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The Beneficial Effect of Adenophorae Radix on DSS‐induced Colitis in Mice
Ji?Wook Jung,Sa?Rang Oh,Eun?Mi Ahn,Eun?Ju Yang,Su?Jin Kim 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.3
Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Adenophorae Radix (AR) has been used as a traditional medicine for various diseases including strengthening cardiac function, allaying a fever, and easing pain and cough. However, the regulatory effects of AR in intestinal inflammation are not yet understood. This study attempted to determine the effect of AR in dextran sulfate sodium (DSS) ? induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of AR attenuated weight loss, colon shortening and inhibited the levels of interleukin (IL) ? 6 in DSS ? treated colon tissues. These results provide experimental evidence that AR might be a useful therapeutic medicine for patients with UC.
이지윤,윤주영,장사랑 노인간호학회 2008 노인간호학회지 Vol.10 No.1
Purpose: The purpose of this study was to evaluate the validity and reliability of a patient assessment instrument for patients in long-term care hospitals. Method: The participants in this study were 90 patients admitted to 3 long-term care hospitals. The data were collected in May and June 2007. Criterion related validity of the K-ADL (Korean Activities of Daily Living) was tested using Spearman correlation with the K-MBI (Korean Modified Barthel Index). Inter-rater reliability between two nurses was tested using weighted kappa and agreement percentage. Results: Criterion related validity of the K-ADL with the K-MBI was good with average Spearman correlation coefficient =0.96. Correlation coefficients of items were between 0.63 and 0.96. Inter-rater reliability was satisfactory with the average weighted kappa equal to 0.76. Items with weighted kappa of more than 0.4 numbered 122 (86.5%) and of more than 0.75, 74 (52.5%) Conclusion: The patient assessment instrument for patients in long-term care hospitals is reliable and K-ADL is valid for classifying these patients based on resource utilization, and for quality monitoring indicators.
여대생의 흡연에 대한 태도 및 요인 분석 : 김천대학 여대생 중심
송애랑 ; 박지원 김천대학교 2004 김천대학교 논문집 Vol.25 No.-
The purpose of this study was to explore the attitudes about smoking and factor analysis among college women. The subject were 347 female students selected by random sampling from Gimcheon College in Korea. The data were collected by survey methods a period of 7days. The data were analyzed by SPSS 10.0 version, T-test. F-test and factor analysis. Analysis of the data resulted in identification of 8 factors in general group and 5 factors in smoking group. Major factor were involved in curiosity, viewpoint of smoking, health belief, friend-relationship, image, body weight loss, fault, and viewpoint of opposite sex The characteristics of smoking behavior: 1. The meaning of smoking behavior in college women is justifiable orregretable. 2. Smoking behavior is related to the perception of harmfulness to health, influence of 2nd generation. 3. Smoking in college women is not caused by antagonism toward male smokers. 4. The first smoking time was middle school students It is suggested that the results of this study may contribute to the development of strategies for the purpose of decreasing smoking behav-ior among female college students.
