Θ1 globin gene의 upstream 부위의 유전자 분석

장혜영 고신대학교 자연과학연구소 1993 고신대학교 자연과학연구소 논문집 Vol.3 No.-

Θl globin gene of human α-globin gene family that was identified recently shows the high possibility of normal gene expression as identifying the structure of the gene. At the upstream of CCAAT sequence of the promoter region of Θl globin gene there are 2 Alu repeating sequence which has different direction. The first Alu sequence consisting of 241-bp was the same direction to the gene transcription but the second Alu sequence consisting of 38-bp was short and has the opposite transcription direction to the gene. The promoter A which located in the first Alu sequence has the exact consensus sequence of the Alu common gene but the promoter B matches 7 positions out of 9 with 2 transitions. Containing CCAAT and TATA in the second Alu sequence it surely showed that there are some relations between Alu sequence and the possible regulation of RNA polymerase Ⅱ dependent genes.

Machiavelli의 政治思想 再評價 : 군주론을 중심으로 With Special Reference to "The Prince"

張海光 계명대학교 국제학연구소 1999 국제학논총 Vol.4 No.-

공동주택 최상층과 지상1층 차별화계획의 효과 및 개선방안 연구

장한두,이규인,제해성 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

The purpose of this research is to analyze various types of the additional design alternatives of apartment housing units at ground and top floors which is recently supplied by developers in Korea, and to find out their effects on residents and to suggest design enhancements. For this research, first, eleven apartment housing estates are selected through literature review and field survey, and types of design alternatives are categorized. Second, the effects of the design alternatives on the residents are analyzed based upon survey. Third, a direction of design enhancement is suggested through analyzing residents' behavior and needs. The results of this study are (1)to verify the seven types of the design alternatives. They are ⅰ)attic at top floor unit, ⅱ)rooftop terrace at top floor unit, ⅲ)living room enlarged floor height at top floor unit, ⅳ)duplex unit at top floor, ⅴ)private garden at ground floor unit, ⅵ)private accessibility at ground floor unit, ⅶ)underground storeroom at ground floor unit, (2)to analyze the effects of design alternatives on the residents, which are composed of the spacial feasibilities of ⅰ)connection to ground, ⅱ)exposition to open air, ⅲ)diversity of composing interior space, ⅳ)flexibility of various usage and ⅴ)openness of interior space, and (3)to suggest a direction of design enhancement of the alternatives at ground and top floors for higher performance.

한랭노출과 고혈압의 연관성

장태원,김윤규,윤동영,이창희,홍영습,신해림,정갑열,김준연 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

Objectives : This study was carried out to suggest preventive methods for hypertension in cold-exposed workers. Methods : In 11 refs·iteration industries, 68 workers working in refrigerated areas more than one time per day were selected as the exposed group, and 68 workers not exposed to cold were selected as the control group. We interviewed the subjects with a questionnaire covering occupational history, and conducted clinical and laboratory tests including measurements of blood pressure and core temperature. Results : The systolic blood pressure in the exposed group(130.0±13.3 mmHg) was significantly higher than that recorded In the control group(118.3±12.1 mmHg), as was the diastolic blood pressure in the exposed group(82.7±8.5 mmHg) versus the control group(77.4±8.7 mmHg). The core temperature in the exposed group(36.1±0.7℃) was significantly lower than that experienced in the control group (36.4±0.5℃). In logistic regression analysis, age, cold exposure severity and milk intake were significant variables, with odds ratios of 5.204(95 % CI 1.440∼18.812), 2.674(95 % CI 1.080∼6.618), and 0.364(95 % Cl 0.141∼0.942) , respectively. Conclusions : Our study suggests that cold-exposed workers have higher a higher risk of hypertension, and that their core temperature is lower. Risk factors affecting hyper-tension of cold-exposed workers include age, cold exposure severity and milk intake. For the prevention of hypertension, cold-exposed workers should minimize cold-exposure time as much as possible.

팥 신장기 과습처리에 의한 생육특성 및 단백질 발현

정해룡, 유장환, 윤성현, 권수정, 우선희 충북대학교 농업과학기술연구소 2022 農業科學硏究 Vol.38 No.2

Adzuki bean is sensitive to waterlogging stress. The overall study on the waterlogging stress is limited comparing to the study on the drought and any environmental stress. Therefore, the present study was conducted to investigate the changes in growth characteristics and the expression patterns of proteins at the 5-leaf stage periods of adzuki bean. The domestic cultivar, Arari (Miryang No. 8) was used to test the waterlogging stress. In the waterlogging treatment for 3 days, the plant height showed slightly decrease in the treatment at 3 days of waterlogging, but root fresh weight showed significantly changes at 3 days of the waterlogging treatment. Chlorophyll contents showed also significantly different at 3 days of waterlogging treatment compared to control the plants. The waterlogging stress gradually influenced the growth differences between the control and the treatment respectively. More than 350 pro- tein spots were identified on 2-D gels using an image analysis. Moreover, a total of 28 proteins were analyzed using LTQ-FT-ICR MS. Among these 28 proteins, a total of 18 proteins were up-regulated, and 10 proteins were down-regulated under waterlogging treatment. According to biological process, the most of the proteins were found to be involved in carbohydrate metabolism. Regarding the subcellular local- ization, most of the proteins were localized into chloroplasts in 5-leaf stage.

