MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis

Ji, Tian-Xing,Zhi, Cheng,Guo, Xue-Guang,Zhou, Qiang,Wang, Guo-Qiang,Chen, Bo,Ma, Fei-Fei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk. Materials and Methods: Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk. Results: A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias. Conclusions: The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.

EMBRYOS OF EARLY CRETACEOUS CHORISTODERA (REPTILIA) FROM THE JEHOL BIOTA IN WESTERN LIAONING, CHINA

Qiang Ji,Shu-an Ji,Junchang Lu,Hailu You,Chong-xi Yuan 한국고생물학회 2006 고생물학회지 Vol.22 No.1

Choristodera는 잘 알려지지 않은 그룹이지만 매우 독특한 해양 파충류로 후기 트라이아스기에서부터 후기 올리고세까지 아시아, 북미, 유럽에 걸쳐 산출된다. 비록 수천 개의 choristodera 표본이 중국 전기 백악기 Jehol biota에서 수집되었지만 바다거북처럼 난태생이였는지 Pachypleurosauria (해양파충류) Keichousaurus hui처럼 태생이었는지 아직 확실하게 밝혀지지 않았다. 우리는 이 논문에서 중국 서부 요녕성의 Jiufotang층에서 산출된 가죽질의 알껍데기가 함께 잘 보존된 Hyphalosaurus baitaigouensis (파충류, Choristodera)를 보고한다. 이것은 Hyphalosaurus baitai-gouensis 같은 choristoderian 파충류가 남중국 Guizhou에서 산출된 후기 트라이아스기 Keichousaurus hui처럼 태생이었을 것임을 지시하는 직접적인 첫 번째 증거다. The Choristodera is a poorly known clade, but very a distinctive group of aquatic reptiles, which has been found from the Late Triassic to the Late Oligocene in Asia, North America and Europe. Although thousands of choristoderian specimens have been collected from the Early Cretaceous non-marine beds in Liaoning, China, no direct evidences have been found to determine whether they were oviparous like sea turtles or viviparous like Keichousaurus hui of Pacbypleurosauria (marine reptiles). Here we report a well-preserved specimen of Hyphalosaurus baitaigouensis with leathery embryonic eggs from the Jiufotang Formation in western Liaoning, China. It provides the first direct evidence to indicate that choristoderian reptiles are most likely viviparous like Late Triassic Keichousaurus hui from Guizhou, Southern China.

Quantum Bee Colony Optimization and Non-dominated Sorting Quantum Bee Colony Optimization Based Multi-relay Selection Scheme

( Qiang Ji ),( Shifeng Zhang ),( Haoguang Zhao ),( Tiankui Zhang ),( Jinlong Cao ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.9

In cooperative multi-relay networks, the relay nodes which are selected are very important to the system performance. How to choose the best cooperative relay nodes is an optimization problem. In this paper, multi-relay selection schemes which consider either single objective or multi-objective are proposed based on evolutionary algorithms. Firstly, the single objective optimization problems of multi-relay selection considering signal to noise ratio (SNR) or power efficiency maximization are solved based on the quantum bee colony optimization (QBCO). Then the multi-objective optimization problems of multi-relay selection considering SNR maximization and power consumption minimization (two contradictive objectives) or SNR maximization and power efficiency maximization (also two contradictive objectives) are solved based on non-dominated sorting quantum bee colony optimization (NSQBCO), which can obtain the Pareto front solutions considering two contradictive objectives simultaneously. Simulation results show that QBCO based multi-relay selection schemes have the ability to search global optimal solution compared with other multi-relay selection schemes in literature, while NSQBCO based multi-relay selection schemes can obtain the same Pareto front solutions as exhaustive search when the number of relays is not very large. When the number of relays is very large, exhaustive search cannot be used due to complexity but NSQBCO based multi-relay selection schemes can still be used to solve the problems. All simulation results demonstrate the effectiveness of the proposed schemes.

