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PRENYLATED FLAVANONES FROM DERRIS LAXIFLORA
KIM, YOUNG HO,LEE, EUNG-SEOK,KOONCHANOK, NUPHAVAN M.,GEAHLEN, ROBERT L.,ASHENDEL, CURTIS L.,CHANG, CHING-JER 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
A new prenylated flavanone 1 [laxiflorin (2S)-5, 7, 3', 4'-tetrahydroxy-6-(β-hydroxyethyl)-8-(γ, γ-dimethylallyl)flavanone] and four known flavanones (6, 8-diprenyleriodictyol, hiravanone, senegalensein and lupinifolin) were isolated from the leaves and twigs of Derris laxiflora.. Laxiflorin with a β-hydroxyethyl group at C-6 exhibited significant inhibitory activity against protein-tyrosine kinase.
Poster Session : PS 0059 ; Cardiology : Lymphoma with Constrictive Pericarditis
( Zhen Yu Liao ),( Jer Young Liou ),( Kou Gi Shyu ),( Huey Ming Lo ),( Jun Jack Cheng ),( Chiung Zuan Chiu ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Patients with pericardial diseases usually present with nonspecifi c symptoms, these diseases may not be detected until they have reached an advanced stage. It is therefore important to distinguish between normal pericardial structure and disease. Pericardial constriction is typically chronic, but variants include subacute, transient, and occult constriction. Pathologically, this results in chronic infl ammation and, frequently, calcifi cation. Constrictive pericarditis has multiple etiologies and can lead to disablingsymptoms and severe heart failure with poor quality of life. We described a patient who presented with symptoms of heart failure and was found to have diastolic heart failure. Several investigations pointed to the diagnosis of constrictive pericarditis which was later confi rmed by cardiac catheterisation. The etiology turns out to be primary cardiac lymphoma which is extremely rare in immunocompetent patients.
Do Rego, Jean Luc,Seong, Jae Young,Burel, Delphine,Leprince, Jerô,me,Luu-The, Van,Tsutsui, Kazuyoshi,Tonon, Marie-Christine,Pelletier, Georges,Vaudry, Hubert Elsevier 2009 Frontiers in neuroendocrinology Vol.30 No.3
<P><B>Abstract</B></P><P>Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.</P>
Park, Junghyun,Lee, Jung Mo,Chiu, Jer‐,Ming,Kim, Woohan,Kim, Won‐,Young Seismological Society of America 2015 Bulletin of the Seismological Society of America Vol.105 No.2
<P>Determination of reliable hypocenters of earthquakes is crucial to earthquake seismology and to evaluate hazards associated with earthquakes. There are many associated computer codes for this purpose; however, most of the location algorithms are designed to determine hypocentral parameters based on previously determined velocity models. In contrast, we employed a location method that is independent of the initial velocity model, using a genetic algorithm (GA) to determine an optimal 1D velocity model and the locations of earthquakes. Using this GA, we relocated earthquakes that occurred in the New Madrid Seismic Zone (NMSZ) in the central United States between October 1989 and August 1992. The goal of this work was to delineate the possible fault planes by reliable relocation of those earthquakes and to determine a 1D velocity structure for the NMSZ. A total of 502 earthquakes recorded by 37 Portable Array for Numerical Data Acquisition (PANDA) stations were used in the relocation study. In the relocation process, the root mean square travel‐time residuals were reduced by ∼35%, corresponding to an average of 2.3 km deeper in depth, 0.7 km shift in latitude, and 0.8 km shift in longitude compared with those in the initial catalog locations. The hypocenters of the earthquakes can be subdivided into four groups based on their spatial distributions. The group that corresponds to the Cottonwood Grove fault (CGF) in the southwestern NMSZ represents a very steep plane, whereas the other three groups fall into Reelfoot fault (RF). We inverted <I>P</I>‐ and <I>S</I>‐wave travel times from the new hypocentral parameters to determine 1D velocity models. The resulting eight‐layered velocity models consist of a 2 km thick surface layer followed by seven 2 km thick layers, with <I>V</I><SUB><I>P</I></SUB> ranges from 5.36 to 6.74 km/s and <I>V</I><SUB><I>S</I></SUB> ranges from 2.83 to 3.90 km/s for both CGF and RF regions.</P><P><I>Online Material: </I>Interactive visualizations of hypocentral distributions.</P>
Okada, Yukinori,Sim, Xueling,Go, Min Jin,Wu, Jer-Yuarn,Gu, Dongfeng,Takeuchi, Fumihiko,Takahashi, Atsushi,Maeda, Shiro,Tsunoda, Tatsuhiko,Chen, Peng,Lim, Su-Chi,Wong, Tien-Yin,Liu, Jianjun,Young, Terr Nature Publishing Group, a division of Macmillan P 2012 Nature genetics Vol.44 No.8
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function??related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function??related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 ? 10<SUP>??8</SUP>). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ??10,347 individuals. We identify pleiotropic associations among these loci with kidney function??related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.