Effects of Propranolol on the Left Ventricular Volume of Normal Subjects During CT Coronary Angiography

Yuan Heng Mo,Fu Shan Jaw,Yung Cheng Wang,Chin Ming Jeng,Shinn Forng Peng 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.3

Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m2; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m2, 66.5 ± 5.1% and 63.5 ± 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed. Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m2; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m2, 66.5 ± 5.1% and 63.5 ± 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed.

On Antenna Orientation for Inter-Cell Interference Coordination in Cellular Network MIMO Systems

Jeng-Shin Sheu,Shin-Hong Lyu,Chuan-Yuan Huang 한국통신학회 2016 Journal of communications and networks Vol.18 No.4

Next-generation (4G) systems are designed to supportuniversal frequency reuse (UFR) to achieve best use of valuablespectra. However, it leads to undesirable interference level nearcell borders. To control this, 4G systems adopt techniques, suchas network multiple-input multiple-output (MIMO) and inter-cellinterference coordination (ICIC), to improve cell-edge throughput. Network MIMO aims at mitigating inter-cell interference towardscell-edge users (CEUs) through multi-cell cooperation, where eachcollaborative base station serves both cell-center users (CCUs) andCEUs, including other cells’ CEUs, under a power constraint. The present ICIC strategies cannot be directly applied to networkMIMO because they were designed in absence of multi-cell coordination. In the presence of network MIMO, this paper investigatesantenna orientations in ICIC and the method of power management. Results show that a proper antenna orientation can improvethe cell-edge capacity and meantime lower the interferenceto CCUs. Capacity inconsistency between CCUs and CEUs is detrimentaltomobile communications. Simulation results show that theproposed power management for ICIC in network MIMO systemscan achieve a uniform data rate regardless users’ position.

On Antenna Orientation for Inter-Cell Interference Coordination in Cellular Network MIMO Systems

Sheu, Jeng-Shin,Lyu, Shin-Hong,Huang, Chuan-Yuan The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.4

Next-generation (4G) systems are designed to support universal frequency reuse (UFR) to achieve best use of valuable spectra. However, it leads to undesirable interference level near cell borders. To control this, 4G systems adopt techniques, such as network multiple-input multiple-output (MIMO) and inter-cell interference coordination (ICIC), to improve cell-edge throughput. Network MIMO aims at mitigating inter-cell interference towards cell-edge users (CEUs) through multi-cell cooperation, where each collaborative base station serves both cell-center users (CCUs) and CEUs, including other cells' CEUs, under a power constraint. The present ICIC strategies cannot be directly applied to network MIMO because they were designed in absence of multi-cell coordination. In the presence of network MIMO, this paper investigates antenna orientations in ICIC and the method of power management. Results show that a proper antenna orientation can improve the cell-edge capacity and meantime lower the interference to CCUs. Capacity inconsistency between CCUs and CEUs is detrimental to mobile communications. Simulation results show that the proposed power management for ICIC in network MIMO systems can achieve a uniform data rate regardless users' position.

Design of A Semi-spherical Microphone Array Based Sound Localization System

Ming-Yuan Shieh,Ming-Hung Tsai,Chin-Chien Chen,Jeng-Han Li 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

This paper proposes a semi-spherical microphone array based sound localization system for a service robot. The hardware of the proposed system basically contains 12 capacitor microphones disposed in two layers on the semi-sphere of 19 cm diameter. It aims to estimate the degree relationship between the main speaker and the robot and provides the robot useful information for more effective human-robot interactions. The proposed system can determine the location of the voice according to energy information between the main speaker and robot not only in normal environment but also in blatant and/or reverberative spaces. The experimental results show that the proposed system has obtained satisfactory recognition efficiency, moreover, raised the robotic friendliness and adaptability.

Spousal Concordance and Cross-Disorder Concordance of Mental Disorders: A Nationwide Cohort Study

Hsieh Ming-Hong,Ju Po-Chung,Chiou Jeng-Yuan,Wang Yu-Hsun,Wang Jong-Yi,Chang Cheng-Chen 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.10

Objective Although both partners of a married couple can have mental disorders, the concordant and cross-concordant categories of disorders in couples remain unclear. Using national psychiatric population-based data only from patients with mental disorders, we examined married couples with mental disorders to examine spousal concordance and cross-disorder concordance across the full spectrum of mental disorders.Methods Data from the 1997 to 2012 Taiwan Psychiatric Inpatient Medical Claims data set were used and a total of 662 married couples were obtained. Concordance of mental disorders was determined if both spouses were diagnosed with mental disorder of an identical category in the International Classification of Diseases, Ninth Revision, Clinical Modification; otherwise, cross-concordance was reported.Results According to Cohen’s kappa coefficient, the most concordant mental disorder in couples was substance use disorder, followed by bipolar disorder. Depressive and anxiety disorders were the most common cross-concordant mental disorders, followed by bipolar disorder. The prevalence of the spousal concordance of mental disorders differed by monthly income and the couple’s age disparity.Conclusion Evidence of spousal concordance and cross-concordance for mental disorders may highlight the necessity of understanding the social context of marriage in the etiology of mental illness. Identifying the risk factors from a common environment attributable to mental disorders may enhance public health strategies to prevent and improve chronic mental illness of married couples.

