선천성 완전방실차단이 동반된 신생아 루프스 1예

정재현,이은지,이은주,황진원,송영진,최병진,김일환,김종윤,허민영,김동욱 인제대학교 2009 仁濟醫學 Vol.30 No.-

Neonatal lupus is a rare syndrome occurring In neonates with tranplacentally acquired maternal autoantibodies, In particular anti-SSA/Ro-SSB/Ra antibodies. Manifestations include congenital heart block, cutaneous lesions, thrombocytopenia, neutropenia, pulmonary or neurological disease and hepatitis. The non-cardiac manifestations resolve by 6 months of age, congenital heart block is irreversible. We experienced a case of neonatal lupus with congenital complete heart block in a newborn of asyptomatic mother with anti-SSA/Ro-SSB/Ra antibodies.

저작근 골막하 박리를 이용한 만성 재발성 탈구의 치험례

심재환,김기홍,문진석,민병진,이원학,홍광진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.3

Chronic recurrent dislocation(CRD) of the jaw has various etilogical causes, including trauma, congenital or acquired neurological illness, ingestion of certain medicines, incorrdination of the neuromuscular astivity of the chewing muscles, articular anatomical alteration, etc. Various surgical methods have been advocated for the treatment of the CRD. They may be divided into two groups: procedures designed to limit translation of the condyle and procedures eliminating obstacles in the condylar path. Hypomobility of mandible can be developed after BSSRO and it is probably caused by scar contracture, atrophy, and myofibrosis. Many authors, therefore, emphasized the importance of physical therapy especially after BSSRO to prevent the complication. Based on that idea, we designed more conservative surgical method to limit mandibular openning compared the methods that previously introduced and tried to treat the CRD. This new method consists of extensive subperiosteal dissection of masseter and the temporalis muscle under local anesthesia and use of intermaxillary elastics for some periods.

ESO 기법을 이용한 컴플라이언트 메커니즘 설계

이원구,박재용,김상락,유진식,한석영 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

A compliant mechanism is a mechanism that produces its motion by the flexibility of some or all of its members when the input forces are applied. Whereas the topology optimization based on homogenization and SIMP parameterization has been successfully applied for compliant mechanism design, an ESO approach has not been considered yet for the optimization of these types of systems. This work presents a modified version of the evolutionary structural optimization (ESO) Procedure for its application in topology optimization of compliant mechanisms, It will be shown that an additive version of this method must be adopted in order to achieve the optimum design, since the traditional ESO method's element removal technique is not efficient in this case. The methodology is based on a mutual energy concept for formulation of flexibility and the ESO method. A multi-objective optimization problem is formulated as an application of compliant mechanism design. The procedure has tested in several numerical applications and benchmark examples to illustrate and validate the approach.

사람 태아간의 산호성 과립백혈구형성에서 산호성 과립형성에 대한 미세구조 연구

송재섭,김경용,이원복,김동창 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.4

The developmental processes of eosinophilic granule formation were ultrastructural investigation of eosinophilic granulopoiesis in 15 cases of human fetal livers from 8 to 34 weeks of gestation. 1) Numerous vesicles, microgranules and small agranular and granular vacuoles were distributed around the distended Golgi apparatus in myeloblast and eosinophilic promyelocyte. 2) Granular matrix of vacuoles contained small granular vacuoles, serveral vesicles and mutilamellar structures. The granular substance exhibited higher electron density than that of cystic rough endoplasmic reticulum(RER) and was similar partly to that of immature eosinophilic granules. 3) Distended cystic RER was fused to produce matrix of maturing granules with granular vacuoles and immature eosinophilic granules. 4) Immature eosinophilic granule which began to be produced in eosinophilic promyelocyte, had myelin sheath-like structure and debris of vesicles and granular vacuoles and those disappeared immediately. The charicteristic crystalloid inclusions began to develop in immature eosinophilic granule of myelocyte. In summary, it is suggested that vesicles and granular vacuoles as well as RER in the myelocyte and promyelcyte are participating in the formation of immature eosinophilic granules which become mature with the appearance of charicteristic crystalloid inclusion

급성 골수성 백혈병 환자에서 관해 유도 항암 화학요법 후 발생한 베르니케 뇌증

황진원,정재현,서광원,최병진,송영진,김종윤,이은지,임홍규,이상민 인제대학교 2009 仁濟醫學 Vol.30 No.-

Wernicke's encephalopathy is characterized by the triad of ocular symptoms, ataxia, and mental confusion and neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use, hyperemesis gravidarum, anorexia nervosa, hemodialysis, uremia, and acquired immunodeficiency syndrome(AIDS). Chemotherapy in patient with malignanacy and long term total parenteral nutrition following bone marrow transplantation are related with Wernicke's encephalopathy. A 48-year-old woman had been treated with Daunorubicin and Cytarabine for remission induction chemotherapy of acute myeloblastic leukemia and intravenous hyperalimentation due to persistent hematochezia and ileus caused by infiltration of leukemic cell in terminal ileum. She suddenly complained of diplopia, tremor, and mental confusion at 32th day after chemotherapy and generalized tonic-clonic seizure at 34th day after chemotherapy. The diagnosis of Wernicke's encephalopathy was made with clinical presentations and brain MRI. Brain MR T2-weighted & Flair image revealed a high signal intensity lesions bilaterally at the medial thalamus and peri-acueductal grey matter of the midbrain. The patient was successfully treated with vitamin B1. We presented a case of acute Wernicke's encephalopathy developed after remission induction chemotherapy followed by intravenous hyperalirnentation in a patient with acute myeloblastic leukemia.

