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Han, Ji-Wung,La, Tae-Min,Kim, Ji-Hoon,Choi, In-Soo,Song, Chang-Seon,Park, Seung-Yong,Lee, Joong-Bok,Lee, Sang-Won Elsevier 2018 INFECTION GENETICS AND EVOLUTION Vol.65 No.-
<P><B>Abstract</B></P> <P>We determined a complete genome sequence of the Korean field strain, KUMC-62, of human adenovirus type 3 (HAdV-3) and performed comparative genome analyses. Interestingly HAdV-3 has a distinct genomic sequence for the fiber CDS region on average 62.46% of nucleotide sequence identity to other types of HAdV-B1, while remaining genomic region of HAdV-3 is very similar (on average 95.71% of nucleotide sequence identity) to other types of HAdV-B1. The blast results showed that the fiber CDS region of HAdV-3 exhibited the highest nucleotide sequence identity with that of simian adenovirus type 32 (SAdV-32), except other strains of HAdV-3. In the Simplot analysis, a potential recombination event was detected between HAdV-7 and SAdV-32, which might have created HAdV-3 in the past. These findings suggest that HAdV-3 highly likely was created by a natural inter-species recombination event between human and non-human primate AdVs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First complete genome sequencing of the Korean strain of human adenovirus type 3 using high-throughput sequencing technology. </LI> <LI> Shows distinct nucleotide sequences of the fiber CDS region of human adenovirus type 3 in comparative genome analysis. </LI> <LI> Evidence of multiple recombination events between adenoviruses from human and non-human primates. </LI> </UL> </P>
Ni-Mn 전착층의 기계적 성질에 미치는 공정조건의 영향
신지웅 ( Ji Wung Shin ),양승기 ( Seung Gi Yang ),황운석 ( Woon Suk Hwang ) 한국부식방식학회(구 한국부식학회) 2014 Corrosion Science and Technology Vol.13 No.3
Nickel electrodeposition from sulfamate bath has several benefits such as low internal stress, high current density and good ductility. In nickel deposited layers, sulfur induces high temperature embrittlement, as Ni-S compound has a low melting temperature. To overcome high temperature embrittlement problem, adding manganese is one of the good methods. Manganese makes Mn-S compound having a high melting temperature above 1500℃. In this work, the mechanical properties of Ni-Mn deposited layers were investigated by using various process variables such as concentration of Mn(NH2SO3)2, current density, and bath temperature. As the Mn content of electrodeposited layers was increased, internal stress and hardness were increased. By increasing current density, internal stress increased, but hardness decreased. With increasing the bath temperature from 55 to 70℃, internal stress of Ni deposit layers decreased, but hardness didn``t change by bath temperature. It was likely that eutectoid manganese led to lattice deformation, and the lattice deformation increased hardness and internal stress in Ni-Mn layers. Increasing current density and decreasing bath temperature would increase a mount of H2 absorption, which was a cause for the rise of internal stress.
권지웅 ( Ji Wung Kwon ),이희권 ( Hee Kwon Lee ),박희전 ( Hee Jeon Park ),송지영 ( Ji Young Song ) 한국식품조리과학회(구.한국조리과학회) 2012 한국식품조리과학회지 Vol.28 No.1
This study was carried out to evaluate biological activities concerning extracts according to extraction methods from unripened fruit of Rubus coreanus Miq. The extraction methods were HWE (hot water extraction for 4 hr at 100℃), SFE (extraction for 3 hr at 40℃ under 300 bar, 100% of CO2 fluid), USE (ultrasonification extraction for 4 hr at 50℃ with water), USE+HWE (hot water extraction for 2 hr at 100℃ after ultrasonification process for 2 hr), VE (vacuum extraction for 4 hr at 90℃ under 0.9 bar with water). VE extract showed the highest contents of total polyphenol (178.78±3.79 mg/g) and total flavonoid (40.93±0.68 mg/g). IC50 values of DPPH radical scavenging activity, linoleic acid peroxidation inhibition activity and LDL (low density lipoprotein) oxidation inhibition activity of HWE extract showed the lowest 35.39±0.25 μg/mL, 12.61±0.31 μg/mL and 1.31±0.02 μg/mL among other all extracts, respectively. IC50 values of α-glucosidase inhibitory activities of VE and HWE extracts showed lower 14.34±0.20 μg/mL and 15.83±0.20 μg/mL than those of other extracts, respectively. Specifically, HWE and VE extracts have relatively better biological activities than other extracts; these could be potentially used as a bioactive source for health functional foods.