급속 충전에서 탱크 내부의 수소 온도 변화에 관한 이론 연구

이길초(JI-CHAO LI),이길강(JI-QIANG LI),허항(HENG XU),최병철(BYUNG CHUL CHOI),권정태(JEONG-TAE KWON) 한국수소및신에너지학회 2023 한국수소 및 신에너지학회논문집 Vol.34 No.6

The fast filling process of high-pressure hydrogen has an important impact on the filling efficiency and safety. In this paper, a specific study is carried out on the thermophysical phenomena during the fast filling process. Starting from the gas state equation of hydrogen, the change law of the hydrogen storage temperature is obtained, and then the temperature rise prediction is constructed. The model can clarify the relationship between the filling parameters and the temperature rise during the fast filling process, thereby revealing the flow and heat transfer laws of the fast charging process. To improve the theoretical research basis for the evaluation of vehicle-mounted hydrogen fast charging capacity, temperature prediction and optimization of hydrogenation methods.

Overexpression of ENA1 from Yeast Increases Salt Tolerance in Arabidopsis

( Xiang Qiang Kong ),( Xiu Hua Gao ),( Wei Huan Li ),( Ji Qiang Zhao ),( Yan Xiu Zhao ),( Hui Zhang ) 한국식물학회 2008 Journal of Plant Biology Vol.51 No.2

In yeast, the plasma membrane Na+/H+ antiporter and Na+ -ATPase are key enzymes for salt tolerance. Saccharomyces cerevisiae Na+ -ATPase (Ena1p ATPase) is encoded by the ENA1/PMR2A gene; expression of ENA1 is tightly regulated by Na+ and depends on ambient pH. Although Ena1p is active mainly at alkaline pH values in S. cerevisiae, no Na+ -ATPase has been found in flowering plants. To test whether this yeast enzyme would improve salt tolerance in plants, we introduced ENA1 into Arabidopsis (cv. Columbia) under the control of the cauliflower mosaic virus 35S promoter. Transformants were selected for their ability to grow on a medium containing kanamyin. Southern blot analyses confirmed that ENA1 was transferred into the Arabidopsis genome and northern blot analyses showed that ENA1 was expressed in the transformants. Several transgenic homozygous lines and wild-type (WT) plants were evaluated for salt tolerance. No obvious morphological or developmental differences existed between the transgenic and WT plants in the absence of stress. However, overexpression of ENA1 in Arabidopsis improved seed germination rates and salt tolerance in seedlings. Under saline conditions, transgenic plants accumulated a lower amount of Na+ than did the wild type, and fresh and dry weights of the former were higher. Other experiments revealed that expression of ENA1 promoted salt tolerance in transgenic Arabidopsis under both acidic and alkaline conditions.

Synthesis, Crystal Structure and Quantum Chemistry of a Novel Schiff Base N-(2,4-Dinitro-phenyl)-N'-(1-phenyl-ethylidene)-hydrazine

Ji, Ning-Ning,Shi, Zhi-Qiang,Zhao, Ren-Gao,Zheng, Ze-Bao,Li, Zhi-Feng Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.4

A novel Schiff base N-(2,4-dinitro-phenyl)-N'-(1-phenyl-ethylidene)-hydrazine has been synthesized and structurally characterized by X-ray single crystal diffraction, elemental analysis, IR spectra and UV-vis spectrum. The crystal belongs to monoclinic with space group P21/n. The molecules are connected via intermolecular O-$H{\cdots}O$ hydrogen bonds into 1D infinite chains. The crystal structure is consolidated by the intramolecular N-$H{\cdots}O$ hydrogen bonds. weak intermolecular C-$H{\cdots}O$ hydrogen bonds link the molecules into intriguing 3D framework. Furthermore, Density functional theory (DFT) calculations of the structure, stabilities, orbital energies, composition characteristics of some frontier molecular orbitals and Mulliken charge distributions of the title compound were performed by means of Gaussian 03W package and taking B3LYP/6-31G(d) basis set. The time-dependent DFT calculations have been employed to calculate the electronic spectrum of the title compound, and the UV-vis spectra has been discussed on this basis. The results show that DFT method at B3LYP/6-31G(d) level can well reproduce the structure of the title compound.

