구후차단을 이용한 백내장수술시 진정 목적으로 사용한 Midazolam 과 Midazolam-Ketamine 의 비교

김진수,박종완,김일호,한찬수,김천숙,김유재,안기량 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.34 No.6

Background : Many ophthalmic procedures can be performed using a retrobulbar regional anesthetic technique. However, retrobulbar block is painful and most of patients express anxiety about the procedure. In addition, several life-threatening complications may occur. We compared the effects of midazolam and midazolam-ketamine as a sedative during retrobulbar block in cataract surgery. Methods : Thirty patients undergoing cataract surgery were randomly allocated into two groups, group I(n=15) was received midazolam and group II(n=15), midazolam-ketamine. Mean arterial pressure(MAP), heart rate(HR), and peripheral oxygen saturation(SpO2) were compared before administration of drugs and 1, 2, 3, 4, 5, 10, 20, and 30 min after administration of drugs. Patients' movement requiring restraint were also checked. In the recovery room, postoperative nausea and vomiting, recall, delirium and/or hallucinations, and ocular complications were recorded. Results : There were no significant differences in MAP and SpO2 between groups but heart rates were significantly increased at 1, 2, 3, 4, and 5 min than baseline in group II. Movement score was significantly lower in Group II than in Group I during the block(p<0.05). Recall during performance of the nerve block occured more often in Group I than in Group II(p<0.05). Conclusions : Low-dose midazolam-ketamine sedation sequence was superior to a midazolam technique regarding patients' movement and recall. (Korean J Anesthesiol 1998; 34: 1136∼1143)

자궁경부상피내종양의 치료에서 환상투열요법 (LLETZ) 시행 후 잔류병변의 예측인자

김용범,박노현,이철민,김재원,송용상,강순범,이효표,김성일,심순섭 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.3

