양극성 장애 환자에 있어서 Tyrosine Hydroxylase 유전자의 VNTR 다형성

권용실,도규영,전태연,백인호 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

목 적: Tyrosine Hydroxylse는 대뇌 카테콜아민 합성에 관여하는 속도 제한 효소로서 양극성 장애의 주요원인 유전자로서 관심의 대상이 되고 있다. 이에 저자들은 tyrosine hydroxylse 유전자의 첫 번째 intron내 VNTR 다형성 부위와 양극성 장애와의 유전적 연관성을 알아보고자 본 연구를 시행하였다. 방 법: 115명의 양극성 장애 환자와 85명의 정상 대조군을 대상으로(TCAT) 반복 염기 서열을 포함하는 VN-TR 다형성 부위를 중합효소연쇄 반응을 이용하여 증폭한 후 유전자를 동정하였다. 분리된 4종류의 대립 유전자를(TCAT) 반복 횟수에 의한 다형성에 의거하여 각각 A : (TCAT)6, C ; (TCAT)7 C : (TCAT)a, 그리고 D : (TCAT)9로 나누어 대립유전자와 유전자형에 따른 빈도 차이를 비교하였고, 환자군을 가족력유무와 발병 연령에 따른 임상 아형으로 나눈 후 각 대립유전자의 빈도를 조사하여 비교하였다. 결과 1) 환자군과 대조군 사이의 대립유전자 비교에서는 환자군이 대조군보다 A형의 빈도가 유의하게 낮았고 D형의 빈도는 유의하게 높음을 보였다. 또한 유전자형에 따른 비교에서 BD형이 환자군에서 유의하게 높았다. 2) 환자군을 가족력 유무에 따라 가족력이 있는 군과 가족력이 없는 군으로 나누어 각각 및 대조군과 대립유전자 빈도를 비교하였을 때 가족력이 있는 군과 가족력이 없는 군 사이에서는 차이가 없었으나. 대조군과 비교시 가족력이 있는 군에서 A형이 유의하게 낮았고 D형이 유의하게 높은 빈도를 보였다. 3) 환자군을 발병 연령에 따라 조기 및 만기 발병 군으로 나누어 각각 및 대조군과 대림유전자 빈도를 비교하였을 때 조기 발병군이 만기 발병군에 비해 D형이 유의하게 높았고, 대조군과 비교시 조기 발병군 에서 A형이 유의하게 낮았고 D형이 유의하게 높은 빈도를 보였다. 결 론: 본 연구를 통하여 저자들은 TH 유전자 첫 번째 intron내의 VNTR 다형성 좌위가 양극성 장애와 유전적 연관이 있음을 추정할 수 있었으며, 특히 대림유전자 A형과 D형이 양극성 장애와 관련된 유전자로서 작용할 가능성이 있음을 알 수 있었다. Objectives :Tyrosule hydroxylase(TH) is a rate-limiting enzyme in the synthesis of catecholamines, and could be a candidate gene for causing the bipolar disorders. Therefore, we designed this study to investigate the association of the VNTR(variable number of tandem repeats) polymorphic locus in the first intron of the TH gene with bipolar disorders. Methods: We typed VNTR polymorphic region of the TH gene using PCR in 115 bipolar patients and 85 normal controls. Four types of alleles(A, B, C, D) were typed according to the difference of the repeat(TCAT)6-9 number. The frequencies of allele and genotype were compared between patients and normal controls, and in patients and normal controls allelic frequencies were compared respectively in terms of family history of affective disorders and age of onset. Results . 1) The allelic frequencies were significantly lower in type A, and significantly higher in type D in patient group compared to control. The genotype frequencies were significantly higher in type BD in patient group than in control group. 2) In comparing the allelic frequencies among patient group with and without family history and control group, there were no significant differences between groups with and without family history, whereas patient group with family history showed lower significance in type A and higher significance in type D compared to control group. 3) In comparing the allelic frequencies among patient groups with early onset and late onset and control group, patient group with early onset showed higher significance in type D than patient group with late onset and showed lower significance in type A and higher significance in type D compared to control group. Conclusions : The authors conclude that the VNTR polymorphic region of the TH gene might be associated with bipolar disorders, and type A and type D alleles might be susceptibility genes of bipolar disorder.

