FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

골다공증 환자에서 Alendronate (Marvil)의 1년간 치료효과

김효정,박지원,이수진,이관우,김현만,정윤석 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: Alendronate는 골흡수 억제작용을 가진 비스포스포네이트 제재 중 하나로 골다공증의 치료와 예방에 사용되고 있으며 골밀도를 증가시키고 골다공증으로 인한 골절의 빈도를 감소시킨다고 보고되고 있다. 방법: 본 연구는 alendronate(Marvil??)가 골다공증의 치료에 미치는 효과를 검증하기 위하여 138명의 골다공증 진단을 받은 환자를 대상으로 시작하였고 1년 후 50명에서 골대사지표와 골밀도를 추적관찰하였다. 결과: Alendronate를 1년간 투여하였을 때 혈청 ALP는 38.3% 감소하였고 요중 DPD는 40.5% 감소하였다. Alendronate를 1년간 투여하였을 때 L2-4의 평균 골밀도는 6.7% 증가하였고 대퇴골의 평균 골밀도는 20.% 증가하였다. 4명(8%)에서 1년 이내에 새로운 골절이 발생하였고 이 중 3명은 척추골절, 1명은 대퇴골절이었다. 부작용으로 투약을 중단한 환자는 8명(5.8%)이었고 이 중 7명(5.1%)이 소화기증상을 호소하였다. 결론: 이상의 결과로 골다공증 환자에서 alendronate(Marvil??)의 1년간 투여가 골밀도를 증가시킴을 알 수 있었다. Background: To evaluate the effects of alendronate in preventing bone loss at the spine and hip in Korean cases of primary osteoporosis, we treated 138 patients with 10㎎ of alendronate daily. Of the 138 patients treated, 50 were treated for one complete year, and at their final visit, measurements were taken to assess the completed outcome of reatment, and the results from this small group were compared with those of the rest. The way this has been written causes ambiguity concerning exactly who was being studied. Check that my rewrite of this section conveys correctly the group that was studied, and how. Methods: The serum levels of calcium(Ca) and phosphorous(P), total alkaline phosphatase(ALP), the urine calcium creatinine ratio(Uca/cr) and urine deoxypyridinoline(DPD) were measured before, during, and after the 1 year treatment period. The bone mineral densities(BMDs) at the spine and hip were also measured before and after the treatment period. New clinical fractures and side effects, were evaluated during the treatment period. Results: The total serum ALP and urine DPD were decreased significantly, after the treatment period, by 38.3 and 40.5% respectively. The bone mineral density at the spine and hip were significantly increase after 1 year, by 6.7 and 2.0%, respectively. Of the 50 subjects who had completed a full year of treatment, only 4(8%) had developed new clinical fractures. Of the 138 patients who had been treated, 8(5.7%) discontinued the medication due to side effects. Of these, 7 had gastrointestinal symptoms, and 1 had skin eruption. Conclusion: Alendronate significantly decreased the total serum ALP and urine DPD and significantly increase spine and hip bone mineral density. Alendronate 10㎎ was effective in preventing bone loss in Korean cases of primary osteoporosis (J Kor Soc Endocrinol 18:56∼62, 2003)

푸드뱅크 기탁식품의 안전성 확보를 위한 HACCP 제도 적용

김철재,박현신,배현주,이지해,양일선,강혜승 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.3

The purpose of this study was to analyze the problems arising from the actual conditions of the Foodbank, and to implement the HACCP system as a solution in terms of increasing the safety of donated food within the Foodbank. In order to apply HACCP system, the entire Foodbank working process such as preparation, collection, transportation, division, and distribution was considered and analyzed to decide the application point for CCPs. Donated foods mainly consisted of processed foods, raw materials, lunch boxes, and cooked foods from mass catering establishments, which dominated over the others in terms of quantity. Cooked foods were divided into three groups based on menu-types and processing methods. Temperature, pH, and aw were measured on cooked foods, and Total Plate Count, Coliforms, E. coli, Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, and E. coli O157:H7 were conducted in order to apply a HACCP plan. Form these experiments, temperature, pH, and aw of donated food were likely contributed to microbial growth. Donated foods before HACCP implementation showed high numbers in terms of total plate count and Coliforms, both well over the acceptable standard levels. By setting the CCPs on maintenance of donated food below 10℃ and using a 75 ℃ reheating method, microbiological hazard levels were able to be controlled and lowered. From these results, it is concluded that in order to guarantee food safety, foods donated to the Foodbank must not only maintain a reasonable level of initial microbiological growth, but also must be handled properly through time and temperature controls within the Foodbank system. Furthermore, in terms of implementing the HACCP plan within the Foodbank management structure, basic food safety and sanitation measures, such as reheating facilities and various cold chain systmes such as refrigerated vehicle for food transportation are importantly needed. The training and education of Foodbank personnel and management in areas such as awareness of hygiene and safe food handling and practice are also required and necessary.

