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Vertebrobasilar Dolichoectasia 4례 : 증례보고 A Case Report
목진호,김한식,이규춘,이영배 동국대학교 경주대학 1998 東國論集 Vol.17 No.1
Dolichoectasia란 혈관이 연장되고 방추상으로 팽창된 것을 말하며 두경부 혈관에서는 추골-기저동맥과 내경동맥에 주로 발생하며 중대뇌동맥이나 전대뇌동맥에는 드물게 발생한다 Vertebrobasilar dolichoectasia는 대부분 무증상이지만, 일분 환자에서는 뇌간이나 뇌신경들을 압박하거나 뇌허혈을 유발하여 증상을 나타낼 수 있고 임상증상에 따라 1) ischemic symptom 2) cranial nerve compression symptom 3) pseudotumor symptom 으로 구분할 수 있다. 그러나 임상경과중 반복적인 뇌 허혈증상 또는 뇌간 경색증을 유발하여 심각한 임상경과와 불량한 예후를 나타낼 수도 있다. 따라서 Vertebrobasilar dolichoectasia로 진단된 환자에서는 적극적으로 고혈압을 치료하며, 임상증상이 없더라도 항응고 제제나 항혈소판 제제를 투약하며 주의 깊게 관찰하여야 할 것이다. 자들은 일과성 허혈성 발작이나 뇌신경기능 장애를 보이는 Vertebrobasilar dolichoectasia 4례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The dolichoectasia of cerebral arteries is an uncommon entity and the term dolichoectasia (elongation-distention) has been used to describe these vessels, which are characterized by elongation and fusiform dilatation. The vertebrobasilar system and intracranial internal caroted arteries are more frequently involved and the diagnosis can be made by cerebral angiography, brain CT or brain MRI. It is generally asymptomatic, but may present with a variety of symptoms. Headache, cranial nerve paresis and cerebral ischemia are the most common clinical presentations. Cerebral ischemia, especially brain stem infarction, due to vertebrobasilar dolichoectasia is rare, but its development may be fatal. When the dolichoectasia is diagnosed by CT findings, even if it is clinically asymptomatic, it may be better to treat patients with medical therapy used to prevent ischemic stroke. We report four cases with vertebrobasilar dolichoectasia, all of them had ischemic symptoms and were treated with medical therapy.
기체 전기방전을 이용한 리액티브 블루 4의 분해에 관한 연구
목영선,조진오,이호원 제주대학교 공과대학 첨단기술연구소 2006 尖端技術硏究所論文集 Vol.17 No.1
Gaseous electrical discharge is an effective method available for the production of ozone and ultraviolet light. The wastewater treatment system of this study was designed to utilize both ozone and ultraviolet light produced by the electrical discharge for the degradation- of organic contaminants. The electrical discharge device (DBD reactor) consisted of a quartz cylinder, a coaxial ceramic tube inside of which a steel rod was placed (discharging electrode), and a steel wire that was helically wound around the quartz cylinder (ground electrode). The DBD reactor was immersed in the wastewater in order that the ultraviolet light could irradiate the wastewater. The ozone-containing gas from the DBD reactor was sparged throughout the wastewater. An anthraquinone-based dye, Reactive Blue 4, was chosen as the organic contaminant. The experimental results showed that the present system was very effective for the degradation of the organic contaminant. The energy requirement for the degradation was found to be 0.42kJ/mg, on the basis of 90% chromaticity removal.
