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Kim, Jandee,Lee, Jaesung,Kim, Sechul,Kim, Young-Rae,Rhee, Choong Kyun American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.42
<P>This work presents formation of single-layered Pt islands on Au electrodes using the CO route, and the electrochemical behavior of CO, hydrogen, and ethanol was investigated with scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS), and cyclic voltammetry. The conventional route, consisting of irreversible adsorption of Pt precursor ions (10<SUP>–3</SUP> M PtCl<SUB>4</SUB><SUP>2–</SUP> in 0.05 M H<SUB>2</SUB>SO<SUB>4</SUB>) and subsequent electrochemical reduction, resulted in multiple-layered Pt islands; the CO route, utilizing CO adsorption to protect pre-existing Pt islands from irreversible adsorption of Pt, exclusively produced single-layered Pt islands. Furthermore, STM results implied that single-layered Pt islands on Au(111) were islands of alloyed Pt in a (√3 × √3)<I>R</I>30° arrangement, while multiple-layered islands were stacked layers of Pt in an (1 × 1) array. The coverages of deposited Pt estimated from STM and XPS measurements were quantitatively consistent with each other to confirm existence of the single-layered Pt islands. Coulometric analyses of adsorbed CO and hydrogen indicated lower adsorption stoichiometry of hydrogen on Pt islands prepared by the two deposition routes, especially when the deposited amount of Pt was small. Comparison of the coulometric coverages of CO and hydrogen with electrochemically active Pt coverages estimated with STM results supported that the adsorption stoichiometries of CO and hydrogen were higher on single-layered Pt islands than on multiple-layered ones, roughly by a factor of ∼1.8. Also, ethanol oxidation was enhanced on single-layered Pt islands approximately ∼4 times on average referring to Pt(poly), while the enhancement factor on multiple-layered ones was ∼1.5. Thus, this work demonstrated that the CO route exclusively produced single-layered Pt islands on Au, contrasting with multiple-layered islands in various electrochemical aspects.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-42/jp5062557/production/images/medium/jp-2014-062557_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp5062557'>ACS Electronic Supporting Info</A></P>
GLI1 Transcription Factor Affects Tumor Aggressiveness in Patients With Papillary Thyroid Cancers
Lee, Jandee,Jeong, Seonhyang,Lee, Cho Rok,Ku, Cheol Ryong,Kang, Sang-Wook,Jeong, Jong Ju,Nam, Kee-Hyun,Shin, Dong Yeob,Chung, Woong Youn,Lee, Eun Jig,Jo, Young Suk Williams & Wilkins Co 2015 Medicine Vol.94 No.25
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>A significant proportion of patients with papillary thyroid cancer (PTC) present with extrathyroidal extension (ETE) and lymph node metastasis (LNM). However, the molecular mechanism of tumor invasiveness in PTC remains to be elucidated.</P><P>The aim of this study is to understand the role of Hedgehog (Hh) signaling in tumor aggressiveness in patients with PTC.</P><P>Subjects were patients who underwent thyroidectomy from 2012 to 2013 in a single institution. Frozen or paraffin-embedded tumor tissues with contralateral-matched normal thyroid tissues were collected. Hh signaling activity was analyzed by quantitative RT-PCR (qRT-PCR) and immunohistochemical (IHC) staining. Datasets from Gene Expression Omnibus (GEO) (National Center for Biotechnology Information) were subjected to Gene Set Enrichment Analysis (GSEA). BRAFT1799A and telomerase reverse transcriptase promoter mutation C228T were analyzed by direct sequencing.