음악성 발달을 위한 음악놀이 프로그램에 관한 연구

김인실 聖潔敎神學大學校 社會科學硏究所 1998 社會科學硏究 Vol.5 No.1

AbstractThe purpose of this study was to examine the effects of the play-centered-musical education-program(hereafter PCMP), with reference to the improvement of children's creativity.The subjects in this study were sixty-five five year old kindergarten children(twenty -nine males and thirty-six females) and eighty-two seven year old first graders in elementary school(forty-three males and thirty-nine females). Subjects were randomly sampled and assigned to the PCMP according to age and sex. The program had sixteen sessions of 30-40 minutes for eight weeks.In order to monitor the effects of PCMP, tow kinds of measurement procedures were used: Measures of Creativity in Sound and Music(Wang, 1985) and Torrance Test of Creativity in Thinking-Figural Form A(Cho, 1983), both of which were translated and adapted by the researcher.In this experimental design of the study, the indepenent variable was PCMP, the intermediate variales were age and sex, the depennet variables were post-test score of musical creativity(fluency, imagination, originality), and general creativity(fluency, originality, elaboration, abstraction).The three-way MANCOVA and ANCOVA procedures in SPSS-PC were applied to test the hypotheses of this study.Major conclusions of this research are as follows: First, for the improvement of musical creativity, 1. In musical fluency, PCMP was found to be effective. However, there was no difference was noticed in the two classification of the children by age and sex. 2. In musical imagination, PCMP was more effective on five year old children than on seven year olds, and more on girls than on boys. 3. In musical originality, however, PCMO showed no difference among the children. Secondly, for the improvement of general creativity, 1. In general fluency, PCMP was more effective on seven year olds than on five year olds. 2. In general originality, five year olds were effected more by PCMP than seven year olds. 3. In general elaboration, all the children did not show improvement by PCMP. No noticeable sex and age differences were found. 4. In general abstraction, all the children showed generally identical improvement by PCMP, however, no noticeable sex and age differences. Finally, it was found that PCMP was effective in the development of general creativity of the children, as well as in the development of musical creativity, through the improvement of musical sensibility of the children.

英雄小設의 人物像比較硏究 : 三國志演義와 韓國英雄小設의 比較

梁仁實 건국대학교 1979 論文集 Vol.10 No.1

The purpose of the study consists in comparing and examining the images of a variety of heroes appearing in Samgukjiyuneui(삼국지연의), one of the old heroic Chinese novels, and in some Korean ones. The sketch of the study is as follows: 1.Although we cannot say exactly when the Chinese novel was introduced to Korea, we assume from some ancient relevant documents that it was brought to this country during the reign of king Seonjo XIV of the Yi Dynasty. In connection with this historical fact, it is to be noted that almost all out heroic novels made an appearance following the two great wars of the Imjin(임진) war (the Hideyoshi Invasion) and the Byungia(병자)war. The wars broke out about the same period of the king. The introduction of the Chinese novel and the appearance of the heroic novels in Korea are supposed to have some similarity with each other in timing. (connection) 2.But, the heroic image of Korean novels and that of the Chinese navel are quite different from each other, which deserves our keen curiosity and is well worth making a serious study of. 3.Strong in the sense of justice are such heroes as Yoobi(유비), Kwanoonjang(관운장) Changbi(장비), Chegalyang(제갈량), Chocho(조조), etc. appearing in the Chinese novel. That's why they are well depicted as the characters who act on their own judgement or will. 4.On the other hand, their Korean counterparts, namely Lim Kyungup(임경업), Yoo Choongyul(유충렬), Cho ung(조웅), and so on place the greatest priority on their being loyal to their rulers, which invites us to think that their personality is not clearly described and that they do not act on their own will, but on the orders of those whom they faithfully serve. 5.We also find in the Korean novels that the heroes' eventful life and some sensational happenings resulting from love affairs wind up with happy endings, whose motive is to emphasize entertaining elements and ideal aspects in the make-up of the works, without de-emphasizing the inherent images of the principal heroes. 6.The background for the images taken on by the heroes is to be found from the fact that the society of the Yi dynasty was characterized by the social morality based on confucianism. The mainstream of the then confucian thought was to establish absolute obedience toward kings as the standard of judgement in the feudal society. 7.We never read ancient heroic Korean novels without discovering that heroes make a fortune after serving the country (the king in particular) with great distinction, meet arid marry beautiful women and live in happiness. Such development often to be found in heroic novels of ancient Korea is motivated by the miserable circumstances under which the reading people were living. which the writers must have taken into consideration from the beginning. It is commonly acknowledged that anyone who succeeds in life after hard struggle can be happy, which is a note-worthy point in making up heroic novels in ancient Korea.

