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김교신,류제천,김송만,박춘수 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.2
Ground settlement and displacements of support structures due to deep excavation in urban area affect the stability of adjacent structures and retaining walls. Especially, the magnitude and distribution of ground settlements may directly give effects on the behavior of adjacent structures. So it comes to be important to judge precisely the effects on adjacent grounds and structures due to excavation. This can be achieved by means of ground settlements and differential settlements of structures, but present evaluating method on the ground settlement neglect the presence of adjacent structures. In this study, I have made Bowles and Bauer Method programs in order to find adjacent ground settlements. The results of program are like these. First, when you use measured horizontal displacement, the ratio of settlements of Bowles Method programs to Bauer is 0.86. Secondly, when you use measured horizontal displacement, settlements which Bowles Method program find is 5 times larger than settlements which Bauer Method program find when you use evaluated horizontal displacement.
Preparation and Characterization of Solid Dispersion of Ipriflavone with Polyvinylpyrrolidone
Jeong, Je Kyo,Kim, Junghoon,Khang, GilSon,Rhee, John M.,Lee, Hai Bang 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.3
Solid dispersions of ipriflavone with PVP were prepared by a spray-drying method in order to improve the bioavailability. They were measured with scanning electron microscopy, differential scanning calorimetry, x-ray powder diffraction, and Fourier transform infrared spectroscopy to evaluate the physicochemical interaction between ipriflavone and PVP and study the correlation between these physicochemical characteristics and bioavailability. Ipriflavone exhibited crystallinity, whereas PVP was almost amorphous. The area of the endotherm(△H) of freezer milled ipriflavone, freezer milled ipriflavone physically mixed with freezer milled PVP, and physically mixed ipriflavone with PVP was almost the same, whereas △H of the solid dispersed ipriflavone with PVP was much smaller than that of the other preparation types. Also, the crystallinity and the crystal size of ipriflavone in the solid dispersed ipriflavone with PVP were much smaller than those of the other preparation types. Form the in vivo test, the AUC of the solid dispersed ipriflavone with PVP was approximately 10 times higher than that of the physically mixed ipriflavone with PVP. The solid dispersion using the spray-drying method with a water-soluble polymer, PVP, may be effective for the improvement of the bioavailability.
The Effect of Solvents on Sold Dispersion of Ipriflavone with Polyvinylpyrrolidone In Vivo
Jeong, Je-Kyo,Ahn, Yong-San,Moon, Byung-Kwan,Choi, Myung-Kyu,Khang, Gil-Son,Rhee, John-M.,Lee, Hai-Bang The Korean Society of Pharmaceutical Sciences and 2005 Journal of Pharmaceutical Investigation Vol.35 No.1
ABSTRACT -Ipriflavone is a synthetic flavonoid derivate that improves osteoblast cell activity inhibiting bone resorption. In order to improve the bioavailability, solid dispersions of ipriflavone with PVP (poly-N-vinylpyrrolidone, MW=40,000 g/mole) were prepared by a spray-drying method. During the manufacturing of solid dispersion, various solvents [ethanol (EtOH), acetonitrile, methylene chloride and cosolvent-EtOH:acetone=1:1] were used to dissolve the ipriflavone and PVP. Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) were used to evaluate the physicochemical interaction between ipriflavone and PVP. Particle size, crystallinity and the area of the endotherm $({\Delta}H)$ of solid dispersed ipriflavone using the acetonitrile as solvent were much smaller than those of the other preparation types. Bioavailability of ipriflavone in vivo was changed by solvents. When considering the result of in vivo test, solid dispersion of ipriflavone using the acetonitrile as solvent showed the best choice.