목진자 단국대학교 1998 論文集 Vol.33 No.-
With the digital revolution, the boundaries recognized and codified between breadcasting and telephony in the 1934 Communications Act have broken down. In the early 1990s there are important trends observable in the field of world communication that have a considerable impact on the daily lives of people around the world. The four most essential current trends and their impact originate in the 1980s and mature in the 1990s. They are digitization, consolidation, deregulation, and globalization. Digitization means that technologies for the processing and transmission of information have gegun to use the same language. This is the computer language of the binary code. This digital language facilitates the convergence of computer, telecommunications, office technologies and assorted audio-visual consumer electronics. This digital integration offers speed, flexibility, reliability, and low costs. Channels greatly expand their capacity, the Electro Magnetic Spectrum can be more efficiently used, there is more consumer choice and more possibilities for interactive systems. Due to digitization, the telephone, cable, broadcast, and computer industries are converging the create these integrated broadband systems, which are relatively independent in the past. Convergence is facilitated by federal policy in the U.S. by the Telecommunications Act of 1996, which opens all communications services to competition, creating a ‘digital free-for-all’. Indeed the barriers between all forms of communication ar breaking down, and communication laws everywhere are becoming outdated. President Clinton announced the Telecommunications Act in 1996. The overarching purposed of the 1996. Telecommunications Act is to deregulate all communication industries and to permit the market, not public policy, to determine the course of the information highway and the communications system. Recently it is playing a main role in shaping of the global communications marketplace. It is more likely that deregualtion will lead to 1) merger activity, 2) increased concentration, and 3) continued downsizing. In this milieu, the Full Service Network(FSN) stared its multimedia service in Orlando, Florida at the end of 1994 for the first time in the world. The Orlando Project in mainly sponsored by Time Warner, Silicon Graphics, and AT&T with the investment of 500 million dollars for two years. The main services of FSN are video-on-demand(VOD) service, network game, on-line shopping, sports-on-demand, and interactive TV using the optical fiber network. With the above background, the situation of Full Service Network, the Orlando Project, will be examined to explore the benefits and problems for the future multimedia market of Korea.
목직호,김한식,이규춘,이영배 동국대학교 경주대학 1997 東國論集 Vol.16 No.2
1995년 7월부터 1997년 7월까지 최근 2년간 본원 신경외과에 입원한 343례의 두부손상 환자중 사망한 25례를 조기사망군(7일이내)과 후기사망군(7일후)으로 분류하여 분석해본 결과 7.3%의 사망률을 보였으며 남자 사망자는 여자에 비해 3.2배였으며, 연령 별로는 조기사망군은 40대이상에서 많았고 후기 사망군은 60대 이상의 고령에서 다소 많았다. 조기사망군에서는 낮은 GCS, 비정상적인 동공반사 반응, 타장기 손상, 저혈압, 저산소증, 고혈당, 심한 정중전이, 뇌실압박, 두개골 골절, 개두술의 빈도가 높게 조사되었다. 이송시간은 조기사망군에서 1시간 이내에 도착한 경우가 많아 신속한 후송이 이루어졌다. 한편 후기사망군에서는 저이산화탄소혈증, 빈혈, 고나트륨혈증등이 높게 조사되었다. 사인은 조기사망군에서 1차성두개강내 병변 및 저혈량 등이 많았고 후기사망례는 폐렴, 성인성 호흡곤란 증후군, 외상후성 뇌경색증 등이 주요 사망 원인이었다. 따라서 생존기간별로 위험도가 높은 요소를 찾아 그에 대한 적극적인 치료를 하는 것이 두부 손상으로 인한 사망률을 개선하는데 바람직한 것으로 생각된다. We present a study the variable factor in the early(within one week) and late death(after one week) after head injury. The multiple factors were analysed on the clinical, imaging, and laboratory characteristics of 25 patients who were dead among 343 head injured persons during recent 2 years form July, 1995 to July, 1997. The mortality rate was 7.3% and the ratio of male to female was 3.2 to 1. The early death were younger than late death(5th decade vs 7th decade). Mechanism of injury were motor vehicle accident(64%), followed by work-related, slip and fall, and unknown. The early death had a higher percentage of low GCS score, abnormal pupil reflex, other associated injury, hypotension, hypoxemia, hyperglycemia, midline shift, ventricle compression, skull fracture, and craniotomy compared with the late death. On the other hand, the late death had a higher incidence of hypocarbia, anemia, and hypernatremia than the early death. The main causes of death were primary intracranial lesions and hypovolemia in the early death and pneumonia, ARDS, and posttraumatic cerebral infarction in the late death.