Si 기판 위에 CeO_2 유전체 박막 성장

한재원,김상훈,한영기,최무용 성균관대학교 기초과학연구소 1994 論文集 Vol.45 No.1

CeO_2 single target을 사용하여 on-axis rf magnetron 스퍼터링 방법으로 Si(100) 단결정기판 위에 CeO_2 유전체 박막을 성장시킬 때 기판온도, 산소 부분압력, rf input power, 두께 등의 성장변수들이 박막 성장에 미치는 영향을 조사하여 (ℓ00) 방향 in-situ 성장의 적정조건을 찾는 연구를 하였다. 각기 다른 조건에서 제조된 박막의 X-ray 회절 방법에 의한 구조 분석과 SEM(Scanning Electron Microscopy)에 의한 표면의 미세 구조 분석을 통하여 그 특성을 조사한 결과 기판 온도, 산소 부분압력, rf input power 세기, 박막의 두께가 박막 성장에 결정적인 영향을 미치는 중요 성장 변수임을 확인하였다. CeO_2 박막은 target과 기판사이 거리 50㎜, 총압력 30mTorr일 때 기판 온도 800℃, 산소 부분압력 3 mTon, power 90 W(이때 성장속도 0.83Å/s), 성장시간 2시간(이때 두께 500Å)일 때(ℓ00) 방향으로 잘 성장되는 것을 발견하였다. We have studied systematically the optimum condition for in-situ perparation of CeO_2 thin film on Si(100 substrate by single-target rf-magnetron sputtering method. We examined effects of the substrate temperature, oxygen partial pressure, rf input power, and thickness by studying X-ray diffraction patterns and photographs of scanning electron microscopy of the grown films. We found that all of these parameters influence decisively on the struture of the grown films. We also found that the CeO_2 thin film grows well at∼800℃ of the substrate temperature, 3 mTorr of the oxygen partial pressure, 90 W of the rf input power(corresponding to 0.83Å/s of the deposition rate), and 5000 Å of the thickness for the total sputtering gas of 30 mTorr and the sputtering target of 2 inch diameter used.

냉각탑용 프로펠러 팬의 설계

김재원,이정민 선문대학교 중소기업기술지원연구소 2001 선문공대 연구/기술 논문집 Vol.6 No.1

냉각탑에 쓰이는 프로펠러 팬의 설계와 개발은 선행 수치해석과 풍동에 의한 실험적 확인으로 이루어졌다. 팬의 날개 형상에서 가장 중요한 것은 공기 역학적 현상의 최적 설계이다. 본 연구에서의 수치해석 방법은 FINE/TURBO라는 상용 프로그램을 이용하여 날개 근처의 자세한 유선과 유량 등의 공학적 자료를 얻었다. 전산 해석 연구에서 얻어진 수치 해석의 결과는 풍동을 이용한 실험 결과와의 비교에서 우수한 정확도를 보여 주었다. 또한, 새로이 제안한 날개의 수치 해석결과 현재 시장에서 판매하고 있는 모델보다 상대적으로 우수한 결과가 도출되었다. Design and developments of a propeller fan for a cooling tower have been accomplished by both numerical prediction of performance and experimental validation with a wind tunnel. Main interest lies on blade geometry of a fan for optimal design of aerodynamic performance. A commercial program, Fine/Turbo used for the present numerical estimation, which gives us engineering information such as flow details near the blades and flow rate of the system. The numerical results are compared with experimental output and show good agreement in comparison between the two data. Also, new proposed model of a blade show improved performance relative to present model in the market.

國民年金制度 發展方向

朴在元 대구보건대학 1994 대구보건대학 論文集 Vol.14 No.-

The national pension system is the most important social security system along with health insurance program to realize a welfare state. To develop and fix the system in the hopeful direction earily, first of all, national pension program must be expanded to the farmers and fishermen due to the worst income per capita at farm villages that are much lower than cities', Uruguay Round compromises and rapid aging society etc as wll as to one's own businessmen, and also must be studied the methods which are able to grasp their income correctly. To keep a stable management of national pension fund, highly profitable goods must be shared in a higher rate when the investment of financial sector has been made. Not only that, public sector must be operated in the minimum range under the consideration of financial stabiliazation for the fund.

디클로페낙 프로드럭들의 흰쥐 피부 투과

도희정,조원제,용철순,이치호,김대덕 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Various alkyl ester prodrugs of diclofenac were synthesized in order to investigate the relationship between their skin permeation characteristics and physicochemical properties. Solubility in various vehicles was measured at room temperature. I -Octanol/water partition coefficients (Log P) and capacity factors (k') were measured to determine the lipophilicity of the prodrugs. Stability of prodrugs in the skin extract and homogenate was also investigated before conducting the skin permeation studies. Increases in the Log P and capacity factor values were observed when alkyl esters of diclofenac were prepared. Since the aqueous solubility of the prodrugs was not high enough, they were saturated in propylene glycol (PG) for skin permeation studies. Prodrugs were rapidly metabolized to diclofenac, both in skin homogenate and in dermal extract of skin. The skin permeation rate of alkyl ester prodrugs was significantly higher than diclofenac with shorter lag time. Moreover, a parabolic relationship was observed between the permeation rate and the log P values of prodrugs, and the maximum flux was achieved at a log P value of around 4.0.

항진균제 알릴아민류의 합성과 생물학적 평가

정병호,조원제,천승훈,박면지,유진철,천문우 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2

For the development of antifungal agents. modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole. piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds. (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyndylmethyl)amine(3D) showed relatively noticeable activity(MIC=50㎍/㎖). On the other hand. the other compounds had no activity.