흰쥐에서 Deferoxamine이 신 허혈 후 재관류에 의해 유발되는 신손상에 미치는 영향

배인수,정희창,박동춘 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.7

<i>In vitro</i> and <i>in vivo</i> evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition

Park, Dae Sung,Bae, In-Ho,Jeong, Myung Ho,Lim, Kyung Seob,Sim, Doo Sun,Hong, Young Joon,Lee, So-Youn,Jang, Eun Jae,Shim, Jae-Won,Park, Jun-Kyu,Lim, Han Chul,Kim, Han Byul Elsevier 2018 Materials Science and Engineering C Vol.91 No.-

<P><B>Abstract</B></P> <P>Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO<SUB>2</SUB>) and verify its efficacy by <I>in vitro</I> and <I>in vivo</I> assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO<SUB>2</SUB> stent, everolimus-eluting N-TiO<SUB>2</SUB> (N-TiO<SUB>2</SUB>-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO<SUB>2</SUB> film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO<SUB>2</SUB> deposition (37.0%). The platelet adhesion on the N-TiO<SUB>2</SUB> surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO<SUB>2</SUB>-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO<SUB>2</SUB>-EVL group compared to that in the BMS group. The results (BMS; 47.0 ± 11.00%, N-TiO<SUB>2</SUB>-EVL; 31.7 ± 10.50%, and EES; 29.1 ± 11.21%, <I>n</I> = 10, <I>p</I> < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO<SUB>2</SUB> deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-TiO<SUB>2</SUB> surfaces can help to reduce the platelet adhesion. </LI> <LI> In porcine model, N-TiO<SUB>2</SUB> everolimus decreased in-stent restenosis and fibrin deposition. </LI> </UL> </P>

五加皮의 造血 및 免疫調節效果에 대한 實驗的 硏究

任中根,徐榮培,金東熙,薛仁燦 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

In order to investigate the reinforcemental Effects of Acanthopanax Radicis Cortex about immunity and hematogenic action. The various immune responses were studied. The results were obtained as follows: 1. Positive cell was significantly increased at the 0.25 d r n P degree of density in the effect of CD4 about the spleen cell. 2. In the effect of IgG positive cell was significantly increased as comrared with the data of control only at the 0.25 mg/ml degree of density. 3. In the effect of Mac-1 positive cell was significantly increased in all treated degree of density. 4. In result of observing the change of WBC after Cyclophosphamide-processing the number of WBC was significantly increased in treated Group. 5. Measurement of RT-PCR in Hematopoietic stem cell TPO PCR products was increased as compared with medium at the 1 ㎛/ml degree of density. 6. In reinforcemental effect about Stem cell factor SCF PCR product was increased as compared with medium at the low degree of density. 7. In reinforcemental effect about IL-3 PCR product was increased as compared with medium at the low degree of density. 8. In reinforcemental effect about IL-6 PCR product was significantly increased as compared with all treated group. 9. Assay about positive cell in the spleen cell, the positive cell was significantly increased in CD4, CD19. 10. Created amount NO was treated group significantly increased all degree of density. 11. In promotional dissolution-effect, treated group was increased one and half times or twice all degree of density as compared with negative control. According to the above results, Acanthopanax Radicis Cortex increase coherence with T-cell by dint of activating CD of T-cell, presentate an antigen, activate IL-3, IL-6 which stimulate B-cell mading an antibody, activate IFN- y which appeal anti-viral activity by dint of activating macrophage, activate IgG which being made in B-cell neutralize Virus directly, increase immunity by means of promoting dissolution of Spleen cell which involve immune cell and strengthen hematogenic action by dint of activating TPO, SCF. Although Acanthopanax Radicis Cortex was used in retrogressional joint disease of deficiency syndrome by reinforcing Liver and Kidney, strengthening bones and sinews, because IFN- 7 which appeal anti-viral activity and IL-6 which almost appear in arthritis increased significantly, in future we should make an effort in looking into action of Acanthopanax Radicis Cortex about common cold by infection and arthritis of excess syndrome.