목적: LLETZ(Large loop excision of transformation zone)는 자궁경부상피내종양(CIN)의 정확한 진단목적 뿐만 아니라 치료목적으로도 사용되고 있다. 그러나 LLETZ 후 자궁경부내 잔류병변의 가능성 및 예측인자에 대하여 명확히 밝혀져 있지 않기 때문에, CIN 치료 방법으로서 LLETZ의 안정성, LLETZ 시술 후 어떤 경우에 자궁절제술 등의 추가 치료를 실시할 것인가에 대하여 논란이 있다. 따라서 본 연구에서는 LLETZ시술 후 잔류병변 여부를 예측할 수 있는 관련인자들을 확인하고 절단면 양성의 임상적 의의를 알아보고자 하였다. 연구방법: 1993년 8월부터 1995년 7월까지 서울대학교 산부인과에서 LLETZ 시행 후 자궁절제술을 시행한 133명을 대상으로 임상기록을 검토하였다. 잔류병변 양성이란 자궁절제술 후 최종병리학적 소견에서 CIN이나 침윤암 등의 잔류병변이 확인된 경우로 정의하였고, 잔류병변이 없는 경우를 LLETZ를 통한 치료에 성공한 것으로 하였다. 잔류병변의 존재 여부에 연령, 병변의 등급, 절단면의 상태 등의 인자들이 관여하는지 확인하였으며, 통계학적 분석 방법으로 Student t-test, χ2 test와 Fisher's exact test를 사용하였다. 결과: LLETZ 후 자궁절제술을 시행한 환자의 85.7%(114/133)에서는 잔류병변이 없었으나 14.3%(19/133)에서 잔류병변이 발견되었고 이 중 미세침윤암이 3례에서 확인되었다. 잔류병변이 없는 환자군의 평균연령은 42.5세(27-71세)인 반면 잔류병변이 있는 환자군의 평균연령은 49.1세(33-72)로서 유의하게 높았다(p=0.005). LLETZ 후 조직검사에서 절단면 음성인 군에서 잔류병변이 발견된 경우는 9.6%(9/94)이었고 절단면 양성인 군에서 잔류병변이 발견된 경우는 25.6%(10/39)로서 두 군간에 유의한 차이를 보였다(p=0.032). LLETZ 후 조직검사에서 CIN II인 군과 CIN III인 군에서 잔류병변이 발견된 경우는 두 군에서 모두 14.3%(2/14, 17/119)로서 두 군간에 차이가 없었다. 결론: LLETZ 후 절단면 양성 여부가 잔류병변의 존재 여부와 일치하지 않는 경우가 많으며, 폐경 이후의 연령이 많은 여성이나, 절단면 양성인 경우 등 잔류병변 양성 가능성이 높은 환자의 경우에는 보다 철저한 추적관찰 혹은 광범위 원추생검술이나 자궁절제술 등의 보다 적극적인 치료가 고려되어야 할 것으로 사료된다. Objective: Large loop excision of transformation zone(LLETZ) is gaining popularity as an alternative to other ablative or cone methods for the treatment of cervical intraepithelial neoplasia(CIN). The optimal management of CIN after LLETZ, however, remains controversial and the reliable predictors of residual disease after LLETZ have not been consistently identified. This study was performed to identify factors to predict residual disease after LLETZ. Methods: From August 1993 to July 1995, 133 patients who received subsequent hysterectomy after LLETZ in Department of Obstetrics and Gynecology at Seoul National University Hospital were retrospectively reviewed. Residual disease was defined as positive findings of CIN or further advanced findings in hysterectomy specimen. The age of patients, the severity of disease and the status of resection margin(RM) were analyzed for predictive values of residual disease. The Chi-square test, Fisher's exact test and Student t-test were used for statistical analysis. Results: The residual disease after hysterectomy was negative in 85.7%(114/133) and positive in 14.3%(19/133). Among 19 cases with positive residual disease, 3 cases were revealed to be microinvasive cervical cancer. The mean age of patients with no residual disease was 42.5 years(range; 27-71) and that of patients with residual disease was 49.1 years(range; 33-72). Nine out of 94 cases(9.6%) with negative RM and 10 out of 39 cases(25.6%) with positive RM in LLETZ had residual disease. Two out of 14 cases(14.3%) with CIN II and 17 out of 119 cases(14.3%) with CIN III in LLETZ had residual disease. The success of LLETZ which means no residual disease was influenced by the age of patients(p=0.005) and the status of resection margin of LLETZ(p=0.032). Conclusion: The negative resection margin in LLETZ does not always guarantee that there is no residual disease. Close preoperative workup and more aggressive treatment plan(wide conization or hysterectomy) should be considered in patients who has higher possibility of positive residual disease such as old age and positive resection margin in LLETZ.

