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토끼 신장 근위세뇨관 일차 배양 세포에서 Bradykinin의 Phospholipase D(PLD)에 의한 신호 전달 기전
정성현,박경협,정지창 慶熙大學校 1993 論文集 Vol.22 No.-
Recently, phospholipase D (PLD) is known to be involved in several bioactive materials-mediated signal transduction pathway. In order to investigate how bradykinin works in renal tissue, we in this study wants to figure out whether bradykinin mediates its physiological actions through activation of PLD or not. Bradykinin, which is a well known neuroactive peptide and plays many important physiological roles as vasodilatation, hyperalgia, has been reported to activate PLD in PC12 cells. As a corollary of our experimental results, we are first group ever to reveal the positive involvement of PLD in bradykinin-mediated signal transduction mechanism in the rabbit kidney proximal tubule cells.
Chung, Hwa-Jee,Cho, In Sook,Kim, Jee-Hyub,In Dong Su,Hur, Cheol Goo,Song, Ji Sook,Woo, Sung Sick,Choi, Dong-Woong,Liu, Jang Ryol 한국식물학회 2003 Journal of Plant Biology Vol.46 No.3
Researchers have widely adopted the hairy mot culture system as a means for producing secondary metabolites, including ginsenosides from ginseng. Although bacterial genes are involved, the aspects of plant gene expression are unclear. Using a cDNA microarray approach, we identified genes that are differentially expressed in ginseng hairy roots after Agrobacterium rhizogenes infection. Our goal was to gain an initial understanding of the correlation between hairy root morphology and ginsenoside production. Among the 250 genes analyzed here, 63 (including 14 that are unclassified) were differentially expressed in a hairy root line containing a high level of ginsenosides. Of the genes that had been functionally categorized, 29% and 17% were active in metabolism and stress responses, respectively. Most were primarily associated with ribosomal proteins, thereby functioning in protein synthesis and destination. Their expression was down-regulated in hairy roots having less lateral branching. This phenotype may have resulted from the manipulation of metabolic activities by the translational machinery.
췌장 낭성 종양으로 오인된 췌장 내 부비장의 유표피 낭종 2예
김지현 ( Jee Hyun Kim ),정광현 ( Kwang Hyun Chung ),오수연 ( Soo Yeon Oh ),이준영 ( June Young Lee ),장승현 ( Seung Hyeon Jang ),이상협 ( Sang Hyub Lee ),류지곤 ( Ji Kon Ryu ),김용태 ( Yong Tae Kim ) 대한췌장담도학회 2014 대한췌담도학회지 Vol.19 No.1
Epidermoid cyst in the intrapancreatic accessory spleen is extremely rare condition which could be mistaken for pancreatic cystic neoplasm. We report two cases of epidermoid cysts of intrapancreatic accessory spleen which mimicking pancreatic cystic neoplasm. Two patients, both male, aged 47 and 53 respectively were referred to our department for pancreatic mass. One was asymptomatic, whereas the other presented worsening abdominal pain and progressive weight loss. In both cases, the mass with cystic component was detected in the pancreatic tail in a computed tomography scan. Under a suspicion of pancreatic cystic neuronendocrine tumor, they underwent a distal pancreatectomy. Pathologic feature of resected specimens were shown to benign squamous lined cyst with splenic tissue in and around cyst wall which suggested that epidermoid cysts in the accessory spleen. We should take into account the possibility of epidermoid cyst in the intrapancreatic accessory spleen in the differential diagnosis of pancreatic cystic lesion. Korean J Pancreatobiliary 2014;19(1):52-58
A Case of Primary Cutaneous Sporotrichoid Nocardiosis Caused by Nocardia asteroides
Choi, Jee Ho,Sung, Kyung Jeh,Moon, Kee Chan,Koh, Jai Kyoung,Lee, Sang Hyub,Suh, Chi Woo 대한피부과학회 1999 Annals of Dermatology Vol.11 No.2
We report a case of a 42-year-old woman who suffered from recurrent nodular skin lesions on her left foot. Sporotrichoid fungal infection was suspected and two linear nodular skin lesions that had occurred after trauma in a public pool were treated with itraconazole for 4 months. These nodular skin lesions were completely flattened. However, four months after complete flattening, a new lesion developed in the scar of a previous nodule. N. asteroides, which is extremely rare far sporotrichoid cutaneous nocardiosis, was cultured from the relapsed lesion. We treated this case with trimethoprim-sulfamethoxazole r 6 months under an emperical basis and this resulted in complete healing, and sensitivity of N. asteroide to trimethoprim-sulfamethoxazole was confirmed later. There has been no recurrence for 3 years. To our knowledge, our case is the first report in the english literature of primary sporotrichoid cutaneous nocardioss caused by N. asteroides in terms of anatomic location below the knee and host immunocompetency.
Bcl - 2 단백을 이용한 면역조직학적 방법에 의한 기저세포암과 모낭 상피종의 감별
이상협 ( Sang Hyub Lee ),서호석 ( Ho Suk Suh ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1
Background: It is important to distinguish trichoepitheliomas from basal cell carcinomas because, despite the similarity of clinical and histological findings, the treatments and prognoses are different. bcl-2 is a newly characterized protooncogene that has been shown to suppress programmed cell death(apoptosis), which is involved in tumorigenesis, and its expression has been demonstrated within tumor cells in a variety of neoplasms. Objective : We tried to evaluate the staining pattern of bcl-2 protooncogene in basal cell carcinomas and trichoepitheliomas. Methods : We examined cases of basal cell carcinomas and trichoepitheliomas with the immunohistochemical method of labelled streptavidin-biotin complex in paraffin-embedded sections using the antigen retrieval method. Results : 1. The bcl-2 staining pattern in basal cell carcinomas was diffuse throughout the tumor lobules, but multifocal absences of bcl-2 staining were identified in sites of follicular differentiation. Also, inhomogeneous staining patterns were observed around the cystic, glandular structure of several subtypes of basal cell carcinoma. 2. The trichoepitheliomas showed staining of tumor cells limited to the outer layers of the tumor lobules. 3. Normal skin showed staining of basal keratinocytes, rnelanocytes in the epidermis, and eccrine gland secretory cells, basal layer of follicular structures, and dermal hair papilla in the dermis. Conclusion : The immunohistcchemical bcl-2 staining is helpful for the differentiation of basal cell carcinomas from trichoepitheliomas particularly in borderline cases and the explanation of different biologic courses for the two diseases. Further investigation of bcl-2 staining in other malignant skin diseases should be undertaken, and its practical adaptation should be more widely used in borderline cases. (Kor J Dermatol 1996;34(1): 31-37)
접촉피부염 환자의 조직 병변에서 보인 Incidental Acantholysis
이상협 ( Sang Hyub Lee ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3
Incidental acantholysis is a rare histologic findings, and reported in basal cell carcinoma, keratoacanthoma, psoriasis, tinea corporis, etc. We describe a case of contact dermatitis in a 64-year-old female who suffered from recurrent itchy, erythematous patches on face, neck, and shoulder. She presented with recently aggravated itchy skin lesions after using perfume and Tiger balm. Patch test showed strong positive reaction to balsam of Peru, fragrance anix, and Tiger balm. A biopsy specimen showed lichenoid dermatitis and incidental focal acantholysis which was not previously reported in literatures. (Kor J Dermatol 1996;34(3): 422-425)