경력단절여성 재취업 유망직업 선정에 관한 연구

장서영,은혜경,오민홍 한국직업능력개발원 2009 직업능력개발연구 Vol.12 No.1

이 연구는 경력단절여성 재취업 유망직업 선정을 목적으로 한다. 이를 위해 경력단절여성에게 취업기회가 높은 직업을 유망직업 기준으로 삼고, 3단계 과정을 통해 유망직업을 선정하였다. 1단계에서는 고용보험 DB와 워크넷 DB를 기초로 한 양적자료 분석과 직업상담사 및 매체 추천을 통한 질적자료 수집을 통해 후보직업을 발굴하였다. 2단계에서는 1단계에서 발굴된 후보직업을 정리, 통합하였으며, 3단계에서는 1) 나이·경력·학력에 구애를 덜 받아 경력단절여성이 노동시장에 진입하기 용이한 직업, 2) 관련 경력이 없어도 경력단절여성이 직업훈련을 통해 노동시장에 진입 가능한 직업 , 3) 남성지배직업이어서 상대적으로 취업가능성이 낮은 편이나 경력단절여성 재취업 사례가 있어 경력단절여성에게 도전감을 줄 수 있는 직업으로 선정기준을 확정하여 총 55개 직업을 경력단절여성 재취업 유망직업으로 선정하였다. 결론에는 본 연구의 의의와 추후 연구를 위한 제언을 기술하였다. The purpose of this paper is to investigate occupations that is of high probabilities for career-interrupted women to reenter the labor market. A process of 3 steps was performed to find such occupations. Using Employment Insurance and Work-net Database, it has been found occupations that career-interrupted women empirically reemployed with high frequencies and preference. We then surveyed promising jobs through career counsellors and media, In the second step, occupations collected through the first two steps has been assorted and selected as promising jobs. Finally, we pin down total 55 jobs for career-interrupted women based on the following criteria; 1) easiness to reenter the labor market regardless of age, job experience, and education background, 2) whether job training can help their qualification to reenter the labor market, and 3) whether to challenge them with prior success examples.

음악활동이 통합 어린이집 발달지체유아의 사회 정서발달에 미치는 영향

장혜원 국립특수교육원 2012 특수교육연구 Vol.19 No.1

The main aim of this study is to verify effectiveness of developmental delay children's social and emotional development by music activities which made of music elements facilitate social and emotional skills in the inclusion setting. Forty children with developmental delay attending a inclusive child-care center participated in 16 sessions consist of 30 minutes from september to february. Intervention was music activities to facilitate social and emotional skills. Study design is pretest-posttest control group design. As results of this study, music activities which facilitate social and emotional development improved the developmental delay children's social emotional development in the inclusion setting. Music activities which facilitate social and emotional skills improved the developmental delay childrens' social interaction, self concepts, social role, expression of emotion. As study results, music activities improved developmental delay children's social and emotional development regardless of sex. Music activities improved developmental delay childrens' social and emotional development related the degree of disability and ages As a conclusion, music activities which facilitate social and emotional development can be effective intervention program to improve childrens' social and emotional development children with developmental delay in inclusion settings. 본 연구는 음악활동이 통합 어린이집 발달지체유아의 사회 정서발달에 미치는 영향을 밝히고, 발달지체유아의 개인 변인인 성별, 장애등급, 나이에 따른 음악활동의 영향력을 살펴보았다. 이를 위해 통합 어린이집에서 교육을 받고 있는 40명의 발달지체유아를 대상으로 연구를 실시 하였다. 연구 기간은 6개월이었으며 중재는 주 1회 30분씩 총 16회기 간 발달지체유아가 생활하고 있는 본래 학급에서 실시되었다. 중재 프로그램은 사회 정서발달을 유도하는 음악의 요소가 삽입된 음악활동으로 구성하였으며 연구설계는 사전-사후 비교집단 실험설계이었다. 연구결과 음악활동이 발달지체 유아의 사회 정서발달인 타인과의 상호작용 발달, 자아개념 발달, 대처기능 및 사회적 역할 발달, 감정 정서표현 발달에서 긍정적인 영향을 미쳤다. 음악활동은 성별에 상관없이 발달지체유아의 사회 정서발달에 긍정적인 영향을 미쳤으나 장애등급과 나이에 따라 평균점수는 차이를 보이고 있다. 이상의 연구결과에 비추어 음악활동은 통합 어린이집 발달지체 유아의 사회 정서발달을 위한 프로그램으로서 적용 가능성을 보여주었다는 것에 의의를 찾을 수 있다.

