MACC1 Expression Correlates with PFKFB2 and Survival in Hepatocellular Carcinoma

Ji, Dong,Lu, Zhong-Tang,Li, Yao-Qing,Liang, Zhe-Yong,Zhang, Peng-Fei,Li, Chao,Zhang, Jun-Li,Zheng, Xin,Yao, Ying-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Objective: To validate the relationship between MACC1 and 6-phosphofructo-2-kinase/fructose 2, 6 bisphosphatase (PFKFB2) expression as well as its clinicopathological features and prognostic significance in hepatocellular carcinoma. Methods: By using immunohistochemistry, we investigated the MACC1 and PFKFB2 protein expression in 60 pairs of hepatocellular carcinoma and corresponding non-tumor tissues. Using the Mann-Whitney U test, the Chi-square test, Kaplan-Meier survival analysis, Cox proportional hazard regression analysis and Spearman analysis, we studied the relationship between MACC1 and PFKFB2 protein expression and postoperative overall survival (OS) of the HCC patients. Results: MACC1 and PFKFB2 positive staining rates were significantly higher in hepatocellular carcinoma than in the corresponding nontumor tissues (P=0.012 and 0.04, respectively). The clinicopathological features evaluation revealed that positive expression of MACC1 was associated with a high Edmondson classification (P=0.007) and advanced TNM stage (P=0.027). Similar findings were evident for PFKFB2 expression (P=0.002 and P=0.027). MACC1 and PFKFB2 positive expression was associated with a lower OS rate (P=0.004 and 0.03, respectively). Kaplan-Meier survival and Cox proportional hazard regression analyses revealed MACC1 positive expression to be a prognostic factor for postoperative OS, but PFKFB was not. Conclusion: Highly expressed MACC1 and PFKFB2 protein were associated with TNM stage, Edmondson-Steier classification and overall survival. MACC1 may affect tumor metabolism partly through expression and phophorylation of PFKFB2.

A Game Theory Based Interaction Strategy between Residential Users and an Electric Company

Jidong Wang,Kaijie Fang,Yuhao Yang,Yingchen Shi,Daoqiang Xu,Shuangshuang Zhao 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.1

With the development of smart grid technology, it has become a hotspot to increase benefits of both residential users and electric power companies through demand response technology and interactive technology. In this paper, the game theory is introduced to the interaction between residential users and an electric company, making a mutually beneficial situation for the two. This paper solves the problem of electricity pricing and load shifting in the interactive behavior by building the game-theoretic process, proposing the interaction strategy and doing the optimization. In the simulation results, the residential users decrease their cost by 11% mainly through shifting the thermal loads and the electric company improves its benefits by 5.6% though electricity pricing. Simulation analysis verifies the validity of the proposed method and shows great revenue for the economy of both sides.

Metabolic Syndrome Is Associated with Delayed Heart Rate Recovery after Exercise

Jidong Sung,Yoon Ho Choi,박정배 대한의학회 2006 Journal of Korean medical science Vol.21 No.4

Heart rate (HR) recovery after exercise is a function of vagal reactivation, and its impairment is a predictor of overall mortality and adverse cardiovascular events. While metabolic syndrome is associated with sympathetic overactivity, little is known about the relationship between metabolic syndrome and HR recovery. A symptom-limited exercise stress test in healthy subjects (n=1,434) was used to evaluate HR recovery. Metabolic syndrome was defined according to the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP-III) criteria. Seventeen percent of subjects had ≥≥3 criteria for metabolic syndrome. HR recovery was lower in men than women and in smokers than nonsmokers. The subject with metabolic syndrome (vs. without) showed lower HR recovery (10.3 ±±11.6 vs. 13.6 ±±9.7 per minute) and higher resting HR (64.3 ±±10.3 vs. 61.6 ±±9.1 per minute). HR recovery correlated inversely to age (r=-0.25, p<0.0001), but not to resting HR or maximal oxygen uptake. Delayed HR recovery was associated with metabolic syndrome after an adjustment for age, sex, resting HR and smoking (p<0.01). Metabolic syn-drome is associated with impaired vagal reactivation. Adverse cardiovascular out-comes associated with metabolic syndrome may be mediated by the failure of vagal reactivation in addition to sympathetic overactivity.