Natural products used as a chemical library for protein–protein interaction targeted drug discovery

Jin, Xuemei,Lee, Kyungro,Kim, Nam Hee,Kim, Hyun Sil,Yook, Jong In,Choi, Jiwon,No, Kyoung Tai Elsevier 2018 Journal of molecular graphics & modelling Vol.79 No.-

<P><B>Abstract</B></P> <P>Protein–protein interactions (PPIs), which are essential for cellular processes, have been recognized as attractive therapeutic targets. Therefore, the construction of a PPI-focused chemical library is an inevitable necessity for future drug discovery. Natural products have been used as traditional medicines to treat human diseases for millennia; in addition, their molecular scaffolds have been used in diverse approved drugs and drug candidates. The recent discovery of the ability of natural products to inhibit PPIs led us to use natural products as a chemical library for PPI-targeted drug discovery. In this study, we collected natural products (NPDB) from non-commercial and in-house databases to analyze their similarities to small-molecule PPI inhibitors (iPPIs) and FDA-approved drugs by using eight molecular descriptors. Then, we evaluated the distribution of NPDB and iPPIs in the chemical space, represented by the molecular fingerprint and molecular scaffolds, to identify the promising scaffolds, which could interfere with PPIs. To investigate the ability of natural products to inhibit PPI targets, molecular docking was used. Then, we predicted a set of high-potency natural products by using the iPPI-likeness score based on a docking score-weighted model. These selected natural products showed high binding affinities to the PPI target, namely XIAP, which were validated in an <I>in vitro</I> experiment. In addition, the natural products with novel scaffolds might provide a promising starting point for further medicinal chemistry developments. Overall, our study shows the potency of natural products in targeting PPIs, which might help in the design of a PPI-focused chemical library for future drug discovery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper provides <I>in silico</I> drug discovery strategy to identify natural products capable to inhibit the protein–protein interactions. </LI> <LI> The predicted PPI inhibitor-like natural products were validated in an in vitro experiment. </LI> <LI> The XIAP inhibitor LENP0044 could be used as a potent template for further chemical optimization. </LI> <LI> Natural products can be used as potent candidates in the design of a PPI-focused chemical library for drug discovery. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

Lee, Min-Woo,Chanda, Dipanjan,Yang, Jianqi,Oh, Hyunhee,Kim, Su Sung,Yoon, Young-Sil,Hong, Sungpyo,Park, Keun-Gyu,Lee, In-Kyu,Choi, Cheol Soo,Hanson, Richard W.,Choi, Hueng-Sik,Koo, Seung-Hoi Elsevier 2010 Cell metabolism Vol.11 No.4

<P><B>Summary</B></P><P>Endoplasmic reticulum (ER)-bound transcription factor families are shown to be involved in the control of various metabolic pathways. Here, we report a critical function of ER-bound transcription factor, CREBH, in the regulation of hepatic gluconeogenesis. Expression of CREBH is markedly induced by fasting or in the insulin-resistant state in rodents in a dexamethasone- and PGC-1α-dependent manner, which results in the accumulation of active nuclear form of CREBH (CREBH-N). Overexpression of constitutively active CREBH activates transcription of <I>PEPCK-C</I> or <I>G6Pase</I> by binding to its enhancer site that is distinct from the well-characterized CREB/CRTC2 regulatory sequences in vivo. Of interest, knockdown of CREBH in liver significantly reduces blood glucose levels without altering expression of genes involved in the ER stress signaling cascades in mice. These data suggest a crucial role for CREBH in the regulation of hepatic glucose metabolism in mammals.</P> <P><B>Highlights</B></P><P>► PGC-1α/GR activates CREBH expression under fasting or insulin-resistant conditions ► CREBH enhances hepatic gluconeogenesis via a CRTC2-dependent manner ► Depletion of CREBH in the liver ameliorates fasting hyperglycemia in diabetic mice</P>

