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Jia Jia,Kang Xigang,Liu Yanfang,Zhang Jianwei 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.5
Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptosis and PI3K/AKT pathway. The results showed that evodiamine exhibits potent antiproliferative effects against two human liver cancer cell lines (HepG2 and PLHC-1) with an IC50 of 20 μM. Nonetheless, the cytotoxic effects of evodiamine were comparatively low against the normal cells as evident from the IC50 of 100 μM. The growth inhibitory effects of evodiamine were found to be due to the induction of apoptosis as revealed by the DAPI, AO/EB and annexin V/PI staining assays. The induction of apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expression in a concentration dependent manner. The wound healing and transwell assay revealed that evodiamine caused a significant decline in the migration and invasion of the HepG2 and PLHC-1 cells. Investigation of the effects of evodiamine on the PI3K/AKT signalling revealed that evodiamine inhibited the phosphorylation of PI3K and AKT proteins. Taken together, the results showed that evodiamine inhibits the growth of human liver cancer via induction of apoptosis and deactivation of PI3K/AKT pathway. The results point towards the therapeutic potential of evodiamine in the treatment of liver cancer.
Jia-Kang Wang,Shu-jun Guo,Bao-qing Tian,Chnag-jun Nie,Hai-long Wang,Jia-lang Wang,An Hong,Xiao-jia Chen 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4
Fibroblast growth factors(FGFs) and their receptors (FGFRs) modulate a wide range of biological functions, especially tumor genesis. The aim of this study was to investigate the possible association of FGFR expression with the susceptibility of digestive system and reproductive system cancers in Chinese population. In total, 343 patients with digestive or reproductive system cancers were enrolled in this study. The expression levels of four highly-conserved FGFRs including FGFR1, FGFR2, FGFR3 and FGFR4 were measured by immunohistochemistry (IHC). The expression levels of FGFRs were compared between carcinoma and para-carcinoma tissues. FGFR1 expression significantly differed between carcinoma and para-carcinoma tissues in colon and gastric cancers. FGFR2 expression significantly differed between carcinoma and para-carcinoma tissues in esophageal cancer. FGFR3 expression was significantly different between carcinoma and para-carcinoma tissues in liver and gastric cancers. FGFR2 showed the highest expression probability in all the selected cancers and FGFR4 showed the lowest expression probability. FGFR1 and FGFR3 showed comparable moderate expression probabilities. Our findings have demonstrated significant differences regarding FGFR expression levels between carcinoma and para-carcinoma cells in digestive or reproductive system cancer patients. The data also implicated that FGFR2 and FGFR4 could serve as two prominent factors closely related to the susceptibility of digestive and reproductive system cancers.
Performance Evaluation of Ethernet Frame Burst Mode in EPON Downstream Link
Wen-Kang Jia,Yaw-Chung Chen 한국전자통신연구원 2008 ETRI Journal Vol.30 No.2
We apply IEEE 802.3 frame burst mode (FBM) to the Ethernet passive optical network (EPON) downstream link and compare its performance with non-frame burst mode for various traffic patterns. Although in light traffic loads (ρ<0.5) the efficiency of the FBM mechanism is not significant, it does feature high throughput, small jitter, low queue occupancy, and short queuing delay in optical line terminals under various traffic loads with various numbers of optical network units (ONUs). The FBM performance always approaches that of full-duplex mode, especially under heavy traffic loads (ρ>0.5). Moreover, an increase in number of ONUs will decrease the burst performance. Our work shows that FBM scheme is very useful for EPON transmission and has low design complexity.
Wen-Jia Yang,Kang-Kang Xu,Wei Dou,Can Li,JinjunWang 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.3
3-Hydroxy-3-methyl glutaryl coenzyme A reductase (HMGR) is an important rate-limiting enzyme in the mevalonate pathway, which is critical for the synthesis of juvenile hormone and insect development. In this study, a full-length cDNA encoding HMGR (BdHMGR) was cloned from the oriental fruit fly, Bactrocera dorsalis (Hendel). The open reading frame of BdHMGR encoded 928 amino acids and shared a high degree of identity with other known HMGRs. The expression levels of BdHMGR were high during the early and lately pupal stages, and were low at the larval and mid pupal stages. In the adult stages, the highest level of BdHMGR was detected on day-10 of the adult lifecycle, and the expression levels in females were greater than those in males. The highest tissuespecific expression was in the ovary, followed by fat body and other tissues. Injection of double-stranded RNA (dsRNA) of BdHMGR into adult females significantly reduced BdHMGR transcript levels, and inhibited ovarian development and affected the expression of two yolk protein genes. After dissection, we found that one or two of the spheroids of ovaries from the BdHMGR dsRNA-injected flies were amorphous and reduced in size as compared with the controls. The results suggest that BdHMGR is required for ovarian development in B. dorsalis and may be a potential target for pest control.
