결핵균 약제감수성 검사의 비용효율성에 관한 다기관 연구

정석훈,이대동,최재철,김선주,신정환,정윤성,이은엽,오승환,배길한,장철훈 대한감염학회 2005 감염과 화학요법 Vol.37 No.1

목적 : 우리나라에서의 결핵균 감수성 검사는 검출 균주의 일부에서만 시행되고 있다. 본 연구에서는 모든 검출 균주들에 대해서 감수성검사를 실시하면서, 진료에 필요한 결과를 충분히 제공하고 경제적이면서 현실적인 감수성검사 방안을 제시하고자 한다. 재료 및 방법 : 5개 대학병원에서 일정기간 연속적으로 의뢰된 502균주의 감수성 결과를 분석하였다. 검사결과의 해석 및 2차 약제 감수성검사의 필요성은 NCCLS approved standard M24-A의 권고 기준에 따라 판단하였다. 결과 : 최소한 1가지 이상의 약제에 내성을 보인 경우는 초치료 환자의 10% (38/363), 재치료 환자의 61%(85/139)였으며, 다약제 내성을 보인 경우는 초치료 환자의 3% (11/363), 재치료 환자의 44% (61/139)였다. NCCLS 권고에 따라 2차 약제에 대한 감수성 검사를 시행하지 않아도 되는 경우는 초치료 환자의 96%, 재치료환자의 47%였다. 결론 : 초치료 환자는 95%에서 1차 약제에 대한 검사만으로 충분하므로 필요한 경우에만 2차 약제를 추가로 검사하고 재치료 환자에서는 1, 2차 약제를 동시에 검사할 필요가 있을 것으로 생각한다. Background : The anti-mycobacterial susceptibility test is performed on only a small percentage of clinical isolates in Korea. The aim of this study is to propose an anti-mycobacterial susceptibility testing scheme, which is not only economic and practical but also fully informative to physicians. Materials and Methods : The anti-mycobacterial susceptibility test results of 502 strains, isolated from five university-affiliated hospitals, were analysed. The interpretation of the results and the need for second-line drug susceptibility test were judged according to the recommendation of NCCLS M24-A guidelines. Results : The isolates from 10% (38/363) of treatment-navie patients and 61% (85/139) of retreatment patients showed resistance to at least one of the anti-mycobactial agents; 3% (11/363) and 44% (61/139) of isolates from each group were multi-drug resistant. According to the recommendation by NCCLS, the percentage of patients not needing the susceptibility test results for second-line drugs were 96% for treatment-naive and 47% for re-treatment patients. Conclusion : Since the susceptibility test against first-line drug is sufficient for 95% of treatment-navie patients with tuberculosis patients, susceptibility test against second-line drugs may be performed only when it is necessary. As for the re-treatment patients with tuberculosis, susceptibility test for both first-line and second-line drugs should be performed simultaneously.

國家發展과 發展企劃 : National Development and Development Planning

尹正吉 건국대학교 행정대학원 1976 建國大學校 行政大學院 硏究論叢 Vol.4 No.-

情報管理의 重要性과 그 시스팀 組織에 關한 硏究

朴正吉 慶星大學校 1981 부산수산대학 논문집 Vol.2 No.1

「讀書學點賦課制度」를 爲한 大學生 讀書實態 調査·分析

박정길 경성대학교 2000 論文集 Vol.21 No.1

The purpose of this study is to adopt the Reading grade-point Achievement system Collegiate with the survey and analysis of the actual Conditions of the College students' reading. The reading survey has been performed seven times consecutively from 1987 to 1999. The results analyzed, evaluated interpreted from the reading survey data are followed like below. 1) In case the college students have free time, 55.36% of them would spend time with TV or Radio and only 21.33% would lean to Reading. 2) 8.1% of all students have been guided for Reading, and 91.9% have not been guided. 3) Since the entrance to the college, students would read 19 books per year(average number of books read for one student). This amount, however, is only 25% of Japanese students' average number of books read, 50 books per year. 4) Students' Reading data selectivity is so insignificant. Up to 41.89% of all surveyed students were not confident to select the right books for their research. 5) 67.57% of surveyers admitted their ineffectiveness of daily Ready and strongly showed their eagerness and desire to make more efforts Reading. As a result from the above Reading Actual Condition Data Analysis and Interpretation, 「Reading Grade-point Achievement system」for the college students is desperately requested in order to systematically encourage their personality cultivation and culture.