대학생의 노인복지에 대한 인식도

차병준,김무룡,김기열,차경미,김귀희,김현실,서인선,임상규,이순자,위광복,남철현 慶山大學校 保健福祉硏究所 1999 保健福祉硏究 Vol.2 No.-

The purpose of this study is to grasp the change of consciousness of young people in order to seek new approach of policy for aged era. 1,200 students attending collages and universities in three small or medium sized cities were inquired for 2 months, from October 1 to November 30, 1996. The result is as follows. 1. The characteristic of the respondents of this survey is that they include 72.1% of women, 40.4% of people aged between 20 to 21, and 49.1% of people who do not have any religion. Those who are from big cities and those who are form farming villages or fishing village occupy equally 40.2%, those who reside in that cities for a long period 49.0%, and those who live with their family 60.9%. 2. The family feature of the subject is that 31.5% of them are those whose father is the age of 55 and more than 55, 10% of them are those whose mothers age is so, 33.1% of them have 5 family members, 29.5% of them have the family income of 1,000,000 to 1,490,000 won, 83.9% of them are from middle class, 47.7% of them are the people whose grand parents have passed away, 70.4% of them live apart from their grand parents, and 60.9% of them are second child. 3. 64.0% of males, 70% of respondents who are aged over 24, 58.1% of respondents who are from rural communities, 62.4% of respondents who live in rural area, and 58.3% of respondents who live alone, prefer to live with grand parents, marked higher rate than other groups. The groups whose father and mother are the age of more than 55 marked higher rate of 55.9% and 58% each than any other groups(p<0.05). The groups whose family member is less than three, whose grand parents both have passed away in middle class, who live with their grand parents, and who are second children, give more positive answers than any other groups. 4. Those who are older, who are buddhists, who are from rural area or live in rural area, whose family is small, whose family income is small, who are from lower class and whose grand parents are still alive, shows preference to support their parents after marriage. 5. Females(89.4%), those who are from small or medium sized cities(89%), who live with their family(85.6%), whose father is the age of 55 and more than 55, whose mother is the age of 54 and less than 54, whose family member is 6, who are from middle class, whose grandparents are still alive and who are the eldest child in their family, give more response that they prefer to live apart from their children in their old age than any other groups. 6. What elderly people need most right now is past time(42.3%), and the respondents whose age is 20 to 21, who are buddhists, who are from middle sized cities and live alone, whose parents are the age of more than 55, who have small family income, who live with their grand parents and who are second children show higher level than any other groups. 7. 76.8% of respondents answer that they do not need their parent's fortune, marked still higher rate than the opposite answer. Those who are older, who are buddhists, who are from big cities, who reside in rural area, who live alone and have smaller family, who are in bad family economic conditions and who live with grand parents present higher rate of positive response. 8. 59.3% of respondents reply that they think about death from time to time, and those who are female, who are in the age of 20 to 21, who are christian, who live with their family, whose siblings or other family members offer their education expenses show higher rate than any other groups. 9. 92.3% of respondents answer that the budget for welfare facility for elderly people is very small. The younger the respondents are and the worse economic condition they have among those who live in big cities, the more answered that. 10. 50% of respondents think social security should provide for their old age, and 42.8% of them believe they themselves provide against it. The respondence that social security ought provide for it appeared more among those whose age are over 24, who are female, who reside in rural area, who are christian, who are in bad economic condition, and who ever used medical institutions in recent one month, marked higher level than other groups. 11. The adequate time of retirement is 59.97±5.60 for public officers, the highest and 59.28±6.35 for teachers, the next. 12. 35.2% of respondents reply that the adequate budget for the old age after their retirement at the age of 60 is 220 million won, showed the highest level of respondence. 13. The factors which affect on the old people in the charged welfare facilities are sex(p<0.01), the type of housing(p<0.05) and whole family income(p<0.05). 14. The factors which affect on remarriage are sex(p<0.05) and religion(p<0.05). For varying old population and expanded welfare service for them, government and relevant authority should give more attention to secure the budget, establish effective plans to expand various program and the facilities for elderly people in order that elderly people spend the rest of life time more happily and more fruitfully. To do that, each college and university should open Health courses, and educate and inform about health and welfare.

