Antitumor therapeutic and antimetastatic activity of electroporation-delivered human papillomavirus 16 E7 DNA vaccines: a possible mechanism for enhanced tumor control.

Lee, In Hee,Park, Jae-Bok,Cheong, Minseon,Choi, Youn Seok,Park, Daehan,Sin, Jeong-Im Mary Ann Liebert, Inc 2011 DNA and Cell Biology Vol.30 No.12

<P>DNA vaccines are known to be lacking in immunogenicity in humans. Presently, electroporation (EP) is thought to overcome this limitation. Here, we investigate whether human papillomavirus 16 E7 DNA vaccines delivered by EP might elicit potent antitumor activity in animal cervical cancer models, with a focus on the underlying mechanism(s). Intramuscular (IM)-EP delivery of E7 DNA vaccines induced more potent antitumor therapeutic and antimetastatic activity compared with IM delivery. Moreover, the tumor-controlled animals by IM-EP possessed long-term memory responses to parental tumor cells. This improved antitumor effect was concomitant with augmented Ag-specific CTL activities. IM-EP also induced IgG and Th-cell responses higher than IM delivery. Finally, IM-EP resulted in more antigen production in and more attraction of immune cells into the site of DNA injection, suggesting that these biological and immunological changes made by IM-EP might be responsible for enhanced CTL activities and antitumor resistance. Thus, this study shows that IM-EP can induce more potent antitumor activity by augmenting CTL responses possibly through more antigen production in and more attraction of immune cells into the muscle sites. This study also suggests that IM-EP of E7 DNA vaccines might be a potential approach toward treating patients with cervical cancer.</P>

Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

DISCOVERY OF A FAINT QUASAR AT <i>z</i> ∼ 6 AND IMPLICATIONS FOR COSMIC REIONIZATION

Kim, Yongjung,Im, Myungshin,Jeon, Yiseul,Kim, Minjin,Choi, Changsu,Hong, Jueun,Hyun, Minhee,Jun, Hyunsung David,Karouzos, Marios,Kim, Dohyeong,Kim, Duho,Kim, Jae-Woo,Kim, Ji Hoon,Lee, Seong-Kook,Pak, IOP Publishing 2015 ASTROPHYSICAL JOURNAL LETTERS - Vol.813 No.2

<P>Recent studies suggest that faint active galactic nuclei may be responsible for the reionization of the universe. Confirmation of this scenario requires spectroscopic identification of faint quasars (M-1450 > -24 mag) at z greater than or similar to 6, but only a very small number of such quasars have been spectroscopically identified so far. Here, we report the discovery of a faint quasar IMS J220417.92+011144.8 at z similar to 6 in a 12.5 deg(2) region of the SA22 field of the Infrared Medium-deep Survey (IMS). The spectrum of the quasar shows a sharp break at similar to 8443 angstrom, with emission lines redshifted to z = 5.944 +/- 0.002 and rest-frame ultraviolet continuum magnitude M-1450 = -23.59 +/- 0.10 AB mag. The discovery of IMS J220417.92+011144.8 is consistent with the expected number of quasars at z similar to 6 estimated from quasar luminosity functions based on previous observations of spectroscopically identified low-luminosity quasars. This suggests that the number of M-1450 similar to 23 mag quasars at z similar to 6 may not be high enough to fully account for the reionization of the universe. In addition, our study demonstrates that faint quasars in the early universe can be identified effectively with a moderately wide and deep near-infrared survey such as the IMS.</P>

신뢰성 지수에 의한 위상최적화

임민규,박재용,황승민,오영규,박재용,한석영 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

The objective of this work is to integrate reliability analysis into topology optimization problems. The reliability index determines design domain and uncertainty value. The elemental sensitivity numbers are calculated from finite element analysis and then converted to the nodal sensitivity numbers in the design domain. A mesh-independency filter using nodal variables is introduced to determine the addition of elements and eliminate unnecessary structural details below a certain length scale in the design. To further enhance the convergence of the optimization process, the accuracy of elemental sensitivity numbers is improved by its historical information. Application of the RBTO model gives a different topology relative to DTO. It is found that the RBTO model yields more reliable optimal topologies than those produced by DTO.

심음간격의 분석을 이용한 부정맥 및 자율신경계통의 변화에 대한 연구

임재중 인제대학교 1993 仁濟論叢 Vol.9 No.1

Both left ventricular function and central nervous function assessments require the electrocardiogram which requires electrodes. If RSA can be obtained using heart sounds and a relationship can be established it would be a powerful diagnostic tool. The data were obtained from ten healthy males(age span20-35 years old). The subjects were seated in a chair against a wall where a red light was positioned in the subject's field of vision. Each subjects were asked to perform controlled breathing for 20 trials : 5 trials at each of four breathing rates (6,9,12, and 15 breaths per minute). During each trial three signnals were acquired from all subjects, i.e., the ECG, the heart valve sounds at the trachea, and a pneumogram. The TMS32010 high speed digital signal processing chip, TMS9900 controller, and 4K of on board memory were used to collect and process the data. Once a trial was complete and all of the data was in memory, all 200 files were processed and saved the various heart valve sound time interval parameters TBB, T11, T22, T12 for further statistical analysis(regression analysis and t-statistics). The R2 values for TBB, T11, and T22 are high as expected. Also, the estimates for β1 are close to 1 as expected. The results strongly suggest the existance of heart sound RSA. Further, they show a high correlation between the mean estimated heart periods from T11 and T22 are the mean estimated heart period from TBB. The peak to peak interval of the experimental heart sounds is close to the clinically useful LVET. This system would be capable of obtaining the individuals heart and respiratory rates, the condition of his central nervous system and the condition of his heart, however, a better recording system must be developed to insure reliable operation.