</P><P>Among 137 patients with PTC, glioma-associated oncogene homolog 1 (<I>GLI1</I>) group III (patients in whom the ratio of <I>GLI1</I> messenger ribonucleic acid (mRNA) level in tumor tissue to <I>GLI1</I> mRNA level in matched normal tissue was in the upper third of the subject population) had elevated risk for ETE (odds ratio [OR] 4.381, 95% confidence interval [CI] 1.414–13.569, <I>P</I> = 0.01) and LNM (OR 5.627, 95% CI 1.674–18.913, <I>P</I> = 0.005). Glioma-associated oncogene homolog 2 (<I>GLI2</I>) group III also had elevated risk for ETE (OR 4.152, 95% CI 1.292–13.342, <I>P</I> = 0.017) and LNM (OR 3.924, 95% CI 1.097–14.042, <I>P</I> = 0.036). GSEA suggested that higher <I>GLI1</I> expression is associated with expression of the <I>KEGG</I> gene set related to axon guidance (<I>P</I> = 0.031, false discovery rate < 0.05), as verified by qRT-PCR and IHC staining in our subjects.</P><P><I>GLI1</I> and <I>GLI2</I> expressions were clearly related to aggressive clinicopathological features and aberrant activation of GLI1 involved in the axon guidance pathway. These results may contribute to development of new prognostic markers, as well as novel therapeutic targets.</P></▼2>
Kim, Jandee,Lee, Jeongmook,Youn, Young-Sang,Liu, Nazhen,Kim, Jong-Goo,Ha, Yeong-Keong,Bae, Sang-Eun,Shoesmith, David W.,Kim, Jong-Yun Pergamon Press 2017 Electrochimica Acta Vol. No.
<P><B>Abstract</B></P> <P>The influence of Gd-doping level and oxygen stoichiometry on the structural properties and electrochemical reactivity of U<SUB>1−y</SUB>Gd<SUB>y</SUB>O<SUB>2±x</SUB> have been investigated. The stoichiometry of UO<SUB>2</SUB> matrices with different Gd contents was determined using the lattice parameter obtained by XRD. The extent of lattice contraction, defined by a contraction factor, was found to be dependent on the stoichiometry. The surface morphologies exhibited differences in grain size which varied with stoichiometry and its influence on the U atom diffusivity during fabrication. The differences in grain size and, hence, the density of grain boundaries was reflected in variations in electrical conductivity, with hyperstoichiometric specimens with a low number of boundaries, yielding an increase in conductivity with increasing Gd content. Cyclic voltammetry showed that a variation in Gd content had only a minor influence on the electrochemical reactivity of stoichiometric U<SUB>1−y</SUB>Gd<SUB>y</SUB>O<SUB>2</SUB>. By contrast, the reactivity of hypostoichiometric U<SUB>1−y</SUB>Gd<SUB>y</SUB>O<SUB>2−x</SUB> and hyperstoichiometric U<SUB>1−y</SUB>Gd<SUB>y</SUB>O<SUB>2+x</SUB> increased and decreased, respectively, with increasing Gd content. The formation of Gd-O<SUB>v</SUB> clusters in hyperstoichiometric U<SUB>1−y</SUB>Gd<SUB>y</SUB>O<SUB>2+x</SUB> has a more marked influence on reactivity than the accompanying changes in grain size and electrical conductivity.</P>
Adsorptive Behavior of Dimethylglyoxime on Au(111)
Kim, Jandee,Kim, Sechul,Rhee, Choong Kyun American Chemical Society 2011 Langmuir Vol.27 No.23
<P>Dimethylglyoxime (DMG) adsorbed on Au(111) was investigated using electrochemical scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS). STM experiments revealed three different structures of adsorbed DMG at open circuit potential (∼0.07 V versus Ag/AgCl): (2√3×2√3)R30°-α, (2√3×4√3)R30°-β, and (2√3×4√3)R30°-γ. The coverage of adsorbed DMG obtained using XPS was 0.33. A combination of structural and quantitative information identified the adsorbed DMG as an anionic tetramer, held together by intermolecular hydrogen bonding and arrayed in three ordered patterns. Domains of adsorbed DMG underwent phase transitions between the observed structures, most likely due to the influence of the STM tip. However, a significant correlation between the observed structures and the imaging conditions was not found. The ordered layers existed only at open circuit potential as evidenced by their disappearance when the potential was shifted to 0.2 or −0.15 V. The ordered layers were also removed by immersion in a solution of Ni<SUP>2+</SUP>, implying that the adsorbed DMG was converted to a soluble dimer complex with the Ni<SUP>2+</SUP> ion. This particular observation is discussed in terms of the rigidity of the organic network.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2011/langd5.2011.27.issue-23/la202594s/production/images/medium/la-2011-02594s_0002.gif'></P>