구강암 세포주의 이소위 누드마우스 종양 모델

김종현(Jong-Hyun Kim),황영선(Young-Sun Hwang),김현실(Hyun-Sil Kim),남웅(Woong Nam),차인호(In-Ho Cha) 대한구강악안면외과학회 2009 대한구강악안면외과학회지 Vol.35 No.2

In order to make successful oral cancer treatment, we need to understand about tumor biology and effective chemotherapeutic agents. To achieve these studies, it is necessary to develope a proper in-vivo model. Therefore the author will make try to develop more improved animal model of more applicable in various method of cancer study. In this study, the author induced in-vivo tumorigenesis in nude mice by YD-10Bmod cell line used by YD-10B cell line originated from oral tongue squamous cell carcinoma and observed tumor formations and invasiveness of surrounding tissue, and found some results as follows : 1. The experimental group (YD-10Bmod, subcutaneous injection) produced tumors 13 out of 15 mice, while the control group produced none of 5 mice. 2. The inoculation of 1×106cells/mouse produced tumors 3 out of 5 mice and inoculation of 1×107cells/mouse, 2×107cells/mouse produced tumors in every 5 mice. 3. In the histopathologic studies, the inoculation of 1×106cells/mouse group showed the characteristic features of well-differentiated squamous cell carcinoma and demarcated expansile growth, while the inoculation of 1×107cells/mouse, 2×107cells/mouse group showed the expansile growth with partial central necrosis and invasive growth to surrounding fat & connective tissue. These findings suggest that atopic xenograft of YD-10Bmod cell line in nude mice has a improved productivity of tumors, produced tumors showed the characteristics feature of human tumor and invasive growth to surrounding tissue in histopathologic appearance. These atopic nude mouse model of tongue carcinoma might assist in studying oral cancer biology and effective choice of chemotherapeutic agents.

싱가포르 초등교사 양성과정의 다문화 교육과정 연구

최지연(Choi, Ji-Yeun),장인실(Chang, In-Sil) 경인교육대학교 교육연구원 2021 교육논총 Vol.41 No.3

본 연구는 싱가포르의 초등교사 양성기관에서 실시하는 다문화 교육과정 분석을 통해 한국의 다문화 교사교육과정에 주는 시사점을 모색하는 것을 목적으로 한다. 이를 위해 먼저, 다문화교육의 개념과 요소, 싱가포르 사회와 교육 특징, 싱가포르 교사 교육기관의 구성과 다문화교육에 대해 파악하였다. 또한 싱가포르 다문화 교사교육을 분석하기 위하여 싱가포르의 NIE가 제공하는 인문/자연계 학사 학위 프로그램에서 초등 일반과 모국어 과정에 제시된 교육과정을 분석하였다. 분석틀은 Banks(2009)의 다섯 가지 내용 체계(내용통합, 지식 구성 과정, 공평한 교수법, 편견 감소, 학생의 역량을 강화하는 학교 문화와 조직)을 기반으로 분석하였다. 분석 결과는 다음과 같다. 첫째, 싱가포르의 예비 교사들은 초등 일반 전공과 모국어 전공에 상관없이 모두 1-3학년 동안 필수 과목인 ‘다문화연구’ (multicultural studies)를 포함하여 매년 다문화 내용 체계가 포함된 수업을 수강하였다. 두 번째, 싱가포르의 다문화 교사양성기관에서 실행하고 있는 다문화교육 관련 수업들은 Banks의 다섯 가지 내용 체계를 모두 포함하고 있었다. 세 번째, 싱가포르의 다문화교육은 문화 및 인종 간 이해 교육뿐만 아니라, 모국어 중심의 이중언어교육을 강조하였다. 분석 결과에 근거하여 한국 교사양성기관에 주는 시사점으로 초등교사 양성과정에서의 다문화교육의 필수 과목 선정과 타 교육학 과목에서도 다문화교육 내용 체계를 포함하는 범 교과성, 이중언어교육의 활성화, 교육현장에서의 다문화 교육과 주지교과와의 내용 통합 그리고 교사를 위한 실용적인 다문화 교육 연수 필요성을 제시하였다. This study aims to find the implications of multicultural teacher education in South Korea by analyzing the multicultural teacher education of the National Institution of Education (NIE) in Singapore. To this end, this paper examined the teacher education system in Singapore and analyzed the multicultural teacher education statistically and content-wise using Bank s five contents of multicultural education. The results indicated that multicultural education in Singapore highlights not only education for racial and cultural understanding, but also bilingual education, which focuses on students mother tongue. Singaporean pre-service teachers can enroll in lectures that contain multicultural context, including the only essential course, multicultural studies, in every academic year regardless of their major. Additionally, the NIE provides multicultural content-related lectures which include all five components of Bank s multicultural contents. Thus, the implications for South Korea s teacher education systems are the following: The designation of multicultural education as an essential course, the invigoration of the bilingual education curriculum at the statal level, the integration of multicultural content with other education subjects in both teacher and student education, and the reinforcement of multicultural education workshops for in-service teachers.

