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안재억 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2
The purpose of this study was the introduction and development of Health Management Information System(Computer Software Program) and data management. The results were as follows : 1. The Health Management Information System was already used at Korean Industrial Health Association, Soonchunhyang Hospital Health Management Center & Institute of Occupational Medicine, POSCO Health Care Center, Central Gil Hospital Health Management Center, Some commercial program (Junung, BIT, KIMS) was used at local clinic. 2. The first difficulty of development of Health Management Information System in many screening center was Computer Software Program. 3. altogether, Ministry of Labour, Korean Industrial Health Association, the Korean Society for Preventive Medicine, the Korean Society of Occupational Medicine have to make a good Health Management Information System(Computer Software Program) for epidemiologic study. 4. In order to use the health management information for epidemilogic study in the screening test, we have to make much discussion and need much suggestion from the Korean Society for Preventive Medicine and the Korean Society of Occupational Medicine.
신생아에서 자세 및 경사도에 따른 경피적 산소와 이산화탄소의 분압 및 경피적 산소 포화도의 변화에 대한 연구
이상주,이동환,박준수,박상철,안재억 순천향대학교 1992 논문집 Vol.15 No.2
To determine the optimal positino for the newborn, tcp02, tcpc02 and Sp02 were monitored, in 21 healthy term infants, in 21 healthy preterm infants and in those infants with respiratory disease using the Radiometer(Cophenhagen) TCM2 TC oxygen monitor, ECM 20 TC carbon dixide monitor and PULSOX-7(Minolta) oxygen saturation monitor in both supine and prone position. Also, monitored with tilting in each position. When the healthy preterm infants were prone, tcP02 rose by a mean of 5.8mmHg(p=0.0185), an increase of 8.7%, and Sp02 was not significantly increased by a mean of 0.6%(p=0.1859). In those infants with respiratory disease, tcP02 was not significantly increased by a means of 6.9mm/Hg(p=0.1014), and Sa02 was not significantly changed. There was no change of tcPC02 in all infants. This improved oxygenation in the prone position appears to be the result of enhanced ventilation/perfusion ratios. Tilting the body in a 20head-down, or 20 head-down partially produce significant change in tcP02, or Sp02 in the newborns. These findings may have important implications in the management of preterm infants requiring neonatal intensive care and the infants with respiratry disease.
체지방 측정기(Futrex-1000 body fat tester)로 측정한 소아의 체지방율에 관한 연구 : 학동기와 청소년기 아동을 대상으로
박상철,이동환,신상만,이상주,박준수,최석민,안재억 순천향대학교 1992 논문집 Vol.15 No.2
Using the infrared interactance(NIR method), the percentage body fat in 1,401 Korean children, aged 6-18years, was evaluated for normal and standard values. Correlation of percentage of body fat with age, weight, height, overweight(%), Kaup index and Rohrer index was also analyzed. The following results were obtained ; 1) In all the subject, weight and height showed standard growth(50-90 percentile) compared to growth data of korean children. 2) The percentage of body fat was decreased with increasing age and was measured higher in female than male. 3) The percentage of body fat was decreased with increasing height in both sex. 4) The percentage of body fat correlated negatively with age, heght, weight in both sex. In boys, the Rohrer index appeared to have a significant positive correlation with the percentage of body fat. (r=0.52454) In girls, the overweight(%) appeared to have a significant positive correlation with percentage of body fat. (r=0.56994) The Kaup index had no correlation with the percentage of body fat. This NIR method is safe, non-invasive, rapid, easy to use, and may be useful predict percentage of body fat, especially in the mass screening.
Cortical Hubs and Subcortical Cholinergic Pathways as Neural Substrates of Poststroke Dementia
Lim, Jae-Sung,Kim, Nayoung,Jang, Min Uk,Han, Moon-Ku,Kim, SangYun,Baek, Min Jae,Jang, Myung Suk,Ban, Byeolnim,Kang, Yeonwook,Kim, Dong-Eog,Lee, Ji Sung,Lee, Juneyoung,Lee, Byung-Chul,Yu, Kyung-Ho,Blac American Heart Association, Inc. 2014 Stroke Vol.45 No.4
<P><B>Background and Purpose—</B></P><P>A role of neural networks in the development of poststroke dementia has not been clearly established. We hypothesized that stroke-mediated disruption of subcortical cholinergic pathway or large-scale neural networks contributes to poststroke dementia.</P><P><B>Methods—</B></P><P>A matched case–control study was conducted in a predetermined cohort with acute ischemic stroke. Cases were defined as newly developed dementia diagnosed >3 months after stroke using the Korean Vascular Cognitive Impairment Harmonization Standards. Each case was matched to 2 controls for age, education, and initial stroke severity. The Cholinergic Pathways HyperIntensities Scale was applied with some modifications to characterize disruption of cholinergic pathways by acute stroke lesions. Involvement of major cortical hub locations of the default mode network, central executive network, and salience network was also investigated.</P><P><B>Results—</B></P><P>After matching, 38 cases and 66 matched controls were included. Cholinergic Pathways HyperIntensities Scale scores were significantly higher in cases than in controls (2.2±2.9 versus 0.9±1.4). Acute ischemic lesions affecting the default mode and central executive networks were more frequently observed in cases compared with controls (36.8% versus 7.6% and 26.3% versus 6.1%, respectively). These findings remained significant in the multiple logistic regression models adjusted for various sets of potential confounders. Lesion location analysis revealed that cases were more likely to have acute lesions in the left corona radiata, hippocampal formation, and posterior parietal cortex.</P><P><B>Conclusions—</B></P><P>Disruption of cholinergic pathways and major hubs of large-scale neural networks might contribute to newly developed dementia after acute ischemic stroke.</P>
