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Hyunhee Kim(Hyunhee Kim),Jaebum Lee(Jaebum Lee),Heejung We(Heejung We) J-INSTITUTE 2022 International Journal of Human & Disaster Vol.7 No.2
Purpose: This study was analyzed with a qualitative research method by applying a phenomenological method to examine the experiences and perceptions and attitudes about health care of workers participating in rehabil-itation exercises after suffering an industrial accident while working in the K automobile manufacturing industry in Korea. Method: As for the selection of research participants, a total of 12 participants were selected as the final research participants, including 1 female and 11 male, who could provide a wealth of information on the subject of the study. For data collection and analysis, Colaizzi's six-step analysis method was used to identify the partic-ipants' experiences and cognitive changes who participated in the rehabilitation program. Also, the participants' facial expressions and actions were recorded so that they could be used as additional observational data and reflected in the results of further research. Results: As a result of the study, 5 categories, 13 topic collections, 32 topics, and 97 construct meanings were finally confirmed. Specifically, the importance of strengthening the intrinsic motivation of the participants was emphasized in order to continuously practice health promotion after an industrial accident in the automobile manufacturing industry. In addition, it appears that a method of self-awareness of the necessity of exercise, giving fun of the complex program, and preventing and managing it in daily life is needed. Conclusion: The contents derived from the results of this study represent the changing perception of workers toward continuous health promotion management and improvement after an industrial accident. Through the research results, it was an opportunity to confirm the changing perception of health care among workers, and it is expected to be actively used in the future by developing rehabilitation exercise programs at the workplace in the automobile industry.
Hyunhee Lee,양성태,신송엽 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.9
Although Trp-rich antimicrobial peptides (TRAMPs) such as tritrpticin and indolicidin exert potent antimicrobial activity, they have several drawbacks in therapeutic application, such as low cell selectivity and strong hemolytic activity. Here, we designed α-helical TRAMPs with symmetric amino acid sequences based on pseudo-symmetric tritrpticin and indolicidin. Compared with the parental pseudo-symmetric TRAMPs, the symmetric α-helical TRAMPs were highly effective against Gram-positive bacteria, including clinically isolated methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. The symmetric α-helical TRAMPs exhibited negligible or very low toxicity against mammalian cells, including human erythrocytes. The symmetric peptides caused a rapid collapse of bacterial membrane potential and destabilized negatively charged lipid membranes, indicating that they act on the bacterial cytoplasmic membrane as a primary mode of action. Taken together, these findings imply that symmetric TRAMPs with an α-helical structure offer significant potential for development as novel therapeutics to overcome the problem of antibiotic resistance in Gram-positive pathogens.
Exploiting Replicated Cache Blocks to Reduce L2 Cache Leakage in CMPs
Hyunhee Kim,Jung Ho Ahn,Jihong Kim IEEE 2013 IEEE transactions on very large scale integration Vol.21 No.10
<P>Modern chip multiprocessors (CMPs) employ large L2 caches to reduce the performance gap between processors and off-chip memory. However, as the size of an L2 cache increases, its leakage power consumption also becomes a major contributor to the total power dissipation. Managing the leakage power of L2 caches, therefore, is an important issue in realizing low-power CMPs. In CMPs with private L2 caches, each processor makes a copy of the data in its local cache in order to access the data faster, which is called replication. In this paper, we propose a novel leakage management technique that dynamically turns off replications in private L2 caches for leakage power reduction by exploiting two key observations: 1) the cost of an extra cache miss due to the turned-off replication is small because the same cache block exists in another on-chip cache and 2) turning off the replication incurs no extra cache miss if it is invalidated by other processors in order to maintain cache coherence. Since blindly turning off the frequently accessed replications can degrade performance, the proposed technique dynamically controls the number of turned-off replications. The proposed technique can be implemented by slightly modifying the MESI protocol with a new turned-off shared (TOS) coherence state. The TOS state indicates that the corresponding block is shared by other caches but turned off. Experiments on a four-processor CMP with private L2 caches show that the proposed technique reduces the energy consumption of the L2 caches and the main memory by 19.4% on average, with less than 1% performance loss over the existing cache leakage management technique.</P>
Multi-UIs for differently aged user groups
Hyunhee Jung,Jaemyoung Kim,Hong-In Cheng 한국디자인지식학회 2007 한국디자인지식학회 Conference Vol.2007 No.8
Mobile phone has become essential necessaries and various new phones with new design and function are manufactured. Especially differently aged user groups have been studied and their features and behaviors are applied to design better interfaces for mobile phones. However no cellular phones have had multiple interfaces yet. We surveyed and interviewed several users from different aged user groups and found their requirements to suggest multi-UIs. Multi-UIs are classified into general UI, simple UI, silver UI, and teenage UI.
Effects of Tamoxifen at Different Concentrations and Treatment Periods on Proliferation of HeLa
Hyunhee Kim,Gyesik Min 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
This study examined the effects of tamoxifen at different concentrations and treatment periods on proliferation of a human cervical cancer cell line, HeLa. As in the previous studies, Estrogen did not have an effect on the cellular proliferation at low concentrations but significantly reduced proliferation at high concentration (5 ug/ml) based on MTT assay. Treatment with tamoxifen had similar effects. It did not have any significant effect on the HeLa cell proliferation at low concentrations, but significantly reduced proliferation at high concentration (10 uM). In addition, combined treatment with both estrogen and tamoxifen did not alter the inhibitory effects of either estrogen or tamoxifen on cellular proliferation. The inhibitory effects by tamoxifen on HeLa cell proliferation did not differ among different treatment periods. This suggests that tamoxifen may exert anti- proliferative effects at high concentration but does not have synergistic or antagonistic effects against estrogen on HeLa cell proliferation.
Cytoplasmic molecular chaperones in Pseudomonas species
Hyunhee Kim,Seongjoon Moon,Soojeong Ham,Kihyun Lee,Ute Römling,Changhan Lee 한국미생물학회 2022 The journal of microbiology Vol.60 No.11
Pseudomonas is widespread in various environmental and host niches. To promote rejuvenation, cellular protein homeostasis must be finely tuned in response to diverse stresses, such as extremely high and low temperatures, oxidative stress, and desiccation, which can result in protein homeostasis imbalance. Molecular chaperones function as key components that aid protein folding and prevent protein denaturation. Pseudomonas, an ecologically important bacterial genus, includes human and plant pathogens as well as growth-promoting symbionts and species useful for bioremediation. In this review, we focus on protein quality control systems, particularly molecular chaperones, in ecologically diverse species of Pseudomonas, including the opportunistic human pathogen Pseudomonas aeruginosa, the plant pathogen Pseudomonas syringae, the soil species Pseudomonas putida, and the psychrophilic Pseudomonas antarctica.