Thermotherapy for Na⁺/I⁻ symporter-expressing cancer using anti-Na⁺/I⁻ symporter antibody-conjugated magnetite nanoparticles

Jee, Hyeon-Gun,Ban, Hyun Seung,Lee, Jung Hee,Lee, Sang Hun,Kwon, Oh Seok,Choe, Jun Ho Elsevier 2018 Journal of industrial and engineering chemistry Vol.63 No.-

<P><B>Abstract</B></P> <P>Surgery, followed by remnant ablation with radioactive iodine (I-131), is used for treating differentiated thyroid carcinoma (DTC) as the sodium–iodine (Na-I) symporter (NIS) is highly expressed in the thyroid and DTC cells. Our aim was to investigate the feasibility of using anti-NIS antibody-conjugated magnetite nanoparticles (NIS-MNPs) as a diagnostic and therapeutic agent for DTC by studying NIS-MNP in an NIS over-expressing HeLa (HeLa-NIS) cell line and a subcutaneous HeLa-NIS tumor-bearing mouse model. Immunofluorescence was used to determine if NIS-MNP could bind to HeLa-NIS, and its therapeutic effect was investigated using HeLa-NIS cells after alternating magnetic field (AMF) irradiation. Magnetic resonance imaging (MRI) was performed to visualize the normal thyroid gland of nude mice after intravenous injection of NIS-MNP. NIS-MNPs were injected into the cancer nodules of the mouse model, which were irradiated under AMF for 1h twice at 24-h intervals. Accumulation of NIS-MNP was examined using MRI and tumor volume was measured over seven days. Results showed that NIS-MNP bound effectively to the surface of HeLa-NIS cells, and AMF inhibited growth of NIS-MNP-treated HeLa-NIS cells. Normal thyroid glands of mice were enhanced by NIS-MNP treatment in T2-weighted MRI. Inhibition of tumor growth was observed after AMF irradiation in the NIS-MNP group. In conclusion, NIS-MNP is a feasible diagnostic and therapeutic tool for localizing and treating NIS-expressing tumors such as DTC when coupled with AMF irradiation.</P> <P><B>Graphical abstract</B></P> <P>In this study, an anti-NIS antibody-conjugated magnetite nanoparticle (NIS-MNP), which is enhanced on T2-weighted magnetic resonance imaging (MRI) and generates heat in an alternating magnetic field (AMF), was synthesized as an alternative NIS targeting therapy. Our aim was to investigate the feasibility of using NIS-MNPs as a diagnostic and therapeutic agent for DTC by studying NIS-MNP in an NIS overexpressing HeLa (HeLa-NIS) cell line and a subcutaneous HeLa-NIS tumor-bearing mouse model. Results showed that NIS-MNP bound effectively to the surface of HeLa-NIS cells, and AMF inhibited cellular growth of NIS-MNP-treated HeLa-NIS cells. Normal thyroid glands of mice were enhanced by NIS-MNP treatment in T2-weighted MRI. Inhibition of tumor growth was observed after AMF irradiation in the NIS-MNP group.▪</P> <P>[DISPLAY OMISSION]</P>

Developing Elementary School Teachers’ Professionalism Through the IB PYP Curriculum Implementation Experiences

( Jee-hyeon Park ) 경북대학교 중등교육연구소 2023 Asia Pacific Journal of Educational Research Vol.6 No.1

P129 Effects of citron essential oils on VEGF, TRPV1, IL-8 release from normal human epidermal keratinocytes stimulated with TNFα