김재필(Jae Pill Kim),최남수(Nam Su Choi),임성식(Sung Shick Lim),이상억(Sang Eog Lee),홍화정(Hwa Jung Hong),홍성표(Seong Pyo Hong),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim),박원도(Won Do Park),김영훈(Yeong Hoon K 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective: Acute Renal Failure is a clinical syndrome characterized by a sudden decrease in renal function which was previously normal. Despite advances in medical care, prognosis in ARF is variable according to the influence of demographic factors, severity of ARF, nature of disease causing ARF, coexisting disease, treatments applied, and complications. We studied the recent changes of clinical feature of ARF. Mcthods: We studied retrospectively 245 patients with ARF who had been hospitalized at Kyung Hee University Hospital between February 1988 and March 1993. Results: 1) Male to female sex ratio was 1.8:1, and the incidence was high in above fifth decade (67.8%). 2) Acute renal failure was classified, according to clinical background, into medical group 79.6% (195 cases) and surgical group 20.4% (50 cases), and oliguric group 40.8% (100 cases) and non-oliguric group 59.2% (145 cases). 3) Acute renal failure due to medical causes included ARF by hemorrhagic fever with renal syndrome (25.6%), drugs and chemicals (17.9%), sepsis (17.4%) and systemic infection (7.7%) etc. ARF due to surgical causes included ARF by multiple trauma (34%), various surgical procedures (30%), surgical sepsis (14%), burn (12%) etc. 4) During admission, the expired patients had more severe biochemical and clinical characteristics including high BUN and serum potassium (p<0.01), lower serum albumin (p<0,01) than those of survivor. 5) Infections as the cause of ARF were 107 cases (43.7%), which included hemorrhagic fever with renal syndrome 50 cases, sepsis 31 cases, urinary tract infection 7 cases and respiratory tract infection 6 cases etc. The most common infecting organism was Hantavizus (50.5%). There was a greater number of gram-negative organisms than gram-positive organisms (34.1% vs 9.9%). 6) The overall mortality rate in patients with ARF was 31.4Fo. The presumptive causes of death were underlying disease (59.7%) such as sepsis, acute poisoning, cardiogenic and hypovolemic shock, and respiratory failure (14.3%), hyperkalemia (9.1%), pulmonary edeme (6.5%), and metabolic aidosis (2.6%) in order of frequency. 7) The highest mortality rate was 42.6% in patients above 50 years old. Mortality rate in patients with ARF due to surgical causes (52.0%) was significantly high than that of medical causes (26.2%) (p<0.05). Among the expired patients, oliguric group was 72.7%. In conclusion, there have been major trends in the clinical features of acute renal failure in this study. Especially, significant increase in the number of elderly patients, non-oliguric patients, and medical causes such as hemarrhagic fever with renal syndrome or sepsis were observed. Survival rate significantly decreased with increasing age, in acute renal failure by surgical causes, in oligurie patients, and in the presence of complicating factors such as sepsis or shock.
Lee, Eun-Jae,Kim, Jong S.,Chang, Dae-Il,Park, Jong-Ho,Ahn, Seong Hwan,Cha, Jae-Kwan,Heo, Ji Hoe,Sohn, Sung-Il,Lee, Byung-Chul,Kim, Dong-Eog,Kim, Hahn Young,Kim, Seongheon,Kwon, Do-Young,Kim, Jei,Seo, Korean Stroke Society 2018 Journal of stroke Vol.20 No.2
<P><B>Background and Purpose</B></P><P> The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual’s mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. </P><P><B>Methods</B></P><P> This study involved a <I>post hoc</I> analysis of data from EMOTION (ClinicalTrials.gov NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke. Participants were classified into the Baseline-Blue (patients with baseline depression at the time of randomization, defined per the Montgomery-Asberg Depression Rating Scale [MADRS] ≥8) or the Baseline-Pink groups (patients without baseline depression). We compared the efficacy of escitalopram and predictors of 3-month PSD (MADRS ≥8) between these groups. </P><P><B>Results</B></P><P> There were 203 Baseline-Pink and 275 Baseline-Blue patients. The efficacy of escitalopram in reducing PSD risk was more pronounced in the Baseline-Pink than in the Baseline-Blue group (<I>p</I> for interaction=0.058). Several risk factors differentially affected PSD development based on the presence of baseline depression (<I>p</I> for interaction <0.10). Cognitive dysfunction was an independent predictor of PSD in the Baseline-Blue, but not in the Baseline-Pink group, whereas the non-use of escitalopram and being female were more strongly associated with PSD in the Baseline-Pink group. </P><P><B>Conclusions</B></P><P> Responses to escitalopram and predictors of PSD 3 months following stroke differed based on the presence of baseline depression. Our data suggest that PSD pathophysiology is heterogeneous; therefore, different therapeutic strategies may be needed to prevent PSD emergence following stroke.</P>
Lee, Eun-Jae,Oh, Mi-Sun,Kim, Jong S,Chang, Dae-Il,Park, Jong-Ho,Cha, Jae-Kwan,Heo, Ji Hoe,Sohn, Sung-Il,Kim, Dong-Eog,Kim, Hahn Young,Kim, Jei,Seo, Woo-Keun,Lee, Jun,Park, Sang-Won,Kim, Yun Joong,Lee, British Medical Association 2018 Journal of neurology, neurosurgery and psychiatry Vol.89 No.3
<P>Conclusion STin2 VNTR polymorphisms may be associated with poststroke neurological recovery after SSRI therapy. Further studies are needed to identify the role of serotonin in neurological recovery after stroke.</P>