목진호,김한식,이규춘,박용석,이영배 東國大學校醫學硏究所 1999 東國醫學 Vol.6 No.-
긴장성 기두증은 신경외과영역에서 개두수술 후에 발생할 수 있는 드문 합병증으로 특히 만성 뇌경막하 혈종 제거수술이나 좌위에서 후두와 수술을 시행한 경우에 발생할 수 있다. 따라서 개두수술 후에 신경학적 증상의 악화가 있거나 수술 후 예상경과를 취하지 않는 경우에는 긴장성 기두증의 발생 가증성을 항상 고려하여야 한다. 긴장성 기두증의 발생기전은 물병을 거꾸로 세운 것과 같은 기전(Inverted pop-bottle mechanism)으로 뇌척수액이 누수된 만큼 공기방울이 경막하강으로 올라가 빈 공간을 메우는 것이다. 이와 같은 기전으로 두개강내로 들어간 공기가 일정한 압력을 가지게 되어 주변 뇌조직을 압박하여 신경학적 장애를 초래하게 된다. 뇌전산화 단층촬영을 이용하여 쉽게 진단이 가능하며 치료는 두개골 천공을 시행하여 두개강내 공기를 배기시켜 줌으로서 가능하다. 저자들은 복와위에서 후두와 병변 수술 후에 발생한 긴장성 기두증을 뇌전산화 단층촬영을 이용하여 진단하고 전두골을 천공하여 두개강내 공기를 배기시켜 치험하였기에 문헌고찰과 함께 증례를 보고하는 바이다. 중심단어:긴장성 기두증, 후두와 수술, 경막하강, 복와위 Tension pneumocephalus is a rare complication in neurosurgical operation and should be considered whenever a patient fails to recover as expected following surgery. The possible mechanism for the entry of air into the subdural space is analogous to the entry of air into an inverted soda-pop bottle. As the fluid pours out. air bubbles reach the top of the container, Computed tomography permitted rapid diagnosis including localization of the air, thus facilitating prompt treatment. Peaking of frontal lobe. mountain appearance of frontal lobe. and air densities at the cisterns are characteristic findings of' tension pneumocephalus on brain CT scan. This condition is easily diagnosed and treated using twist-drill aspiration. The authors describe a case of subdural tension pneumocephalus complicating the early postoperative course after posterior fossa surgery in the prone position.
법랑아세포종에서 apoptosis 연관 인자 발현과 apoptitic index
목동진,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4
Objective : Ameloblastoma is a common odontogenic benign tumor of the jaw bone. However, it might be able to infiltrate into the adjacent tissue, causing bony destruction and high recurrent rate. The aim of this study is to understand the biologic behavior of ameloblastoma through immunohistochemi cal stainings for apoptosis-related markers of bcl-2, box and caspase-3, examining the apoptosis index and simultanecusly. performing the same tests on MIB-1, which is a marker of cell-proliferationg capacity and p53, which is related with tumor malignancy, and also study the differences between the above marker's expressions and their relationships. Methods and Material : The 39 cases of ameloblastoma were used after the surgery conducted at the Pusan Back Hospital and the Pusan University Hospital during the period from January 1991 to June 2001. The clinical parameters were recorded by patent's age, sex, location of tumor, treatment modality, radiologic findings and recurrences. Based on hematoxylin & eosin findings, they were histologicaly subdivided into follicular and non-follicular. Immunohistochemical stainings for bcl-2, bax, caspase-3. p53 and MIB-1 and TdT-mediated dUTP-biotin nick end labelling method for apoptosis were performed and also statistical analyses were conducted between clinicopathologic parameters and expressions for bcl-2, bax, caspase-3, p53 and MIB-1 and apoptosis. Results : six(15.4%) recurrences were found out of 39 cases. For the patient's age of 40 and above, found a higher recurrence rate(p=0.0182) and multilocular on X-ray(p=0.0640), but there were no significant differences between recurrence rate, sex, location of tumor, treatment modality and histologic subtype. Apoptosis was found in 10(25.6%) of 39 cases and bcl-2 was(20.5%), bax was 21(53.8%), caspase-3 was 19(48.7%). the positive reaction for p53 was 13 cases(33.3%) and 5(12.8) cases for MIB-1. In the positive case of apoptosis and MIB=1, both of them have showed an increasing tendency of high recurrence, but there were no statistical significance. It showed no significant relationship between expression rates of bcl-2, bax, caspase-3 and p53 and recurrence rate. In follicular type, bcl-2 and p53 positive reaction revealed increasing tendency, however, no significant relationship between radiological finding, expressions of apoptosis, bax, caspase-3 and MIB-1 and histologic subtype has found. No significant relationship between apoptosis and apoptosis-related markers as bcl-2, bax, and caspase-3 expressions has found. There was a significant relationship between bcl-2 and p53 expressions(p<0.01), but no significant differences of apoptosis and expressions of bax and caspase-3 according to p53 and MIB-1 expressions have noted. Conclusion : Apoptosis-related bcl-2, bax, caspase-3 expressions and p53 and MIB-1 expressions are involved in the development of ameloblastoma and high recurrent rate is related to the age of more than 40 years, multichambered lesion and the positive reaction for apoptosis and MIB-1. These finding suggest that patient's age, radiologic findings, apoptosis and proliferation activity of ameloblastoma could be useful markers to predict recurrence.