오차드그래스(Dactylis glomerata L.)의 품종에 따른 종자유래의 캘러스 형성률과, 캘러스 크기 및 식물체 재분화 효율의 비교

배은경,이인애,김기용,이병현,손대영,이효신,정민섭,조진기 Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

Comparison results of callus formation ratio from seed explants, callus sizes, regeneration ratios from callus and regeneration efficiency [calculated by following formular; callus formation ratio(%) × regeneration ratio(%)/100]for 27 ochardgrass (Dactylis glomerata L.)varieties imported and Hapsung 2 developed in Korea are as follows; 1. Among ochardgrass varieties showing more than 50% callus formation ratios, the descending order of callus formation ratio after bedding the seed explants for 4 weeks was 93>Sparta>Pizza>Condor>Lidaglo>Glorus>Hapsung2>Frode. 2. The callus sizes after bedding for 4 weeks were in the range of φ 0.43cm~4.2cm in which there was 10 times size difference between the largest one and the smallest one but most of them were between φ2.5cm~4cm. 3. The regeneration ratio from callus among varieties were in the range of 0~36% and descending order of the upper 6 varieties was Plano>Akimidori>Justus>Lidacta>Currie>Hall mark. 4. The regeneration efficiency which is calculated by the ratios of regeneration from seed explant numbers was between 0 to 17.4% among which Justus showed the highest value in the 4-week treatment. 5. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration efficiency were r=0.5765, r=0.6365 and r=0.6246, respectively in 4-week callus and all the correlations were significant on the 1% level. 6. In 6-week callus, the descending order callus formation ratios from seed sxplants for the best 6 varieties was Condor>Sparta>93M>Justus>Potomac>Lidaglo>Frode. 7. The callus sizes formed were between φ1.5~5.7cm in which Sparta, the largest one of φ5.7cm was five times larger than the smallest one. The callus size of the control variety. Hapsung 2 was φ3.8cm, which belonged to larger size. 8. Regeneration ratio showed a great deviation among varieties from 6-week old calli by showing from 0% to 100% in which all the calli were regenerated in Plano while no callus was regenerated in Juno, 9. The range of regeneration effciency was between 0~28% among varieties in which the values from 6-week callus treatment were larger than those from 4-week callus treatment. Especially, the value of Potomac in 6-week was 3 times larger than that in 4-week. 10. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration effciency were r=0.8369, r=0.6683 and r=0.5937, respectively in 6-week callus, and all the correlations were significant on the 1% level.

In_0.5(Ga_1-xAl_x)_0.5P/GaAs 이중 이종접합 구조의 Contactless Electroreflectance에 관한 연구

김정화,조현준,배인호,Kim, Jeong-Hwa,Jo, Hyun-Jun,Bae, In-Ho 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.2

Metal-organic chemical vapour deposition (MOCVD)법으로 성장된 $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs 이중 이종접합 구조의 특성을 contactless electroreflectance (CER) 분광법으로 조사하였다. CER 측정은 변조전압($V_{ac}$), 온도 및 dc 바이어스 전압($V_{bias}$)의 함수로 수행하였다. 상온에서는 5개의 신호가 관측되었는데, 이 신호들은 각각 GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$ 및 $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ 전이에 관련된 것이다. CER 스펙트럼의 온도 의존성으로부터 Varshni 계수 및 평탄인 자를 구하였다. 그리고 인가전압에 따른 신호의 진폭은 순방향 바이어스 전압 인가시 점차로 감소하나, 역방향 바이어스 전압 인가시에는 반대의 경향을 보였다. We have investigated the contactless electroreflectance (CER) properties of $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs double heterostructures grown by metal-organic chemical vapour deposition (MOCVD). The CER measurements on the sample were studied as a function of temperature, modulation voltage ($V_{ac}$), and dc bias voltage ($V_{bias}$). Five signals observed at room temperature are related to the GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$, and $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ transitions, respectively. From the temperature dependence of CER spectrum, the Varshni coefficients and broadening parameters were determined and discussed. In addition, we found that the behavior of the CER amplitude for the reverse bias is larger than that of the forward.