Jia, Y.,Wu, C.,Lee, B.W.,Liu, C.,Kang, S.,Lee, T.,Park, Y.C.,Yoo, R.,Lee, W. Elsevier Scientific Pub. Co 2017 Journal of hazardous materials Vol.338 No.-
In this report, magnetically recoverable sulfur-doped SnFe<SUB>2</SUB>O<SUB>4</SUB>/graphene (S-SFO/GR) nanohybrids have been successfully developed via a facile solvothermal method. The characterizations on the structural, morphology, and optical properties of the nanohybrids indicate that S-SFO particles are successfully embedded on the GR nanosheets. The photocatalytic activity has been evaluated by photocatalytic degradation of chlorotetracycline under visible light irradiation. Among the composites with various mass ratios, the quasi-first-order rate constant of the nanohybrids formed with 9wt% S in SFO and 15wt% GR (9S-SFO/GR-15) can reach as high as 1.83min<SUP>-1</SUP>, which is much higher than that of SFO (0.68min<SUP>-1</SUP>) and SFO/GR (0.91min<SUP>-1</SUP>), confirming the important role of S and GR for the photocatalytic process. The combination of the three components of S, SFO, and GR has enhanced the visible light absorption capability and inhibited the recombination of photogenerated electron-hole. The 9S-SFO/GR-15 nanohybrids can be recovered easily by a magnet and reused for five times with remained photocatalytic efficiency about 70%. A possible catalytic mechanism explaining the efficient photocatalytic performances of the prepared nanohybrids has been proposed.
( Jia Liu ),( Ying Zhu ),( Guixia Kang ),( Yifan Zhang ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.12
In this paper, we investigate power allocation scheme and outage performance for a physical-layer network coding (PNC) relay based secondary user (SU) communication in cognitive multi-antenna relay networks (CMRNs), in which two secondary transceivers exchange their information via a multi-antenna relay using PNC protocol. We propose an optimal energy-efficient power allocation (OE-PA) scheme to minimize total energy consumption per bit under the sum rate constraint and interference power threshold (IPT) constraints. A closed-form solution for optimal allocation of transmit power among the SU nodes, as well as the outage probability of the cognitive relay system, are then derived analytically and confirmed by numerical results. Numerical simulations demonstrate the PNC protocol has superiority in energy efficiency performance over conventional direct transmission protocol and Four-Time-Slot (4TS) Decode-and-Forward (DF) relay protocol, and the proposed system has the optimal outage performance when the relay is located at the center of two secondary transceivers.
Jia Yang,Qiong Kang,Bin Zhang,Xiyu Tian,Shuzheng Liu,Gang Qin,Qiang Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
Ionic conductive hydrogel-based sensors have been capturing growing attention in various areas, but stillcannot satisfy the operating requirements of next generation wearable electronics. Herein, inspired bybiosystems, we demonstrate ionic conductive supramolecular hydrogels with simple one-step methodbased on salting-out effect and multiple hydrogen bond interactions. The supramolecular hydrogels exhibithigh toughness and strength, quick self-recovery, high sensitive sensing performance as well as goodself-healing, fatigue and frost resistances in mechanical and sensing properties, and can monitor largeand subtle movements and physiological activities of the human body sensitively, quickly and stably. Thus, it provides a convenient and promising way to obtain stretchable sensors of excellent comprehensiveproperties, which have tremendous application potential as wearable electronic devices in harshenvironments.
Jia Xie,Do-Hyun Kang,Byung-Chul Woo,Ji-Young Lee,Zheng-Hui Sha,Sheng-Dun Zhao 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.5
Transverse flux machine (TFM) has been proved to be very suitable for high-torque, lowspeed, and direct-drive situation in industry. But the complex structures and costly permanent magnets (PMs) are two key limitations of its wide range of applications. This paper proposes a new claw pole TFM (ACPTFM) which features an assembled claw pole stator and using the lamination steels material to overcome the complex structures. By combining response surface methodology (RSM) with design of experiment, an optimum design method is put forward to improve the PM’s contribution to the torque in order to save the PM’s amount. The optimum design results demonstrate the validity of the proposed optimum design method and the optimized model. Eventually, the finiteelement analysis (FEA) calculation method, which is used in the optimization process, is verified by the experiments in a prototype.