Development of a Novel 3-DOF Suspension Mechanism for Multi-Function Stylus Profiling Systems

Jia Tian,Yanling Tian,Zhiyong Guo,Fujun Wang,Dawei Zhang,Xianping Liu,Bijian Shirinzadeh 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.11

This paper proposes a novel 3-DOF suspension mechanism for multi-function stylus profiling systems. Incorporating an electromagnetic force actuator, the 3-DOF suspension mechanism provides a controlled loading force. For reasons of the thermal and mechanical stability, a triangular flexure structure is utilized to support the stylus. The stiffness matrix method is used to establish the analytical stiffness model of the 3-DOF suspension mechanism. Considering the 3-DOF suspension mechanism as a 3-DOF lumped-mass-spring system, the dynamic model is established. Finite element analysis (FEA) is used to validate the established static and dynamic models of the 3-DOF suspension mechanism. A prototype is fabricated and experimental tests are carried out to characterize the mechanism’s performance. The results show that the 3-DOF suspension mechanism provides a controlled force in a range of up to 10 mN and has a working range in excess of 10 μm with a first natural frequency of 342 Hz in Z axis, indicating good capability for multi-function measurements at the micro/nano scale.

도심형 놀이 공간의 체험형 인터랙티브 디자인 방향성 연구

양지아티엔 ( Yang Jiatian ),이수영 ( Lee Suyoung ) 한국공간디자인학회 2023 한국공간디자인학회논문집 Vol.18 No.8

(연구배경 및 목적) 현대 공공디자인의 실외 놀이 체험공간은 인터랙티브(interactive) 디자인의 흥미와 참여성을 강조한 이벤트 형태로 주목을 끌고 있다. 사용자를 공간 요소의 일부로 다양한 인터랙티브 체험객의 시지각적 참여를 이끌어냄과 동시에 사람과 공간, 경관과의 관계를 수동적 감상에서 능동적 체험으로 변화된 참여와 흥미를 유발하고 있다. 이는 공간의 활용도를 높이고 사용자에게 새롭고 다 감각적 경험을 줄 수 있다. 본 연구의 목적은 도심형 놀이 공간에서의 인터랙티브 디자인 특성을 분석하고 향후 인터랙티브 디자인 발전에 기여하는 것이다. (연구방법)첫째, 문헌, 저널, 학술 논문, 인터넷 데이터 등 을 기반으로 데이터를 수집한다. 둘째, 사례를 바탕으로 도심 공간 내에 위치한 레저·엔터테인먼트 공간의 특성을 조사하였다. 연구의 시간적 범위는 2010~2021년으로 공간적 범위는 인터랙티브 시설, 인터랙티브 시스템, 놀이 공간을 갖춘 시티프라자, 공원 및 거리 등을 10개 사례를 조사한다. 셋째, 설문조사는 놀이 공간의 형태적, 물리적 요소와 인터랙티브 디자인 표현 요소의 세 가지 측면에서 사용자의 선호도를 분석하고 실제 사용자가 놀이 공간에서 관심을 갖는 인터랙티브 디자인 요소를 도출한다. 연구 및 분야의 사례와 분석을 바탕으로 놀이 공간 인터랙티브 디자인 방향에 대한 의의를 탐구한다. (결과) 설문지와 사례를 통한 대화형 디자인의 형태적 요소 표현에서 현대 스크린, 미디어, 영상 및 기타 응용 프로그램이 부족하다는 것을 알 수 있다. 놀이 공간에서 신체 동작을 통해 빛은 공간과 소통하고 상호작용하며 색상이나 조명을 사용하여 사용자를 자극하고 유도한다. 상호작용성은 공간에서 이루어지는 의사소통과 커뮤니케이션의 형태이며, 공간에서 중요한 부분을 차지한다. 다음으로 감성적 표현에서 편안한 색상은 공간의 활력과 매력을 증가시키고, 사용자의 상상력과 흥미를 자극하며, 다양한 심리적, 시각적 감각적 경험을 만족시켜 공간의 감성을 구현한다. (결론) 도시 놀이 공간이 인터랙티브를 매개로 다양한 체험 공간으로 설계될 수 있음을 보여준다. 그 결과 사용자의 심미성과 체험의 요구를 충족시킬 뿐만 아니라 사용자와 공간 간의 다중 상호작용에 더 많은 관심을 기울인다. 현재 놀이 공간의 인터랙티브 디자인은 형태와 기능성이 높은 매체로 구성되어 있으며, 공간 구조가 비교적 합리적이며 놀이성과 상호작용성이 충분하다. 사용자는 공간에서 놀이체험 및 미디어 기술의 적용에 더 많은 관심을 기울이고 후속 디자인은 공간에서의 감성성 표현 및 전문 기술의 적용을 강화할 수 있다. 본 연구를 통하여 인터랙티브 디자인의 방향에 폭넓은 방향성을 제공할 수 있기를 기대한다. (Background and Purpose) Among modern public designs, interactive design is drawing attention as an approach that emphasizes fun and participation in outdoor spaces. Making the user part of the spatial elements encourages visual and perceptual participation in the experience through various interactivations and changes the relationship between people and space, and people and the landscape from passive appreciation to active experience, creating interest in participation. This study introduced the concept of interactive design in urban spaces. The purpose of this study was to analyze the characteristics of interactive design in urban entertainment spaces and contribute to the development of interactive design in the future. (Method) First, data were collected by comprehensive literature search. Second, based on the information gleaned, the characteristics of leisure and entertainment spaces in urban areas were investigated. The temporal range of the study was 2010-2021. The spatial range of the study investigated 10 domestic and international cases of interactive facilities, city plazas with interactive systems, and play spaces, parks, and streets. Third, through a questionnaire analysis of user preferences, we explored the significance of game-space interaction design. (Results) Through questionnaires and cases, we found a lack of modern screens, media, images, and other applications for expressing morphological elements in interactive design. Through body movements in the playspace, light communicates with and interacts with the space, and color or lighting may be used to stimulate and engage the user. Comfortable colors in emotional expressions increase the vitality and appeal of the space, stimulate users' imagination and interest, and enhance various psychological and visual sensory experiences, thus embodying the sensibility of the space. (Conclusion) This study shows that urban entertainment spaces can be designed as a variety of experience spaces through interaction. Such design not only meets the aesthetic and experience requirements of users but also considers the multiple interactions between users and space. At present, the interactive design of a game space is composed of media with prominent form and function; the space structure is reasonable, and the game and interaction are sufficient. Users can pay attention to the gaming experience and application of media technology in the space, and subsequent design can strengthen the perceptual expression and application of professional technology in the space. It is hoped that the results of this study will provide direction for the improvement and adjustment of the interactive design of subsequent game spaces.