Studies on the Quality of Restructured Pressed Smoked Duck Steak

Huang, Chia-Cherng,Wang, Tzu-Yuan,Huang, Andrew Jeng-Fang,Lin, Shirley Chai-Ching Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.9

The objectives of this study were to investigate the quality characteristics of restructured pressed smoked duck steak from the breast meat of Cherry Valley ducks. Different levels of isolated soybean protein (ISP) (0, 15 and $30g{\cdot}kg^{-1}$) or carrageenan (5, 10 and $15g{\cdot}kg^{-1}$) were added to manufacture the restructured pressed smoked duck steak. The results were as follows: No significant differences were observed for moisture, crude fat, crude protein, cooking loss and water holding capacity of products from all treatments. The panel test scores showed that color, flavor and binding ability of products were considered acceptable. The drip loss in control sliced-products was significantly higher than products containing ISP or carrageenan (p<0.05) during storage at $-18^{\circ}C$ for 12 weeks. The pH value, volatile basic nitrogen (VBN) value and thiobarbituric acid (TBA) value of vacuum-packaged products did not change significantly during storage at $-18^{\circ}C$ for 6 weeks. However, TBA values increased with storage time. The viable bacterial counts were about $10^{3}-10^{4}CFU/g$ during storage at $-18^{\circ}C$ for 12 weeks. The products remained good quality during the storage period.

Role of Salivary Immune Parameters in Patients With Primary Sjögren’s Syndrome

Yu-Hung Hung,Yung-Hung Lee,Pei-Pei Chen,Yuan-Zhao Lin,Chia-Hui Lin,Jeng-Hsien Yen 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.1

Background: Several factors, including clinical manifestations and laboratory data, have been used to evaluate the disease activity of Sjögren’s syndrome (SS). We investigated saliva indicators of disease activity in primary SS patients. Methods: We enrolled 138 Taiwanese patients with primary SS and 100 Taiwanese normal controls. Interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha (TNF-α), and rheumatoid factor (RF)-IgA levels in saliva samples were measured using ELISA or fluorescent enzyme-linked immunoassay. Serum IgG, IgA, and IgM levels were measured by nephelometry. Erythrocyte sedimentation rate (ESR) was measured with an automatic ESR analyzer. The t-test and Pearson correlation test were used. Results: IL-6 level was higher in primary SS patients than in normal controls (14.23±14.77 vs 9.87±7.32, P=0.012), but there were no significant differences in IL-17A, TNF-α, and RF-IgA levels. In primary SS patients, IL-6 level correlated weakly with ESR and IgG levels (r=0.252, P=0.015, and r=0.248, P=0.017, respectively), and TNF-α level correlated weakly with IgG level (r=0.231, P=0.024). Conclusions: IL-6 may play a role in SS pathogenesis. Saliva IL-6 might be an indicator of disease activity in primary SS patients.

Association between Thioridazine Use and Cancer Risk in Adult Patients with Schizophrenia-A Population-Based Study

Cheng-Chen Chang,Ming-Hong Hsieh,Jong-Yi Wang,Nan-Ying Chiu,Yu-Hsun Wang,Jeng-Yuan Chiou,Hsiang-Hsiung Huang,Po-Chung Ju 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11

Objective Several cell line studies have demonstrated thioridazine’s anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia. Methods Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy. Results The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer. Conclusion Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.

On the direct insulator-quantum Hall transition in two-dimensional electron systems in the vicinity of nanoscaled scatterers

Liang, Chi-Te,Lin, Li-Hung,Kuang Yoa, Chen,Lo, Shun-Tsung,Wang, Yi-Ting,Lou, Dong-Sheng,Kim, Gil-Ho,Yuan-Huei, Chang,Ochiai, Yuichi,Aoki, Nobuyuki,Chen, Jeng-Chung,Lin, Yiping,Chun-Feng, Huang,Lin, Sh Springer 2011 Nanoscale research letters Vol.6 No.1

<P>A direct insulator-quantum Hall (I-QH) transition corresponds to a crossover/transition from the insulating regime to a high Landau level filling factor ν > 2 QH state. Such a transition has been attracting a great deal of both experimental and theoretical interests. In this study, we present three different two-dimensional electron systems (2DESs) which are in the vicinity of nanoscaled scatterers. All these three devices exhibit a direct I-QH transition, and the transport properties under different nanaoscaled scatterers are discussed.</P>