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김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
이석종,전재복,김도원,정상립 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.4
목적 : Pityrosporum ovale는 지루피부염의 발생에 중요한 역할을 하며 이 친지성 진균은ketoconazole제재에 감수성이 있다고 알려져 있다. 이에 저자들은 두피에 사용하기 편리한 2% ketoconazole 샴푸로 지루피부염을 치료하여 그 효과를 확인하고자 본 조사를 실시하였다. 대상 및 방법 : 두피의 지루피부염 환자 52명에게 소양감의 정도를 설문조사하고 피부과 의사의 육안으로 인설의 양을 검사한 후 광학현미경 고배율하에서 진균학적 검사를 실시하였다. 결과 : 지루피부염 환자의 소양감과 인설의 양은 치료전에 비해 치료 2주와 4주 모두에서 유의하게 감소하였으며(p<0.05) 이들 환자에서 실시한 Pityrosporum ovale의 평균 포자수 역시 치료전에 비해 치료 2주와 4주 모두에서 유의하게 감소하였다(p<0.05). 결론 : ketoconazole 샴푸는 지루피부염의 임상 및 진균학적인 면 모두에서 치료효과가 있는 것으로 판단되며 간접적으로나마 Pityrosporum ovale가 지루피부염의 발생에 관여한다는 사실을 알 수 있었다. It is suggested that Pityrosporum ovale may play an important role in the pathogenesis of seborrheic dermatitis and this organism is sensitive to ketoconazole compound. So the efficacy of 2% ketoconazole shampoo in the treatment of seborrheic dermatitis was tested and was calculated by mean scores of scale, itching and yeast cells. We interviewed fifty two patients with seborrheic dermatitis about the degree of itching and examined with naked eyes the scale of scalp of them. In a group of the patients, mycological study of P. ovale was also performed by direct smear with 20% KOH solution containng 1 : 1 Parker-ink^R The results were as follows : As for itching and scale of the scalp, the scores were significantly decreased at week 2 and week 4 as the duration of treatment prolonged in comparison with that of week 0. The mean yeast cell score at the two points of time was also significantly decreased in comparison with that of week 0. There was no significant difference in the response from the view of age, sex and duration of seborrheic dermatitis. It is suggested that the shampooing with ketoconazole 2% shampoo every three other days gave a good result clinically and mycologically.
정상 인체 멜라닌세포 및 B-16 흑색종 세포주에서 상지(桑枝) 추출물의 티로시나제 활성 억제 효과에 관한 연구
송무현,황재영,박영립,황규왕 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background : Recently, the undesirable effects of UV exposure have been increasing because of destruction of ozone layer and excessive solar exposure in enjoying leisure. Therefore, the chance to have uneven skin pigmentations has been increasing. To keep away from the unwanted skin pigmentation, melanogenesis inhibitors have been developed for use in cosmetic preparations for the purpose of skin whitening. Plant extracts having an inhibitory effect in melanin synthesis may be a good choice as a cosmetic ingredient because they have relatively fewer side effects. Objective : In this study, the inhibitory effects of ramulus mori (young twigs of Morus alba L) on tyrosinase activity were investigated cultured normal human melanocytes and B-16 melanoma cells by using enzyme assay and RT-PCR. Methods : Tyrosinase activity was determined by spectrophotometry. The effects of whitening agents (kojic acid, arbutin, licorice extracts and ramulus mori extracts) on mushroom tyrosinase was compared by measuring the IC_(50), the concentration of the compound at which half of the original tyrosinase activity is inhibited. Normal human melanocytes taken from neonatal foreskin and B-16 melanoma cells, tyrosinase activity inhibition was measured by spectrophotometry. We observed tyrosinase volume in B-16 melanoma cells by using PT-PCR. Results : Ramulus mori extracts showed strong inhibitory effect on tyrosinase activity in both normal human melanocytes and B-16 melanoma cells. We also confirm that they have a inhibitory effect on tyrosinase expression in the RT-PCR. Conclusion : This study showed that ramulus mori extracts had strong inhibitory effect against tyrosinase activity. The results suggests that ramulus mori extracts can be used as a new whitening agent.
장재원(Jae Won Jang),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7
N/A Background: Systemic corticosteroids can arrest the progression of alopecia areata and lead to hair growth in a significant proportion of patients but may also cause unacceptable side effects. Objective: To minimize the side effects, we tried a new approach using minipulse therapy with betamethasone (CelestoneR). We performed a clinical observation of alopecia areata to understand its therapeutic responses. Method: Forty six patients with alopecia areata were given 3mg betamethasone as a single oral dose on 2 consecutive days per week. Therapeutic effects and side reactions were evaluated by dermatologists every month. Results: The extent of hair regrowth varied in different patients and even in different lesions in the same patient. Effective response, which shows vellus and/or terminal hair growth for more than 1 month, was achieved in 67.4% of the patients (31 cases). The side effects included acne in 14 patients, weight gain in 11 patients, gastrointestinal discomfort in 6 patients and facial flushing or edema in 5 patients; 19 patients had no side effects. Conclusions: Oral minipulse therapy with betamethasone seems to be an effective treatment modality to arrest the progression of alopecia areata and also induces hair regrowth. This modality of treatment had minimal and less severe side effects, compared with currently used pulse therapy with methylprednisolone. It deserves to be tried on a large scale to evaluate its advantages and disadvan-tages over the currently useful methods of treatment. (Korean J Dermatol 2001;39 (7) 775-781)