大學圖書館 收書시스템의 問題分析에 관한 硏究

朴正吉 慶星大學校 1987 부산수산대학 논문집 Vol.8 No.4

The library is the center of academic life and that the quality higher edution is not possible without a quality library. The college or university library of today is not the sheltered, awe-inspiring place it was even thirty years ago. It is the hub of a wheel whose spokes reach into every department of the institution. No college or university can develop or produce effective work without a strong library as its center. An educational institution is rated largely by its library. Educational methods have changed and broadens so that both faculty and students are dependent upon the library. The purpose of this study was to investigate the problem analysis in acquisition system of the college and university libraries. The increasing number of the college and university library collection brings some problems in the libraries. The results of this study were as follows; 1) The system of acquistion department of the college and university library have to become organize, and consist of rationalization. 2) It should be maintain accuracy and rapidity in the work of acquisition process. 3) Have to raise not only the quality and quantity a kind of the journal but audio-visual materials, and to practical application of the it ought to be make budget to practical use its. 4) To be necessary a joint developing inter library to develope library automation in the college and university library. 5) Select for positive use. A book should not be simply good, but good for something. Every library collection should be built up according to definite plan on a broad a real foundation

韓國人 讀書問題의 構造的 分析

朴正吉 경성대학교 1984 부산수산대학 논문집 Vol.5 No.1

外國語 敎育에 있어서 Communicative Competence의 理論과 實際

鄭吉正 淸州敎育大學校 1983 論文集 Vol.20 No.-

西海 沿岸의 養殖場 環境 調査 : 2. 高亭理 海域 김養殖場의 水質環境

金容浩,金榮吉,李廷烈,金鍾連 군산대학교 1990 群山水産專門大學 硏究報告 Vol.24 No.1

To understand the effects of oceanographic condition on the harvest of laver and establish the basic environmental data for cultivation farm of laver, a series of survey was carried out in Gojeong-ri sea area, west coast of Korea from January to September, 1987. Variation of water temperature in Gojeong-ri sea area was 3.8-25.8℃, pH was 7.8-8.4, and transparency was 1.3-3.1m. Salinity was changed from 19.57 to 31.99% and lower remarkably in July and August owing to a heavy rain. The concentration of DO in surface water wart varied from 9.4-10.1㎎/ℓ and in lower layer was 8.0-9.99㎎/ℓ . COD was 0-4.28㎎/ℓ by alkalic modification of potassium permanganate method. Distribution of total suspended solid was 13.7-488.7㎎/ℓ and the rate of light penetration in 1m water column was 7.2-15.5%. The concentration of nutrients were changed in 0.48-23.63㎍-at./ℓ for ammonia nitrogen, 0-4.45㎍-at./ℓ for nitrite nitrogen, 0.39-3.13㎍-at./ℓ for nitrate nitrogen, 0-21.42㎍-at./ℓ for phosphate, and 0.84-157.32㎍-at./ℓ for silicate. It was showed high concentration in summertime, raining season in general. The concentration of chlorophyll a was 0.39-20.62㎎/㎥. Total 57 species of phytoplankton and 21 groups of zooplankton were identified from collected samples. Dominant species were Coscinodiscus radiatus, Eucampia zodiacus as a phytoplankton and Noctiluca scinitillans, Cladocera, Copepods sp. as a zooplankton. The total standing crop of phytoplankton was ranged of 5,500-1,524,400cells/ℓ and that of zooplankton was 3,000-43,000 individuals/㎥.

