu-Xian Zhu 한국생화학분자생물학회 2005 BMB Reports Vol.38 No.6