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Optimization of Large - Scale Chromatography of Proteins
Janson, Jan Christer 한국화학공학회 2001 Korean Journal of Chemical Engineering Vol.18 No.2
Protein chromatography is a very complex process based on a combination of thermodynamic, kinetic and mass transport phenomena. By virtue of their complicated and delicate surface structures, the behaviour of proteins on various chromatographic media is not easy to predict. Together with the fact that the majority of the chromatographic media for proteins available today are not very well characterized with regard to their detailed chemical and physical surface structures, protein chromatography still has to be regarded as a predominantly empirical science. I.e. the optimization of separation conditions can only be performed by experiments in the laboratory. The scaling-up is then accomplished primarily by increasing the column diameter. This has been shown work well for column diameters up to at least 1,400 mm. The paper will also deal with the characteristics of the most important protein separation media, silica based, polystyrene based and agarose based, and with how to best optimize the conditions for column productivity, both for adsorption types of chromatography and for gel filtration.
Control Design on a Non-minimum Phase Bilinear System by Backstepping Method
Ahmadin,Janson Naiborhu,Roberd Saragih,Khozin Mu’tamar 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.10
In this paper, we construct a control design of a non-minimum phase bilinear system. Here we apply a coordinate transformation to determine the normal form and the relative degree of the system with a particular class. We use the backstepping method to determine the control variable so that the bilinear system becomes stable. From this design, the output system can track the desired output.
Backward bifurcation of an Sir-Si model with vaccination and treatment
EDWIN SETIAWAN NUGRAHA,NUNING NURAINI,JANSON NAIBORHU 장전수학회 2019 Advanced Studies in Contemporary Mathematics Vol.29 No.1
In the presence of treatment, most epidemic models demon- strate behavior of backward bifurcation. This is important in epidemiol- ogy because it provides signicant information for disease control. How- ever, most models consider only one single population. In this paper, an extended model of two populations in the form SIR-SI involving vaccina- tion and treatment is analyzed. The analysis of local and global stability of equilibria is discussed. By using the center manifold theorem, this model has backward bifurcation behavior when the number of infected people exceeds the treatment capacity. Vaccination decreases the basic reproduction number, but does not aect the backward bifurcation be- havior. This study also showed that under vaccination and treatment, an endemic equilibrium always occurs when R0 > 1.
Benedito Freitas,Heloiza Freitas,Pedro Cesar F dos Santos,Guilherme Janson 대한치과교정학회 2014 대한치과교정학회지 Vol.44 No.5
A Brazilian girl aged 14 years and 9 months presented with a chief complaint of protrusive teeth. She had a convex facial profile, extreme overjet, deep bite, lack of passive lip seal, acute nasolabial angle, and retrognathic mandible. Intraorally, she showed maxillary diastemas, slight mandibular incisor crowding, a small maxillary arch, 13-mm overjet, and 4-mm overbite. After the diagnosis of severe Angle Class II division 1 malocclusion, a mandibular protraction appliance was placed to correct the Class II relationships and multiloop edgewise archwires were used for finishing. Follow-up examinations revealed an improved facial profile, normal overjet and overbite, and good intercuspation. The patient was satisfied with her occlusion, smile, and facial appearance. The excellent results suggest that orthodontic camouflage by using a mandibular protraction appliance in combination with the multiloop edgewise archwire technique is an effective option for correcting Class II malocclusions in patients who refuse orthognathic surgery.