The Effect of Solvents on Solid Dispersion of Ipriflavone with Polyvinylpyrrolidone In Vivo
Jeong, Je Kyo,Ahn, Yong San,Moon, Byung Kwan,Choi, Myung Kyu,Khang, Gilson,Rhee, John M.,Lee, Hai Bang 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1
Ipriflavone is a synthetic flavonoid derivate that improves osteoblast cell activity inhibiting bone resorption. In order to improve the bioavailability, solid dispersions of ipriflavone with PVP (poly-N-vinylpyrrolidone, MW=40,000 g/ mole) were prepared by a spray-drying method. During the manufacturing of solid dispersion, various solvents [ethanol (EtOH), acetonitrile, methylene chloride and cosolvent-EtOH:acetone=1:1] were used to dissolve the ipriflavone and PVP. Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) were used to evaluate the physicochemical interaction between ipriflavone and PVP. Particle size, crystallinity and the area of the endotherm (ΔH) of solid dispersed ipriflavone using the acetonitrile as solvent were much smaller than those of the other preparation types. Bioavailability of ipriflavone in vivo was changed by solvents. When considering the result of in vivo test, solid dispersion of ipriflavone using the acetonitrile as solvent showed the best choice.
이프리플라본 고체분산체의 생체이용률에 미치는 폴리비닐피롤리돈의 분자량 및 혼합비율의 영향
정제교(Je Kyo Jeong),강길선(Gil Son Khang),이종문(John M . Rhee),신호철(Ho Chul Shin),이해방(Hai Bang Lee) 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.4
Ipriflavone (3-phenyl-7-isopropoxy-4H-1-benzopyran-4-one, IP) is a well-known antiosteoporotic drug with poor bioavailability. In the previous study, we reported that the IP formulation prepared by spray-drying method with polyvinylpymolidone (PVP) (SIP) was very effective in improving the bioavailability of IP. In this study, we examined the effects of molecular weight and mixture ratios of PVP to IP on the systemic absorption of IP following oral administration of SIP at a dose of 50 ㎎/㎏ to rats. In the effect of molecular weight, the Cmax of spray-dried IP with PVP K30 (SIP-K30) was significantly higher than those of spray-dried IP with PVP 360 (SIP-360), spray-dried IP with PVP K90 (SIP-K90), and spray-dried IP with PVP K17 (SIP-K17) (p<0.05). The AUC of SIP-K30 was about 2, 3, and 5.5 times higher than those of SIP-360, SIP-K90, and SIP-K17, respectively. The AUC value of SIP-K30 was significantly greater than those of SIP-K17 and SIP-K90 (p<0.05) except for SIP-360. In the ratio of PVP K30 to drug, the C_(max) and the AUC value of 3 : 7 IP-PVP solid dispersion were similar to those of 5 : 5 IP-PVP and significantly higher than those of the other solid dispersions (p<0.05). It was concluded that the spray-dried IP with PVP K30 at the ratio of 3:7 (w/w) was the best formulation for improving the bioavailablity of IP.
정제교(Je Kyo Jeong),강길선(Gil Son Khang),이종문(Jong M . Rhee),신호철(Ho Chul Shin),이해방(Hai Bang Lee) 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.1
Bioavailability of ipriflavone (3-phenyl-7-isopropoxy-4H-1-benzopyran-4-one, IP), an antiosteoporotic drug with poor water-solubility, was studied for various types of pharmaceutical preparation in SD rats. The IP preparation types included ① intact IP, ② freezer milled IP (FIP), ③ freezer milled IP physically mixed with freezer milled poly-N-vinylpyrrolidone (PVP) (FIP+FPVP) and ④ spray-dried IP with PVP (SIP). Upon oral administration, SIP showed significantly higher absorption and elimination half-lives and the lag time (t_(lag)) than those of FIP+FPVP (approximately 2-fold). These results may be due to a sustained releasing effect of IP in the gastrointestinal tract by spray-drying with PVP. The C_(max) of SIP was about 2 and 10 times higher than those of FIP+FPVP and FIP, respectively. The AUC of SIP was about 6 times higher than that of FIP+FPVP and 60 times that of FIP. Scanning electron microscopy (SEM) showed that SIP consisted of the finest particle size and minimal aggregation than other IP preparations. It is concluded that the IP formula prepared by the spray-drying method with PVP is the most effective approach to the improvement of bioavailability of IP.