위암환자에서 수용성 Intercellular Adhesion Molecule-1의 의의

배진선,송인상,김완식 한국의학사 1999 診斷과治療 Vol.19 No.8

In_xGa_1-xN/GaN 다중양자우물 구조의 광학적 성질 연구

김기홍,김인수,박헌보,배인호,유재인,장윤석,Kim, Ki-Hong,Kim, In-Su,Park, Hun-Bo,Bae, In-Ho,Yu, jae-In,Jang, Yoon-Seok 한국진공학회 2009 Applied Science and Convergence Technology Vol.18 No.1

$In_xGa_{1-x}N$/GaN 다중양자우물 구조의 EL 특성을 온도와 주입전류 변화에 따른 특성을 조사하였다 저전류와 고전류 주입시 EL 효율의 온도 의존 변화는 매우 다르게 나타나는데, 이러한 온도와 전류의 변화에 의한 독특한 EL 효율의 변화는 내부전기장의 존재 하에 순방향 바이어스에 기인한 외부전기장의 영향인 것으로 볼 수 있다. 그리고 $In_xGa_{1-x}N$/GaN 다중양자우물 구조에서 In 성비의 증가는 발광파장위치의 적색이동을 보였다. 15K에서 주입 전류의 증가에 따라 녹색 양자우물 구조는 80 meV와 청색 양자우물 구조는 22 meV의 청색 편이를 하였다. 이는 전류의 증가에 의해 단위 시간당 생성되는 캐리어 수가증가하게 되고 그에 따라 subband가 급격히 채워지는 band filling 현상이 일어나게 되어 짧은 파장에서 재결합이 증가하기 때문이다. 그리고 청색과 녹색 다중 양자우물구조의 짧은 파장 쪽으로의 편이 차이는 In 농도에 기인한 것으로 In 농도가 높으면 양자우물 깊이가 증가되어 더 강한 양자속박효과가 작용하여 캐리어 구속력이 증가하기 때문 것으로 볼 수 있다. Temperature and injection current dependence of electroluminescence(EL) spectral intensity of the $In_xGa_{1-x}N$/GaN multi-quantum wells(MQW) have been studied over a wide temperature range and as a function of injection current level. It is found that a temperature-dependent variation pattern of the EL efficiency under very low and high injection currents shows a drastic difference. This unique EL efficiency variation pattern with temperature and current can be explained field effects due to the driving forward bias in presence of internal(piezo and spontaneous polarization) fields. Increase of the indium content in $In_xGa_{1-x}N$/GaN multiple quantum wells gives rise to a redshift of 80 meV and 22 meV for green and blue MQW, respectively. It can be explained by carrier localization by potential fluctuation of multiple quantum well and MQW structures also shows a keen difference owing to the different indium content in InGaN/GaN MQW.

