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방광암조직 acid deoxyribonuclease의 작용기전에 관한 연구
김용석,박무남,고재경 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1
Deoxyribonuclease (DNase) activity was determined in the bladder cancer tissue and was compared with that of the control tissue. The acid DNase known to be associated with carcinogenesis was isolated and purified from the bladder cancer tissue, and the substrate specificity and mechanism of action of the enzyme were studied to investigate the role of the acid DNase in the process involved in carcinogenesis of the bladder cancer. Activities of DNase Ⅰ,Ⅲ and Ⅳ were unchanged, but activity of DNase Ⅱ (acid DNase) was greatly increased in the bladder cancer tissue by a DEAE-cellulose column chromatography and the peak from the enzyme was greater in the cancer than in the control. The partially purified acid DNase from the bladder cancer tissue was highly active toward ds DNA, but still active toward ss DNA (18% of activity with ds DNA). The enzyme did not exhibit species specificity toward the substrates studied. Analyses for the ds DNA digest by the acid DNase from the bladder cancer tissue showed that majority of the products was oligodeoxyribonucleotides with chain length of 5-25. This indicated that the acid DNase was an endonuclease in nature. The acid DNase purified from the bladder cancer tissue was inhibited by RNA and polyribonucleotides, the degree of inhibition being changed with base sequence of the polyribonucleotides studied. The present study indicated that 1) the acid DNase in the bladder cancer tissue was greatly increased, 2) the enzyme was endonuclease in nature and 3) the enzyme activity was inhibited by RNA and polyribonucleotides, suggesting that the acid DNase in the bladder cancer tissue might play an important role in the process involved in carcinogenesis of the bladder cancer and that the process could be modified by RNA or polyribonucleotides.
콘크리트의 壓縮强度에 미치는 굵은 골재 크기의 영향에 관한 基礎的 硏究
윤석천,박서규,남재현,김무한 충남대학교 공업교육연구소 1985 論文集 Vol.8 No.1
The purpose of this study is to research an effect of aggregate size on the compressive strength of concrete. Tests were, therefore, made in sixteen classes of concrete : maximum aggregate sizes of 5, 10, 20, 30^mm with water cement rations of 40% and 60% and with AEA°cement rations of 0.00% and 0.03% for each maximum aggregate size. The results of this experiment are showing the fellowing tendency. 1. Generally, with the range of this experiment program, the smaller maximum aggregate size becomes, the higher the compressive strength of concrete gets. 2. The decreasing tate of the compressive strength of concrete gets higher in lean mix concrete than in rich mix concrete at each age. 3. The compressive strength of concrete is developed faster with not only the increase of maximum aggregate size but also the decrease of water cement ratio. And it shows that the rate of the compressive strength development is higher in AE concrete in spite of water cement ratio.
Review : Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors
( Jai Moo Shin ),( Nayoung Kim ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.1
Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H+, K+ -ATPase via disulfide bond. Cys813 is the primary site responsible for the inhibition of acid pump enzyme, where PPIs bind. Omeprazole was the first PPI introduced in market, followed by pantoprazole, lansoprazole and rabeprazole. Though these PPIs share the core structures benzimidazole and pyridine, their pharmacokinetics and pharmacodynamics are a little different. Several factors must be considered in understanding the pharmacodynamics of PPIs, including: accumulation of PPI in the parietal cell, the proportion of the pump enzyme located at the canaliculus, de novo synthesis of new pump enzyme, metabolism of PPI, amounts of covalent binding of PPI in the parietal cell, and the stability of PPI binding. PPIs have about 1hour of elimination half-life. Area under the plasmic concentration curve and the intragastric pH profile are very good indicators for evaluating PPI efficacy. Though CYP2C19 and CYP3A4 polymorphism are major components of PPI metabolism, the pharmacokinetics and pharmacodynamics of racemic mixture of PPIs depend on the CYP2C19 genotype status. S-omeprazole is relatively insensitive to CYP2C19, so better control of the intragastric pH is achieved. Similarly, R-lansoprazole was developed in order to increase the drug activity. Delayed-release formulation resulted in a longer duration of effective concentration of R-lansoprazole in blood, in addition to metabolic advantage. Thus, dexlansoprazole showed best control of the intragastric pH among the present PPIs. Overall, PPIs made significant progress in the management of acid-related diseases and improved health-related quality of life. (J Neurogastroenterol Motil 2013; 19:25-35).
Twisted Multifilamentary BSCCO 2223 Tapes by Using High Resistive Sheath
Yoo, Jai-Moo,Ko, Jae-Woong,Kim, Hai-Doo,Chung, Hyung-Sik The Korean Superconductivity Society 2000 Progress in superconductivity Vol.1 No.2
Different twist pitches of multi filamentary BSCCO 2223 tapes using high resistivity sheath were fabricated to investigate the effect of twist pitches on the microstructure and critical current property. A conductor with a high resitstivity matrix is possible to allow larger twist pitch for reducing ac losses and reduce eddy current losses simultaneously. The $J_{ct}$ values of 10 mm and 5 mm twisted tapes drop faster than that of untwisted and 20 mm twisted tapes under increasing magneticfield, especially in low field regime (0 $\sim$ 0.03 T). It suggests that weak links in the former are more serious than in the latter, which is in accordance with the microstructure analysis.
MOD 공정에 의해 제조된 YBCO 박막의 압력 의존성
Yoo, Jai-Moo,Chung, Kook-Chae,Ko, Jae-Woong,Kim, Young-Kuk,Wang, Xiao Lin,Dou, Shi Xue 한국초전도저온학회 2006 한국초전도저온공학회논문지 Vol.8 No.1
The growth properties of MOD-YBCO films were investigated. To enhance the growth rate of YBCO layer and inhibit the build-up of HF gas during the annealing process in TFA-MOD for YBCO coated conductors the method of low pressure annealing was employed. Total pressure was changed from 700Torr to 1Torr and its effect on growth of YBCO films was compared with atmospheric one. The lower Pressure was effective to control of the pore size in MOD method . Surface morphology of YBCO films processed at low total pres sure was rough and composed of random YBCO (103) grains. But large pores, usually observed at atmospheric process in MOD disappeared and also the number of pores was reduced at low pressure annealing. Also discussed ate the effects of Fluorine-free Y and Cu precursor solution on the development of microstructure. Dense surface me phology and with less and small pores can be provided through controlling Fluorine content.