Ha, Young Mi,Kim, Jin-Ah,Park, Yun Jung,Park, Daeui,Choi, Yeon Ja,Kim, Ji Min,Chung, Ki Wung,Han, Yu Kyeong,Park, Ji Young,Lee, Ji Yeon,Moon, Hyung Ryong,Chung, Hae Young Royal Society of Chemistry 2011 MedChemComm Vol.2 No.6
<P>In this study, we describe the synthesis and tyrosinase inhibitory activity of a new family of hydroxybenzylidenyl pyrrolidine-2,5-dione compounds. Among them, compound 3f (HMP) exhibited the highest inhibition, 83.87%, at a concentration of 20 μM, on the <SMALL>L</SMALL>-DOPA oxidase activity of mushroom tyrosinase. We also predicted the tertiary structure of tyrosinase, simulated its docking with HMP and confirmed that HMP strongly interacts with tyrosinase residues. This result suggested that the binding activity of HMP with tyrosinase could be high. Based on these results, we determined the IC<SUB>50</SUB> value for HMP inhibition of mushroom tyrosinase activity. HMP inhibited mushroom tyrosinase with an IC<SUB>50</SUB> value of 2.23 ± 0.44 μM, which is more potent than the anti-tyrosinase activity of kojic acid (IC<SUB>50</SUB> = 20.99 ± 1.80 μM), a well-known tyrosinase inhibitor. Kinetic analysis of tyrosinase inhibition revealed that HMP is a competitive inhibitor (<I>K</I><SUB>i</SUB> = 4.24 × 10<SUP>−7</SUP> M at 1.25 μM and <I>K</I><SUB>i</SUB> = 1.82 × 10<SUP>−6</SUP> M at 20 μM). HMP also inhibited melanin production and tyrosinase activity in B16F10 melanoma cells (B16 cells). These data strongly suggest that HMP can suppress the production of melanin <I>via</I> the modulation of tyrosinase activity.</P> <P>Graphic Abstract</P><P>Computational structure prediction for mushroom tyrosinase and docking simulation with compound HMP. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00234h'> </P>
팽화미분 첨가에 따른 탁주의 양조 중 pH, 산도, 색도, 환원당, 총당, 알코올 그리고 관능 성질 변화
김지영(Ji-Young Kim),성기욱(Ki-Wook Sung),배현웅(Hyun-Wung Bae),이영현(Young Hyoun Yi) 한국식품과학회 2007 한국식품과학회지 Vol.39 No.3
팽화미분 첨가량을 0, 25, 50 및 75%(w/w)로 하여 제조한 탁주의 pH, 산도, 색도, 환원당, 총당, 알코올 함량 그리고 관능 성질 변화를 조사하였다. 발효 1일에는 pH가 급격히 저하된 후 5일 까지 서서히 증가하였다. 하지만 6일 이후부터는 모든 시료의 pH가 감소하는 경향을 보였는데 팽화미분 함량이 낮을수록 빨리 감소되어 0%에서 가장 낮았다(p<0.05). 산도는 발효가 진행될수록 모든 시료에서 빨리 증가 하였고 6일 이후부터는 0%가 급격히 증가하였다(p<0.05). L값은 모든 시료에서 발효 1일에 급격히 상승하였고 발효기간이 경과함에 따라 감소하는 경향을 보였다. 동일한 발효일에는 75%에서 L값이 항상 낮았다. 하지만 적색도는 0, 3과 10일을 제외하면 75%가 L값이 항상 높았다(p<0.05). 환원당은 발효 3일까지는 급격한 감소를 보인 후 차이를 나타내지 않았다(p<0.05). 동일한 발효일에는 75%가 높은 경향을 보였다. 총당은 발효 2일에 급격히 감소하였고 동일한 시료에서는 3일 이후부터 차이가 없거나 약간 감소하였다. 발효 4일을 제외한 동일 발효일에는 75%가 다른 시료보다 높거나 같아서 환원당과 유사하였다(p<0.05). 알코올은 발효 2일까지 급격히 증가하였고 6일에 13.0-16.4%(v/v)로 가장 높은 값을 보였다. 팽화미분 첨가량이 증가할수록 알코올 함량도 향상 높았고 발효도 빨리 진행되었다(p<0.05). 관능검사는 팽화미분을 첨가하지 않은 시료와 팽화미분을 25, 50 또는 75% 첨가한 시료간의 유의적인 차이가 없었다. The pH, acidity, color, reducing sugar, total sugar, alcohol, and organoletic characteristics of Takju containing puffed rice powder (0, 25, 50 and 75%) were investigated during fermentation for 10 days. After drastic decrease at Day 1, the pH increased gradually until Day 5 and then tended to decrease after Day 6. A lower concentration of puffed rice powder resulted in a greater pH reduction (p < 