A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer

Ji-Guang Han,Yong-Dong Jiang,Chun-Hui Zhang,Yan-Mei Yang,Da Pang,Yan-Ni Song,Guo-Qiang Zhang 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.2

Purpose: Insufficient sensitivity and specificity prevent the use of most existing biomarkers for early detection of breast cancer. Recently, it was reported that serum microRNAs (miRNAs) may be potential biomarkers in many cancer diseases. In this study, we investigated whether serum levels of 5 miRNAs including miR-21, miR-125b, miR-145, miR-155, and miR-365 could discriminate breast cancer patients and healthy controls. Methods: Serum levels of miRNAs were measured by using quantitative real-time polymerase chain reaction in 99 breast cancer patients and 21 healthy controls. The abundance change of serum miRNAs were also evaluated following surgical resection in 20 breast cancer patients. Receiver operating characteristic (ROC) curve analysis was performed to assess the sensitivity and specificity of miRNAs as diagnostic biomarkers. Results: Serum levels of miR-21 and miR-155 was significantly higher, while miR-365 was significantly lower in breast cancer as compared with healthy controls. The serum levels of miR-21 and miR-155 significantly decreased following surgical resection. Additionally, the serum level of miR-155 at stages I and II was significantly higher compared to stage III. The serum miR-145 level was remarkably higher in progesterone receptor (PR)-positive patients than PR-negative. The positivity of miR-21, miR-155, and miR-365 was high compared to CA 153 and CEA in breast cancer. ROC curve analyses of a combination of miR-21, miR-155, and miR-365 yielded much higher area under curve and enhanced sensitivity and specificity in comparison to each miRNA alone. Conclusion: The combination of serum miR-21/miR-155/miR-365 may potentially serve as a sensitive and specific biomarker that enables differentiation of breast cancer from healthy controls.

Preparation and catalytic activity of K4Zr5O12 for the oxidation of soot from vehicle engine emissions

Qiang Wanga,Ji Hyang Sohn,So Ye Park,Jin Seong Choi,Joo Young Lee,정종식 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.1

Pure phase K4Zr5O12 is synthesized via solid state method in the present work. Various K/Zr ratios and temperatures are applied, and the synthesis process is investigated in detail by means of X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Its catalytic activity for soot oxidation is studied by temperature programmed oxidation with different types of soot/catalyst contacts. It is revealed that K4Zr5O12 is very active in the presence of 2–10% O2 for both tight and loose contacts (Tp(tight) = 335 oC, Tp(ethanol) = 355 oC and Tp(shaking) = 370 oC). Thermal stability study shows that K4Zr5O12 is highly stable up to at least 900 oC.

Tracking Control for a Quadrotor via Dynamic Surface Control and Adaptive Dynamic Programming

Qiang Gao,Xin-Tong Wei,Da-Hua Li,Yue-Hui Ji,Chao Jia 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.1

In this paper, a data-driven control algorithm based on the Dynamic Surface Control and the ActionDependent Heuristic Dynamic Programming is proposed to realize the stable tracking control of the quadrotor. Firstly, the dynamic surface control is addressed for the nonlinear model of the quadrotor, which can overcome the “explosion of complexity” problem encountered in traditional back-stepping method inevitably. The controller designed by Dynamic Surface Control is served as the main controller in the total control structure. Secondly, the Action-Dependent Heuristic Dynamic Programming is investigated to construct a complementary attitude controller by involving the learning mechanism. The adoption of Action-Dependent Heuristic Dynamic Programming can provide the capability of adaptation and disturbance rejection to improve the tracking control performance effectively. The overall closed-loop system is proved to be asymptotically stable by the Lyapunov theorem. Finally, the numerical simulation and flight experiments are presented to demonstrate that the proposed tracking control scheme exhibits an excellent tracking performance in the case of external disturbances.

Effect of the wind direction on the near wake structures of an Archimedes spiral wind turbine blade

Ji, H. S.,Qiang, L.,Beak, J. H.,Mieremet, R.,Kim, K. C. Ohmsha 2016 Journal of Visualization Vol. No.

<P>For urban usage of an Archimedes spiral horizontal axis wind turbine, the effect of wind direction was examined for the confront measurement planes from 0A degrees to 15A degrees. Aerodynamic characteristics in the near wake of wind turbine blade were investigated using the particle image velocimetry method. Ensemble and phase-averaged velocity fields were obtained in both front and lee sides of the blade with various angles of attack. The streamlines are parallel with the incoming flow for the range of attack angles; however, wake velocity is decreasing with increasing angle of attack. It has been found that the trajectory of tip vortices varies significantly in the front side plane compared to that of lee side plane when the angle of attack is higher than 10A degrees. Distance between two consecutive vortices in the front plane decreases monotonically with increasing attack angle, while that in the lee side shows an opporsite manner.</P>