영역 특수적인 입장에서의 과학적 창의성에 대한 정의, 구성요인에 대한 탐색

임성만,양일호,임재근 경북대학교 과학교육연구소 2009 科學敎育硏究誌 Vol.33 No.1

본 연구는 창의성의 영역 특수적인 입장에서 과학적 창의성을 다룬 논문들을 내러티브 리뷰의 방법을 사용하여 탐색한 것이다. 창의성을 바라보는 2가지 입장 중에서 한 가지인 영역 특수적인 입장은 창의성에 대해 “그 아동이 얼마나 창의적인가?”라는 창의성의 일반적인 입장에서 “그 아동은 어느 영역에서 창의적인가”라는 영역 특수적인 접근방법으로 창의성을 바라보는 것이다. 이러한 관점에서 본 연구는 과학을 바라보았을 때, 과학적 창의성은 어떻게 정의될 수 있으며, 또 어떤 구성 요인들로 이루어졌는가를 탐색해 본 연구이다. 과학적 창의성 관련 논문들에 대한 리뷰를 통해 본 연구는 과학적 창의성은 과학적인 지식을 바탕으로 논리적이고 분석적인 사고를 통해 새롭고 적절한 것을 찾아내는 능력으로 정의할 수 있었으며, 과학적 창의성의 구성 요인은 정의적, 인지적, 환경적 요인으로 나눠 살펴본 결과, 영역 특수적인 관점에서 가장 두드러지게 차이를 보이는 과학적 창의성의 인지적 요인은 과학 관련 지식, 과학 탐구과정, 문제 발견력, 문제 해결력 등으로 구성되어짐을 알 수 있었다. 이러한 과학적 창의성에 대한 논의는 보다 과학적 창의성에 대한 실증적인 연구에 대한 좋은 길잡이가 될 것으로 사료된다. The purpose of this study is to identify a domain-specificity of the scientific creativity and the component of scientific creativity. Conducted from theoretical study, this study suggests that a domain-specific view of creativity offers a more useful and constructive components of scientific creativity based on the literature associated with the component of scientific creativity. Scientific creativity has a domain-specific component and so there is need to distinguish scientific creativity from creativity in general. As a result, scientific creativity is different from other creativity it is concerned with scientific knowledge, science process skill, creative scientific problem finding and solving and so on. And since scientific creativity is a kind of ability, it is possible to improve through a scientific creativity program.

지반분리계를 사용한 건물의 진동응답조절

정연경,예광일,김재웅 東亞大學校 建設技術硏究所 1999 硏究論文集 Vol.23 No.1

In recent years introduction of high strength materials has resulted in reduction of member sizes or building weight, which in turn caused buildings to be more flexible and more susceptible to aerodynamic action. Researchers have suggested and investigated the use of many control mechanisms for controlling the effects of seismic and wind loads on buildings. The use of base isolation systems to protect structures against earthquakes has attracted considerable attention in recent years. It is well recognized that flexible structures are sensitive to wind excitations. Also there have been questions raised concerning the sensitivity of base-isolated structures to wind loads. In this paper, vibration control effects and time history responses of base isolation system to wind load is studied. The wind velocity is supposed to be decomposed into mean and random fluctuating parts and can best be modeled by Monte Carlo digital simulations. A parametric study of effectiveness of isolation system with various main structures properties is carried out through the time-history analysis performed by central difference method.

효율적인 군 전직지원체제 정립 방안

정철영,고재관,황원채,윤희철,박가열,김재호,이성식,김동승,표성일,이건남,양안나,최수정,김은석 한국직업능력개발원 2008 직업능력개발연구 Vol.11 No.1

이 연구의 목적은 제대군인에 대한 효율적인 전직지원을 위해서 현행 전직지원 프로세스에 대한 개선 안과 이에 따른 국방부, 국가보훈처 등 제대군인 전직지원관련 기관 간의 역할분담 및 연계방안에 대해서 제안하는 것이다. 연구는 크게 세 가지 과정을 거쳤다. 첫째, 국내 군 전직지원 실태를 분석하여 문제점과 시사점을 도출하였다. 둘째, 이러한 문제점과 시사점, 군 전직지원 선행연구를 종합하여 효율적인 군 전직지원 프로세스 안을 제시하였다. 셋째, 구축한 군 전직지원 프로세스 안에 따라 주요 군 전직지원 관련 기관인 국방부, 국가보훈처의 역할 분담 안을 제안하였다. This study aims to suggest an improvement plan for the support process of effective occupation change for discharged soldiers and then role assignments among related institutions for supporting discharged soldiers such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor and the cooperation plan among the institutions. The study was made in three steps. First, after analyzing currents support facts and status for discharged soldiers, it induced its problems and implications. Second, integrating the findings of previous studies related to support plan on occupation changes for the discharged soldiers, Problems and implications mentioned above, it constructed effective occupation change process for discharged soldiers. Then, according to the established process, it suggested role assignments such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor.