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

한국 다문화교육의 연구동향 분석 : Bennett이론에 근거하여

장인실,차경희 안암교육학회 2012 한국교육학연구 Vol.18 No.1

Multicultural families have literally started to settle in Korea since the late 1980s, yet it was not until the middle of 2000 that multicultural education was actually arisen with its full-scale discussions. Domestic studies on multicultural education have now remarkably been conducted in various aspects and points of views, but with no certain level of collective and comprehensive analysis yet. To seek Korean way of finding out appropriate solutions to its multicultural society, a contemporary major trend in the world, it is necessary to keep developing the theory and practice in Korean multicultural education with constructive criticism over the development. In this thesis, the research trends and characteristics of Korea multicultural education are analyzed according to the three categories: the times of the study, the subjects of the study, and the themes of the study. The analysis of the study themes, in particular, is done based on the four core areas presented by Bennett: equity pedagogy, curriculum reform, multicultural competence, and societal equity. Furthermore, the analysis includes the five additional Korean sub-categories, which are also acquired in the process of our analysis of the thesis: multiculturalism, global multicultural education, counselling research, measurement development, and citizenship education, added to Bennett’s three sub-ones of each area. Overall, based on the analysis data, this study investigates further improvements and subsequent research themes in the following researches on Korean multicultural education. 한국에서 다문화가정이 정착하기 시작한 시기는 1980년대 후반부터이지만, 본격적으로 다문 화교육에 대한 논의가 시작된 것은 2000년대 중반 이후이다. 다문화교육에 대한 국내 연구 는 최근 들어 매우 다양한 각도에서 활발하게 진행되고 있지만 전체적이고 포괄적인 분석이 뒤따르지 않는 실정이다. 본 연구에서는 한국 다문화교육의 연구 동향과 특징을 파악하기 위하여 한국연구재단 등재와 등재후보 학술지에 게재된 다문화교육 관련 논문 302편을 분 석하였다. 분석은 시기별 연구동향, 연구범주 및 연구대상, 연구주제별로 실시되었다. 특히 연구주제 분석은 Bennett이 제시한 다문화교육의 네 가지 핵심 영역- 평등교육, 교육과정개 혁, 다문화적 역량, 사회정의-에 근거하여 이루어졌다. Bennett의 각 영역별 3개씩의 하위영 역 범주에 의한 논문 분석 과정에서 추가로 추출해낸 5개의 한국적 범주인 다문화주의, 외 국의 다문화교육, 상담연구, 척도개발, 시민교육이 추가되어 연구의 분석틀로 사용되었다. 마 지막으로 본 연구의 분석 결과를 바탕으로 한국 다문화교육 연구에 대한 제언을 탐색하였다.