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Engineering function into viruses, vesicles, and gels for unique supramolecular nanomaterials
( Justyn Jaworski ) 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Soft matter, such as gels, liquid crystals, polymer/biopolymers, and membranes, are ubiquitous throughout nature and have many important industrial applications. The most familiar are plastics, paints, foods, and display technologies. A key feature of these systems is their complex self-organization that is generally held together through weak intermolecular forces such as hydrogen bonds, pi-pi stacking interactions, or through the hydrophobic effect. In this presentation, I will discuss how we used these same driving forces to both develop new designs and exploit existing structures for realizing unique supramolecular nanomaterials. Features of our systems include stimuli-responsive behavior, tunable structures, reversible phase transition, controllable shape changes, chemical sensing, as well as actuation. Applications of this work are expected in a range of areas including separation and detection among others. In addition, I will highlight some of our recent advances in moving past traditional self-assembled systems and into guided assembly approaches for the development of an even wider variety of new soft matter composites.
Yarimaga, Oktay,Jaworski, Justyn,Yoon, Bora,Kim, Jong-Man The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.19
<P>While a large variety of conjugated polymers exist, polydiacetylenes (PDAs) remain a major research area among scientists due to their interesting optical, spectral, electronic, and structural properties. Heavily reviewed in regards to their stimuli responsive properties, much is known about the assortment of sensing and detection capabilities of PDAs. In this article, we look more upon the structural diversities of polydiacetylenes that have been achieved in recent years, particularly from a hierarchical perspective of 1, 2, and 3-dimensional configurations. In addition, we examine how these different dimensional arrangements of PDAs have heralded clear applications in several key areas. Successful integration of these stimuli-responsive “smart” materials into various geometries has required researchers to have a comprehensive understanding of both the fabrication and synthesis processes, as well as the signalling mechanism for the optical, fluorogenic or spectral transitions. The on-going discovery of new PDA formulations continues to provide interesting structural manifestations such as liposomes, tubes, fibres, organic/inorganic incorporated hybrids and composite structures. By highlighting some of the recent conceptual and technological developments, we hope to provide a measure of the current pace in new PDA derivative development as core components in efficient sensor, imaging and display systems.</P> <P>Graphic Abstract</P><P>Recent advances in polydiacetylene based sensing, imaging, and display technologies are examined from a morphological perspective, as these stimuli responsive materials have shown the ability to adopt a range of useful and interesting confirmations by self-assembly and patterning. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc17441c'> </P>
Enzyme directed formation of un-natural side-chains for covalent surface attachment of proteins
Cho, H.,Jaworski, J. Elsevier 2014 Colloids and surfaces Biointerfaces Vol.122 No.-
The covalent immobilization of proteins onto surfaces is an essential aspect of several fields of research, including proteomics, sensing, heterogeneous biocatalysis, and more broadly biotechnology. Site-specific, covalent attachment of proteins has been achieved in recent years by the use of expanded genetic codes to produce proteins with controlled placement of un-natural amino acids bearing bio-orthogonal functional groups. Unfortunately, the complexity of developing such systems is impractical for most laboratories; hence, a less complicated approach to generating un-natural amino acid side-chains has been employed. Utilizing a straightforward reaction with formylglycine generating enzyme, we use the site-specific modification of engineered proteins to yield un-natural amino acid side-chains for protein immobilization. Using this approach, we demonstrate the controlled immobilization of various enzymes onto a variety of amine coated surfaces. Our results reveal reusability of the immobilized enzymes via this strategy, and furthermore, we find the activity of the immobilized enzymes to remain even after a month of use indicating significant stability of the linkage.
Lee, Ji Ha,Jaworski, Justyn,Jung, Jong Hwa RSC Pub 2013 Nanoscale Vol.5 No.18
<P>Achieving both high specificity and sensitivity are essential for gas phase chemical detection systems. Recent implementation of Metal-Organic Frameworks (MOFs) have shown great success in separation and storage systems for specific gas molecules. By implementing a MOF structure comprised of Zn(2+) coordinated trans-stilbene derivatives, a gas responsive material has been created which exhibits a high photoluminescence quantum yield, offering new opportunities for chemical sensors. Here, we reveal a nanocomposite material, assembled from azobenzene functionalized graphene oxide and stilbene-MOF, that is capable of luminescent quenching by explosive gases. This unique system displays selectivity to dinitrotoluene (71% quenching) over trinitrotoluene (20% quenching) with sub ppm sensitivity and response times of less than a minute. We show that this implementation of a graphene-based MOF composite provides a unique strategy in the development of molecularly well-defined materials having rapid, reversible, and gas selective fluorescent quenching capabilities. This opens the way for new advances in the assembly of low density frameworks using isomerization suppressed materials.</P>
Fabrication and Applications of Biological Fibers
Augusto M. Tentori,Justyn Jaworski 한국구조생물학회 2014 Biodesign Vol.2 No.3
Fibers derived from processing of biological materials have long been implemented for commercial use as they are widely available from a diverse range of renewable materials. Moreover, their natural mechanical and functional properties continue to provide newfound sources of technological advancement in areas including medicine and filtration among other more traditional fields. While not only providing inspiration, the study of biological fiber formation in organisms such as spiders and silk worms has facilitated fundamental knowledge; however, this review concentrates instead on more recent artificial fabrication techniques that have been adapted for the formation of 1D (one dimensional) fibers from biological materials. In addition, we provide an extensive look at the various biological materials from the standpoint of their applications and fabrication methods. Areas encompassing the latest advancements in fiber processing techniques with respect to compositional and geometric control are discussed and provide a promising outlook of future growth in this continually growing field.