미세 유두 갑상선암의 크기에 따른 임상상 및 단기간 치료 결과
이잔디(Jandee Lee),오동규(Dong-Kyu oh),임승수(Seung Soo Lim),남기현(Kee-Hyun Nam),정웅윤(Woong Youn Chung),소의영(Euy Yong Soh),박정수(Cheong Soo Park) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.1
Purpose :The incidence of papillary thyroid microcarcinoma(PTMC) has increased due to the widespread use of high resolution ultrasonography and fine-needle aspiration biopsy. However, the clinical and biologic behaviors of PTMC is debatable. The aim of this study was to describe clinicopathologic features of PTMC and to suggest whether tumor size(5mm) might prove the useful parameter for determining the surgical strat-egy in PTMC. Material and Methods :From Jan. 2000 to Dec. 2005, 1355 of 2678 patients with papillary thyroid car-cinoma were identified as having PTMC, based on tumor size≤10mm(50.6%). Among patients with PTMC, we further separated tumors<5mm(minute group:group M) from those 5 to 10mm(tiny group:group T). We compared the clinicopathological characteristics and the TNM stagings between two groups. Results :There were 114(8.4%) men and 1241(91.6%) women with a median age of 47 years(range;13-79). During a mean follow-up of 47.3(range;22-93), 13 patients(1.0%) developed locoregional recur-rences and 3 patients(0.2%) showed distant metastases at initial presentation. Statistical analysis revealed that the presence of extracapsular invasion(p<0.0001), invasion to adjacent structure(p<0.0001), multifocality(p< 0.0001), central lymph node metastasis(p<0.0001), and lateral lymph node metastasis(p<0.0001) were all significantly higher in tiny group(tumor≥5mm). Furthermore, minute group demonstrated a significantly lower tumor stage(AJCC TNM classification) compared with tiny group(p<0.0001). Conclusion :Patients with PTMC have a favorable treatment outcomes, although the distinction needs to be made with reference to the clinicopathologic behaviors. It would be reasonable to consider that tumor size(5mm) would be useful parameter for the treatment strategy of PTMC.
이잔디(Jandee Lee),홍 협(Hyeop Hong),정종주(Jong Ju Jeong),남기현(Kee-Hyun Nam),정웅윤(Woong Youn Chung),소의영(Euy-Young Soh),박정수(Cheong Soo Park) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.1
Purpose :The chronic use of immunosuppressive therapy in transplant recipients can increase the long-term risk of carcinoma. The aim of this study was to determine the incidence, biological behaviors, and treatment outcomes in PTC(papillary thyroid carcinoma) in renal allograft recipients. Material and Methods :The present study examined the incidence and biological behavior of PTCs in RA recipients. A total of 1,739 RA patients treated between January 1986 and December 1999 were followed-up for a median 137(84-238) months. During the follow-up period, 129(7.4%) recipients were identified as having posttransplant malignancies. Of those, 12(0.7%) had PTCs, and these comprised six male and six female patients with a median age of 41(23-57) years. Results :Nine cases(incidentalomas) were diagnosed based on ultrasonography(US) screening. Eight of those nine were TNM stage I, and two of the three clinical carcinomas were TNM stage IVa. During a median follow-up of 94(18-159) months, two(16.7%) PTC patients developed loco-regional recurrence, but no patients showed distant metastasis. Posttransplant PTC showed no gender bias, and was often associated with aggressive lymphatic metastasis. However, most incidentalomas showed a favorable treatment outcome. Conclusion :In conclusion, routine surveillance of the thyroid gland using US screening is recommended to ensure early detection, treatment and favorable prognosis in RA patients with PTC.