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Cha, D. R.,Kim, I. S.,Kang, Y. S.,Han, S. Y.,Han, K. H.,Shin, C.,Ji, Y. H.,Kim, N. H. Blackwell Science Ltd 2005 Diabetic medicine Vol.22 No.1
<P>Abstract</P><P>Aims </P><P>The expression of TGF&bgr;-inducible gene h3(&bgr;ig-h3) has been used to assess the biological activity of TGF&bgr; in the kidney. In this study, we investigated whether the urinary concentration of &bgr;ig-h3 is associated with diabetic nephropathy in patients with Type 2 diabetes mellitus. We also evaluated the relationship between the urinary concentration of &bgr;ig-3 and proteinuria and microalbuminuria (AER) in a normal healthy population and in Type 2 diabetes patients.</P><P>Methods </P><P>Four hundred and seventy-nine Type 2 diabetic patients without non-diabetic kidney diseases and 528 healthy control subjects were enrolled. The study subjects were divided into five groups: a non-diabetic healthy control group with normal ACR (<I>n</I> = 443), a non-diabetic healthy control group with microalbuminuria (<I>n</I> = 85), a normoalbuminuric diabetic group (<I>n</I> = 198), a microalbuminuric diabetic group (<I>n</I> = 155) and an overt proteinuria group (<I>n</I> = 126). Urinary levels of &bgr;ig-h3 were measured by enzyme-linked immunosorbent assay.</P><P>Results </P><P>(i) Urinary excretion of &bgr;ig-h3 was significantly higher in the diabetic groups than in the controls, even in the normoalbuminuric stage (25.02 ± 8.84 vs. 18.67 ± 6.56, <I>P</I> = 0.03). In diabetic patients, urinary &bgr;ig-h3 levels increased significantly as diabetic nephropathy advanced (25.02 ± 8.84 vs. 34.06 ± 24.55 vs. 169.63 ± 57.33, <I>P</I> < 0.001). (ii) Proteinuria was found to be significantly correlated with urinary &bgr;ig-h3 (healthy control; <I>r</I> = 0.137, <I>P</I> = 0.019, diabetic patients; <I>r</I> = 0.604, <I>P</I> < 0.001). ACR was also found to be significantly related with urinary &bgr;ig-h3 in diabetic patients (<I>r =</I> 0.383, <I>P</I> = 0.006). (iii) In diabetic patients, urinary &bgr;ig-h3 was significantly related with systolic and diastolic blood pressure (systolic blood pressure: <I>r</I> = 0.436, <I>P</I> = 0.024; diastolic blood pressure, <I>r</I> = 0.365, <I>P</I> = 0.042), total cholesterol and HbA<SUB>1c</SUB> (cholesterol: <I>r</I> = 0.169, <I>P</I> = 0.03, HbA<SUB>1c</SUB>; <I>r</I> = 0.387, <I>P</I> = 0.044). Logistic regression analyses showed that urinary &bgr;ig-h3 was associated with a significant increase in the risk of microalbuminuria and proteinuria in diabetic patients.</P><P>Conclusions </P><P>Longitudinal monitoring of urinary &bgr;ig-h3 may improve the likelihood of detecting diabetic nephropathy at an earlier stage and &bgr;ig-h3 could be a sensitive marker of diabetic kidney disease progression.</P>
Multilocus Sequence Typing and Virulence Factors Analysis of Escherichia coli O157 Strains in China
Xiao W. Ji,Ya L. Liao,Ye F. Zhu,Hai G. Wang,Ling Gu,Jiang Gu,Chen Dong,Hong L. Ding,Xu H. Mao,Feng C. Zhu,Quan M. Zou 한국미생물학회 2010 The journal of microbiology Vol.48 No.6
Escherichia coli O157:H7, an important food-borne pathogen, has become a major public health concern worldwide. The aim of this study was to investigate the molecular epidemiologic feature of E. coli O157:H7strains in China. 105 E. coli O157:H7 isolates were collected from various hosts and places over 9 years. A multilocus sequence typing scheme (MLST) was applied for bacteria genotyping and polymerase chain reaction (PCR) was used for virulence factor identification. Seven new MLST sequence types (STs), namely ST836, ST837, ST838, ST839, ST840, ST841, and ST842 were identified, which grouped into two lineages. Phylogenetic analysis suggested that the most two frequent STs in China, ST837 and ST836, may be the derivatives of E. coli O157:H7 Sakai or E. coli O157:H7 EDL933. Geographical diversity and host variety of E. coli O157:H7 were observed in China. In addition, the different distribution of tccp was detected. The data presented herein provide new insights into the molecular epidemiologic feature of E. coli O157:H7, and aid in the investigation of the transmission regularity and evolutionary mechanism of E. coli O157:H7.