뱀장어 아가미 율혈증에 관한 연구

김영길,장선일,최상훈,박관하,조정곤,최민순,김종면 한국어병학회 1995 한국어병학회지 Vol.8 No.2

뱀장어에 인위적으로 스트레스를 가하여 아가미 울혈증을 발생시킨 후에 NaCl 처리에 따른 CVS의 울혈증의 치료효과 및 혈액성상의 변화에 미치는 영향을 조사하였다. 스트레스 직후에 고빈도의 발병율을 보였던 아가미 및 간의 울혈증은 염처리 후 3일째 까지는 감소되었으나, 4일 이후에는 별 영향이 없었다. 혈액성분중 스트레스 후 증가되었던 Ht, Met-Hb, Ca^(++), GOT, GPT, LDH 및 glucose치 등과 감소되었던 Mg^(++) 및 Hb치 등은 염처리 3일까지는 회복율이 촉진되었으나, 그 이후에는 큰 차이를 보이지 않았다. 그러나 알부민 및 총단백치는 염처리 기간동안 별 변화가 없었다. 이상의 결과는 스트레스에 의해 발병된 아가미 울혈증에 대한 염처리법은 초기 3일까지는 효과가 있으나, 그 이상의 기간에는 전혀 효과적이지 못함을 보여준다. This experiment was carried out in order to elucidate the effect of NaCl(0.85%) acclimation on congestion symptoms in central venous sinuses(CVS) of gill filaments and on the alteration of blood constituents in cultured eels for 1, 2, 3, 4, 5, 6 and 7days after handling stress. After giving a handling stress on eels, the frequency of gill congestion was about 90%. It gradually decreased to 40% on the 3rd day, then increased to 60% on the 7th day in NaCl(0.85%) acclimation. The values of haematocrit(Ht), methemoglobin(Met-Hb), glucose (GLU), calcium(Ca^(++)), lactic dehydrogenase(LDH), glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase(GOT) were lower than those of the control, whereas magnesium(Mg^(++)) and haemoglobin(Hb) were higher than the control. However total protein(Tp) and albumin (ALB) levels similar to the control. When the fish after giving a handling stress were cultured in NaCl-free water as a control, the frequency of gill congestion and the value of blood components showed a similar pattern to that obtained from the NaCl acclimated experiments. However, in the early period(1-3day) after handling stress, NaCl acclimating slightly helped the natural tendancy of recovery. These results suggest that the frequency of gill congestion is not always reduced over the whole period of NaCl acclimation. However, the acclimation to NaCl solution may be a somewhat useful therapy for the gill congestion in stressed eels.

뱀장어 아가미 울혈증에 관한 연구 III. NaCl처리가 울혈증 치료에 미치는 영향

최민순,박관하,최상훈,김영길,김종면,조정곤,장선일,Choi, Min-Soon,Park, Kwan-Ha,Choi, Sang-Hoon,Kim, Young-Gill,Kim, Jong-Myeon,Cho, Jeong-Gon,Jang, Seon-Il 한국어병학회 1995 한국어병학회지 Vol.8 No.2

This experiment was carried out in order to elucidate the effect of NaCl(0.85%) acclimation on congestion symptoms in central venous sinuses(CVS) of gill filaments and on the alteration of blood constituents in cultured eels for 1, 2, 3, 4, 5, 6 and 7days after handling stress. After giving a handling stress on eels, the frequency of gill congestion was about 90%. It gradually decreased to 40% on the 3rd day, then increased to 60% on the 7th day in NaCl(0.85%) acclimation. The values of haematocrit(Ht), methemoglobin(Met-Hb), glucose (GLU), calcium($Ca^{++}$), lactic dehydrogenase(LDH), glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase(GOT) were lower than those of the control, whereas magnesium($Mg^{++}$) and haemoglobin(Hb) were higher than the control. However total protein(Tp) and albumin (ALB) levels similar to the control. When the fish after giving a handling stress were cultured in NaCl-free water as a control, the frequency of gill congestion and the value of blood components showed a similar pattern to that obtained from the NaCl acclimated experiments. However, in the early period(1-3day) after handling stress, NaCl acclimating slightly helped the natural tendancy of recovery. These results suggest that the frequency of gill congestion is not always reduced over the whole period of NaCl acclimation. However, the acclimation to NaCl solution may be a somewhat useful therapy for the gill congestion in stressed eels. 뱀장어에 인위적으로 스트레스를 가하여 아가미 울혈증을 발생시킨 후에 NaCl 처리에 따른 CVS의 울혈증의 치료효과 및 혈액성상의 변화에 미치는 영향을 조사하였다. 스트레스 직후에 고빈도의 발병율을 보였던 아가미 및 간의 울혈증은 염처리 후 3일째 까지는 감소되었으나, 4일 이후에는 별 영향이 없었다. 혈액성분중 스트레스 후 증가되었던 Ht, Met-Hb, $Ca^{++}$, GOT, GPT, LDH 및 glucose치 등과 감소되었던 $Mg^{++}$ 및 Hb치 등은 염처리 3일까지는 회복율이 촉진되었으나, 그 이후에는 큰 차이를 보이지 않았다. 그러나 알부민 및 총단백치는 염처리 기간동안 별 변화가 없었다. 이상의 결과는 스트레스에 의해 발병된 아가미 울혈증에 대한 염처리법은 초기 3일까지는 효과가 있으나, 그 이상의 기간에는 전혀 효과적이지 못함을 보여준다.