A New Method for Joint Timing and Frequency Synchronization in OFDM System

Jidong Wei,Young Soo Kim 한국통신학회 2008 한국통신학회 학술대회논문집 Vol.2008 No.11

Descriptive Study on the Korean Status of Percutaneous Coronary Intervention Using National Health Insurance Service-National Sample Cohort (NHIS-NSC) Database: Focused on Temporal Trend

Jidong Sung,Kyung Pyo Hong 대한심장학회 2019 Korean Circulation Journal Vol.49 No.12

Background and Objectives: Percutaneous coronary intervention (PCI) is an indispensable treatment modality in coronary artery disease. However, there is still inadequacy of comprehensive knowledge on the Korean status and trend of this important procedure using nation-wide and representative data. Methods: National Health Insurance Service-National Sample Cohort is a database containing demographic, health insurance reimbursement for patient management and health screening data of about one million Koreans for 12 years (2002–2013). Annual procedure rate for PCI was estimated by bootstrapping as per 100,000 person-years. Results: Among the whole cohort, total 12,186 PCI's were done during the study period. Mean age of subjects who underwent PCI was 57.6±11.2 years and male:female proportion was 68%:32%. Death from all cause occurred in 1,843 (15.1%), death from ischemic heart diseases in 662 (5.4%), death from all cardiovascular cause in 872 (7.2%) during the follow-up. The proportion of the primary PCI for acute myocardial infarction was estimated to be 24.0%. Estimated annual rate of PCI increased from median 29.1 (95% confidence interval [CI], 26.6–32.1) in 2002 to 107.7 (95% CI, 103.0–113.8) per 100,000 person-years in 2013. In this cohort, PCI was performed in total 180 hospitals, which annually increased from 59 in 2002 to 153 in 2013. Conclusions: PCI had increased in volume from 2002 to 2013. This descriptive data may be considered in policy making and planning further direction of management of coronary artery disease in Korea.

The Long and Winding Road: To the Proper Understanding of High-density Lipoprotein

Jidong Sung 대한심장학회 2020 Korean Circulation Journal Vol.50 No.3

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Lipid and Ischemic Heart Disease Revisited: Mendelian Randomization Analysis

Jidong Sung 대한심장학회 2020 Korean Circulation Journal Vol.50 No.10

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Environmental impact assessment for city logistics distribution systems

Jidong Guo,Shugang Ma 대한환경공학회 2017 Environmental Engineering Research Vol.22 No.4

The external diseconomy is hampering sustainable development of the city logistics sector. Burdens on urban environment imposed by the city logistics industry have been put in the spotlight. Based on the principle of Life Cycle Analysis, the comprehensive environment impact for city logistics systems is measured. Firstly, with the city logistics service chain as a whole, its business processes and their interactions with environment are analyzed. In total four types of major environment impact categories are determined. Secondly, case study is made on three city logistics operators located in Jing-Jin-Ji region of China with different business modes, respectively self-operation mode, joint distribution mode and the 3<SUP>rd</SUP> Party Logistics or 3PL mode. Through analysis of energy consumption and emissions for various business processes, their comprehensive environmental impact values are finally obtained. Thirdly, horizontally comparative analysis is carried out to these three modes of the urban logistics distribution systems. Results show the advantages of the 3PL and the joint distribution modes in developing greener urban logistics distribution. Future research avenues and policy suggestions are proposed finally.

Research on Smart Home Interaction in Sleep Scenarios Based on User Needs

Jidong Liu,Yuanchen Wu,Meile Le 한국HCI학회 2024 한국HCI학회 학술대회 Vol.2024 No.1

This study explores the interaction methods of smart homes in sleep scenarios based on user needs, aiming to enhance user interaction experience with a user-centric interaction philosophy, and shift the development direction of smart homes from technologydriven to consumer needs-driven. The results indicate that in the sleep aid stage, Focused Interaction is the primary method, supported by Peripheral and Implicit Interactions. During the sleep stage, Implicit Interaction is the main method, supplemented by Peripheral and Focused Interactions. In the awakening stage, a foundation of Peripheral and Implicit Interactions with minimal Focused Interaction aligns more closely with consumer habits. This model can prevent the blind development of new interaction methods in smart homes within sleep scenarios, reducing the occurrence of unnecessary or unreasonable human-machine interactions.

Wind Power Interval Prediction Based on Improved PSO and BP Neural Network

Jidong Wang,Kaijie Fang,Wenjie Pang,Jiawen Sun 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.3

As is known to all that the output of wind power generation has a character of randomness and volatility because of the influence of natural environment conditions. At present, the research of wind power prediction mainly focuses on point forecasting, which can hardly describe its uncertainty, leading to the fact that its application in practice is low. In this paper, a wind power range prediction model based on the multiple output property of BP neural network is built, and the optimization criterion considering the information of predicted intervals is proposed. Then, improved Particle Swarm Optimization (PSO) algorithm is used to optimize the model. The simulation results of a practical example show that the proposed wind power range prediction model can effectively forecast the output power interval, and provide power grid dispatcher with decision.