노인에서의 외과 환자에 대한 임상적 연구

배진선,강민규,송인상 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

378 patients over 65 years old were reviewed, who were admitted during the period from June. 1. 1985 to December 31. 1988 in the Department of Surgery, Chungnam National University Hospital. The results were as followings: 1. The rate of patients over 65 years to all who were admitted during same period was 11.3%. 2. The number of male patients was 183, that of female 195, the overall ratio of male to female being 1:1.07. In benign diseases, that was 1:0.95, and in malignant diseases 1:1.26. 3. Hemoglobin value at admission was below 10.0gm% in 7.5% of patients with benign diseases and in 15.0% of patients with malignant diseases. 4. Serum albumin at admission was below 3.5gm% in 60% of patients with benign diseases and in 50% of patients with malignant diseases. 5. As to the distribution of benign diseases, disease in biliary system was most frequent(33%), followed by appendicitis(25%), ileus and trauma in jejunum and ileum(13%), and peptic ulcer(6%) in the order of frequency. 6. As to the distribution of malignant diseases, stomach cancer(51%) was most frequent, followed by colorectal cancer(25%), and hepatobiliary cancer(10%) in the order of frequency. 7. 47% of patients with benign diseases and 44% of that with malignant diseases had associated diseases, among which hepertension was most frequent, followed by lung disease, hearth disease, diabetes mellitus, liver disease and renal disease in the order of frequency. 8. Complications were most prevalent in the patients with hepatobiliary diseases, followed by appendicitis and colorectal cancer, and among complications, would infection was most frequent, followed by urinary tract infection and respiratory infection in the order of freguency. In the patients with colorectal cancer, mechanical lieus was second frequent complication after wound infection. 9. The mortality rate was highest in the patient with colorectal cancer(22.2%), followed by in those with benign biliary disease(10%), overall mortality rate being 4.3%. 10. Major causes of deaths were sepsis, respiratory failure, bile peritonitis and renal failure.

