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Jean-Luc Malo,Susan Stock,Masaharu Kumashiro 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-
Duration of work absence has a major impact on health costs related to musculoskeletal injuries. Primary prevention has not proven to be an efficient solution to manage all cases of musculoskeletal disorders (MSD) particularly for low back pain. Secondary prevention by the means of an early return to work is a scientifically supported avenue to reduce the burden of MSD. This presentation describes the integration of ergonomics into the return to work process. The main example is described in the publication “Work-related Musculoskeletal Disorders: Guide and Tools for Modified Work”, meant to assist companies in managing return to work. The guide includes a follow-up algorithm, six steps to build a return to work program, worksheets to estimate the physical work demands of return to work tasks and forms to communicate with the treating physician.
Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation
Cadet, Jean,Douki, Thierry,Ravanata, Jean-Luc,Di Mascio, Paolo Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.7
The survey is aimed at critically reviewing information on the UVA-mediated oxidative reactions to cellular components with emphasis on DNA as the result of mostly photosensitized pathways. It appears clearly that UVA radiation is relatively much more efficient than UVB photons in inducing oxidative processes. The main UVA-induced oxidative degradation pathways of DNA are reported and discussed mechanistically. They are mostly rationalized in terms of a major contribution of singlet molecular oxygen ($^1O_2$) and to a lesser extent of hydroxyl radical (${\cdot}OH$), that in the latter case originates from Fenton-type reactions. This leads to the predominant formation of 8-oxo-7,8-dihydroguanine together with smaller amounts of oxidized pyrimidine bases and DNA strand breaks in UVA-irradiated cells.
Steroid Biosynthesis within the Frog Brain : A Model of Neuroendocrine Regulation
Rego, Jean-Luc Do,Seong, Jae Young,Burel, Delphine,Luu-The, Van,Larhammar, Dan,Tsutsui, Kazuyoshi,Pelletier, Georges,Tonon, Marie-Christine,Vaudry, Hubert Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1163 No.1
<P>There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [(3)H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.</P>
Genetic optimization of vibrating stiffened plates
Marcelin, Jean Luc Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.5
This work gives an application of stochastic techniques for the optimization of stiffened plates in vibration. The search strategy consists of substituting, for finite element calculations in the optimization process, an approximate response from a Rayleigh-Ritz method. More precisely, the paper describes the use of a Rayleigh-Ritz method in creating function approximations for use in computationally intensive design optimization based on genetic algorithms. Two applications are presented; their deal with the optimization of stiffeners on plates by varying their positions, in order to maximize some natural frequencies, while having well defined dimensions. In other words, this work gives the fundamental idea of using a Ritz approximation to the response of a plate in vibration instead of finite element analysis.
Do Rego, Jean Luc,Seong, Jae Young,Burel, Delphine,Leprince, Jerô,me,Luu-The, Van,Tsutsui, Kazuyoshi,Tonon, Marie-Christine,Pelletier, Georges,Vaudry, Hubert Elsevier 2009 Frontiers in neuroendocrinology Vol.30 No.3
<P><B>Abstract</B></P><P>Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids are also involved in the control of a number of behavioral, neuroendocrine and metabolic processes such as regulation of food intake, locomotor activity, sexual activity, aggressiveness, anxiety, depression, body temperature and blood pressure. In this article, we summarize the current knowledge regarding the existence, neuroanatomical distribution and biological activity of the enzymes responsible for the biosynthesis of neurosteroids in the brain of vertebrates, and we review the neuronal mechanisms that control the activity of these enzymes. The observation that the activity of key steroidogenic enzymes is finely tuned by various neurotransmitters and neuropeptides strongly suggests that some of the central effects of these neuromodulators may be mediated via the regulation of neurosteroid production.</P>
Ayitou, Anoklase Jean-Luc,Ugrinov, Angel,Sivaguru, J. Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.6
O-tert-Butylacrylanilides with N-H substitution undergo $6{\pi}$-photocyclization at the unsubstituted ortho carbon, whereas the corresponding N-methyl derivatives cyclize at the ortho carbon bearing the tert-butyl with the eventual loss of 2-methylpropene.