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Causes, Features, and Outcomes of Drug-Induced Liver Injury in 69 Children from China
( Yun Zhu ),( Yong Gang Li ),( Jia Bo Wang ),( Shu Hong Liu ),( Li Fu Wang ),( Yan Ling Zhao ),( Yun Feng Bai ),( Zhong Xia Wang ),( Jian Yu Li ),( Xiao He Xiao ) 대한소화기학회 2015 Gut and Liver Vol.9 No.4
Background/Aims: Drug-induced liver injury (DILI) is a frequent cause of pediatric liver disease; however, the data on DILI are remarkably limited. Methods: All 69 children hospitalized with DILI between January 2009 and December 2011 were retrospectively studied. Results: A total of 37.7% of the children had medical histories of respiratory infection. The clinical injury patterns were as follows: hepatocellular 89.9%, cholestatic 2.9%, and mixed 7.2%. Liver biopsies from 55 children most frequently demonstrated chronic (47.3%) and acute (27.3%) hepatitis. Hypersensitivity features, namely, fever (31.9%), rash (21.7%), and eosinophilia (1.4%), were found. Twenty-four children (34.8%) developed chronic DILI. Antibiotics (26.1%) were the most common Western medicines (WMs) causing DILI, and the major implicated herbs were Ephedra sinica and Polygonum multiflorum. Compared with WM, the children whose injuries were caused by Chinese herbal medicine (CHM) showed a higher level of total bilirubin (1.4 mg/dL vs 16.6 mg/dL, p=0.004) and a longer prothrombin time (11.8 seconds vs 17.3 seconds, p=0.012), but they exhibited less chronic DILI (2/15 vs 18/39, p=0.031). Conclusions: Most cases of DILI in children are caused by antibiotics or CHM used to treat respiratory infection and present with hepatocellular injury. Compared with WM, CHM is more likely to cause severe liver injury, but liver injury caused by CHM is curable. (Gut Liver 2015;9:525-533)
Disruption of ecdysis in Leptinotarsa decemlineata by knockdown of chitin deacetylase 1
Jian-Jian Wu,Li-Li Mu,Zhong-Chao Chen,Kai-Yun Fu,Wen-Chao Guo,Chao Li,Guo-Qing Li 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2
Chitin deacetylases (CDAs) catalyze N-deacetylation of chitin, a crucial process for chitin modification. In the present paper, LdCDA1 was identified in Leptinotarsa decemlineata. It was copiously expressed in larval foregut, hindgut and epidermis. Just before the molt in the first, second and third larval instars, the mRNA levels of LdCDA1 were high. In the fourth (final)-instar larvae, a peak occurred 4 days after ecdysis. In vivo results revealed that LdCDA1 transcriptionally responded, positively and negatively respectively, to 20-hydroxyecdysone and juvenile hormone titers. Moreover, knockdown of LdCDA1 significantly reduced foliage consumption, lengthened developing period and prevented growth in the final instar larvae. Three distinct lethal phenotypes were noted in the LdCDA1 RNAi larvae. About 30% of the RNAi larvae became moribund and finally died; approximately 50% of deformed pupae died as pharate adults; and around 20% of LdCDA1 depleted pupae finally emerged as abnormal adults and eventually died within 1 week after emergence. Furthermore, chitin content was low and the mRNA levels of five chitin biosynthesis transcripts (LdUAP1, LdUAP2, LdChSAa, LdChSAb and LdChSB) were significantly declined in the LdCDA1 RNAi larvae. In addition, glucose, trehalose and glycogen contents were increased in the LdCDA1 depleted hypomorphs, along with highly expressed genes coding for trehalose and glycogen synthesis enzymes. The findings provide a compelling piece of evidence that CDA1 is critical for chitin deposition in L. decemlineata. Moreover, LdCDA1 may be a potential target for control of the larvae.
A Weibo Topic Tracking System based on K-means
Yun Liu,Kun-Peng Xia,Jian-Xun Zhao 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6
This article studied weibo text representation. For the weibo features such as short, real-time, colloquialism and originality, in the original vector space model, we propose a suitable method for weibo text representation. Make all the content words as feature words after participation. And we proposed T-TFIDF weight calculation method according to the features of weibo. According to the vector space model, we proposed a weibo adaptive topic tracking methods based on K-means clustering. Simulation analysis shows that, the method can by comparing the similarity micro-blog and sub topic vector set, determine whether weibo belonging to the topic.
Zhou, Yun-Feng,Zhang, Guang-Bo,Qu, Ping,Zhou, Jian,Pan, Hui-Xin,Hou, Jian-Quan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Background: Prostate cancer (Pca) is one of the most common complex and polygenic diseases in men. The X-ray repair complementing group 1 gene (XRCC1) is an important candidate in the pathogenesis of Pca. The purpose of this study was to evaluate the association between single nucleotide polymorphisms in the XRCC1 gene and susceptibility to Pca. Materials and Methods: XRCC1 gene polymorphisms and associations with susceptibility to Pca were investigated in 193 prostate patients and 188 cancer-free Chinese men. Results: The c.910A>G variant in the exon9 of XRCC1 gene could be detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Significantly increased susceptibility to prostate cancer was noted in the homozygote comparison (GG versus AA: OR=2.95, 95% CI 1.46-5.42, ${\chi}^2$=12.36, P=0.001), heterozygote comparison (AG versus AA: OR=1.76, 95% CI 1.12-2.51, ${\chi}^2$=4.04, P=0.045), dominant model (GG/AG versus AA: OR=1.93, 95% CI 1.19-2.97, ${\chi}^2$=9.12, P=0.003), recessive model (GG versus AG+AA: OR=2.17, 95% CI 1.33-4.06, ${\chi}^2$=8.86, P=0.003) and with allele contrast (G versus A: OR=1.89, 95% CI 1.56-2.42, ${\chi}^2$=14.67, P<0.000). Conclusions: These findings suggest that the c.910A>G polymorphism of the XRCC1 gene is associated with susceptibility to Pca in Chinese men, the G-allele conferring higher risk.
