Percutaneous transhepatic biliary drainage catheter fracture

Jia Rui Kwan,Keith Sheng Hng Low,Rahul Lohan,Vishal G Shelat 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.3

Percutaneous transhepatic biliary drainage (PTBD) is safe treatment for biliary decompression given certain indications. However, this is temporary until definitive drainage is established. We report on a 76-year-old lady with recurrent pyogenic cholangitis and PTBD catheter fracture. She had hepatitis B virus-related Child-Pugh class A liver cirrhosis, hypothyroidism, hyperlipidaemia, and previous atrial fibrillation with a background of mild mitral, tricuspid and aortic valvular regurgitation. She had history of laparoscopic cholecystectomy in the past. She was deemed to be a high operative risk and declined hepatic resection. She had undergone multiple endoscopic and percutaneous biliary interventions to control sepsis and stone burden. A bilateral PTBD catheter was left in situ with plans for 3-monthly change. However, she defaulted follow-up and presented 11 months later with complaints of pain over the drain site and inability to flush the right catheter. Abdominal X-ray and computed tomography scans detected right catheter fracture at two places, making three fragments. She underwent percutaneous removal of the proximal fragment by an interventional radiology team. A temporary 4 Fr catheter was inserted to maintain biliary access. Endoscopic removal of the intra-biliary fragments was done the next day. Complete removal was confirmed on fluoroscopy. Finally, the 4 Fr catheter was replaced by a new 12 Fr catheter. The patient was discharged well.

Isolation of Eight DM domains of Dmrt genes in Rana Livida (Amphibia: Anura)

Rui Jia,Liu Wang Nie,Jing Jing Wang,Ning Wang 한국유전학회 2008 Genes & Genomics Vol.30 No.6

The Dmrt gene family encodes putative transcription factors, sharing a highly conserved DNA-binding domain-the DM domain, related to the sexual regulators Doublesex from Drosophila melanogaster and MAB-3 from Caenorhabditis elegans. Besides sex determination or differentiation, this gene family has evolved to adopt functions in other developmental pathways. In this paper, eight distinct DM related transcription factor (Dmrt) genes from both male and female and detected using PCR and the SSCP technique. No sexual differences were observed. These fragments (named RlDmrt1a, RlDmrt1b, RlDmrt2a, RlDmrt2b, RlDmrt2c, RlDmrt3, RlDmrt4, RlDmrt5) exhibited 98%, 98%, 95%, 95%, 95%, 99%, 92% and 83% similarity respectively to the corresponding homologous human Dmrt genes. Phylogenetic analysis based on DM domain amino acid sequence similarities suggested that vertebrate and invertebrate Dmrt genes can be grouped into seven distinct subfamilies. Interestingly, sequence analysis further illustrates that the gene Dmrt1 and 2 found in R. livida are duplicated. The DM domains of R. livida genes contained two conserved zinc-chelating sites (CCHC and HCCC). Identification of these genes is a potential step in understanding development regulations including sex determination in green cascade frog.

Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation

Rui Shi,Jia-Wen Xu,Zi-Ting Xiao,Ruo-Fei Chen,Yi-Lin Zhang,Jia-Bi Lin,Ke-Ling Cheng,Gu-Yi Wei,Pei-Bo Li,Wen-Liang Zhou,Wei-Wei Su 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.9

Naringin and its aglycone, naringenin, occur naturally in our regular diet and traditional Chinese medicines. This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive and antiasthmatic on rat tracheal smooth muscle. The relaxant effect was determined by measuring muscular tension with a mechanical recording system in rat tracheal rings. Cytosolic Ca2+ concentration was measured using a confocal imaging system in primary cultured tracheal smooth muscle cells. In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction. This epithelium-independent relaxation could be suppressed by BaCl2, tetraethylammonium, and iberiotoxin (IbTX), but not by glibenclamide. After stimulating primary cultured tracheal smooth muscle cells by CCh or high KCl, the intracellular Ca2+ increase could be inhibited by both naringin and naringenin, respectively. This reaction was also suppressed by IbTX. These results demonstrate that both naringin and naringenin can relax tracheal smooth muscle through opening big conductance Ca2+-activated K+ channel, which mediates plasma membrane hyperpolarization and reduces Ca2+ influx. Our data indicate a potentially effective therapeutic approach of naringin and naringenin for CVA.

