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      • KCI등재

        Fine mapping of grain weight QTL, tgw11 using near isogenic lines from a cross between Oryza sativa and O. grandiglumis

        Ji‐Min Oh,Sangshetty Balkunde,Paul Yang,Dong‐Beom Yoon,안상낙 한국유전학회 2011 Genes & Genomics Vol.33 No.3

        In our previous study, we reported the grain weight (GW)QTL, tgw11 in isogenic lines derived from a cross between Oryza sativa ssp. Japonica cv. Hwaseong and O. grandiglumis. The O. grandiglumis allele at tgw11 decreased GW in the Hwaseong background. To fine-map tgw11, one F5 plant homozygous for the O. grandiglumis DNA in the target region on chromosome 11 was selected from F_4 line,CR1242 segregating for tgw11 and crossed with Hwaseong to produce secondary F_2 and F_3 populations. QTL analysis using 760 F_2 plants confirmed the existence of tgw11 with an R^2 value of 15.0%. This QTL explained 32.2% of the phenotypic variance for GW in 91 F_3 lines. Substitution mapping with 65 F_3 lines with informative recombination breakpoints in the target region was carried out to narrow down the position of the tgw11. The result indicated that tgw11 was located in the 900-kb interval between two SSR markers, RM224 and RM27358. QTLs for grain width and grain thickness were also located in the same interval suggesting that a single gene is involved in controlling these three traits. Analysis of F3 lines indicated that the variation in TGW is associated with variation in grain shape, specifically grain thickness and grain width. Genetic analysis indicated that the O. grandiglumis allele for small seed was dominant over the Hwaseong allele. SSR markers tightly linked to the GW QTL would be useful in marker-assisted selection for variation in GW in breeding program.

      • KCI등재

        The Beneficial Effect of Adenophorae Radix on DSS‐induced Colitis in Mice

        Ji?Wook Jung,Sa?Rang Oh,Eun?Mi Ahn,Eun?Ju Yang,Su?Jin Kim 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.3

        Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Adenophorae Radix (AR) has been used as a traditional medicine for various diseases including strengthening cardiac function, allaying a fever, and easing pain and cough. However, the regulatory effects of AR in intestinal inflammation are not yet understood. This study attempted to determine the effect of AR in dextran sulfate sodium (DSS) ? induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of AR attenuated weight loss, colon shortening and inhibited the levels of interleukin (IL) ? 6 in DSS ? treated colon tissues. These results provide experimental evidence that AR might be a useful therapeutic medicine for patients with UC.

      • KCI등재

        백련결사 보현도량의 의미에 관한 고찰

        오지연(Oh, ji-yeon) 불교학연구회 2012 불교학연구 Vol.33 No.-

        백련결사와 정혜결사는 한국불교사에서 대표적인 두 결사이다. 정혜결사의 뜻은 간화(看話)의 선맥을 통해서 지금까지도 계승되어 오고 있지만, 법화예참도량이었던 백련결사의 취지는 오늘날 찾아보기가 힘들다. 원묘의 비문에서는, 우리나라에 불교가 전래된 이래로 보현도량을 열어서 널리 선관[禪]과 송경[誦]을 행하도록 권한 것은 처음이었다고 한다. 백련사의 보현도량은 근본적으로 법화 일불승(一佛乘)의 뜻을 천명하며 그것을 실현하고자 한 도량이었다. 그것을 네 측면으로 말하면, 삼승의 가르침들을 묘법(妙法)으로 회통해내는 교일(敎一), 송경(誦經)과 선정 등의 여러 수행법들이 모두 한결같이 성불도(成佛道)라고 하는 행일(行一), 모든 사람이 신분차이나 남녀노소에 관계없이 모두 부처와 다름없다고 인식하는 인일(人一), 사(事)법과 이(理)법이 둘이 아니라고 깨닫는 이일(理一) 등의 네 가지 일승[四一]을 그대로 실현하고자 한 도량이었다고 할 수 있다. There have been two famous and important Buddhist practice communities in Korean dynasties, one was the practice community of the Meditation and wisdom (定慧結社) by Ji-nul (知訥), the other was the practice community of White Lotus (白蓮結社) by Yo-sae (了世). Even if the point of the former still exists through Koan meditation, the purpose of the latter which was the gathering of the repentance method of the Lotus Samadhi would be hard to find these days. The epitaph of Yo-sae, the first president of the community of White Lotus, says: ‘It was the first time to recommend dhyāna-contemplation (禪觀) and reciting sūtras (誦經) to the public through opening the practicing site of Samantabhadra since the introduction of Buddhism in Korea.’ In essence, the community of White Lotus was the meeting to clarify and actualize the essential of the One Vehicle in Lotus sutra. Again in four aspects, the four ones [四一]: the first, to unite the three other teachings in one subtle dharma is called ‘the teaching of one vehicle (敎一)’, the second, including many other practices like recitation or meditation are one and the same way to the ultimate enlightenment called ‘the sole Buddha procedure (行一)’, the third, the thinking that everybody regardless of sex, age or class is none other than Buddha is called ‘men all and only as Buddha (人一)’, the fourth, the understanding that Noumenon and phenomena are non-dual is called ‘one ultimate truth of the reality of all existence (理一)’.