道路에 인접한 構造物이 汚染物의 空間分布에 미치는 影響

임제빈,정태섭,이재웅 全北大學校 附設 都市및環境硏究所 1995 都市 및 環境硏究 Vol.10 No.1

The purpose of this study is to estimate the spatial distribution of atmospheric pollutants due to the structure near the street. Especially, transport mechanism in complex area at the midtown district with the lofty buildings is complicated. So this study estimates spatial distribution of atmospheric pollutants according to the height of the building and the distance from the street. The results of this study are as follows. 1. If the building is stationed in the flat area, the flow of air mass near the building changes. The changing range of air flow is varied with the height of a building and the arrangement of a building. 2. The spatial distribution of atmospheric pollutants varied with the height of building. However, this rate of variation decreases with the increment of height. 3. The accumulation of atmospheric pollutants is higher at the front of the building than the rear of the building. This phenomenon is, however, reversed according as the structure becomes more distant from the street. 4. The highest concentration appeared at a distance from the front of the building in case of high building. 5. The concentration near the structure is decreased with the downwind direction. However the change is small. 6. The wind speed doesn't affect the spatial range of the high level concentration but has an effect on the concentration.

違法性阻却事由의 客觀的 前提條件에 관한 錯誤

임재호,문채규 安東大學 1987 安東大學 論文集 Vol.9 No.1

Das Irrumsproblem bezieht sich auf das Wesen des Tatbestandes und Vorsatzes, deshalb haben wir von ihren Wesen auf die Auflosung des Irrtumsproblems zu schlieBen zu versuchen. Nun aber da Tatbestand das Ganze der Verbotsmaterie ist, wir mussen alle Verbotsmaterie regulierenden Merkmale, es sei positives, es sei negatives, fur die Tatbestandsmerkmale halten. Strafrechtlicher Vorsatz ist nun aber inhaltlich rechtlicher Vorsatz od. Unrechts-vorsatz mit UnrechtsbewuBtsein. Es zeigt sich also, daB der Vorsatz bis an alle Verbotsmaterie(Unrecht) regulierenden Merkmale reichen muB. Mit anderen Worten, auch die objektiven Voraussetzungen der Rechtfertigungsgrunde als negative Tatbestandsmerkmale sind die Erkenntnisgegenstande des Vorsatzes. Der Irrtum uber die objektiven Voraussetzungen der Rechtfertigungsgrunde ist nach allem der Tatbestandsirrtum, und aufehebt den strafrechtlichen Vorsatz.

프랜차이즈 사업본사의 대위책임 : <MYSZKOWSKI v. PENN STEOUD HOTEL, Inc. 634 A. 2d 622(Pa. Ct. 1993)>

林載鎬 한국상사판례학회 2001 상사판례연구 Vol.12 No.-

One area of franchise law which has proven especially problematic is the allocation of tort liability for accidents caused by franchisees. To remedy this gap in the law, American courts have extended a traditional respondeat superior theory, that of vicarious liability for franchisors through the principles of agency rule. American courts have applied vicarious liability rule to the franchisor when franchisees are apparent agents. In this case, court didn't impose vicarious liability on the franchisor. Because in this Best Western-Penn Stroud relationship, there was neither master-servant relationship(or actual agency relationship) nor apparent agency relationship.

Adenosine 수용체 길항제인 플라보노이드 유도체의 3D-QSAR

임채욱,최세경,민지홍,유재학,임철부 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-

3D-QSAR of flavonoid derivatives as adenosine receptor antagonist was performed with the comparative molecular field analysis (CoMFA). Their activities were well correlated with their steric field, electrostatic field, and lipophilicities.

진행성파괴를 고려한 보강모래지반의 지지력에 관한 연구

임종철,이재열,홍석우 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

지지력에 관한 이론들이 조밀한 모래지반에서 동시파괴(전반전단파괴)가 발생한다고 가정하고 있다. 그러나, 본 논문에서 실시한 모형실험의 결과 조밀한 모래지반이라도 진행성파괴가 발생한다는 것을 알 수 있으므로, 지지력산정시 동시파괴에 의한 지지력계수가 아닌 진행성이 고려된 지지력계수를 사용하는 것이 중요하다. 본 연구결과에 의하면, 매트로 보강된 모래지반의 경우 근입깊이의 증가로 인해 지지력이 증가되는 요인과 흙과 매트의 마찰저항에 의해 지지력이 증가되는 효과 또한 지지력산정시 고려되어져야 한다. 그리고, 제안된 방법에 의해 계산된 값과 모형실험에 의한 결과를 비교하였다. In most of the theories about bearing capacit of footing, it is assumed that the general shear failure occurs in dense sandy ground. But, according to the test results of this study, progressive failure occurs in dense sandy ground also. So, in order to calculate bearing capacity, it is important to sue bearing capacity factor in which progressive failure is considered. By the results of this study, it is known that the effects of bedding depth and friction between soil and mat should be considered to get a bearing capacity of footing on the sandy ground reinforced by mat. And bearing capacity calculated by proposed method and test results are compared.