김혜영(Kim, Hye-Young),이정숙(Lee, Jung-Sug),황지윤(Hwang, Ji-Yun),권세혁(Kwon, Sehyug),정해랑(Chung, Hae Rang5),곽동경(Kwak, Tong-Kyung),강명희(Kang, Myung-Hee),최영선(Choi, Young-Sun) 한국영양학회 2017 Journal of Nutrition and Health Vol.50 No.2
본 연구는 생애주기별 영양지수 중 청소년을 위한 영양지수 (Nutrition Quotient for Adolescents, NQ-A) 모형을 개발하고자 수행되었다. 영양지수 평가항목 선정을 위해 식품섭취영역에서 20개 문항, 식행동·식습관 영역에서 21개 문항의 총 41개 문항으로 구성된 파일럿 조사용 체크리스트를 개발하였다. 청소년 213명을 대상으로 1일의 식사 섭취실태 조사를 포함한 파일럿 조사를 수행하고, 체크리스트 항목 점수와 식사섭취실태 관련 변수들 간의 상관관계가 높은 24개의 평가항목으로 구성된 전국단위 조사용 체크리스트를 개발하였다. 전국단위 조사는 시도별 집락별로 층화추출된 중고등학생 1,547명에 대해 구조화된 설문지로 면대면 조사를 수행하였고, 탐색적 요인분석을 수행하여 청소년 영양지수의 평가 항목을 19개 항목의 5개 요인으로 분류하고, 구조방정식 모형을 이용해 평가 항목의 구성타당도를 검증하고 추정된 경로계수를 가중치로 적용하였다. 청소년 영양지수를 위한 5개의 요인과 가중치는 각각 균형 0.25, 다양 0.15, 절제 0.25, 환경 0.15, 실천 0.20이었다. 균형 영역에는 과일 섭취 빈도, 흰 우유 섭취 빈도, 콩류 섭취 빈도, 생선 섭취 빈도의 4개 항목이 포함되었고, 다양 영역은 채소 반찬 섭취 빈도, 반찬 골고루 먹는 정도, 편식 정도의 3개 항목, 절제 영역은 과자 또는 달거나 기름진 빵 섭취 빈도, 가공 음료 섭취 빈도, 라면 섭취 빈도, 카페인 음료섭취 빈도, 야식 섭취 빈도, 길거리 음식 섭취 빈도의 6개 항목, 환경 영역은 아침식사 빈도, 식탁에 앉아서 식사하는 정도, TV·핸드폰·컴퓨터 사용 시간의 3개 항목, 그리고 실천 영역은 영양 표시 확인 정도, 음식 먹기 전 손 씻는 정도, 운동 빈도의 3개 항목이 포함되었다. 전국단위 조사대상자의 영양지수 (NQ-A) 평균 점수는 56.0점이었고, 세부 영역별로는 균형 58.6점, 다양 55.6점, 절제 48.1점, 환경 70.6점, 실천 52.1점이었다. 영양지수 점수와 각 영역별 등급은 전국 조사 결과의 백분위수 분포를 기준으로 75~100 백분위의 경우 ‘상’ 등급, 25 ~ <75 백분위의 경우 ‘중’ 등급, 0 ~ <25 백분위는 ‘하’ 등급으로 분류하였다. 영양지수의 경우 63.1~100점은 ‘상’ 등급, 49.0~63점은 ‘중’ 등급, 0~48.9점은 ‘하’ 등급으로 판정되었다. 본 연구에서 개발된 청소년을 위한 영양지수는 19개 항목으로 구성된 식행동 체크리스트를 통해 영양지수 점수와 균형, 다양, 절제, 환경, 실천 영역의 점수를 산출할 수 있으며, 상대적인 NQ 등급 부여를 통해 식사의 질과 식행동이 양호한 지를 판정할 수 있다. 본 연구에서 개발된 청소년용 영양지수 (NQ-A)가 청소년의 식사의 질과 식행동 평가 및 영양교육의 효과 평가 등에 많이 활용될 것으로 기대된다. Purpose: The purpose of this study was to develop a nutrition quotient for adolescents (NQ-A) to assess overall dietary quality and food behavior of Korean adolescents. Methods: Development of the NQ-A was undertaken in three steps: item generation, item reduction, and validation. Candidate items of the NQ-A checklist were selected based on literature reviews, results of the fifth Korea National Health and Nutrition Examination Survey data, dietary guidelines for Korean adolescents, expert in-depth interviews, and national nutrition policies and recommendations. A total of 213 middle and high school students participated in a one-day dietary record survey and responded to 41 items in the food behavior checklist. Pearson"s correlation coefficients between the responses to the checklist items along with nutritional status of the adolescents were calculated. Item reduction was performed, and 24 items were selected for the nation-wide survey. A total of 1,547 adolescents from 17 cities completed the checklist questionnaire. Exploratory factor and confirmatory factor analyses were performed to develop a final NQ-A model. Results: Nineteen items were finalized as the checklist items for the NQ-A. Checklist items were composed of five factors (balance, diversity, moderation, environment, and practice). The five-factor structure accounted for 47.2% of the total variance. Standardized path coefficients were used as weights of the items. The NQ-A and five-factor scores were calculated based on the obtained weights of the questionnaire items. Conclusion: Nutrition Quotient for adolescents (NQ-A) would be a useful instrument for evaluating dietary quality and food behavior of Korean adolescents. Further research on NQ-A is needed to reflect changes in adolescent"s food behavior and environment.