( Mohamed Azab ),( Loomee Doo ),( Daniel H. Doo ),( Yousif Elmofti ),( Muazer Ahmed ),( John Jay Cadavona ),( Xibei B. Liu ),( Amaan Shafi ),( Moon Kyung Joo ),( Ji Won Yoo ) 대한간학회 2017 Gut and Liver Vol.11 No.6
Background/Aims: Although proton pump inhibitors (PPIs) have been widely used for the prevention and treatment of stress gastric ulcers in hospital settings, there are concerns that PPIs increase the risk of Clostridium difficile infection (CDI). However, little is known about the risk of CDI following PPI and histamine-2 receptor antagonist (H2RA) use. We evaluated the comparative hospital-acquired CDI occurrence risk associated with the concurrent use of PPIs versus H2RAs. Methods: A systematic search of PubMed, MEDLINE/Ovid, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and Google Scholar through August 19, 2016, identified 12 studies that reported the hospital-acquired CDI occurrence following H2RA and PPI use for the prevention and treatment of stress gastric ulcers. Random-effects pooled odds ratios and 95% confidence intervals were estimated. Heterogeneity was measured using I2, and a meta-regression analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the overall quality of the evidence. Results: A total of 74,132 patients from 12 observational studies were analyzed. Compared to H2RAs, PPIs increased the risk of CDI by 38.6% (pooled odds ratio, 1.386; 95% confidence interval, 1.152 to 1.668; p=0.001; I2=42.81%). Subgroup analyses of the purpose of study medication use, study site, and study design confirmed the consistency of a greater CDI risk with PPIs than with H2RAs. The overall quality of evidence was rated as low. Conclusions: The use of PPIs for both the prevention and treatment of stress ulcers was associated with a 38.6% increased risk of hospital-acquired CDI occurrence compared to H2RA use. (Gut Liver 2017;11:781-788)
Inhibition of sulfide mineral oxidation by surface coating agents: Batch and field studies
Ji, M.K.,Gee, E.D.,Yun, H.S.,Lee, W.R.,Park, Y.T.,Khan, M.A.,Jeon, B.H.,Choi, J. Elsevier Scientific Pub. Co 2012 Journal of hazardous materials Vol.229 No.-
The potential of several surface coating agents to inhibit the oxidation of metal sulfide minerals from Young-Dong coal mine and the Il-Gwang gold mine was examined by conducting laboratory scale batch experiments and field tests. Powdered pyrite as a standard sulfide mineral and rock samples from two mine outcrops were mixed with six coating agents (KH<SUB>2</SUB>PO<SUB>4</SUB>, MgO and KMnO<SUB>4</SUB> as chemical agents, and apatite, cement and manganite as mineral agents) and incubated with oxidizing agents (H<SUB>2</SUB>O<SUB>2</SUB> or NaClO). For the observed time period (8 days), Young-Dong coal mine samples exhibited the least sulfate (SO<SUB>4</SUB><SUP>2-</SUP>) production in the presence of KMnO<SUB>4</SUB> (16%) or cement (4%) while, for Il-Gwang mine samples, the least SO<SUB>4</SUB><SUP>2-</SUP> production was observed in presence of KH<SUB>2</SUB>PO<SUB>4</SUB> (8%) or cement (2%) compared to control. Field-scale pilot tests at the Il-Gwang site also showed that addition of KH<SUB>2</SUB>PO<SUB>4</SUB> decreased SO<SUB>4</SUB><SUP>2-</SUP> production from 200 to 13mgL<SUP>-1</SUP> and it also reduced Cu and Mn from 8 and 3mgL<SUP>-1</SUP>, respectively to <0.05mgL<SUP>-1</SUP> (below ICP-OES detection limits). The experimental results suggested that the use of surface coating agents is a promising alternative for sulfide oxidation inhibition at acid mine drainage sites.