      • 捻轉法이 竝行된 鍼刺戟 및 電鍼刺戟이 鎭痛效果에 미치는 影響

        Park, Dong-Seok,Kim, Ji-Hoon,Min, Byung-Il,Oh, Soo-Myung 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

        Dong-Seok Park¹, Ji-Hoon Kim¹ and Byung-Il Min, Soo-Myung Oh,³¹Department of Acupuncture and Moxibustion, College of Medicine, ²Department of Physiology, College of Medicine, And ³East-West Medical Research Institute, Kyung Hee University,Seoul, Korea. Analgesic Effect of Manual Acupuncture and Electroacupuncture combined with Twirling Method. Proceeding of International Symposium on East-West Medicine Seoul. 187-200, 1999.-Twirling the needle (TN) is one of several needing methods frequently used for acupuncture in the oriental medicine. The present study was conducted to see if TN enhanced the antinociceptive effect produced by plain-or electroacupuncture in the rat tail flick test. Rats (Sprague-Dawley, 200-300g)lightly anesthetized with thiopental sodium(40mg/kg, i.p.) were used in the tail-flick test. The basal reaction time for tail-flick was 2 sec. For "plain" acupuncture(PA), a needle was inserted for 20 min into a Chock-samni (ST36) acupuncture point which (is located at the anterior tibial muscle and about 10mm below the knee joint). For electroacupuncture(EA), train-pulses(3 Hz,0.3-ms pulse width, 0.2-0.3mA) were applied to the inserted needle for the period of insertion. For combining TN with either PA or EA, TN was performed during the each acupuncture period. Two methods for TN were used; twirling 3 times for 1 second persisted for 1 min in every 5 mins(long-duration and long-interval;LDLI) and twirling 3 times for 1 second persisted for 10 sec in every 1 min(short-duration and short-interval;SDSI). PA and EA produced an increase in tail flick latency (TFL); peak increases were 21.3±5.1% and 42.1±17.3% of the pre-acupunture control, respectively, and occurred immediately after cessation of 20min-acupuncture. Performing TN combined with PA increased TFL more than PA itself by showing a greater peak increase in TFL when performed with a SDSI-TN than with a LDLI-TN(60.6±12.5% and 42.7±22.7% of the pre-acupuncture control, respectively). Performing TN combined with EA also increased TFL more than EA itself and a greater peak increase in TFL was observed with a SDSI-TN as compared to a LDLI-TN(77.5±13.8% and 67.3±14.0% of the pre-acupuncture control, respectively). These results indicate that TN enhances both PA-and EA-produced antinociception where an greater enhanced antinociception than a LDLI-TN. It is suggested that performing a SDSI-TN combined with EA seems to be one of the most effective ways to produce analgesia.

      • 유방암의 위와 대장전이

        유현아,김은영,서민지,정은,조민정,오현진,장지혜,박지찬,이정의,박석영 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2

        Gastric metastasis from breast cancer is rare and only six cases have been reported in Korea. Colon metastasis is more rare than gastric metastasis. We report a 63-year-old woman with gastric and colon metastases of invasive lobular carcinoma of breast. She was diagnosed as right breast cancer, received right modified radical mastectomy 10 years ago and has been treated with chemotherapy and hormone therapy. Investigating for melena and a small caliber of stool, we found gastric and colon metastases. The diagnosis of metastatic breast cancer was made through gross pathologic and immunohistochemistry staining. We report a case with gastric and colon metastases from breast cancer and a review of the associated six case reports in Korea.