( Ji Hoon Ha ),( A Rang Kim ),( Keon-soo Lee ),( Song Hua Xuan ),( Hee Cheol Kang ),( Dong Hwan Lee ),( Mi Yeon Cha ),( Hye Jin Kim ),( Mi An ),( Soo Nam Park ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.1
The effects of Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts were determined, and the conversion of its components was also analyzed. Fermentation was performed at varying L. angustifolia extract and MRS medium concentrations, and optimal fermentation conditions were selected. L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1 expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented extract. This was observed even at fermented extract concentrations lower than those of non-fermented extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less reduction in collagen production upon UVB irradiation than those treated with non-fermented extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50% higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin and apigenin glycosides of L. angustifolia were converted during fermentation, and identified using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract on MMP-1 expression and collagen decrease in UVB-irradiated human skin fibroblasts were increased through fermentation by P. pentosaceus.
( Ji Hye Lee ),( Hee Yoon Kang ),( Sa Rang Kim ),( Hee Kyung Yoo ),( Hee Jin Kim ),( Young Kil Park ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.2
Background: Variable-number tandem repeat (VNTR) typing is a promising method to discriminate the Mycobacterium tuberculosis isolates in molecular epidemiology. The purpose of this study is to determine the optimal VNTR combinations for discriminating isolated M. tuberculosis strains in Korea. Methods: A total of 317 clinical isolates collected throughout Korea were genotyped by using the IS6110 restriction fragment length polymorphism (RFLP), and then analysed for the number of VNTR copies from 32 VNTR loci. Results: The results of discriminatory power according to diverse combinations were as follows: 25 clusters in 83 strains were yielded from the internationally standardized 15 VNTR loci (Hunter-Gaston discriminatory index [HGDI], 0.9958), 25 clusters in 65 strains by using IS6110 RFLP (HGDI, 0.9977), 14 clusters in 32 strains in 12 hyper-variable VNTR loci (HGDI, 0.9995), 6 clusters in 13 strains in 32 VNTR loci (HDGI, 0.9998), and 7 clusters in 14 strains of both the 12 hyper-variable VNTR and IS6110 RFLP (HDGI, 0.9999). Conclusion: The combination of 12 hyper-variable VNTR typing can be an effective tool for genotyping Korean M. tuberculosis isolates where the Beijing strains are predominant.
Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro
( Ji Wook Jung ),( Su Jin Kim ),( Eun Mi Ahn ),( Sa Rang Oh ),( Hye Ja Lee ),( Ji Ahn Jeong ),( Ju Young Lee ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.6
However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects of R. fasciculatum on both compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of R. fasciculatum, we evaluated the effects of R. fasciculatum on the production of inflammatory mediators in LPS-stimulated macrophage cells. Treatment of R. fasciculatum significantly reduced compound 48/80- or histamine-induced the pruritus in mice. R. fasciculatum attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE levels in AD model. Additionally, R. fasciculatum inhibited the production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The maximal rates of TNF-α and IL-6 inhibition by R. fasciculatum (1 mg/ml) were approximately 32.12% and 46.24%, respectively. We also showed that R. fasciculatum inhibited the activation of nuclear factor-kappa B in LPS-stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of R. fasciculatum as a potential molecule for use in the treatment of allergic inflammatory diseases.