0.05). Acidity increased quickly with days, especially for the 0% after Day 6 (p < 0.05). After a sudden rise at Day 1, the Hunter “L” value tended to decrease with days of fermentation. At the same day, the 75% showed the lowest Hunter “L” value, however, it had the highest Hunter “a” value except on Days 0, 3 and 10 (p < 0.05). After a rapid reduction in reducing sugar on Day 3, no differences were observed in the samples (p < 0.05). The 75% tended to be higher in reducing sugar. Total sugar decreased rapidly at Day 2, and then either remained unchanged or decreased after Day 3. With the exception of Day 4, the 75% had higher amounts of total sugar than the others at the same day (p < 0.05). The Highest alcohol contents [13.0-16.4% (v/v)] occurred on Day 6. Higher alcohol concentrations were observed with higher puffed rice powder (p < 0.05). In the sensory evaluation, no differences were detected between the 0% and those with puffed rice powder added (p < 0.05).
( Gun Wung Na ),( Sang Goon Shim ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Chang Uk Jeong ),( Ji Eun Oh ),( Hyun Chin Cho ),( Kwang Min Kim ),( Hyoun Soo Lee ),( Man Je Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In men, erectile dysfunction (ED), which is defi ned as the inability to achieve or maintain an erection suffi cient for satisfactory sexual performance, is an important issue. There were extensive investigations in clinical and pathophysiological mechanisms with sexual dysfunction during the last decade. However, ED in patients with chronic viral hepatitis has been investigated in few and limited studies, which are often not comparable because they use different survey and patient-sampling methodologies. Moreover, few have evaluated the association of ED and depression in patients with chronic viral hepatitis. Therefore, we assessed the prevalence of ED, and their association with depression in patients with chronic viral hepatitis. Methods: This cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis between the age of 18 and 80 years were considered eligible. The exclusion criteria included well established causes of erectile dysfunction such as liver cirrhosis and alcohol abuse. Erectile dysfunction was assessed with the International Index of Erectile Function-5 (IIEF-5) scale. The Beck Depression Inventory (BDI) scale was used to assess depression of the patient. Results: The prevalence of erectile dysfunction among the patients with chronic viral hepatitis was 40%. Age, employment, peg-interferon, IIEF-5 scores and BDI scores were statistically associated with erectile dysfunction. And also, IIEF-5 scores correlated negatively with age, employment and BDI scores. In a multiple logistic regression analysis, age and depression were independently associated with erectile dysfunction. Conclusions : Patients with chronic viral hepatitis have a high prevalence of erectile dysfunction. Age and depression are independent factors of erectile dysfunction in male patients with chronic viral hepatitis. Evaluation of depression must be included to properly manage erectile dysfunction.