Study and Design of High Strength and Low Heat Generation Polymer Composites by Molecular Dynamics Simulation

Rui-Rui Zhang,Bin Wu,Peng Chen,Jia-Sheng Qian 한국고분자학회 2020 폴리머 Vol.44 No.6

The molecular dynamics simulation was used to study and design a polymer composites system with excellent mechanical strength and less heat generation in a dynamic process. A series of system factors such as filler loading, surface modification onto filler, and network of cross-linking filler particles on mechanical and heat generation of polymer composites are systematically considered. It is found that the surface grafting onto fillers can restrain the heat generation of polymer composite in the dynamic process, while it shows less effect on the mechanical property. A network of cross-linking filler particles can be fabricated by a combination of grafting chains onto fillers. By filling such a network into the polymer, the mechanical and heat generation properties of polymer composites are significantly improved. Simulation results can help experimental fabrication of polymer composites with excellent mechanical and heat generation properties.

Asymptotical Stability for 2-D Stochastic Coupled FMII Models on Networks

Jia-Rui Cui,Qing Li,Guang-Da Hu,Zhi-Yu Tao,Zhen-Yu Lu 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.6

In this paper, computable stability criteria for two dimensional stochastic coupled FMII models on networks are studied based on Kronecker product and nonnegative matrices theory. Necessary and sufficient condition for two dimensional stochastic coupled FMII models on networks is presented, this is the first time that has been proposed. Then, computable mean-square asymptotic stability criteria are derived via Kronecker product and the nonnegative matrix theory. The criteria are only sufficient conditions. Finally, illustrative examples are provided.

Interpretation of coefficient of consolidation from CRS test results

Jia, Rui,Chai, Jinchun,Hino, Takenori Techno-Press 2013 Geomechanics & engineering Vol.5 No.1

Constant rate of strain (CRS) consolidation tests were conducted for undisturbed Ariake clay samples from three boreholes in Saga Plain of Kyushu Island, Japan. The coefficients of consolidation ($c_{\nu}$) were interpreted from the CRS test results by small- and large-strain theory. Large-strain theory was found to interpret smaller $c_{\nu}$ values and less strain rate effect on $c_{\nu}$ than that by small-strain theory. Comparing the theoretical strain distributions within a soil specimen to those obtained by numerical simulation shows that the small-strain theory can be used only for the dimensionless parameter $c_{\nu}/\dot{\varepsilon}H_0^2{\geq}50$ (where $\dot{\varepsilon}$ is strain rate and $H_0$ is the specimen height), and the large-strain theory can be used for a larger range of strain rates. Applying the criterion to undisturbed Ariake clay with a $c_{\nu}$ value of about $1{\times}10^{-7}\;m^2/s$, it is suggested that the large-strain theory should be adopted for calculating the $c_{\nu}$ value when $\dot{\varepsilon}$ > 0.03%/min.

Parameter Estimation of 2-D Stochastic FM Model based on Two Step Estimation Procedure

Jia-Rui Cui,Qing Li,Guang-Da Hu,Zhen-Yu Lu 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.3

This paper considers the problem of estimating the parameters of two-dimensional (2-D) stochastic FM models. First, the estimators of the parameters of 2-D stochastic FM model are obtained using two step estimation procedures by Kronecker product and least square method. Then, the asymptotic properties of the estimators are given. It is shown that the estimators are to be consistent and to have a distribution which converges to that of a normally distributed random vector under fairly general conditions. Finally, the performance of the proposed methods is illustrated by examples.