Characterization of a Korean Domestic Cyanobacterium Limnothrix sp. KNUA012 for Biofuel Feedstock
Ji Won Hong(홍지원),Seung-Woo Jo(조승우),Oh Hong Kim(김오홍),Mi Rang Jeong(정미랑),Hyeon Kim(김현),Kyung Mok Park(박경목),Kyoung In Lee(이경인),Ho-Sung Yoon(윤호성) 한국생명과학회 2016 생명과학회지 Vol.26 No.4
사상체 토착 남세균을 경상남도 합천군 합천호의 수화시료로부터 무균적으로 분리하였으며, 형태적 · 분자적 동정 결과 림노트릭스 속에 속하는 것으로 밝혀졌다. 따라서, 본 남세균 균주는 림노트릭스 속 KNUA012 균주로 명명하였으며, 분리균주의 최적생장 온도는 섭씨 25도였다. 지질성분 분석 결과, 에스테르 교환반응을 거치지 않고 직접 연료로 사용할 수 있는 펜타데칸(C15H32)과 헵타데칸(C17H36)과 같은 알칸들이 본 균주에 의해 광독립 영양적으로 생합성 된다는 것이 밝혀졌다. 또한 알칸 생합성에 관여하는 유전자들이 본 남세균 내에 존재하는 것을 발견하였다. 일반적인 미세조류 바이오디젤 구성성분으로 알려진 미리스트올레산(C14:1), 팔미트산(C16:0) 및 팔미톨레산(C16:1) 역시 KNUA012 균주에 의해 주요 지방산 성분으로서 생산되는 것으로 확인되었다. 근사분석 결과 KNUA012 균주의 휘발성물질 함량은 86.0%였으며, 원소분석 결과 고위발열량은 19.8 MJ kg<SUP>-1</SUP>으로 나타났다. 또한, 본 분리균주는 고부가가치 항산화물질로 알려져 있는 피코시아닌을 광독립영양적으로 21.4 mg g<SUP>-1</SUP>의 농도로 생산할 수 있는 것을 확인하였다. 따라서, 본 연구결과는 KNUA012 균주가 미세조류 기반 바이오연료와 바이오매스 원료의 경제적인 생산에 있어 이상적인 자원이 될 수 있음을 제시하였다. A filamentous cyanobacterium, Limnothrix sp. KNUA012, was axenically isolated from a freshwater bloom sample in Lake Hapcheon, Hapcheon-gun, Gyeongsangnam-do, Korea. Its morphological and molecular characteristics led to identification of the isolate as a member of the genus Limnothrix. Maximal growth was attained when the culture was incubated at 25°C. Analysis of its lipid composition revealed that strain KNUA012 could autotrophically synthesize alkanes, such as pentadecane (C15H32) and heptadecane (C17H36), which can be directly used as fuel without requiring a transesterification step. Two genes involved in alkane biosynthesis-an acyl-acyl carrier protein reductase and an aldehyde decarbonylase-were present in this cyanobacterium. Some common algal biodiesel constituents-myristoleic acid (C14:1), palmitic acid (C16:0), and palmitoleic acid (C16:1)-were produced by strain KNUA012 as its major fatty acids. A proximate analysis showed that the volatile matter content was 86.0% and an ultimate analysis indicated that the higher heating value was 19.8 MJ kg<SUP>-1</SUP>. The isolate also autotrophically produced 21.4 mg g<SUP>-1</SUP> phycocyanin-a high-value antioxidant compound. Therefore, Limnothrix sp. KNUA012 appears to show promise for application in cost-effective production of microalga-based biofuels and biomass feedstock over crop plants.
Permanent Pacemaker Implantation in a patient with MELAS syndrome
( Ji Hyun Min ),( Choong Hwan Kwak ),( Jong Hwa Ahn ),( Na Young Kim ),( Jeong Rang Park ),( Seok Jae Hwang ),( Yong Whi Park ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
A 35-year-old male patient with heart and renal failure and pneumonia was transferred to our department due to recurrent cardiac standstill with seizure-like activity. He had been diagnosed as and treated for MELAS syndrome since 3 years ago. His electrocardiography (ECG) showed Wolff-Parkinson-White (WPW) pattern, and an echocardiogram showed hypertrophic cardiomyopathy (HCM). He developed seizure-like activities intermittently and ECG monitoring showed intermittent bradycardia. His Holter monitoring showed several episodes of 5 to 16 seconds of sinus arrest. We performed electrophysiologic study for evaluation of his arrhythmia. During atrial and ventricular extrastimuli, cardiac standstill has developed several times and the duration of pauses varied from 2.5 to 3.2 seconds. Abrupt asystolic events have also developed accompanying seizure-like activities which were not related to extrastimuli. We decided to implant a permanent pacemaker. After the implantation of DDD type pacemaker, the patient`s seizure-like activity disappeared.