뇌졸중 후 치매환자에서 도네피질(아리셉트^(?))이 인지기능 및 일상생활 수행능력, 삶의 질에 미치는 효과

이상열,장혁,송재은,조성옥,류정미,이미경,조진호,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1

Background: This study evaluated the efficacy of administering Donepezil(Aricept^(?)) for improving cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia. Methods: Patients(n=99; mean age, 69.89 years; 48.5% men) with post-stroke dementia, according to criteria of the DSM-IV and MRI, were treated with donepezil 5mg/day or 10mg/day during 24 weeks. They were examined using Mini-mental Status Examination(MMSE), Chinical Dementia Rating(CDR), Barthel Activities of daily living(B-ADL), Instrumental Activities of daily living(I-ADL), Short Form 36 Health Survey-Korean(SF-36-K), and Geriatric Depression Scale(GDS) at before treatment and 24 weeks after treatment. Results: The 97 patients completed the trial. At 24 weeks, they showed significant improvement in MMSE(p<0.001), CDR(p<0.001), B-ADL(p=0.002), I-ADL(p<0.001), and SF-36-K(p=0.003) except GDS(p=0.288). Donepezil was well tolerated. There was no withdrawal due to adverse events. Conclusion: This results demonstrate that donepezil was beneficial in improving the cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia and was well toleraetd.

복합 관동맥병변에서의 Rotational Atherectomy : 초기결과

김진우,박성욱,홍명기,이상곤,이일수,이철환,최기준,강덕현,송재관,김재중,박승정 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

Melittin Suppresses HIF-1α/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinama Cells

( Jae Moon Shin ),( Yun Jeong Jeong ),( Hyun Ji Cho ),( Kwan Kyu Park ),( Ii Kyung Chung ),( In Kyu Lee ),( Jong Young Kwak ),( Hyeun Wook Chang ),( Cheorl Ho Kim ),( Sung Kwon Moon ),( Wun Jae Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

OBJECTIVE: Melittin (MEL), a major component of bee venom, has been associated with various diseases including arthritis, rheumatism and various cancers. In this study, the anti-angiogenic effects of MEL in CaSki cells that were responsive to the epidermal growth factor (EGF) were examined. METHODOLOGY/PRINCIPAL FINDINGS: MEL decreased the EGF-induced hypoxia-inducible factor-1α (HIF-1α) protein and significantly regulated angiogenesis and tumor progression. We found that inhibition of the HIF-1α protein level is due to the shortened half-life by MEL. Mechanistically, MEL specifically inhibited the EGF-induced HIF-1α expression by suppressing the phosphorylation of ERK, mTOR and p70S6K. It also blocked the EGF-induced DNA binding activity of HIF-1α and the secretion of the vascular endothelial growth factor (VEGF). Furthermore, the chromatin immunoprecipitation (ChIP) assay revealed that MEL reduced the binding of HIF-1α to the VEGF promoter HRE region. The anti-angiogenesis effects of MEL were confirmed through a matrigel plus assay. CONCLUSIONS: MEL specifically suppressed EGF-induced VEGF secretion and new blood vessel formation by inhibiting HIF-1α. These results suggest that MEL may inhibit human cervical cancer progression and angiogenesis by inhibiting HIF-1α and VEGF expression.

Proteomic Analysis of Early Stage Placenta Derived from Cloned Cat Embryos

Jae-II Bang,Gautam Kumar Deb,Su-Jin Cho,Tae-Hyeon Kwon,Byung-Hyun Choi,A-Na Ha,Shukia Rani Dey,Il-Keun Kong 한국동물번식학회 2010 Reproductive & Developmental Biology(Supplement) Vol.34 No.2s

Proteomic Analysis of Term Placenta Derived from Cloned Cat Embryos

Jae-II Bang,Dong-Won Bae,Young-Sang Kwon,Hyo-Sang Lee,Xian-Feng Yu,Gautam Kumar Deb,Su-Jin Cho,Eu-Gene Choi,Tae-Hyeon Kwon,Byung-Hyun Choi,II-Keun Kong 한국동물번식학회 2009 Reproductive & Developmental Biology(Supplement) Vol.33 No.2s