초어 및 백련의 종묘 생산에 관한 연구

金仁培 釜山水産大學校 1970 釜山水産大學 硏究報告 Vol.10 No.1

1970년 여름 부산수산대학 양어장에서 뇌하수체 및 Synahorin Hormone 주사에 의하여 초어와 백련을 채란 시키고 부화를 성취한 후, 이어서 산업적 규모로 종묘용 치어 생산을 하였다. 이 연구에 사용한 치어는 1963년 저자가 한국에서는 처음으로 도입한 치어로부터 육성시킨 것이다. 이 실험 연구를 통하여 다음과 같은 점을 파악 관찰하였으므로 이에 보고하는 바이다. 1. 1969년에 실시한 금(1970)의 결과와 비교하여 볼 때, 치어의 저밀도 수용고 철저한 영양 관리가 채란된 알의 부화를 가능케 하는데 일차적인 원인이 되었다고 생각된다. 2. 초어, 백련의 성숙은 기온이 낮으면 저수온의 영향으로 지연되는 것 같고, 금년에는 6월 과 7월초의 일기불순에 의하여 7월 중순에 이르러 채란 부화가 가능하였다. 그리고, 백련의 실험에 의하면 8월 중순, 하순에도 소량의 채란 부화는 가능했지만, 포란된 알의 감소 때문에 충분한 채란이 가능한 개체가 갑자기 감소하고 8월 말에는, 거의 없어졌다. 3. 백련의 채란용 친어지에는 다량의 잉어를 혼합하면 잉어의 습성에 의한 저토 교반으로 진흙 물을 만들고, 따라서 광합성 방해로 인한 식물성 Plankton 발생이 감소되어 먹이의 부족을 초래한다. 그러므로 다량의 잉어를 혼합하는 것은 좋지 못하다고 인정된다. 4. Hormone의 제1차 주사 후 채란될 때까지의 소요 시간은 수온 24℃기준으로 12-15시간 가량이 적당하며 그보다 시간이 많이 경과하여 채란한 알은 경과 시간과 더불어 부화율이 갑자기 저하하였다. 5. 부화시의 수류는 수량이 많은 것은 좋지만 수류가 너무 강한 것은 좋지 못하다고 인정된다. 6. 부화 직후의 자어는 수류가 약하고 수량이 많은 부화기에서는 2일간 더 수용하여 유영 능력이 있을 때 까지 관리 할 수 있지만, 수류가 비교적 강하고, 바닥이 좁은 원추형 부화기에서는 부화 후 즉시 자어망으로 옮기는 것이 좋다. 7. 녹색 Plankton이 발생하는 물속에서는 태양 광선이 쬐면 광합성으로 인하여 산소 과포화 상태로 되기 쉽고, 그러한 조건에서는 자어망 속의 자어는 쉽게 기포병에 걸리고 대량 폐사를 한다. 그 예방책으로는 맑은 물을 주입시켜 물을 유통시키든가, 황토 흙 진흙 물을 유입시켜 광선의 수중 투과를 막으면 효과가 있다. Aeration에 의한 과포화 기체의 축출은 충분한 효과를 내지 못하였다. 8. 초어의 초기 치어의 천연 사료로서는 식물성 Plankton은 적합하지 못하였고, 동물성 Plankton인 Daphnia류 등이 적당하였다. 인공 사료로서는 등겨, 밀가루, 어분 등을 배합한 것, 유추용 사료등이 적당하다고 인정되었으며, 이러한 사료를 너무 많이 주면 과식으로인하여배가 터져서 죽는 것이 많이 생겼다. 9. 백련 치어는 실험실 수조 내 실험에서는 식물성 Plankton 단독으로 잘 성장하는 것을 관찰했지만, 치어지에서의 적용은 앞으로의 야외 비교 연구가 필요하다. 10. 초어 치어는 쫓으면 다수 밀집하여 바닥의 발자욱등 구석진 곳에 모이는 습성이 있으므로 그물로 잡은 때는 끌고 간 흙으로 이들 밀집한 치어를 묻는 일이 있으므로 주의를 요한다. 11. 여름철 백련 치어지에 그물질을 하면, 잡은 치어는 물론 못에 남은 치어도 대량 폐사하는 일이 있으므로 이에 관한 주의를 요한다. 12. 포획한 치어를 축양하는 동안 세균병의 1종인 Columnaris병에 의하여 대량 소모를 당하는 일이 있었는데, 그 방지책으로는 Furan계 약품이 효과가 있었고, 특히 Furanace(p-7138)는 특효가 있었다. 일반 정수지에 수용하면 Columnaris에의한 폐사는 곧 중지되었으나, 유수지에서 고밀도로 축양했을 때는 이 병의 발생이 심했다. During the summer of 1970, a series of experiments on the propagation of Chinese carps was carried out using the induction of spawning by hypophysation at Pusan Fisheries College ponds. As a result of this experiment a number of fingerlings were produced and distributed tolocal farmers. The adults used for this experiment were first transplanted in Korea in 1963 from Japan and reached maturity. The following are some important aspects for consderation in future work of this kind: 1. In comparison with a previous experiment (Kim,1970) carried out in 1969, successful egg development was apparently the result ofthe good health of the egg bearing adult fish. 2. It appears that the maturation season was postponed by low water temperature in June and early July of this year, and thus it was possible to induce spawning in the middle of July. In an experiment carried out on silver carp, eggs greatly degenerated by the middle of August, even though some egg taking and hatching was possible by the end of August. 3. Because of the digging behavior of the common carp and the resultant muddy water, combining a large number of the common carpwith the silver carp adults should be avoided. Muddy water reduces water blooming causing a food shortage for the silver carp. 4. At a water temperature of 24℃, about 12- 15 hours elapsed between the 1st pituitary injection and spawning, and generally the eggs spawned at this time developed into larvae. Eggs spawned at a later time reach a higher mortalty during their development, and finally the whole eggs spawned very late are subject to 100% mortality. 5. Water should be abundantly supplied tothe incubator, but a water current which is too strong should be avoided. 6. For the larval development, holding of hatched fry in the incubator for two days may be recommended when the water current is gentle, but in the case of a conical incubator with a stonger current the fry should be transfered into the fry net cage right after hatching. 7. The early fry kept in water where planktonic algae grow rapidly in daylight, become gas-diseased easily due to an over-saturation of oxygen produced by the photosynthesis of the growing algae. To prevent gas disease of the fry anf ample amount of fresh clean water should be supplied. Muddy water also prevents gas disease by reducing sunlight penetration of the water. Aeration with several air stones, however, did not completely prevent this disease. 8. As tothe natural food for fry and early fingerlings of grass carp, the planktonic algal food alone did not produce a good result for an even and healthy growth, but the fry stocked in a pond with a heavy growth of zooplankton, mainly Daphnia and related species, grew very quickly and evenly. 9. Silver carpfry kept in an aquarium with phytoplankton alone grew normally and there was not much difference when co,pared with those fed with zooplankton. 10. In the case of catching grass carp fingerlings, they gather in numbers in pond corners or bottom foot print holes, etc. and often may be burried by bottom mud conveyed in the movement of the hauling seine, therefore, care should be taken when seining in muddy ponds. 11. Catching silver carp fingerlings by seining during the hot summer season may kill many fish to include not only those caught in the net but also those left in the pond. 12. While holding fingerlings in a small pond for distribution or restocking during the hot summer season, many fish were attacked by columnaris disease and died, A nitrofuran drug, Furanace(P-7138) proved to be very effective in preventing and curing this disease even when a 0.05 ppm concentration was used in the holding pond. The columnaris disease may be prevented by stocking the diseased fish in a stillwater pond, but when the fingerlings are held in a small running water pond the disease rages uncontrolled if not treated.

