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Magdalena Hofman-Bieniek,Robert Pietrzak,Katarzyna Jasiewicz 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.2
Preparation of polymeric membranes based on polyethersulfone (PES) modified by adding different amountsof a pore-forming agent (PVP) is presented, and potential application of the membranes obtained for removal of phenolfrom the liquid phase is examined. The addition of various amounts of PVP has been shown to bring about changesin the content of the surface oxygen groups, but has no significant effect on the chemical character of the groups andacidic groups dominate. Filtration by phenol solution leads to significant changes in the total content of surface oxides;however, the acidic groups remain dominant. Membranes characterized by higher porosity exhibited more stable andhigher rejection ratio for phenol removal. Although all the membranes were characterized by similar rejection ratiosfor phenol removal, the cake resistance (Rc) and pore resistance (Rp) values were found to depend significantly onthe structure and porosity of the membrane applied for filtration.
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Solek Przemyslaw,Mytych Jennifer,Sujkowska Ewelina,Grzegorczyk Magdalena,Jasiewicz Patrycja,Sowa-Kucma Magdalena,Stachowicz Katarzyna,Koziorowski Marek,Tabecka-Lonczynska Anna 한국독성학회 2022 Toxicological Research Vol.38 No.2
The increasing number of depression cases leads to a greater need for new antidepressant treatment development. It is postulated that antidepressants may harm male fertility, but the cellular mechanism is still poorly understood. The role of growth factors and klotho protein in maintaining normal male reproductive function is well documented. Hence, the study aimed to investigate the effect of the antidepressant drug – imipramine (tricyclic AD), and other substances with antidepressant potential (ALS), administered in combination or in combination with LPS (an animal model of depression) on gene expression and protein synthesis of IGF-2 (insulin-like growth factor 2), TGF-β1 (transforming growth factor β1), NGF (nerve growth factor), KGF (keratinocyte growth factor) and protein synthesis of VEGF-A (vascular endothelial growth factor A), IGF-IR (insulin-like growth factor receptor 1), EGFR (epidermal growth factor receptor) and klotho in the testis of mice. Mice were injected intraperitoneally with selected ALS and LPS or 10% DMSO (controls) (n = 7/group) once a day for 14 days. Animals were decapitated and testes collected for RNA and protein purification. PCR and western blot methods were employed for the evaluation of growth factors and klotho expression. The results obtained indicated a decreased level of most of the analyzed genes and proteins, except KGF; its expression increased after treatment with MTEP and IMI administrated individually and after NS-398, and IMI in combination with LPS. Our results may suggest that the tested ALS and LPS can contribute to a reduction of male fertility, but NS-398, IMI, and IMI+NS-398 may also act as stimulants after LPS.
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