AA5083-H18판재의 마찰 교반 점 용접 공정에 대한 전산 해석
김돈건(Dongun Kim),Badarinarayan Harsha,유일(Ill Ryu),김지훈(Ji Hoon Kim),김종민(Chongmin Kim),Okamoto Kazutaka,Wagoner R. H.,정관수(Kwansoo Chung) 한국소성가공학회 2009 한국소성가공학회 학술대회 논문집 Vol.2009 No.5
Thermo-mechanical simulation of the Friction Stir Spot Welding (FSSW) processes was performed for the AA5083-H18 sheets, utilizing commercial Finite Element Method (FEM) and Finite Volume Method (FVM) which are based on Lagrangian and Eulerian formulations, respectively. The Lagrangian explicit dynamic FEM code, PAM-RASH, and the Eulerian Computational Fluid Dynamics (CFD) FVM code, STAR-CD, were utilize to understand the effect of pin geometry on weld strength and material flow under the unsteady state condition Using FVM code, material flow pattern near the tool boundary was analyzed to explain the weld strength difference between the weld by cylindrical pin and the weld by triangular pin, while the frictional energy concept using the FEM code had limitation to explain the weld strength difference.
Food Label Utilization Rate Analysis Based on Purchasing Situation and Recall Experiments
( Ji¸ J. H. ),( S. H. Kim ),( S. H. Lee ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2020 강원 농업생명환경연구 Vol.32 No.S
The present study evaluated what kind of knowledge could be useful to improve the food label utilization rate by consumers and whether it differed considering the characteristics of the products. A better understanding of the consumer perspective on food label utilization may help stablish future commercial and marketing plans for different products. The collected data revealed that the food label utilization rate may vary depending on the perception of consumers on how important the food label may be during the purchasing process. Therefore, in order to enhance the food label utilization rate by consumers, it is necessary to find ways to promote the food label program and raise awareness among consumers on the importance of food label information.
Ji‐Rui Wang,Yu-Zhou Du,Jon H. MARTIN,Zhi-Hong XU 한국곤충학회 2018 Entomological Research Vol.48 No.5
A new whitefly species, Pealius yunnanensis sp. nov., collected from Mengzi, Caoba village (Yunnan, China) on Ficus microcarpa Linn. f. (Urticales: Moraceae), is described with morphology, line illustrations, photographs and scanning electron microscope images. In addition, a checklist of Chinese species of Pealius is provided and all Pealius species recorded from Ficus around the world are listed. Specimens have been deposited in the Insect Collection of Zhejiang Agriculture & Forestry University (ZAFU), Lin'an, China.
Ji, C.Y.,Kim, Y.H.,Kim, H.S.,Ke, Q.,Kim, G.W.,Park, S.C.,Lee, H.S.,Jeong, J.C.,Kwak, S.S. Elsevier Science B.V., Amsterdam. 2016 Plant Physiology and Biochemistry Vol. No.
<P>Tocopherol (vitamin E) is a chloroplast lipid that is presumed to be involved in the plant response to oxidative stress. In this study, we isolated and characterized five tocopherol biosynthetic genes from sweetpotato (Ipomoea batatas [L.] Lam) plants, including genes encoding 4-hydroxyphenylpyruvate dioxygenase (IbHPPD), homogentisate phytyltransferase (IbHPT), 2-methyl-6-phytylbenzoquinol methyltransferase (IbMPBQ MT), tocopherol cyclase (IbTC) and gamma-tocopherol methyltransferase (IbTMT). Fluorescence microscope analysis indicated that four proteins localized into the chloroplast, whereas IbHPPD observed in the nuclear. Quantitative RT-PCR analysis revealed that the expression patterns of the five tocopherol biosynthetic genes varied in different plant tissues and under different stress conditions. All five genes were highly expressed in leaf tissues, whereas IbHPPD and IbHPT were highly expressed in the thick roots. The expression patterns of these five genes significantly differed in response to PEG, NaCl and H2O2-mediated oxidative stress. IbHPPD was strongly induced following PEG and H2O2 treatment and IbHPT was strongly induced following PEG treatment, whereas IbMPBQ MT and IbTC were highly expressed following NaCI treatment. Upon infection of the bacterial pathogen Pectobacterium chrysanthemi, the expression of IbHPPD increased sharply in sweetpotato leaves, whereas the expression of the other genes was reduced or unchanged. Additionally, transient expression of the five tocopherol biosynthetic genes in tobacco (Nicotiana bentamiana) leaves resulted in increased transcript levels of the transgenes expressions and tocopherol production. Therefore, our results suggested that the five tocopherol biosynthetic genes of sweetpotato play roles in the stress defense response as transcriptional regulators of the tocopherol production. (C) 2016 Elsevier Masson SAS. All rights reserved.</P>