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楊爾琳 단국대학교부설 중국연구소 1981 中國硏究 Vol.3 No.-
中共所以能占據中國大陸, 「統一戰線」(簡稱「統戰」)的運用占有極重要的地. 在統戰策略的運用方面, 文藝又是重要的統戰工具. 一九四二年五月, 毛澤東在延安的支藝座談會上, 就己作了明白的表示. 他說 : 中共的解放鬪爭有文武兩個戰線, 在文的文化戰線上, 文學和藝術是一個重要的有成就的部門. 事實上也是如此. 中共利用文藝, 確實是收到了全面的, 深入約, 難以고量的效果, 尤其是對於靑年.
최일용(IY Choi) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.12
과거에는 임부가 Lumbago를 Complain 하든지 둔부 또는 대퇴부의 Radiating pain을 complain 하드라도 의례히 분만하면 소실될 것이다라고 환자에게 말해 왔었다. 그러나 금번 문헌 ㅁ치 기타 조사를 통하여 임부의 pain complaints를 경하게 다룰 것이 아니라 과 로를 피하고 한정을 취해 보아도 pain이 경감 또는 소실되지 않으면 곧 정형외과전문의에게 정밀 한 진단을 받도록 권해야 겠다는 결론을 얻게 되었다.
홍인이(In Iy Hong),최수근(Soo Keun Choi) 한국조리학회 2014 한국조리학회지 Vol.20 No.1
The purpose of this study is to develop value-added functional gruel by adding fresh burdock & burdock powder. For burdock, we put fresh burdock (1.0, 2.0, 3.0, 4.0%) and burdock powder(0.3, 0.6, 0.9, 1.2%) into burdock gruel and get results from mechanical tests and sensory tests. Moisture content of fresh burdock gruel increased with more addition of fresh burdock, while burdock powder gruel had less moisture content as the addition of burdock powder increased. Lightness and pH decreased in both groups as more amount of burdock was added. From the result of an attribute difference test, 4% fresh burdock gruel showed the strongest burdock flavor and astringent taste. Among the burdock powder groups, the gruel added with 1.2% burdock powder scored the highest point in color intensity, graininess, savory taste, astringent taste, thickness and aftertaste. For overall acceptability, the gruel added with 3% fresh burdock scored the highest point and the gruel added with 0.6% burdock powder was the highest among the burdock powder groups. Based on the results of this study, the gruel added with 0.6% burdock powder and the gruel added with 3% fresh burdock were the optimum for their good characteristics and overall acceptability when produced.
HAN, SONG IY,HA, KWON-SOO,KANG, KWANG IL,KIM, HAN DO,KANG HO SUNG 부산대학교 유전공학연구소 2000 분자생물학 연구보 Vol.16 No.-
Upon exposure to elevated growth temperatures, mammalian cells exhibit a variety of cellular responses, such as the expression of heat-shock proteins (HSPs) and the activation of stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK). In this study, we show that heat shock transiently induces morphological change (cell elongation) and polymerization of actin, but not of microtubules, in human erythroleukaemic K562 cells. Pretreatment with actinomycin D or cycloheximede did not prevent the heat shock-induced cell elongation and actin reorganization, indicating that gene transcription and protein synthesis are not required for this phenomenon. The alterations in cell morphology and actin struture in response to heat shock were specifically inhibited by genistein, a tyrosine kinase inhibitor, but not by other kinase inhibitors, including tyrosine kinase inhibitors(herbimycin and tyrphostin) and protein kinase C inhibitors (staurosporin and H7). The activities of genistein-sensitive tyrosine kinase (GTK) and c-Src were enhanced by heat-shock treatment. In addition, a 75 kDa protein was highly phosphorylated in its tyrosine residues(s) by heat shock, and the phosphorylation was highly phosphorylated in its tyrosine residues(s) by heat shock, and the phosphorylation was prevented by genistein pretreatment. Genistein also inhibited the heat-shock- induced SAPK/JNK activation and HSP expression. In contrast, while colchicine, a microtubule-disrupting agent, was able to induce actin polymerization and SAPK/JNK activation, these events were not inhibited by genistein. These results suggest that the heat-shock-induced actin polymerzation. HSP expression, and SAPK/JNK activation may be mediated by the specific signal pathway involving GTK(s), while colchicine-induced actin polymerization and SAPK/JNK activation is regulated in a different manner.
Hong, Ran,Han, Song Iy The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.5
The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we examined the characteristics of gastric carcinoma (GC) cells under conditions of extracellular acidity and attempted to identify a means of enhancing treatment efficacy. Acidic conditions caused several changes in GC cells adversely affecting chemotherapeutic treatment. Extracellular acidity did inhibit GC cell growth by inducing cell cycle arrest, but did not induce cell death at pH values down to 6.2, which was consistent with down-regulated cyclin D1 and up-regulated p21 mRNA expression. Additionally, an acidic environment altered the expression of atg5, HSPA1B, collagen XIII, collagen XXAI, slug, snail, and zeb1 genes which are related to regulation of cell resistance to cytotoxicity and malignancy, and as expected, resulted in increased resistance of cells to multiple chemotherapeutic drugs including etoposide, doxorubicin, daunorubicin, cisplatin, oxaliplatin and 5-FU. Interestingly, however, acidic environment dramatically sensitized GC cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Consistently, the acidity at pH 6.5 increased mRNA levels of DR4 and DR5 genes, and also elevated protein expression of both death receptors as detected by immunoblotting. Gene silencing analysis showed that of these two receptors, the major role in this effect was played by DR5. Therefore, these results suggest that extracellular acidity can sensitize TRAIL-mediated apoptosis at least partially via DR5 in GCs while it confers resistance to various type of chemotherapeutic drugs.