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Michihiro Iwaki,Hideki Fujii,Hideki Hayashi,Hidenori Toyoda,Satoshi Oeda,Hideyuki Hyogo,Miwa Kawanaka,Asahiro Morishita,Kensuke Munekage,Kazuhito Kawata,Tsubasa Tsutsumi,Koji Sawada,Tatsuji Maeshiro,H 대한간학회 2024 Clinical and Molecular Hepatology(대한간학회지) Vol.30 No.2
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative disease concept to nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prognosis of patients with biopsy-confirmed MASLD using data from a multicenter study. Methods: This was a sub-analysis of the Clinical Outcome Nonalcoholic Fatty Liver Disease (CLIONE) study that included 1,398 patients with NAFLD. Liver biopsy specimens were pathologically diagnosed and histologically scored using the NASH Clinical Research Network system, the FLIP algorithm, and the SAF score. Patients who met at least one cardiometabolic criterion were diagnosed with MASLD. Results: Approximately 99% of cases (n=1,381) were classified as MASLD. Patients with no cardiometabolic risk (n=17) had a significantly lower BMI than patients with MASLD (20.9 kg/m2 vs. 28.0 kg/m2, P<0.001), in addition to significantly lower levels of inflammation, ballooning, NAFLD activity score, and fibrosis stage based on liver histology. These 17 patients had a median follow-up of 5.9 years, equivalent to 115 person-years, with no deaths, liver-related events, cardiovascular events, or extrahepatic cancers. The results showed that the prognosis for pure MASLD was similar to that for the original CLIONE cohort, with 47 deaths and one patient who underwent orthotopic liver transplantation. The leading cause of death was extrahepatic cancer (n=10), while the leading causes of liver-related death were liver failure (n=9), hepatocellular carcinoma (n=8), and cholangiocarcinoma (n=4). Conclusions: Approximately 99% of NAFLD cases were considered MASLD based on the 2023 liver disease nomenclature. The NAFLD-only group, which is not encompassed by MASLD, had a relatively mild histopathologic severity and a favorable prognosis. Consequently, the prognosis of MASLD is similar to that previously reported for NAFLD.
High thermal stable blue-emitting alkali silicate phosphor, Eu2+-activated Na2Mg2Si6O15
Masato Iwaki,Kazuma Sugimoto,Masaru Watanabe,Kazuyoshi Uematsu,Kenji Toda,Mineo Sato 한양대학교 세라믹연구소 2019 Journal of Ceramic Processing Research Vol.20 No.3
White LEDs based on near ultraviolet LED and red/green/blue phosphors have been attracted in terms of outstanding colorrendering index. In particular, we focus on the blue emitting phosphors because the commercial BaMgAl10O17:Eu2+ needs hightemperature in order to be obtained. In this study, we succeeded in synthesizing Eu2+-activated Na2Mg2Si6O15 phosphors asa single phase by the conventional solid state reaction. Eu2+-doped Na2Mg2Si6O15 phosphors showed the broad blue emissionfrom 400-550 nm due to the 4f-5d allowed transition of Eu2+ under the ultraviolet light excitation. Moreover, the emissionintensity of Eu2+-activated Na2Mg2Si6O15 phosphor at high temperature kept about 85% at 423 K, which indicated the thermalstability of Na2Mg2Si6O15:Eu2+ was extremely higher than that of other Eu2+-activated silicate phosphors. Thus, Eu2+-activatedNa2Mg2Si6O15 phosphor is able to become the novel luminescent material for White LED based on the near-ultraviolet LED.
Hyun Jin Kim,Nami Iwaki 현대영어교육학회 2008 현대영어교육 Vol.9 No.3
The study is intended to investigate the relationships among actual L2 competence and learner variables affecting L2 communication such as L2 communication anxiety, perceived L2 competence, and L2 willingness to communicate (WTC), and to investigate the role of L2 communication anxiety in biases in L2 self-perceptions in the Korean and Japanese contexts. Thirty-eight Korean students and thirty-nine Japanese students responded to the questionnaires measuring their L2 communication anxiety, perceived L2 competence, and L2 willingness to communicate, and participated in the oral task performance measuring their actual proficiency. The results of the study are as follows: there were correlations between communication anxiety and perceived competence in both groups of students; communication anxiety plays a role in biases in self-perception of L2 competence with Korean students, but not with Japanese students.
Nonalcoholic Fatty Liver Disease as a Systemic Disease and the Need for Multidisciplinary Care
Yoneda Masato,Kobayashi Takashi,Iwaki Michihiro,Nogami Asako,Saito Satoru,Nakajima Atsushi 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.6
Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, and there has been a rapid increase in cases worldwide. NAFLD is rapidly becoming the leading cause of hepatocellular carcinoma and is also associated with an increased risk of cardiovascular disease or exacerbation of other organ diseases, thus posing a significant health problem from both a medical and a socioeconomic perspective. NAFLD is a systemic disease and requires the involvement of numerous medical professionals. Multidisciplinary collaboration, in which different professionals within different specialties come together and work together toward a common goal, supports better patient care by integrating perspectives of multiple experts and facilitating the exchange of opinions. Due to the large number of potential patients, gastroenterologists and hepatologists cannot manage the patients alone, and collaboration between specialists in various fields, including family doctors, dentists, nutritionists, and pharmacists is required for treatment of NAFLD. This review will discuss NAFLD from the perspective of various specialties and introduce multidisciplinary collaboration.