( Hyeon Woo Jeon ),( Soo Hyeon Bae ),( Sook Jung Yun ),( Seung-chul Lee ),( Jee-bum Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Citron is well-known for it’s abundant antioxidative ingredients such as vitamin C, polyphenol compounds, and limonoids. Objectives: We aimed to evaluate the anti-oxidant and anti-inflammatory activities of citron essential oils on the activated keratinocytes in vitro. Methods: We used normal human epidermal keratinocytes (NHEKs) derived from neonatal foreskin. In order to evaluate the antioxidant activities of citron, DPPH radical scavenging activity, intra- and extracellular ROS generation and expressions of anti-oxidant enzymes (HO-1, Prx-1, CAT, SOD-2; Mn-SOD) were analyzed. Also, to evaluate the anti-inflammatory activity of citron essential oils on epidermal cells, NHEKs were stimulated with TNFα and vascular endothelial growth factor (VEGF), transient receptor potential vanilloid 1 (TRPV1), IL-8 were induced. These mediators were analyzed after treatment of citron seed and unripe citron oils, and also EGCG as a control. The analysis was performed by semi-quantitative RT-PCR, immunocytofluorescence and ELISA. Results: mRNA and protein levels of VEGF, TRPV1, and IL-8 of activated keratinocytes were suppressed by citron seed and unripe citron oils. Conclusion: These results show that citron essential oils possess both anti-inflammatory and anti-angiogenic properties, which indicate that this agent may be a valuable adjuvant treatment candidate for rosacea.

[PF-0015] A Study on the Genetic Pattern of polyembryony in the F1 Population of citrus (‘Citrus kiyomi’ x ‘Citrus sunki’)

Jee-Soo Park(Jee-Soo Park ),Cheol-Woo Choi(Cheol-Woo Choi ),Su-Hyeon Yoon(Su-Hyeon Yoon ),Suk-Man Park(Suk-Man Park ),Seong-Beom Jin(Seong-Beom Jin ) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Epidural Blood Patch for Recurrent Altered Consciousness due to Severe Spontaneous Intracranial Hypotension: A Case Report

Hyeon Sook Jee,Keoung Ah Kim,Woo Seog Sim,Dae Won Lee,Jin Young Lee 대한통증연구학회 2020 International Journal of Pain Vol.11 No.2

Spontaneous intracranial hypotension (SIH) is characterized by orthostatic headache, nausea, vomiting, and blurred vision. Rarely, behavioral or consciousness changes, parkinsonian symptoms, and/or coma manifest. The use of an epidural blood patch (EBP) is generally considered for sealing a cerebrospinal fluid (CSF) leak. Herein we report a case of progressive altered consciousness due to severe SIH that was managed with an EBP. Brain magnetic resonance imaging depicted diffuse pachymeningeal enhancement with bilateral subdural hemorrhage, consistent with SIH. She was diagnosed with brain sagging due to SIH. An EBP was performed at C7- T1 and she was discharged with improvement; however, 1 day after discharge she visited the emergency room exhibiting aggressive behavior and cognitive changes. Whole spine magnetic resonance imaging revealed CSF leakage at T1-T5, and she was diagnosed with recurred SIH with SDH. EBP was performed at T2-T3 level with autologous blood. Follow-up myelography depicted improvement of the CSF leakage at the T spine level. Targeted EBP may be suitable for alleviating severe SIH-induced confusion and altered consciousness.

Symposium on Strategy for Drug Research and Development : The Role and Regulation of MCL - 1 Proteins in Apoptosis Pathway

(Jee Hyeon Bae) 서울시립대학교 산업기술연구소 2002 국제학술SYMPOSIUM논문집 Vol.10 No.1

Control of Oral Malodor Using a Dentifrice Containing Tocopherol Acetate, Calcium Phosphate Tribasic, and Dental Type Silica: A Clinical Study

Jee-Hyeon Shim,Su-Kyung Jwa 대한예방치과학회 2017 International Journal of Clinical Preventive Denti Vol.13 No.4

Objective: The aim of this study was to identity the effect of dentifrice including tocopherol acetate, calcium triphosphate and dental silica on lowering a halitosis. Methods: Thirty participants with moderate to heavy bad breath between 20 to 50 years employed the specific dentifrice for 4 weeks. Subjects brushed their teeth with the rolling methods three times per day for 3 minutes. Measurement of oral odor was performed at baseline, after 1 week, 2 weeks and 4 weeks. Results: The B & B checker Value (BBV) by using BB Checker was 72.41±21.26 BBV (baseline), 59.10±22.87 BBV (after 1 week), 58.41±28.84 BBV (after 2 weeks), 47.00±26.32 BBV (after 4 weeks), respectively, and bad breath was significantly reduced at every measurement (p<0.05). The amount of volatile sulfur compounds decreased at each measurement interval: 4.45±4.93 ng/10 ml (baseline), 2.80±2.44 ng/10 ml (after 1 week), 2.83±2.23 ng/10 ml (after 2 weeks), 2.05±1.18 ng/10 ml (after 4 weeks). There was a statistically significant decrease at 1 week, 2 weeks, and 4 weeks compared with baseline (p<0.05). Conclusion: The results of the present study supported the fact that the dentifrice including tocopherol acetate, calcium triphosphate and dental silica has a positive effect on lowering a halitosis.