Young Girl Bra’s Market Research and Product Development Based on Functionality Value Study
Cai, Jian-mei;Wen, Yingyu;Gan, Wen-yun 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.1
The young girl bra market awaked, it created the industrial value would be unable to estimate. This study sets out to focus on the analysis of young girl bra’s market research and product development based on functionality value. The methodology for this research involves multiple case studies involving girl bra target consumers. Functionality value and related theory guide product development concept as the key point. The research has identified young girl bra market is a size able blank in China. How to guide consumers’consumption awareness correctly by developing the functionality girl bra would be this research’s achievement. The paper linked scientific theory with practical market demand closely, comprehensive analysis of characteristics of adolescent girls in perfect underwear market segment, correct guidance bra consumer market, meet the girl consumer demand, and on the basis of functionality value in girls bra development would better reflected. The observations and analyses of girl bra functionality value would be the core of this paper, which is rarely known by people.
Cai, Xiao-Yan,Wang, Jia-Xing,Yi, Yong,He, Hong-Wei,Ni, Xiao-Chun,Zhou, Jian,Cheng, Yun-Feng,Jin, Jian-Jun,Fan, Jia,Qiu, Shuang-Jian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Objectives: TCR-gamma-delta+T cells (${\gamma}{\delta}$ T cells) are non-conventional T lymphocytes that can recognize and eradicate tumor cells. Our previous studies showed that infiltration and function of ${\gamma}{\delta}$ T cells were substantially attenuated in hepatocellular carcinoma (HCC). However, their prognostic value was not clarified. Methods: The association between ${\gamma}{\delta}$ T cells and the clinical outcomes was determined by immunohistochemistry (IHC) in a HCC patient cohort (n = 342). Results:Immunohistochemistry showed decreased infiltration of ${\gamma}{\delta}$ T cells in tumoral tissues compared with paired peritumoral tissues. The counts of ${\gamma}{\delta}$ T cells in peritumoral tissues were negatively correlated with tumor size (P = 0.005). Survival analysis showed that the levels of peritumoral ${\gamma}{\delta}$T cells were related to both time to recurrence (TTR) and overall survival (OS) (P = 0.010 and P = 0.036, respectively) in univariate analysis, and related to TTR in multivariate analysis (P = 0.014, H.R. [95% CI] = 0.682 [0.502-0.927]). Furthermore, the level of peritumoral ${\gamma}{\delta}$ T cells showed independent prognostic value for TTR in Barcelona Clinic Liver Cancer (BCLC) stage A patients (P = 0.038, H.R. [95% CI] = 0.727 [0.537-0.984]). However, tumoral ${\gamma}{\delta}$ T cells did not show independent prognostic value for either TTR or OS in HCC patients. Conclusions: Low counts of ${\gamma}{\delta}$ T cells in peritumoral liver tissue are related to a higher incidence of recurrence in HCC and can predict postoperative recurrence, especially in those with early-stage HCC.
Jian Li,Da-Woon Choi,Chang-Hum Cho,Dae-Hyun Koo,Yun-Hyun Cho IEEE 2011 IEEE transactions on magnetics Vol.47 No.10
<P>This paper investigates eddy-current in an axial flux permanent magnet (AFPM) machine, which consist of the segmented stator teeth and concentrated winding, with one inner rotor and double stators. Analytical methods was developed to calculate the eddy-current loss of PMs and other solid components, including effect of winding harmonics and permeance variation due to slot opening. Eddy-current losses were analyzed by time-stepping three dimensional finite element analysis (3D FEA) in two rotor models, when magnets are insulated or noninsulated. A prototype machine was manufactured based on analysis results, and was tested as a generator. It is found that rotor stainless PM holder should be used in order to reduce eddy-currents and insulation of PMs further reduces eddy-current losses.</P>
Influence of Various Heat Treatment Stages on Evolution of Microstructure and Grain in H407 Steel
Jian Sun,Kai Ji,Chen Wei Jiang,Yun Chang Zhang 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.5
Regarding heat treatment as one of the main methods for improving property of die steel, dead annealing, quenching, once tempering, twice tempering, and thrice tempering treatment of H407 die steel were conducted in this thesis. Microstructure conversion and grain size development in various stages of heat treatment were analyzed, and then magnitude, shape, and distribution of secondary phase during heat treatment were investigated to explore the function mechanism of microalloyed elements on evolution of microstructure and grain during heat treatment. The steel achieves homogeneous microstructure and composition after this heat treatment. The final phase constituent is α and γ phase as well as the final microstructure consists of tempered martensite, trace retained austenite and granular carbides. A large number of fine and dispersive MC as well as M7C3 type granular carbides containing V, Mo and Cr precipitate in trice tempered microstructure. After this heat treatment grain is finer with grain size of 5.96 μm.