      • 악안면 골격 형태에 따른 교합평면각의 변화에 관한 두부 방사선학적 연구

        오세윤,김웅철,김지환,이준석,김진완,유진호,김태석 高麗大學校 倂設 保健大學 保健科學硏究所 1999 保健科學論集 Vol.25 No.1

        A correlation analysis was made to understand the interaction between the growth patterns of some craniofacial skeletal components and occlusal plane inclination. 5 angular measurements(S.a. Ar.a, Go.a, UGo.a, LGo.a), 6 linear measurements(ACBL, PCBL, RH. MBL. AFH. PFH) and OP/SN. obtained from 83 cephalometric tracing records, were selected and the relationship between the occlusal plane angle and those measurements were analyzed statistically. Ramus Height(r=-0.55), Posterior Facial Height(r=-0.41), were found to be negatively related with Occlusal Plane angle, while Lower Gonial angle(r= 0.35), Saddle angle(r= 0.24) were found to be positively related with Occlusal Plane angle(p(0.05). The results obtained from the above analysis were further assessed with stepwise regression analysis, using Occlusal Plane angle as a dependant variable, and RH, LGo.a and S.a as explanatory variables. Stepwise regression analysis revealed that all the explanatory variables were found to be significant.(p<0.05) [OP/SN] = -8.74-0.33(RH)+0.23(S.a)+0.20(LGo.a). (R²=0.44). This stepwise regression analysis explains, to some extent, the relationship between the growth patterns of some craniofacial skeletal components and the occlusal plane inclination. 1. The inclination of Occlusal Plane angle is noticeably related with the growth patterns of some craniofacial skeletal components, i.e. RH, PFH, Saddle angle and Lower Gonial angle 2. In high Occlusal Plane angle, the Ram us Height tends to be shorter, and the Saddle angle and Lower Gonial angle tend to be obtuse.

      • 南 ·北韓 中學校 數學科 敎育課程 및 敎科書 比較分析硏究

        吳厚鎭,崔智閔 공주대학교 사범대학 과학교육연구소 2000 과학교육연구 Vol.31 No.1

        통일 환경이 급변하고 있다. 이러한 상황에서 남북간의 이질화를 극복하고 민족의 동질성을 추구하기 위한 통일대비 노력으로써 북한의 실정을 바르게 이해하는 것은 무엇보다도 중요하다. 본 연구의 목적은 현장에 있는 교사들에게 남북한의 중학교 수학교육과정 및 교과서를 비교분석 함으로서 북한사회에 대한 이해를 돕고자 하는 데 있다. 북한을 이해하는 가장 효율적인 방법중에 하나가 그들의 교육을 이해하는 것이다. 그래서 본 연구는 북한의 중학교 수학교과서 및 교육과정, 내용체계등을 이해함으로써 통일한국을 준비하는 데 있다. 아무쪼록, 남북한의 통일 후 통합된 수학교육을 만드는데 도움이 되길 바란다. The situation of unification has been changing in the rapid speed. In this condion it is most important that we understand North Korea's current situation correctly, by overcoming the differences between South and North Korea and trying to pursuit the national homogeneity. The purpose of this thesis is to help the teachers in school to widen the knowledge and to understand the North Korean society by comparative analysis of South and North Korean junior high school's mathematics education process and text books. One of the most effective ways to understand North Korea is to understand their education. So, I wrote this thesis as a way of getting ready for the united Korea by knowing mathematics texts and their system, composition, contents of junior high school in North Korea Anyway, I hope that this study will be helpful to the integration of mathematics education after unification of North and South.

      • SCOPUSKCI등재

        조직확장법,술중 조직확장법 및 술전 봉합법의 임상적 응용에 관한 비교 연구

        오석준,하지운,김응춘,서인석,조세흠 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

        The purpose of soft tissue defect reconstruction is minimal scar with aesthetic and functional good results. Reconstruction of head and neck, upper extremity, chest, and lower extremity defects has been reported with standard available tissue expansions. Various surgical methods have been used in an attempt to achieve a normallooking skin color, texture, sensation, thickness and same skin adenexa. Therefore, in accordance with defect size and location, the operative method was considered so we select adequate method. Authors achieved good results from 48 cases of tissue expansion, 18 cases of ISLE (intraoperative sustained limited expansion), and 35 cases of presuturing technique. 1)The most common cause of reconstruction for soft tissue defect was post grafted scar 51cases(51%), next was tattoo 20 cases(19.6%), traumatic soft tissue defect 16cases(15.7% ) and nevus 8 cases(7.8%)in order. 2)Males(55.9%)were affected more often than females(44.1%)in the ratio 1, 3 : 1 and the most frequently affected group was the age of 20 to 30 years as 36% . 3)The distribution of incidence and location were as follow : face(39.2%), upper extremity(25.5%), scalp(17.6%), lower extremity(9.8%) and trunk(7.8%). 4)The cause and distribution were scalp in 20 cases(39.2%), face in 40 cases(29.4%) in the post grafted scar, upper extremity 18 cases(90.0%) in the tattoo, upper extremity 4 cases(50.0%), face 2 cases(25.0%) in the nevus and even distribution in the traumatic soft tissue defects. 5)The presuturing technique was best recommended method for soft tissue defect in 4cm diameter lesion on extremity, but ISLE method was used in the open traumatic soft tissue defect. Over 9cm wide scar was resurfaced by expanded skin using tissue expander.

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