Identification of adhesion-associated extracellular matrix component thrombospondin 3 as a prognostic signature for clear cell renal cell carcinoma

Xiangling Chen,Jiatian Lin,Min Chen,Qiaoling Chen,Zhiming Cai,Aifa Tang 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.1

Purpose: Clear cell renal cell carcinoma (ccRCC) is a highly aggressive disease, and approximately 30% of patients are diagnosed at the metastatic stage. Even with targeted therapies, the prognosis of advanced ccRCC is poor. The aim of this study was to investigate clinical prognosis signatures by analyzing the ccRCC datasets in The Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the function of thrombospondin 3 (THBS3) in ccRCC. Materials and Methods: We analyzed the ccRCC datasets in TCGA and CPTAC to search for extracellular matrix (ECM)-related and adhesion-associated genes, and conducted overall survival, Cox, and receiver operating characteristic analyses. We also performed CCK8, colony formation, and transwell assays to compared the proliferation and migration ability of THBS3 knockout cells with those of cells without THBS3 knockout. Results: Comprehensive bioinformatics analysis revealed that THBS3 is a novel candidate oncogene that is overexpressed in ccRCC tumor tissue and that its elevated expression indicates poor prognosis. Our study also showed that knockdown of THBS3 inhibits proliferation, colony formation, and migration of ccRCC cells. Conclusions: In summary, our data have revealed that THBS3 is upregulated in cancer tissues and could be used as a novel prognostic marker for ccRCC. Our findings thus offer theoretical support with bioinformatics analyses to the study of ECM and adhesion proteins in ccRCC, which may provide a new perspective for the clinical management of ccRCC.

Corrigendum: Correction Of The Figure. Identification of adhesion-associated extracellular matrix component thrombospondin 3 as a prognostic signature for clear cell renal cell carcinoma

Xiangling Chen,Jiatian Lin,Min Chen,Qiaoling Chen,Zhiming Cai,Aifa Tang 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.5

none

Expression and Changes of Hyperoxidized Peroxiredoxins in Non-Pyramidal and Polymorphic Cells in the Gerbil Hippocampus During Normal Aging

Yoo, Ki-Yeon,Park, Ok Kyu,Yu, Jiatian,Yan, Bingchun,Li, Hua,Lee, Choong Hyun,Choi, Jung Hoon,Kim, Dae Won,Hwang, In Koo,Won, Moo-Ho Springer-Verlag 2009 Cellular and molecular neurobiology Vol.29 No.3

Neuroprotective Actions of an Indole-3-propinoic Acid Against Ischemic Damage

Ki-Yeon Yoo,In Koo Hwang,Hua Li,Ok Kyu Park,Jiatian Yu,Bingchun Yan,Moo Ho Won 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

Effects of Treadmill Exercise on Cell Proliferation and Differentiation in the Subgranular Zone of the Dentate Gyrus in a Rat Model of Type II Diabetes

Yi, Sun Shin,Hwang, In Koo,Yoo, Ki-Yeon,Park, Ok Kyu,Yu, Jiatian,Yan, Bingchun,Kim, Il Yong,Kim, Yo Na,Pai, Tongkun,Song, Wook,Lee, In Se,Won, Moo-Ho,Seong, Je Kyung,Yoon, Yeo Sung Springer-Verlag 2009 Neurochem Res Vol.34 No.6