노후아파트 리모델링의 입주후평가에 관한 연구 : 마포용강아파트를 대상으로 A Case Study on Mapo Yonggang Apartment

장한두,고성진,제해성 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

The purpose of this study is to analyze apartment remodeling designs and process influenced residents' opinions on a private initiated apartment remodeling case, and to evaluate remodeling executed and to find out next remodeling program by analyzing inequality between residents' needs and satisfaction on their residential environment, This is a previously elementary research for Improvement of diagnostication and evaluation methodology to measure residential adaptation and satisfaction For this study, first, remodeling design plans and details of case apartment are examined by document survey, and the present conditions of apartment are examined by field survey Second, interview survey are executed with architect, engineers and representative of resident Union participated on remodeling design Third, questionnaire survey are executed to find out residents' needs, satisfaction and attitude to apartment remodeling experienced Mapo-Yonggang Apartment, a remodeling case for this. study, is located in Mapo-gu, Seoul, Korea, and the first example of private-initiated apartment remodeling in Korea being controlled Korea National Housing Corporation as a model Field survey and interview survey were executed from June to August, 2004

유치 수복물에 따른 주변 법랑질의 탈회 저항성 : QLF를 이용한 연구

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구에서는 유치 수복물의 불소 방출 여부에 따른 주변 법랑질의 탈회 저항성과 재광화 효과를 살펴보고자 하였다. 건전 유전치 48개를 16개씩 임의로 세 군으로 나누어, FiltekTM Z250(1군), F2000(2군), KetacTM N100(3군)을 사용하여 제조사의 지시에 따라 충전하였다. 3일 동안 인공 우식 병소를 유발한 후, 14일 동안 인공 타액에 담가 재광화를 유발하였다. Quantitative light-induced fluorescence(QLF)를 이용하여 실험 단계와 시간에 따른 무기질 소실량(ΔQ)의 변화를 관찰한 결과는 다음과 같다. 1. 탈회가 일어난 인공 우식 병소의 ΔQ 값은 3군, 2군, 1군 순으로 작게 나타났고, 이 중 3군은 1군에 비해 유의한 탈회 저항성을 보였다. 2. 1군, 2군, 3군 모두 재광화 1일 후부터 초기 인공 우식 병소의 ΔQ 값과 비교 시 유의한 차를 보였으며, 관찰 기간 동안 지속적인 증가 양상을 나타내었다. 3. 재광화 속도를 의미하는 Δ(ΔQ)/일 값은 각 군에서 처음 1일 동안 유의성 있게 크게 나타났으며, 그 이후 급속히 감소하였다. 4. 수복 재료에 따른 재광화 정도는 각 군 간에 유의한 차이가 없었다. The objective of this in vitro study was to detect and monitor demineralization and remineralization of primary teeth according to restorative materials using quantitative light-induced fluorescence (QLF). A single bur hole was drilled on the each sound forty eight primary anterior teeth, and the specimens were divided into three groups. The cavity was restored with FiltekTM Z250(Group 1), F2000(Group 2), KetacTM N100(Group 3) following the manufacturer's instructions. The teeth were subjected to the demineralizing buffer for 3 days, and then subjected to a remineralizing buffer for 14 days. The change of mineral loss(ΔQ) according to the stages was evaluated by QLF and the following results were obtained: 1. When demineralization was done, ΔQ was increased as follows. : Group 1 (-110.79 ± 27.77) < Group 2 (-104.84 ± 28.95) < Group 3 (-90.16 ± 21.87) : Resistance to demineralization was statistically significant in Group 3. 2. There was a statistically significant increase in ΔQ of all groups since 1st day of remineralization 3. The rate of remineralization, Δ(ΔQ)/day, showed significant high value in each group on the 1st day then decreased rapidly. 4. There was no statistically significant difference in the degree of remineralization among restorative materials.

결식아동의 실태와 특성

박장숙,전진호,김성준,손혜숙,이종태 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : The unprivileged children without lunch(UCWL) has been being markedly increased and becoming one of the social problem in Korea. This study was performed to assist the development of efficient support program through the investigation of the status and characteristics of the UCWL. Methods and Material : Subjects were 104 students sho were receiving the meal aid from the six social welfare facilities and 110 ordinary students of an elementary school in Pusan area. Questionnaire survey was conducted from February to March, 2001. Data was analyzed using SPSS program(ver 10.0). Results : There was no difference in gender and school years' distribution. The phenomenon of family deficient, instability of parents' job, unsatisfaction to the home's atmosphere, ill adaptation to their school life, and be alienated from their colleague were more frequent in UCWL(p<0.05). Impulse of runaway from home and suicide showed no difference, however, the present worries, preference of way for assist showed differences(p<0.05), The majority(88%) of UCWL has been giving the meal and less than on year. The most common way was food stuff(76%) and financial support for school meal program(73%), while the most preferred way was financial support for everyday life(43%). Conclusion : UCWL satisfied and gave thankful mind to the present supports, however, showed negative aspects - like emotional unstability and difficulties in their school life. Therefore, it thought to be needed the touch on the emotional aspects, not only on the formal and economic aids.