19세기 刑政風俗圖에 나타난 형벌의 특징에 관한 고찰

차인배(Cha In-bae) 한국역사민속학회 2014 역사민속학 Vol.0 No.44

19세기 풍속화가로 알려진 金允輔와 金俊根이 그린 형정풍속화가 ≪형정도첩≫과 <기산풍속첩> 등에 전하고 있다. 이들 형정풍속화는 범죄 단속, 처벌, 고문, 재판 등 다양한 형정에 관한 내용을 담고 있어 조선시대 법전에 기록된 형정 내용을 시각적으로 확인할 수 있다. 특히 이들 가운데 일부는 기존의 문헌에서도 찾아볼 수 없는 독특한 형벌체계를 소개하고 있어 형정연구에 대한 충분한 자료적 가치를 지니고 있다. 본 논문에서는 기존의 형정과 형벌에 관한 연구 성과를 토대로 형정풍속도를 조명해 보고자 한다. 19세기에 활동했던 김윤보와 김준근의 형정풍속도를 종합적으로 수집ㆍ분석하고, 개별 그림의 내용을 기존 형정에 관한 연구 성과와 비교 고찰해보고자 한다. 이를 위해 두 풍속화가의 형정풍속도를 오형ㆍ고문ㆍ사회범죄 등 몇 가지 형벌체계로 분류한 후, 그림내용의 내용을 분석해 각각의 특징을 고찰하고 그 공통점을 통해 당대의 형정의 특성을 고찰하였다. 또한 각론에서는 기왕에 알려진 형정에 관한 내용과 그림 묘사의 비교를 통해 그 집행 과정과 내용을 보다 면밀히 고찰함으로써 역사적 사실에 접근하고자 하였다. Genre paintings depicting scenes of penal administration by Yun-bo Gim and Jun-geun Gim are included in the Hyeongjeong docheop (Album of Genre Paintings Depicting Scenes of Penal Administration) and Gisan pungsok docheop (Album of Gisan’s Genre Paintings), respectively. These genre paintings depict various scenes of penal administration including crime enforcement, punishment, torture and trial, allowing visual confirmation of contents of penal administration that was recorded in the legal codes of the Joseon Dynasty. In particular, some of the paintings have significant value in respect of research on penal administration as they introduce unique punishment systems that are not found in existing literature. In existing studies on the penal administration of the Joseon Dynasty, genre paintings were undervalued, only used as supplementary visual material to help understanding of penal administration. Although some of the paintings were exaggerated due in part to commercial purposes, the genre paintings realistically reflect the penal administration of the time to such an extent as to even depicting trivial customs of the executor that could not be ascertained in literature. Thus, this paper classified the genre paintings of the two painters by several punishment systems, examined the each of their characteristics through the differences in the content of the paintings, and studied the characteristics of the penal administration of the time through their similarities. Moreover, in each section, the paper sought to approach historical truths by thoroughly studying the process and content of execution by comparing and contrasting the details of the paintings with the existing knowledge on penal administration.