Clay 또는 은 나노 입자를 함유한 불포화 폴리에스테르 수지의 물성에 관한 연구
인교진,목진규,신동현,김주영 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-
본 연구에서는 불포화 폴리에스테르 수지에 clay 또는 평균 10 nm의 은 나노 입자를 분산시켜 나노 복합체를 제조하여 그 물성 변화를 관찰하였다. clay를 함유한 나노 복합체에 대하여 XRD 분석을 한 결과, clay 층상 구조에 해당하는 회절 피크가 나타나지 않는 것으로 보아 clay의 층간 거리가 벌어져 있음을 알 수 있었다. 그러나 TEM 관찰 결과를 보면 clay 층이 완전히 박리 된 것은 아니고, clay 층 사이에 고분자 사슬이 삽입되어 있는 삽입형 나노 복합체임을 확인할 수 있었다. 또 불포화 폴리에스테르 은 나노 복합체의 경우 수지 내에 은 나노 입자가 고르게 분산되어 있음을 알 수 있었다. clay를 함유한 나노 복합체의 기계적 물성을 DMA로 분석한 결과 저장 탄성률(E´)은 최대 57% 증가함을 보였다. TGA로 분석한 열적 물성에서는 열분해 온도가 최대 18℃ 정도 증가하였다. 이는 clay가 불포화 폴리에스테르 수지의 기계적, 열적 성질에 영향을 주었기 때문인 것으로 판단되었다. 불포화 폴리에스테르 은 나노 복합체의 경우도 은 나노 입자가 고분자 매트릭스와의 상호작용으로 인해 기계적, 열적 물성이 향상되었다. 또, 은 나노 복합체의 경우 은 특유의 성질인 항균성에 있어서 매우 우수한 물성을 나타내었다. In this study, made nanocomposites that dispersed clay or silver nanoparticles of average 10 nm is unsaturated polyester resins and observed change of the properties. According to the result of XRD analysis about nanocomposites containing clay, diffraction peak that correspond to structure of layerd-clay does not appear and could know that exfoliation of distance between layerd-clay. But, seeing TEM image, layerd-clay is not exfoliated perfectly, and could confirm Intercalated Nanocomposites that polymer chain is intercalated between clay layer. Also, it could know that silver nanoparticles is dispersed in unsaturated polyester resins in the case of unsaturated polyester-silver nanocomposites. The result that analyze mechanical properties of nanocomposites which containing clay by DMA showed Storage Modulus(E´) increased maximum 57 %. Also, Pyrolysis temperature increased maximum 18 ℃ in thermal properties that analyze by TGA. Because clay influenced in mechanical and thermal property of unsaturated polyester resins. In case of UP-silver nanocomposites, advanced mechanical and thermal properties because silver nanoparticles interacted with polymer matrix. Also, it appeared properties in Antibacterial that is silver characteristic property in silver nanocomposites.