Performance and Spatial Succession of a Full-Scale Anaerobic Plant Treating High-Concentration Cassava Bioethanol Wastewater

( Gao Rui Fang ),( Xu Feng Yuan ),( Jia Jia Li ),( Xiao Fen Wang ),( Xu Cheng ),( Wan Bin Zhu ),( Zong Jun Cui ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.8

A novel two-phase anaerobic treatment technology was developed to treat high-concentration organic cassava bioethanol wastewater. The start-up process and contribution of organics (COD, total nitrogen, and NH4+-N) removal in spatial succession of the whole process and spatial microbial diversity changing when sampling were analyzed. The results of the start-up phase showed that the organic loading rate could reach up to 10 kg COD/m3d, with the COD removal rate remaining over 90% after 25 days. The sample results indicated that the contribution of COD removal in the pre-anaerobic and anaerobic phases was 40% and 60%, respectively, with the highest efficiency of 98.5%; TN and NH4+-N had decreased to 0.05 g/l and 0.90 g/l, respectively, and the mineralization rate of total nitrogen was 94.8%, 76.56% of which was attributed to the anaerobic part. The microbial diversity changed remarkably among different sample points depending on the physiological characteristics of identified strains. Moraxellaceae, Planococcaceae, and Prevotellaceae were dominant in the pre-anaerobic phase and Bacteroidetes, Campylobacterales, Acinetobacter, Lactobacillus, Clostridium, and Bacillus for the anaerobic phase. Methanosarcinaceae and Methanosaeta were the two main phylotypes in the anaerobic reactor.

Liver Cancer Mortality Characteristics and Trends in China from 1991 to 2012

Fang, Jia-Ying,Wu, Ku-Sheng,Zeng, Yang,Tang, Wen-Rui,Du, Pei-Ling,Xu, Zhen-Xi,Xu, Xiao-Ling,Luo, Jia-Yi,Lin, Kun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

Purpose: To investigate the distribution of liver cancer mortality as well as its developing trend from 1991 to 2012, forecast the future five-year trend, and provide a basis for the comprehensive prevention and management. Materials and Methods: Mortality data for liver cancer in China from 1991 to 2012 were used to describe characteristics and distribution of liver cancer mortality. Trend surface analysis was used to study the geographical distribution of liver cancer mortality. Curve estimation, time series modeling, gray modeling (GM) and joinpoint regression were used to predict and forecast future trends. Results: The mortality rate of liver cancer has constantly increased in China since 1991. Rates in rural areas are higher than in urban areas, and in males are higher than in females. In addition, our data predicted that the trend will continue to increase in the next 5 years. The age-specific mortality of liver cancer increases with age and peaks in the group of 80-84 years old. Geographical analysis showed the liver mortality rate was higher in the southeast provinces, such as Jiangsu, Zhejiang and Guangdong, and southwest regions like Guangxi Province. Conclusions: The standardized mortality rate of liver cancer in China has consistently increased from 1991 to 2012, and the upward trend is predicted to continue in the future. Much better prevention and management of liver cancer is needed in high mortality areas (the southwestern and southeastern parts of China) and high mortality age groups (80- to 84-year-olds), especially in rural areas.

Radioactive Seed Implantation and Lobaplatin Chemotherapy Are Safe and Effective in Treating Patients with Advanced Lung Cancer

Li, Jia-Rui,Sun, Yu,Liu, Lin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Objecive: To investigate the clinical safety and efficacy of CT-guided $^{125}iodine$ (125I) seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol in treating patients with advanced lung cancer. Materials and Methods: Patients with advanced lung cancer and treated with spiral CT-guided $^{125}I$ seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol were recruited. Results: Of the 36 patients, there were 40 nidi in total. The contrast-enhanced CT evaluation was conducted 60 d after treatment. Response evaluation suggested that 4 patients achieved complete remission (CR), 24 partial remission (PR), 4 stable disease (SD) and 4 progression disease (PD), with a total response rate of 77.8% (28/36). Conclusions: CT-guided $^{125}I$ seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol are safe and effective in treating patients with advanced lung cancer.